P06151

PR
Gene name
Ldha (Ldh-1, Ldh1)
Protein name
L-lactate dehydrogenase A chain
Names
LDH-A, LDH muscle subunit, LDH-M
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:16828
EC number
1.1.1.27: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-47 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P06151

Entry ID Method Resolution Chain Position Source
AF-P06151-F1 Predicted AlphaFoldDB

14 variants for P06151

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388906225 42 K>N No EVA
rs3388895304 58 L>H No EVA
rs3388911732 100 Q>H No EVA
rs3388915183 103 G>R No EVA
rs3388912441 105 S>R No EVA
rs3388912484 106 R>P No EVA
rs3388891242 178 L>P No EVA
rs241968661 183 L>M No EVA
rs3388909958 203 G>D No EVA
rs3388909895 204 V>M No EVA
rs3388886437 210 S>F No EVA
rs3388910145 233 Q>L No EVA
rs3388910070 243 K>R No EVA
rs3388906302 266 N>H No EVA

No associated diseases with P06151

3 regional properties for P06151

Type Name Position InterPro Accession
domain Lactate/malate dehydrogenase, N-terminal 22 - 160 IPR001236
active_site L-lactate dehydrogenase, active site 190 - 196 IPR018177
domain Lactate/malate dehydrogenase, C-terminal 164 - 324 IPR022383

Functions

Description
EC Number 1.1.1.27 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
oxidoreductase complex Any protein complex that possesses oxidoreductase activity.
sperm fibrous sheath A cytoskeletal structure surrounding the axoneme and outer dense fibers of the sperm flagellum. Consists of two longitudinal columns connected by closely arrayed semicircular ribs that assemble from distal to proximal throughout spermiogenesis. The fibrous sheath probably influences the degree of flexibility, plane of flagellar motion, and the shape of the flagellar beat.

5 GO annotations of molecular function

Name Definition
identical protein binding Binding to an identical protein or proteins.
kinase binding Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group.
L-lactate dehydrogenase activity Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+.
lactate dehydrogenase activity Catalysis of the reaction: lactate + NAD+ = H+ + NADH + pyruvate.
NAD binding Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.

7 GO annotations of biological process

Name Definition
cellular response to extracellular stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.
glucose catabolic process to lactate via pyruvate The anaerobic enzymatic chemical reactions and pathways resulting in the breakdown of glucose to lactate, via canonical glycolysis, yielding energy in the form of adenosine triphosphate (ATP).
lactate biosynthetic process from pyruvate The chemical reactions and pathways resulting in the formation of lactate from other compounds, including pyruvate.
lactate metabolic process The chemical reactions and pathways involving lactate, the anion of lactic acid.
NAD metabolic process The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid.
positive regulation of apoptotic process Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
pyruvate metabolic process The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5E9B1 LDHB L-lactate dehydrogenase B chain Bos taurus (Bovine) PR
P19858 LDHA L-lactate dehydrogenase A chain Bos taurus (Bovine) PR
Q5R1W9 LDHA L-lactate dehydrogenase A chain Pan troglodytes (Chimpanzee) PR
P07195 LDHB L-lactate dehydrogenase B chain Homo sapiens (Human) PR
P07864 LDHC L-lactate dehydrogenase C chain Homo sapiens (Human) PR
P00338 LDHA L-lactate dehydrogenase A chain Homo sapiens (Human) PR
P16125 Ldhb L-lactate dehydrogenase B chain Mus musculus (Mouse) PR
P00339 LDHA L-lactate dehydrogenase A chain Sus scrofa (Pig) PR
P04642 Ldha L-lactate dehydrogenase A chain Rattus norvegicus (Rat) PR
Q66KB7 uevld Ubiquitin-conjugating enzyme E2 variant 3 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q6DBY5 uevld Ubiquitin-conjugating enzyme E2 variant 3 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MATLKDQLIV NLLKEEQAPQ NKITVVGVGA VGMACAISIL MKDLADELAL VDVMEDKLKG
70 80 90 100 110 120
EMMDLQHGSL FLKTPKIVSS KDYCVTANSK LVIITAGARQ QEGESRLNLV QRNVNIFKFI
130 140 150 160 170 180
IPNIVKYSPH CKLLIVSNPV DILTYVAWKI SGFPKNRVIG SGCNLDSARF RYLMGERLGV
190 200 210 220 230 240
HALSCHGWVL GEHGDSSVPV WSGVNVAGVS LKSLNPELGT DADKEQWKEV HKQVVDSAYE
250 260 270 280 290 300
VIKLKGYTSW AIGLSVADLA ESIMKNLRRV HPISTMIKGL YGINEDVFLS VPCILGQNGI
310 320 330
SDVVKVTLTP EEEARLKKSA DTLWGIQKEL QF