P16125
Gene name |
Ldhb (Ldh-2, Ldh2) |
Protein name |
L-lactate dehydrogenase B chain |
Names |
LDH-B, LDH heart subunit, LDH-H |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:16832 |
EC number |
1.1.1.27: With NAD(+) or NADP(+) as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P16125
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P16125-F1 | Predicted | AlphaFoldDB |
13 variants for P16125
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388863036 | 26 | V>I | No | EVA | |
| rs3388863057 | 28 | G>S | No | EVA | |
| rs3388863023 | 31 | Q>* | No | EVA | |
| rs3388830947 | 47 | D>E | No | EVA | |
| rs3388859173 | 47 | D>N | No | EVA | |
| rs3388872307 | 51 | L>M | No | EVA | |
| rs3388865612 | 57 | D>G | No | EVA | |
| rs3388850610 | 66 | L>P | No | EVA | |
| rs3388868504 | 71 | L>S | No | EVA | |
| rs3388850673 | 73 | L>F | No | EVA | |
| rs3388875657 | 75 | T>I | No | EVA | |
| rs3388862503 | 163 | G>V | No | EVA | |
| rs3388869941 | 189 | W>S | No | EVA |
No associated diseases with P16125
Functions
| Description | ||
|---|---|---|
| EC Number | 1.1.1.27 | With NAD(+) or NADP(+) as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| membrane raft | Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions. |
| mitochondrial inner membrane | The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| myelin sheath | An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system. |
| oxidoreductase complex | Any protein complex that possesses oxidoreductase activity. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| identical protein binding | Binding to an identical protein or proteins. |
| kinase binding | Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group. |
| L-lactate dehydrogenase activity | Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+. |
| lactate dehydrogenase activity | Catalysis of the reaction: lactate + NAD+ = H+ + NADH + pyruvate. |
| NAD binding | Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| lactate biosynthetic process from pyruvate | The chemical reactions and pathways resulting in the formation of lactate from other compounds, including pyruvate. |
| lactate metabolic process | The chemical reactions and pathways involving lactate, the anion of lactic acid. |
| NAD metabolic process | The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid. |
| pyruvate metabolic process | The chemical reactions and pathways involving pyruvate, 2-oxopropanoate. |
11 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P19858 | LDHA | L-lactate dehydrogenase A chain | Bos taurus (Bovine) | PR |
| Q5E9B1 | LDHB | L-lactate dehydrogenase B chain | Bos taurus (Bovine) | PR |
| Q5R1W9 | LDHA | L-lactate dehydrogenase A chain | Pan troglodytes (Chimpanzee) | PR |
| P00338 | LDHA | L-lactate dehydrogenase A chain | Homo sapiens (Human) | PR |
| P07864 | LDHC | L-lactate dehydrogenase C chain | Homo sapiens (Human) | PR |
| P07195 | LDHB | L-lactate dehydrogenase B chain | Homo sapiens (Human) | PR |
| P06151 | Ldha | L-lactate dehydrogenase A chain | Mus musculus (Mouse) | PR |
| P00339 | LDHA | L-lactate dehydrogenase A chain | Sus scrofa (Pig) | PR |
| P04642 | Ldha | L-lactate dehydrogenase A chain | Rattus norvegicus (Rat) | PR |
| Q66KB7 | uevld | Ubiquitin-conjugating enzyme E2 variant 3 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q6DBY5 | uevld | Ubiquitin-conjugating enzyme E2 variant 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MATLKEKLIA | SVADDEAAVP | NNKITVVGVG | QVGMACAISI | LGKSLADELA | LVDVLEDKLK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GEMMDLQHGS | LFLQTPKIVA | DKDYSVTANS | KIVVVTAGVR | QQEGESRLNL | VQRNVNVFKF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IIPQIVKYSP | DCTIIVVSNP | VDILTYVTWK | LSGLPKHRVI | GSGCNLDSAR | FRYLMAEKLG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IHPSSCHGWI | LGEHGDSSVA | VWSGVNVAGV | SLQELNPEMG | TDNDSENWKE | VHKMVVDSAY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EVIKLKGYTN | WAIGLSVADL | IESMLKNLSR | IHPVSTMVKG | MYGIENEVFL | SLPCILNARG |
| 310 | 320 | 330 | |||
| LTSVINQKLK | DDEVAQLRKS | ADTLWDIQKD | LKDL |