Q9FFY6
Gene name |
ELCL |
Protein name |
Protein ELC-like |
Names |
ESCRT-I complex subunit VPS23 homolog 2, Protein VACUOLAR PROTEIN SORTING 23B, Vacuolar protein sorting-associated protein 23 homolog 2 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G13860 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9FFY6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9FFY6-F1 | Predicted | AlphaFoldDB |
26 variants for Q9FFY6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_5_4474251_C_G | 23 | G>A | No | 1000Genomes | |
| tmp_5_4474236_G_A | 28 | P>L | No | 1000Genomes | |
| ENSVATH03054336 | 36 | L>V | No | 1000Genomes | |
| ENSVATH10736273 | 55 | T>M | No | 1000Genomes | |
| tmp_5_4474131_C_G | 63 | G>A | No | 1000Genomes | |
| tmp_5_4474098_G_T | 74 | T>K | No | 1000Genomes | |
| ENSVATH06964128 | 94 | E>Q | No | 1000Genomes | |
| tmp_5_4473873_C_G | 149 | S>T | No | 1000Genomes | |
| ENSVATH00621009 | 151 | A>T | No | 1000Genomes | |
| ENSVATH10736272 | 163 | R>S | No | 1000Genomes | |
| tmp_5_4473795_C_T | 175 | G>E | No | 1000Genomes | |
| tmp_5_4473768_T_C | 184 | Q>R | No | 1000Genomes | |
| tmp_5_4473757_C_G | 188 | A>P | No | 1000Genomes | |
| tmp_5_4473723_C_A | 199 | R>M | No | 1000Genomes | |
| tmp_5_4473703_C_T | 206 | G>S | No | 1000Genomes | |
| tmp_5_4473683_C_A | 212 | R>S | No | 1000Genomes | |
| tmp_5_4473619_C_G | 234 | E>Q | No | 1000Genomes | |
| ENSVATH00621008 | 253 | Q>L | No | 1000Genomes | |
| tmp_5_4473548_A_C | 257 | I>M | No | 1000Genomes | |
| ENSVATH10736271 | 286 | D>V | No | 1000Genomes | |
| tmp_5_4473366_G_A | 318 | S>L | No | 1000Genomes | |
| tmp_5_4473360_C_G | 320 | R>T | No | 1000Genomes | |
| ENSVATH00621007 | 327 | D>V | No | 1000Genomes | |
| tmp_5_4473254_C_T | 355 | M>I | No | 1000Genomes | |
| ENSVATH00621006 | 355 | M>T | No | 1000Genomes | |
| tmp_5_4473226_T_A | 365 | R>W | No | 1000Genomes |
No associated diseases with Q9FFY6
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| ESCRT I complex | An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| ubiquitin binding | Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| endosome to lysosome transport | The directed movement of substances from endosomes to lysosomes. |
| protein modification process | The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q99816 | TSG101 | Tumor susceptibility gene 101 protein | Homo sapiens (Human) | PR |
| Q61187 | Tsg101 | Tumor susceptibility gene 101 protein | Mus musculus (Mouse) | PR |
| Q6IRE4 | Tsg101 | Tumor susceptibility gene 101 protein | Rattus norvegicus (Rat) | PR |
| Q66KB7 | uevld | Ubiquitin-conjugating enzyme E2 variant 3 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q6DBY5 | uevld | Ubiquitin-conjugating enzyme E2 variant 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAPPPAKMQE | IHQFLSSALT | QRGPSALPYA | ENTKSLIRQH | LLNLISSYTS | LDPKTATFTH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NDGRSVILLQ | ADGTIPMPFQ | GVSYNIPVVI | WLLESYPQYP | PCVYVNPTRD | MIIKRPHSNV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SPSGLVSLPY | LQNWIYPSSN | LVDLASHLSA | AFSRDPPLYS | QRRPPPQPSP | SIGSGYSRPL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PPRQTDDAAE | VYKKNAINRI | VEMVHGDIVL | MRSAREVETE | GLLSLQSDLK | RREEEINNGF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KEMVIEKETL | EQQLQVIAMN | TDVLGSWIRE | NQGKAKDLLV | DLDVDDSFEC | IDSLSKQMLE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| CTALDLAIED | VVYSMDKSFR | DGSLPFDQYL | RNVRLLSREQ | FFHRATAEKV | REIQMDAQVA |
| SIAARLHS |