Q9ZR72

PR
Gene name
ABCB1 (MDR1, PGP1, At2g36910, T1J8.9)
Protein name
ABC transporter B family member 1
Names
ABC transporter ABCB.1, AtABCB1, Multidrug resistance protein 1, P-glycoprotein 1, AtPgp1
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT2G36910
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-54 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9ZR72

Entry ID Method Resolution Chain Position Source
AF-Q9ZR72-F1 Predicted AlphaFoldDB

43 variants for Q9ZR72

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH13555514 8 P>A No 1000Genomes
ENSVATH05668689 20 K>N No 1000Genomes
tmp_2_15502231_A_G 24 I>V No 1000Genomes
ENSVATH05668690 26 G>R No 1000Genomes
ENSVATH13555545 27 V>I No 1000Genomes
ENSVATH05668691 28 A>D No 1000Genomes
ENSVATH01958204 80 E>D No 1000Genomes
ENSVATH13555547 140 T>I No 1000Genomes
ENSVATH05668700 156 V>I No 1000Genomes
ENSVATH14591746 177 V>A No 1000Genomes
tmp_2_15502986_T_A 200 L>M No 1000Genomes
tmp_2_15503022_C_G 212 L>V No 1000Genomes
tmp_2_15503225_T_C 237 I>T No 1000Genomes
tmp_2_15503269_G_A 252 A>T No 1000Genomes
ENSVATH13555577 299 H>Q No 1000Genomes
ENSVATH00262702 300 H>Q No 1000Genomes
ENSVATH14591748 357 S>F No 1000Genomes
ENSVATH05668711 365 T>M No 1000Genomes
tmp_2_15503756_C_T 381 P>L No 1000Genomes
ENSVATH13555581 390 C>S No 1000Genomes
tmp_2_15503797_G_T 395 A>S No 1000Genomes
tmp_2_15503852_T_C 413 V>A No 1000Genomes
tmp_2_15503854_T_A 414 S>T No 1000Genomes
tmp_2_15503992_G_A 431 G>R No 1000Genomes
tmp_2_15504598_G_T 523 K>N No 1000Genomes
tmp_2_15504677_G_A 550 D>N No 1000Genomes
tmp_2_15504752_G_A 575 A>T No 1000Genomes
ENSVATH01958252 702 L>I No 1000Genomes
tmp_2_15505291_G_A 727 V>I No 1000Genomes
ENSVATH14591751 734 E>K No 1000Genomes
tmp_2_15505430_C_A 773 T>N No 1000Genomes
tmp_2_15505837_A_C 883 Q>P No 1000Genomes
tmp_2_15505839_C_T 884 L>F No 1000Genomes
tmp_2_15505857_G_A 890 A>T No 1000Genomes
tmp_2_15505893_G_A 902 A>T No 1000Genomes
ENSVATH14591752 920 F>L No 1000Genomes
ENSVATH05668723 994 R>Q No 1000Genomes
tmp_2_15506194_G_A 1002 R>Q No 1000Genomes
ENSVATH13555683 1019 R>W No 1000Genomes
ENSVATH14591753 1043 R>H No 1000Genomes
ENSVATH05668726 1088 K>I No 1000Genomes
tmp_2_15506569_C_T 1127 A>V No 1000Genomes
tmp_2_15506997_G_T 1270 V>L No 1000Genomes

No associated diseases with Q9ZR72

8 regional properties for Q9ZR72

Type Name Position InterPro Accession
domain ABC transporter-like, ATP-binding domain 368 - 604 IPR003439-1
domain ABC transporter-like, ATP-binding domain 1024 - 1260 IPR003439-2
domain AAA+ ATPase domain 395 - 581 IPR003593-1
domain AAA+ ATPase domain 1051 - 1243 IPR003593-2
domain ABC transporter type 1, transmembrane domain 46 - 333 IPR011527-1
domain ABC transporter type 1, transmembrane domain 701 - 988 IPR011527-2
conserved_site ABC transporter-like, conserved site 507 - 521 IPR017871-1
conserved_site ABC transporter-like, conserved site 1163 - 1177 IPR017871-2

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
  • Non-polar distribution in apical cells
  • Predominant basal (top) localization in root tissues above the elongation zone, especially in mature cortical and endodermal cells
  • Basal and apical localization in the root elongation zone
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
plasmodesma A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.

5 GO annotations of molecular function

Name Definition
ABC-type transporter activity Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATPase-coupled transmembrane transporter activity Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source.
auxin efflux transmembrane transporter activity Enables the transfer of auxin, from one side of a membrane to the other, out of a cell.
auxin influx transmembrane transporter activity Enables the transfer of auxin, from one side of a membrane to the other, into a cell.

13 GO annotations of biological process

Name Definition
anthocyanin accumulation in tissues in response to UV light The aggregation of the pigment anthocyanin in a particular location in a tissue, occurring in response to a UV light stimulus.
auxin export across the plasma membrane The directed movement of auxins from inside of a cell, across the plasma membrane and into the extracellular region.
auxin polar transport The unidirectional movement of auxin in the stem from tip to base along the vector of gravity or basipetally.
auxin-activated signaling pathway The series of molecular signals generated by the binding of the plant hormone auxin to a receptor, and ending with modulation of a downstream cellular process, e.g. transcription.
photomorphogenesis The control of plant growth, development, and differentiation by the duration and nature of light, independent of photosynthesis.
positive gravitropism The orientation of plant parts towards gravity.
regulation of cell size Any process that modulates the size of a cell.
response to auxin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auxin stimulus.
response to blue light Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a blue light stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm.
response to nematode Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a nematode.
response to red or far red light Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red or far red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs.
stamen development The process whose specific outcome is the progression of the stamen over time, from its formation to the mature structure.
transmembrane transport The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O95342 ABCB11 Bile salt export pump Homo sapiens (Human) PR
P08183 ABCB1 ATP-dependent translocase ABCB1 Homo sapiens (Human) PR
P06795 Abcb1b ATP-dependent translocase ABCB1 Mus musculus (Mouse) PR
P21440 Abcb4 Phosphatidylcholine translocator ABCB4 Mus musculus (Mouse) PR
P21447 Abcb1a ATP-dependent translocase ABCB1 Mus musculus (Mouse) PR
Q9QY30 Abcb11 Bile salt export pump Mus musculus (Mouse) PR
O70127 Abcb11 Bile salt export pump Rattus norvegicus (Rat) PR
Q8H1R4 ABCI10 ABC transporter I family member 10 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LJX0 ABCB19 ABC transporter B family member 19 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M0G9 ABCB24 ABC transporter B family member 24, mitochondrial Arabidopsis thaliana (Mouse-ear cress) PR
Q9FUT3 ABCB23 ABC transporter B family member 23, mitochondrial Arabidopsis thaliana (Mouse-ear cress) PR
Q9LVM1 ABCB25 ABC transporter B family member 25, mitochondrial Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MDNDGGAPPP PPTLVVEEPK KAEIRGVAFK ELFRFADGLD YVLMGIGSVG AFVHGCSLPL
70 80 90 100 110 120
FLRFFADLVN SFGSNSNNVE KMMEEVLKYA LYFLVVGAAI WASSWAEISC WMWSGERQTT
130 140 150 160 170 180
KMRIKYLEAA LNQDIQFFDT EVRTSDVVFA INTDAVMVQD AISEKLGNFI HYMATFVSGF
190 200 210 220 230 240
IVGFTAVWQL ALVTLAVVPL IAVIGGIHTT TLSKLSNKSQ ESLSQAGNIV EQTVVQIRVV
250 260 270 280 290 300
MAFVGESRAS QAYSSALKIA QKLGYKTGLA KGMGLGATYF VVFCCYALLL WYGGYLVRHH
310 320 330 340 350 360
LTNGGLAIAT MFAVMIGGLA LGQSAPSMAA FAKAKVAAAK IFRIIDHKPT IERNSESGVE
370 380 390 400 410 420
LDSVTGLVEL KNVDFSYPSR PDVKILNNFC LSVPAGKTIA LVGSSGSGKS TVVSLIERFY
430 440 450 460 470 480
DPNSGQVLLD GQDLKTLKLR WLRQQIGLVS QEPALFATSI KENILLGRPD ADQVEIEEAA
490 500 510 520 530 540
RVANAHSFII KLPDGFDTQV GERGLQLSGG QKQRIAIARA MLKNPAILLL DEATSALDSE
550 560 570 580 590 600
SEKLVQEALD RFMIGRTTLI IAHRLSTIRK ADLVAVLQQG SVSEIGTHDE LFSKGENGVY
610 620 630 640 650 660
AKLIKMQEAA HETAMSNARK SSARPSSARN SVSSPIMTRN SSYGRSPYSR RLSDFSTSDF
670 680 690 700 710 720
SLSIDASSYP NYRNEKLAFK DQANSFWRLA KMNSPEWKYA LLGSVGSVIC GSLSAFFAYV
730 740 750 760 770 780
LSAVLSVYYN PDHEYMIKQI DKYCYLLIGL SSAALVFNTL QHSFWDIVGE NLTKRVREKM
790 800 810 820 830 840
LSAVLKNEMA WFDQEENESA RIAARLALDA NNVRSAIGDR ISVIVQNTAL MLVACTAGFV
850 860 870 880 890 900
LQWRLALVLV AVFPVVVAAT VLQKMFMTGF SGDLEAAHAK GTQLAGEAIA NVRTVAAFNS
910 920 930 940 950 960
EAKIVRLYTA NLEPPLKRCF WKGQIAGSGY GVAQFCLYAS YALGLWYASW LVKHGISDFS
970 980 990 1000 1010 1020
KTIRVFMVLM VSANGAAETL TLAPDFIKGG QAMRSVFELL DRKTEIEPDD PDTTPVPDRL
1030 1040 1050 1060 1070 1080
RGEVELKHID FSYPSRPDIQ IFRDLSLRAR AGKTLALVGP SGCGKSSVIS LIQRFYEPSS
1090 1100 1110 1120 1130 1140
GRVMIDGKDI RKYNLKAIRK HIAIVPQEPC LFGTTIYENI AYGHECATEA EIIQAATLAS
1150 1160 1170 1180 1190 1200
AHKFISALPE GYKTYVGERG VQLSGGQKQR IAIARALVRK AEIMLLDEAT SALDAESERS
1210 1220 1230 1240 1250 1260
VQEALDQACS GRTSIVVAHR LSTIRNAHVI AVIDDGKVAE QGSHSHLLKN HPDGIYARMI
1270 1280
QLQRFTHTQV IGMTSGSSSR VKEDDA