Q9LJX0
PR
Gene name |
ABCB19 (MDR1, MDR11, PGP19, At3g28860, MLD15.2) |
Protein name |
ABC transporter B family member 19 |
Names |
ABC transporter ABCB.19, AtABCB19, Multidrug resistance protein 11, P-glycoprotein 19 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G28860 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9LJX0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9LJX0-F1 | Predicted | AlphaFoldDB |
48 variants for Q9LJX0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH00361095 | 4 | T>P | No | 1000Genomes | |
| ENSVATH05958101 | 5 | N>H | No | 1000Genomes | |
| ENSVATH05958100 | 9 | A>S | No | 1000Genomes | |
| ENSVATH00361094 | 14 | A>P | No | 1000Genomes | |
| ENSVATH11157322 | 28 | K>E | No | 1000Genomes | |
| tmp_3_10877164_C_A | 41 | M>I | No | 1000Genomes | |
| ENSVATH11157321 | 75 | D>N | No | 1000Genomes | |
| tmp_3_10877046_G_T | 81 | H>N | No | 1000Genomes | |
| ENSVATH14057840 | 91 | V>F | No | 1000Genomes | |
| ENSVATH05958098 | 95 | L>M | No | 1000Genomes | |
| tmp_3_10874605_A_T | 292 | V>D | No | 1000Genomes | |
| tmp_3_10874329_A_T | 353 | L>M | No | 1000Genomes | |
| tmp_3_10874305_C_T | 361 | V>I | No | 1000Genomes | |
| tmp_3_10874243_C_T | 381 | M>I | No | 1000Genomes | |
| ENSVATH05958026 | 425 | L>V | No | 1000Genomes | |
| ENSVATH02240574 | 428 | G>S | No | 1000Genomes | |
| ENSVATH11156992 | 467 | D>G | No | 1000Genomes | |
| tmp_3_10873876_G_A | 475 | A>V | No | 1000Genomes | |
| tmp_3_10873826_C_T | 492 | G>S | No | 1000Genomes | |
| tmp_3_10873568_C_G | 550 | M>I | No | 1000Genomes | |
| tmp_3_10873549_C_T | 557 | V>I | No | 1000Genomes | |
| ENSVATH05958023 | 575 | Q>H | No | 1000Genomes | |
| tmp_3_10873465_G_A | 585 | H>Y | No | 1000Genomes | |
| ENSVATH11156990 | 587 | E>D | No | 1000Genomes | |
| tmp_3_10873451_A_C | 589 | I>M | No | 1000Genomes | |
| tmp_3_10873438_C_A | 594 | A>S | No | 1000Genomes | |
| ENSVATH11156989 | 607 | T>I | No | 1000Genomes | |
| tmp_3_10873299_C_T | 640 | R>K | No | 1000Genomes | |
| tmp_3_10872732_C_A | 803 | A>S | No | 1000Genomes | |
| tmp_3_10871492_G_T | 852 | L>I | No | 1000Genomes | |
| tmp_3_10871374_A_G | 891 | I>T | No | 1000Genomes | |
| tmp_3_10871357_G_A | 897 | H>Y | No | 1000Genomes | |
| tmp_3_10871348_G_A | 900 | R>C | No | 1000Genomes | |
| tmp_3_10871296_A_T | 917 | F>Y | No | 1000Genomes | |
| tmp_3_10871218_A_C | 943 | V>G | No | 1000Genomes | |
| ENSVATH02240539 | 985 | S>L | No | 1000Genomes | |
| ENSVATH05957997 | 992 | R>K | No | 1000Genomes | |
| ENSVATH11156863 | 1002 | P>T | No | 1000Genomes | |
| ENSVATH05957995 | 1014 | H>L | No | 1000Genomes | |
| ENSVATH02240538 | 1015 | V>I | No | 1000Genomes | |
| tmp_3_10870968_C_T | 1026 | M>I | No | 1000Genomes | |
| ENSVATH14057762 | 1056 | A>V | No | 1000Genomes | |
| ENSVATH11156862 | 1101 | T>M | No | 1000Genomes | |
| tmp_3_10870709_C_T | 1113 | A>T | No | 1000Genomes | |
| tmp_3_10870691_T_C | 1119 | I>V | No | 1000Genomes | |
| tmp_3_10870394_C_A | 1218 | V>L | No | 1000Genomes | |
| tmp_3_10870337_G_A | 1237 | P>S | No | 1000Genomes | |
| tmp_3_10870291_A_G | 1252 | I>T | No | 1000Genomes |
No associated diseases with Q9LJX0
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ABC-type transporter activity | Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATPase-coupled transmembrane transporter activity | Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source. |
| auxin efflux transmembrane transporter activity | Enables the transfer of auxin, from one side of a membrane to the other, out of a cell. |
18 GO annotations of biological process
| Name | Definition |
|---|---|
| acropetal auxin transport | The unidirectional movement of auxin from the base towards the apex of an organ, including the shoot, leaf, primary root, or lateral root. |
| anthocyanin accumulation in tissues in response to UV light | The aggregation of the pigment anthocyanin in a particular location in a tissue, occurring in response to a UV light stimulus. |
| auxin polar transport | The unidirectional movement of auxin in the stem from tip to base along the vector of gravity or basipetally. |
| auxin transport | The directed movement of auxin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Auxins are a group of plant hormones that regulates aspects of plant growth. |
| auxin-activated signaling pathway | The series of molecular signals generated by the binding of the plant hormone auxin to a receptor, and ending with modulation of a downstream cellular process, e.g. transcription. |
| basipetal auxin transport | The unidirectional movement of auxin from the apex to base of an organ, including the shoot, leaf, primary root, or lateral root. |
| formation of plant organ boundary | The regionalization process that specifies plant organ primordium boundaries resulting in a restriction of organogenesis to a limited spatial domain and keeping the organ separate from surrounding tissues. |
| lateral root development | The process whose specific outcome is the progression of the lateral root over time, from its formation to the mature structure. A lateral root is one formed from pericycle cells located on the xylem radius of the root, as opposed to the initiation of the main root from the embryo proper. |
| photomorphogenesis | The control of plant growth, development, and differentiation by the duration and nature of light, independent of photosynthesis. |
| positive gravitropism | The orientation of plant parts towards gravity. |
| regulation of cell size | Any process that modulates the size of a cell. |
| response to auxin | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auxin stimulus. |
| response to blue light | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a blue light stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm. |
| response to far red light | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of far red light stimulus. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs. |
| response to red or far red light | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red or far red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs. |
| root development | The process whose specific outcome is the progression of the root over time, from its formation to the mature structure. The root is the water- and mineral-absorbing part of a plant which is usually underground, does not bear leaves, tends to grow downwards and is typically derived from the radicle of the embryo. |
| stamen development | The process whose specific outcome is the progression of the stamen over time, from its formation to the mature structure. |
| transmembrane transport | The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O95342 | ABCB11 | Bile salt export pump | Homo sapiens (Human) | PR |
| P08183 | ABCB1 | ATP-dependent translocase ABCB1 | Homo sapiens (Human) | PR |
| P06795 | Abcb1b | ATP-dependent translocase ABCB1 | Mus musculus (Mouse) | PR |
| P21440 | Abcb4 | Phosphatidylcholine translocator ABCB4 | Mus musculus (Mouse) | PR |
| P21447 | Abcb1a | ATP-dependent translocase ABCB1 | Mus musculus (Mouse) | PR |
| Q9QY30 | Abcb11 | Bile salt export pump | Mus musculus (Mouse) | PR |
| O70127 | Abcb11 | Bile salt export pump | Rattus norvegicus (Rat) | PR |
| Q8H1R4 | ABCI10 | ABC transporter I family member 10 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZR72 | ABCB1 | ABC transporter B family member 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M0G9 | ABCB24 | ABC transporter B family member 24, mitochondrial | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FUT3 | ABCB23 | ABC transporter B family member 23, mitochondrial | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LVM1 | ABCB25 | ABC transporter B family member 25, mitochondrial | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSETNTTDAK | TVPAEAEKKK | EQSLPFFKLF | SFADKFDYLL | MFVGSLGAIV | HGSSMPVFFL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LFGQMVNGFG | KNQMDLHQMV | HEVSRYSLYF | VYLGLVVCFS | SYAEIACWMY | SGERQVAALR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KKYLEAVLKQ | DVGFFDTDAR | TGDIVFSVST | DTLLVQDAIS | EKVGNFIHYL | STFLAGLVVG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FVSAWKLALL | SVAVIPGIAF | AGGLYAYTLT | GITSKSRESY | ANAGVIAEQA | IAQVRTVYSY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VGESKALNAY | SDAIQYTLKL | GYKAGMAKGL | GLGCTYGIAC | MSWALVFWYA | GVFIRNGQTD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GGKAFTAIFS | AIVGGMSLGQ | SFSNLGAFSK | GKAAGYKLME | IINQRPTIIQ | DPLDGKCLDQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VHGNIEFKDV | TFSYPSRPDV | MIFRNFNIFF | PSGKTVAVVG | GSGSGKSTVV | SLIERFYDPN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SGQILLDGVE | IKTLQLKFLR | EQIGLVNQEP | ALFATTILEN | ILYGKPDATM | VEVEAAASAA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NAHSFITLLP | KGYDTQVGER | GVQLSGGQKQ | RIAIARAMLK | DPKILLLDEA | TSALDASSES |
| 550 | 560 | 570 | 580 | 590 | 600 |
| IVQEALDRVM | VGRTTVVVAH | RLCTIRNVDS | IAVIQQGQVV | ETGTHEELIA | KSGAYASLIR |
| 610 | 620 | 630 | 640 | 650 | 660 |
| FQEMVGTRDF | SNPSTRRTRS | TRLSHSLSTK | SLSLRSGSLR | NLSYSYSTGA | DGRIEMISNA |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ETDRKTRAPE | NYFYRLLKLN | SPEWPYSIMG | AVGSILSGFI | GPTFAIVMSN | MIEVFYYTDY |
| 730 | 740 | 750 | 760 | 770 | 780 |
| DSMERKTKEY | VFIYIGAGLY | AVGAYLIQHY | FFSIMGENLT | TRVRRMMLSA | ILRNEVGWFD |
| 790 | 800 | 810 | 820 | 830 | 840 |
| EDEHNSSLIA | ARLATDAADV | KSAIAERISV | ILQNMTSLLT | SFIVAFIVEW | RVSLLILGTF |
| 850 | 860 | 870 | 880 | 890 | 900 |
| PLLVLANFAQ | QLSLKGFAGD | TAKAHAKTSM | IAGEGVSNIR | TVAAFNAQSK | ILSLFCHELR |
| 910 | 920 | 930 | 940 | 950 | 960 |
| VPQKRSLYRS | QTSGFLFGLS | QLALYGSEAL | ILWYGAHLVS | KGVSTFSKVI | KVFVVLVITA |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| NSVAETVSLA | PEIIRGGEAV | GSVFSVLDRQ | TRIDPDDADA | DPVETIRGDI | EFRHVDFAYP |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| SRPDVMVFRD | FNLRIRAGHS | QALVGASGSG | KSSVIAMIER | FYDPLAGKVM | IDGKDIRRLN |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| LKSLRLKIGL | VQQEPALFAA | TIFDNIAYGK | DGATESEVID | AARAANAHGF | ISGLPEGYKT |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| PVGERGVQLS | GGQKQRIAIA | RAVLKNPTVL | LLDEATSALD | AESECVLQEA | LERLMRGRTT |
| 1210 | 1220 | 1230 | 1240 | 1250 | |
| VVVAHRLSTI | RGVDCIGVIQ | DGRIVEQGSH | SELVSRPEGA | YSRLLQLQTH | RI |