Q9LVM1

PR
Gene name
ABCB25 (ATM3, STA1, At5g58270, MCK7.14)
Protein name
ABC transporter B family member 25, mitochondrial
Names
ABC transporter ABCB.25, AtABCB25, ABC transporter of the mitochondrion 3, AtATM3, Iron-sulfur clusters transporter ATM3, Protein STARIK 1
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G58270
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

37-141 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

5 structures for Q9LVM1

Entry ID Method Resolution Chain Position Source
7N58 EM 340 A A/B 1-728 PDB
7N59 EM 360 A A/B 1-728 PDB
7N5A EM 395 A A/B 1-728 PDB
7N5B EM 380 A A/B 1-728 PDB
AF-Q9LVM1-F1 Predicted AlphaFoldDB

23 variants for Q9LVM1

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_5_23562216_C_T 17 R>C No 1000Genomes
tmp_5_23562288_A_T 41 N>Y No 1000Genomes
ENSVATH07444636 80 Q>P No 1000Genomes
tmp_5_23562478_C_G 104 T>S No 1000Genomes
tmp_5_23562483_G_A 106 E>K No 1000Genomes
ENSVATH12839892 119 A>G No 1000Genomes
tmp_5_23562570_G_C 135 D>H No 1000Genomes
ENSVATH07444637 172 A>P No 1000Genomes
ENSVATH07444638 176 G>V No 1000Genomes
ENSVATH07444639 184 F>L No 1000Genomes
ENSVATH14639071 229 R>Q No 1000Genomes
tmp_5_23563218_G_A 266 S>N No 1000Genomes
ENSVATH03447798 374 D>N No 1000Genomes
ENSVATH12839928 376 A>V No 1000Genomes
ENSVATH00740681 410 M>V No 1000Genomes
ENSVATH07444655 490 P>R No 1000Genomes
tmp_5_23565265_T_G 495 L>V No 1000Genomes
ENSVATH14639078 497 G>R No 1000Genomes
tmp_5_23565304_G_A 508 V>M No 1000Genomes
tmp_5_23565688_G_A 557 V>I No 1000Genomes
tmp_5_23566017_G_A 584 E>K No 1000Genomes
tmp_5_23566565_A_G 629 T>A No 1000Genomes
tmp_5_23566924_G_T 691 V>L No 1000Genomes

No associated diseases with Q9LVM1

4 regional properties for Q9LVM1

Type Name Position InterPro Accession
domain ABC transporter-like, ATP-binding domain 479 - 713 IPR003439
domain AAA+ ATPase domain 504 - 690 IPR003593
domain ABC transporter type 1, transmembrane domain 144 - 445 IPR011527
conserved_site ABC transporter-like, conserved site 616 - 630 IPR017871

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion inner membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
chloroplast envelope The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid.

3 GO annotations of molecular function

Name Definition
ABC-type transporter activity Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATPase-coupled transmembrane transporter activity Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source.

12 GO annotations of biological process

Name Definition
cellular iron ion homeostasis Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
chloroplast organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the chloroplast.
chromosome organization A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome.
ion transport The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
Mo-molybdopterin cofactor biosynthetic process The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands.
pollen development The process whose specific outcome is the progression of the pollen grain over time, from its formation to the mature structure. The process begins with the meiosis of the microsporocyte to form four haploid microspores. The nucleus of each microspore then divides by mitosis to form a two-celled organism, the pollen grain, that contains a tube cell as well as a smaller generative cell. The pollen grain is surrounded by an elaborate cell wall. In some species, the generative cell immediately divides again to give a pair of sperm cells. In most flowering plants, however this division takes place later, in the tube that develops when a pollen grain germinates.
regulation of catalytic activity Any process that modulates the activity of an enzyme.
regulation of chlorophyll biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors.
response to cadmium ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
response to lead ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus.
root development The process whose specific outcome is the progression of the root over time, from its formation to the mature structure. The root is the water- and mineral-absorbing part of a plant which is usually underground, does not bear leaves, tends to grow downwards and is typically derived from the radicle of the embryo.
transmembrane transport The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P40416 ATM1 Iron-sulfur clusters transporter ATM1, mitochondrial Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q9NP58 ABCB6 ATP-binding cassette sub-family B member 6 Homo sapiens (Human) PR
Q9DC29 Abcb6 ATP-binding cassette sub-family B member 6 Mus musculus (Mouse) PR
O70595 Abcb6 ATP-binding cassette sub-family B member 6 Rattus norvegicus (Rat) PR
Q9FUT3 ABCB23 ABC transporter B family member 23, mitochondrial Arabidopsis thaliana (Mouse-ear cress) PR
Q9M0G9 ABCB24 ABC transporter B family member 24, mitochondrial Arabidopsis thaliana (Mouse-ear cress) PR
Q9LJX0 ABCB19 ABC transporter B family member 19 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZR72 ABCB1 ABC transporter B family member 1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSRGSRFVRA PGLLLCRVNL QPQPKIPSFS YSLRSDYRLH NGFSNYIRRN SIRTSPVINA
70 80 90 100 110 120
FLSDNSPSPS PSPSPIRFVQ RSSMLNGRLF STSTPNPDQT TTKTKEIKTT SSDSDSAMAD
130 140 150 160 170 180
MKILRTLAGY LWMRDNPEFR FRVIAALGFL VGAKVLNVQV PFLFKLAVDW LASATGTGAS
190 200 210 220 230 240
LTTFAATNPT LLTVFATPAA VLIGYGIART GSSAFNELRT AVFSKVALRT IRSVSRKVFS
250 260 270 280 290 300
HLHDLDLRYH LSRETGGLNR IIDRGSRAIN FILSAMVFNV VPTILEISMV SGILAYKFGA
310 320 330 340 350 360
AFAWITSLSV GSYIVFTLAV TQWRTKFRKA MNKADNDAST RAIDSLINYE TVKYFNNEGY
370 380 390 400 410 420
EAEKYDQFLK KYEDAALQTQ RSLAFLNFGQ SIIFSTALST AMVLCSQGIM NGQMTVGDLV
430 440 450 460 470 480
MVNGLLFQLS LPLNFLGSVY RETIQSLVDM KSMFQLLEEK SDITNTSDAK PLVLKGGNIE
490 500 510 520 530 540
FENVHFSYLP ERKILDGISF VVPAGKSVAI VGTSGSGKST ILRMLFRFFD TDSGNIRIDG
550 560 570 580 590 600
QDIKEVRLDS LRSSIGVVPQ DTVLFNDTIF HNIHYGRLSA TEEEVYEAAR RAAIHETISN
610 620 630 640 650 660
FPDKYSTIVG ERGLKLSGGE KQRVALARTF LKSPAILLCD EATSALDSTT EAEILNALKA
670 680 690 700 710 720
LASNRTSIFI AHRLTTAMQC DEIVVLENGK VVEQGPHDEL LGKSGRYAQL WTQQNSSVDM
LDAAIKLE