P40416

PR
Gene name
ATM1
Protein name
Iron-sulfur clusters transporter ATM1, mitochondrial
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YMR301C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-118 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

6 structures for P40416

Entry ID Method Resolution Chain Position Source
4MYC X-ray 306 A A/B/C 98-690 PDB
4MYH X-ray 338 A A/B/C 98-690 PDB
7PSL EM 330 A A/B 92-690 PDB
7PSM EM 340 A A/B 92-690 PDB
7PSN EM 290 A A/B 92-690 PDB
AF-P40416-F1 Predicted AlphaFoldDB

7 variants for P40416

Variant ID(s) Position Change Description Diseaes Association Provenance
s13-869542 29 V>I No SGRP
s13-869441 62 K>N No SGRP
s13-869427 67 F>S No SGRP
s13-869272 119 I>V No SGRP
s13-868855 258 F>I No SGRP
s13-868098 510 K>R No SGRP
s13-867769 620 T>A No SGRP

No associated diseases with P40416

5 regional properties for P40416

Type Name Position InterPro Accession
conserved_site Acyl-CoA dehydrogenase, conserved site 153 - 165 IPR006089-1
conserved_site Acyl-CoA dehydrogenase, conserved site 366 - 385 IPR006089-2
domain Acyl-CoA oxidase/dehydrogenase, middle domain 151 - 246 IPR006091
domain Acyl-CoA dehydrogenase/oxidase C-terminal 258 - 407 IPR009075
domain Acyl-CoA dehydrogenase/oxidase, N-terminal 36 - 147 IPR013786

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion inner membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

4 GO annotations of molecular function

Name Definition
ABC-type transporter activity Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATPase-coupled transmembrane transporter activity Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source.

6 GO annotations of biological process

Name Definition
cellular iron ion homeostasis Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
iron-sulfur cluster assembly The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.
iron-sulfur cluster export from the mitochondrion The directed movement of iron sulfur clusters from inside the mitochondrion into the cytosol by crossing the inner mitochondrial membrane.
iron-sulfur cluster transmembrane transport A process in which an iron-sulfur cluster is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
mitochondrial transmembrane transport The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion.
transmembrane transport The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9NP58 ABCB6 ATP-binding cassette sub-family B member 6 Homo sapiens (Human) PR
Q9DC29 Abcb6 ATP-binding cassette sub-family B member 6 Mus musculus (Mouse) PR
O70595 Abcb6 ATP-binding cassette sub-family B member 6 Rattus norvegicus (Rat) PR
Q9M0G9 ABCB24 ABC transporter B family member 24, mitochondrial Arabidopsis thaliana (Mouse-ear cress) PR
Q9FUT3 ABCB23 ABC transporter B family member 23, mitochondrial Arabidopsis thaliana (Mouse-ear cress) PR
Q9LVM1 ABCB25 ABC transporter B family member 25, mitochondrial Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MLLLPRCPVI GRIVRSKFRS GLIRNHSPVI FTVSKLSTQR PLLFNSAVNL WNQAQKDITH
70 80 90 100 110 120
KKSVEQFSSA PKVKTQVKKT SKAPTLSELK ILKDLFRYIW PKGNNKVRIR VLIALGLLIS
130 140 150 160 170 180
AKILNVQVPF FFKQTIDSMN IAWDDPTVAL PAAIGLTILC YGVARFGSVL FGELRNAVFA
190 200 210 220 230 240
KVAQNAIRTV SLQTFQHLMK LDLGWHLSRQ TGGLTRAMDR GTKGISQVLT AMVFHIIPIS
250 260 270 280 290 300
FEISVVCGIL TYQFGASFAA ITFSTMLLYS IFTIKTTAWR THFRRDANKA DNKAASVALD
310 320 330 340 350 360
SLINFEAVKY FNNEKYLADK YNGSLMNYRD SQIKVSQSLA FLNSGQNLIF TTALTAMMYM
370 380 390 400 410 420
GCTGVIGGNL TVGDLVLINQ LVFQLSVPLN FLGSVYRDLK QSLIDMETLF KLRKNEVKIK
430 440 450 460 470 480
NAERPLMLPE NVPYDITFEN VTFGYHPDRK ILKNASFTIP AGWKTAIVGS SGSGKSTILK
490 500 510 520 530 540
LVFRFYDPES GRILINGRDI KEYDIDALRK VIGVVPQDTP LFNDTIWENV KFGRIDATDE
550 560 570 580 590 600
EVITVVEKAQ LAPLIKKLPQ GFDTIVGERG LMISGGEKQR LAIARVLLKN ARIMFFDEAT
610 620 630 640 650 660
SALDTHTEQA LLRTIRDNFT SGSRTSVYIA HRLRTIADAD KIIVLDNGRV REEGKHLELL
670 680
AMPGSLYREL WTIQEDLDHL ENELKDQQEL