P06795
PR
Gene name |
Abcb1b |
Protein name |
ATP-dependent translocase ABCB1 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:18669 |
EC number |
7.6.2.1: Linked to the hydrolysis of a nucleoside triphosphate |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P06795
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P06795-F1 | Predicted | AlphaFoldDB |
67 variants for P06795
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs259799897 | 6 | N>D | No | EVA | |
| rs3388728945 | 14 | N>K | No | EVA | |
| rs3388742528 | 14 | N>Y | No | EVA | |
| rs3395259527 | 24 | K>M | No | EVA | |
| rs3388717400 | 43 | D>E | No | EVA | |
| rs3388742999 | 45 | L>V | No | EVA | |
| rs3388743389 | 57 | A>P | No | EVA | |
| rs8271349 | 95 | P>L | No | EVA | |
| rs31413216 | 112 | I>M | No | EVA | |
| rs3388739420 | 217 | I>T | No | EVA | |
| rs8271328 | 244 | Q>H | No | EVA | |
| rs248208206 | 270 | Q>K | No | EVA | |
| rs3388739346 | 374 | I>L | No | EVA | |
| rs3388728933 | 377 | F>I | No | EVA | |
| rs3388748946 | 385 | D>Y | No | EVA | |
| rs3388717451 | 386 | S>R | No | EVA | |
| rs3388742490 | 387 | I>T | No | EVA | |
| rs8268091 | 392 | E>D | No | EVA | |
| rs3388726840 | 395 | N>I | No | EVA | |
| rs3388746712 | 413 | N>S | No | EVA | |
| rs3388742841 | 434 | T>S | No | EVA | |
| rs3388743375 | 441 | R>S | No | EVA | |
| rs3388746766 | 451 | S>N | No | EVA | |
| rs3388743378 | 484 | A>S | No | EVA | |
| rs3388740842 | 508 | A>V | No | EVA | |
| rs3388740926 | 561 | D>E | No | EVA | |
| rs3388726792 | 610 | N>D | No | EVA | |
| rs3388742997 | 610 | N>S | No | EVA | |
| rs3388726803 | 612 | D>E | No | EVA | |
| rs1132403588 | 668 | R>K | No | EVA | |
| rs233344542 | 685 | A>T | No | EVA | |
| rs3394630536 | 687 | D>A | No | EVA | |
| rs3395012007 | 687 | D>H | No | EVA | |
| rs3395176036 | 689 | D>H | No | EVA | |
| rs3388746729 | 693 | V>I | No | EVA | |
| rs6277917 | 747 | R>Q | No | EVA | |
| rs3395143261 | 769 | F>I | No | EVA | |
| rs3394894230 | 769 | F>L | No | EVA | |
| rs3413004062 | 819 | D>A | No | EVA | |
| rs3388717463 | 822 | S>G | No | EVA | |
| rs16800179 | 822 | S>N | No | EVA | |
| rs230193816 | 845 | V>L | No | EVA | |
| rs3388735758 | 858 | L>I | No | EVA | |
| rs3395012034 | 865 | L>P | No | EVA | |
| rs3394630547 | 869 | G>S | No | EVA | |
| rs3388735792 | 875 | K>* | No | EVA | |
| rs31409832 | 903 | R>H | No | EVA | |
| rs3395080525 | 917 | M>E | No | EVA | |
| rs3388742827 | 948 | Y>* | No | EVA | |
| rs3388743357 | 948 | Y>C | No | EVA | |
| rs1134888103 | 973 | M>L | No | EVA | |
| rs3388735786 | 989 | T>N | No | EVA | |
| rs3388743053 | 999 | A>T | No | EVA | |
| rs3388735804 | 1012 | K>N | No | EVA | |
| rs3388742857 | 1015 | E>D | No | EVA | |
| rs3388717380 | 1073 | G>R | No | EVA | |
| rs3388743051 | 1078 | V>I | No | EVA | |
| rs3388742511 | 1144 | V>M | No | EVA | |
| rs3388739824 | 1151 | N>Y | No | EVA | |
| rs3388740927 | 1157 | D>E | No | EVA | |
| rs3388739411 | 1161 | D>V | No | EVA | |
| rs3412269866 | 1169 | D>G | No | EVA | |
| rs3388733097 | 1198 | D>Y | No | EVA | |
| rs3388739785 | 1238 | A>S | No | EVA | |
| rs3388733014 | 1248 | K>R | No | EVA | |
| rs3388717372 | 1251 | E>D | No | EVA | |
| rs3394894180 | 1260 | A>V | No | EVA |
No associated diseases with P06795
8 regional properties for P06795
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | ABC transporter-like, ATP-binding domain | 391 - 627 | IPR003439-1 |
| domain | ABC transporter-like, ATP-binding domain | 1033 - 1271 | IPR003439-2 |
| domain | AAA+ ATPase domain | 418 - 610 | IPR003593-1 |
| domain | AAA+ ATPase domain | 1060 - 1248 | IPR003593-2 |
| domain | ABC transporter type 1, transmembrane domain | 50 - 356 | IPR011527-1 |
| domain | ABC transporter type 1, transmembrane domain | 709 - 998 | IPR011527-2 |
| conserved_site | ABC transporter-like, conserved site | 530 - 544 | IPR017871-1 |
| conserved_site | ABC transporter-like, conserved site | 1174 - 1188 | IPR017871-2 |
Functions
| Description | ||
|---|---|---|
| EC Number | 7.6.2.1 | Linked to the hydrolysis of a nucleoside triphosphate |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
10 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| cell surface | The external part of the cell wall and/or plasma membrane. |
| external side of apical plasma membrane | The leaflet the apical region of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| intercellular canaliculus | An extremely narrow tubular channel located between adjacent cells. An instance of this is the secretory canaliculi occurring between adjacent parietal cells in the gastric mucosa of vertebrates. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
11 GO annotations of molecular function
| Name | Definition |
|---|---|
| ABC-type xenobiotic transporter activity | Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out). |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATPase-coupled transmembrane transporter activity | Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source. |
| carboxylic acid transmembrane transporter activity | Enables the transfer of carboxylic acids from one side of a membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-). |
| ceramide floppase activity | Catalysis of the movement of ceramide from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP. |
| efflux transmembrane transporter activity | Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. |
| floppase activity | Catalysis of the movement of a lipid from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP. |
| phosphatidylcholine floppase activity | Catalysis of the movement of phosphatidylcholine from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP. |
| phosphatidylethanolamine flippase activity | Catalysis of the movement of phosphatidylethanolamine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP. |
| ubiquitin protein ligase binding | Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins. |
| xenobiotic transmembrane transporter activity | Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. |
15 GO annotations of biological process
| Name | Definition |
|---|---|
| carboxylic acid transmembrane transport | The process in which carboxylic acid is transported across a membrane. |
| ceramide translocation | The movement of a ceramide molecule from one leaflet of a membrane bilayer to the opposite leaflet. |
| establishment of endothelial blood-brain barrier | Establishment of the endothelial barrier between the blood and the brain. The endothelial cells in the brain capillaries are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier. |
| export across plasma membrane | The directed movement of some substance from inside of a cell, across the plasma membrane and into the extracellular region. |
| G2/M transition of mitotic cell cycle | The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex. |
| phospholipid translocation | The movement of a phospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet. |
| positive regulation of anion channel activity | Any process that activates or increases the frequency, rate or extent of anion channel activity. |
| regulation of chloride transport | Any process that modulates the frequency, rate or extent of chloride transport. |
| regulation of response to osmotic stress | Any process that modulates the rate or extent of the response to osmotic stress. |
| response to xenobiotic stimulus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. |
| Sertoli cell barrier remodeling | The tissue remodeling process by which the Sertoli cell barrier is temporarily disrupted and reorganized to accommodate the transit of preleptotene spermatocytes at stage VIII of the epithelial cycle. |
| stem cell proliferation | The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. |
| transepithelial transport | The directed movement of a substance from one side of an epithelium to the other. |
| xenobiotic detoxification by transmembrane export across the plasma membrane | A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell. |
| xenobiotic transport across blood-brain barrier | The directed movement of a xenobiotic through the blood-brain barrier. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O95342 | ABCB11 | Bile salt export pump | Homo sapiens (Human) | PR |
| P08183 | ABCB1 | ATP-dependent translocase ABCB1 | Homo sapiens (Human) | PR |
| P21440 | Abcb4 | Phosphatidylcholine translocator ABCB4 | Mus musculus (Mouse) | PR |
| P21447 | Abcb1a | ATP-dependent translocase ABCB1 | Mus musculus (Mouse) | PR |
| Q9QY30 | Abcb11 | Bile salt export pump | Mus musculus (Mouse) | PR |
| Q9DC29 | Abcb6 | ATP-binding cassette sub-family B member 6 | Mus musculus (Mouse) | PR |
| O70127 | Abcb11 | Bile salt export pump | Rattus norvegicus (Rat) | PR |
| Q8H1R4 | ABCI10 | ABC transporter I family member 10 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LJX0 | ABCB19 | ABC transporter B family member 19 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZR72 | ABCB1 | ABC transporter B family member 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEFEENLKGR | ADKNFSKMGK | KSKKEKKEKK | PAVGVFGMFR | YADWLDKLCM | ILGTLAAIIH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GTLLPLLMLV | FGNMTDSFTK | AEASILPSIT | NQSGPNSTLI | ISNSSLEEEM | AIYAYYYTGI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GAGVLIVAYI | QVSLWCLAAG | RQIHKIRQKF | FHAIMNQEIG | WFDVHDVGEL | NTRLTDDVSK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| INDGIGDKIG | MFFQSITTFL | AGFIIGFISG | WKLTLVILAV | SPLIGLSSAL | WAKVLTSFTN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KELQAYAKAG | AVAEEVLAAI | RTVIAFGGQQ | KELERYNKNL | EEAKNVGIKK | AITASISIGI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AYLLVYASYA | LAFWYGTSLV | LSNEYSIGEV | LTVFFSILLG | TFSIGHLAPN | IEAFANARGA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AFEIFKIIDN | EPSIDSFSTK | GYKPDSIMGN | LEFKNVHFNY | PSRSEVQILK | GLNLKVKSGQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TVALVGNSGC | GKSTTVQLMQ | RLYDPLEGVV | SIDGQDIRTI | NVRYLREIIG | VVSQEPVLFA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TTIAENIRYG | REDVTMDEIE | KAVKEANAYD | FIMKLPHQFD | TLVGERGAQL | SGGQKQRIAI |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ARALVRNPKI | LLLDEATSAL | DTESEAVVQA | ALDKAREGRT | TIVIAHRLST | VRNADVIAGF |
| 610 | 620 | 630 | 640 | 650 | 660 |
| DGGVIVEQGN | HDELMREKGI | YFKLVMTQTR | GNEIEPGNNA | YGSQSDTDAS | ELTSEESKSP |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LIRRSIYRSV | HRKQDQERRL | SMKEAVDEDV | PLVSFWRILN | LNLSEWPYLL | VGVLCAVING |
| 730 | 740 | 750 | 760 | 770 | 780 |
| CIQPVFAIVF | SRIVGVFSRD | DDHETKRQNC | NLFSLFFLVM | GLISFVTYFF | QGFTFGKAGE |
| 790 | 800 | 810 | 820 | 830 | 840 |
| ILTKRVRYMV | FKSMLRQDIS | WFDDHKNSTG | SLTTRLASDA | SSVKGAMGAR | LAVVTQNVAN |
| 850 | 860 | 870 | 880 | 890 | 900 |
| LGTGVILSLV | YGWQLTLLLV | VIIPLIVLGG | IIEMKLLSGQ | ALKDKKQLEI | SGKIATEAIE |
| 910 | 920 | 930 | 940 | 950 | 960 |
| NFRTIVSLTR | EQKFETMYAQ | SLQVPYRNAM | KKAHVFGITF | SFTQAMMYFS | YAACFRFGAY |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| LVAQQLMTFE | NVMLVFSAVV | FGAMAAGNTS | SFAPDYAKAK | VSASHIIRII | EKTPEIDSYS |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| TEGLKPTLLE | GNVKFNGVQF | NYPTRPNIPV | LQGLSLEVKK | GQTLALVGSS | GCGKSTVVQL |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| LERFYDPMAG | SVFLDGKEIK | QLNVQWLRAH | LGIVSQEPIL | FDCSIAENIA | YGDNSRAVSH |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| EEIVRAAKEA | NIHQFIDSLP | DKYNTRVGDK | GTQLSGGQKQ | RIAIARALVR | QPHILLLDEA |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| TSALDTESEK | VVQEALDKAR | EGRTCIVIAH | RLSTIQNADL | IVVIENGKVK | EHGTHQQLLA |
| 1270 | |||||
| QKGIYFSMVQ | AGAKRS |