O70127

PR
Gene name
Abcb11
Protein name
Bile salt export pump
Names
ATP-binding cassette sub-family B member 11, Sister of P-glycoprotein
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:83569
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-60 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O70127

Entry ID Method Resolution Chain Position Source
AF-O70127-F1 Predicted AlphaFoldDB

No variants for O70127

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O70127

No associated diseases with O70127

7 regional properties for O70127

Type Name Position InterPro Accession
domain ABC transporter-like, ATP-binding domain 420 - 656 IPR003439-1
domain ABC transporter-like, ATP-binding domain 1078 - 1316 IPR003439-2
domain AAA+ ATPase domain 447 - 639 IPR003593-1
domain AAA+ ATPase domain 1105 - 1299 IPR003593-2
domain ABC transporter type 1, transmembrane domain 62 - 385 IPR011527-1
domain ABC transporter type 1, transmembrane domain 756 - 1043 IPR011527-2
conserved_site ABC transporter-like, conserved site 559 - 573 IPR017871

Functions

Description
EC Number
Subcellular Localization
  • Apical cell membrane ; Multi-pass membrane protein
  • Recycling endosome membrane ; Multi-pass membrane protein
  • Endosome
  • Cell membrane ; Multi-pass membrane protein
  • Internalized at the canalicular membrane through interaction with the adapter protein complex 2 (AP-2) (PubMed:22262466)
  • At steady state, localizes in the canalicular membrane but is also present in recycling endosomes
  • ABCB11 constantly and rapidly exchanges between the two sites through tubulo-vesicles carriers that move along microtubules (PubMed:11113123, PubMed:15121884)
  • Microtubule-dependent trafficking of ABCB11 is enhanced by taurocholate and cAMP and regulated by STK11 through a PKA-mediated pathway (PubMed:11113123, PubMed:24643070)
  • Trafficking of newly synthesized ABCB11 through endosomal compartment to the bile canalicular membrane is accelerated by cAMP but not by taurocholate (PubMed:11113123)
  • Cell membrane expression is up-regulated by short- and medium-chain fatty acids (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

13 GO annotations of cellular component

Name Definition
apical part of cell The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
apical plasma membrane The region of the plasma membrane located at the apical end of the cell.
cell surface The external part of the cell wall and/or plasma membrane.
endosome A vacuole to which materials ingested by endocytosis are delivered.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
intercellular canaliculus An extremely narrow tubular channel located between adjacent cells. An instance of this is the secretory canaliculi occurring between adjacent parietal cells in the gastric mucosa of vertebrates.
intracellular canaliculus An apical plasma membrane part that forms a narrow enfolded luminal membrane channel, lined with numerous microvilli, that appears to extend into the cytoplasm of the cell. A specialized network of intracellular canaliculi is a characteristic feature of parietal cells of the gastric mucosa in vertebrates.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
recycling endosome An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.
recycling endosome membrane The lipid bilayer surrounding a recycling endosome.

7 GO annotations of molecular function

Name Definition
ABC-type bile acid transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(in) + ATP + H2O -> bile acid(out) + ADP + phosphate.
ABC-type xenobiotic transporter activity Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATPase-coupled transmembrane transporter activity Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source.
bile acid transmembrane transporter activity Enables the transfer of bile acid from one side of a membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.
canalicular bile acid transmembrane transporter activity The directed movement of bile acid and bile salts out of a hepatocyte and into the bile canaliculus by means of an agent such as a transporter or pore. Bile canaliculi are the thin tubes formed by hepatocyte membranes. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.
carbohydrate transmembrane transporter activity Enables the transfer of carbohydrate from one side of a membrane to the other.

25 GO annotations of biological process

Name Definition
bile acid and bile salt transport The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
bile acid metabolic process The chemical reactions and pathways involving bile acids, a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.
bile acid signaling pathway The series of molecular signals initiated by bile acid binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.
canalicular bile acid transport Enables the transfer of bile acid from one side of a hepatocyte plasma membrane into a bile canaliculus. Bile canaliculi are the thin tubes formed by hepatocyte membranes. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.
cellular response to xenobiotic stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
cholesterol homeostasis Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.
fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
lipid homeostasis Any process involved in the maintenance of an internal steady state of lipid within an organism or cell.
phospholipid homeostasis Any process involved in the maintenance of an internal steady state of phospholipid within an organism or cell.
positive regulation of bile acid secretion Any process that activates or increases the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue.
protein ubiquitination The process in which one or more ubiquitin groups are added to a protein.
regulation of bile acid metabolic process Any process that modulates the frequency, rate or extent of bile acid metabolic process.
regulation of bile acid secretion Any process that modulates the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue.
regulation of fatty acid beta-oxidation Any process that modulates the frequency, rate or extent of fatty acid bbeta-oxidation.
regulation of gene expression Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
response to 17alpha-ethynylestradiol Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 17alpha-ethynylestradiol stimulus.
response to estrogen Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.
response to ethanol Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
response to organic cyclic compound Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
response to oxidative stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
response to xenobiotic stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
transmembrane transport The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
xenobiotic export from cell The directed movement of a xenobiotic from a cell, into the extracellular region. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
xenobiotic metabolic process The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
xenobiotic transmembrane transport The process in which a xenobiotic, a compound foreign to the organim exposed to it, is transported across a membrane. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P08183 ABCB1 ATP-dependent translocase ABCB1 Homo sapiens (Human) PR
O95342 ABCB11 Bile salt export pump Homo sapiens (Human) PR
P21440 Abcb4 Phosphatidylcholine translocator ABCB4 Mus musculus (Mouse) PR
P06795 Abcb1b ATP-dependent translocase ABCB1 Mus musculus (Mouse) PR
P21447 Abcb1a ATP-dependent translocase ABCB1 Mus musculus (Mouse) PR
Q9QY30 Abcb11 Bile salt export pump Mus musculus (Mouse) PR
O70595 Abcb6 ATP-binding cassette sub-family B member 6 Rattus norvegicus (Rat) PR
Q5RKI8 Abcb8 Mitochondrial potassium channel ATP-binding subunit Rattus norvegicus (Rat) PR
Q8H1R4 ABCI10 ABC transporter I family member 10 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZR72 ABCB1 ABC transporter B family member 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LJX0 ABCB19 ABC transporter B family member 19 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSDSVILRSV KKFGEENHAF ESDGSHNNDK KSRLQDKMKE GDIRVGFFEL FRFSSSKDIW
70 80 90 100 110 120
LMLMGGVCAL LHGMAQPGIL IIFGIMTDIF IKYDIERQEL EIPGKACVNN TIVWINSSFH
130 140 150 160 170 180
QNMTNGTVCG LVDIESEMIK FSGIYAGVGM TVLILGYFQI RLWVITGARQ IRRMRKIYFR
190 200 210 220 230 240
RIMRMEIGWF DCTSVGELNS RFADDIEKIN DAIADQLAHF LQRMSTAMCG LLLGFYRGWK
250 260 270 280 290 300
LTLVILAVSP LIGIGAAVIG LSIAKFTELE LKAYAKAGSI ADEVLSSIRT VAAFGGENKE
310 320 330 340 350 360
VERYEKNLVF AQRWGIWKGM VMGFFTGYMW CLIFFCYALA FWYGSTLVLD EEEYTPGTLV
370 380 390 400 410 420
QIFLCVILAA MNIGHASSCL EIFSTGCSAA TNIFQTIDRQ PVIDCMSGDG YKLDRIKGEI
430 440 450 460 470 480
EFHNVTFHYP SRPDVKILDN LSMVIKPGET TALVGSSGAG KSTALQLIQR FYDPCEGMVT
490 500 510 520 530 540
LDGHDIRSLN IRWLRDQIGI VEQEPVLFST TIAENIRFGR EDATMEDIVQ AAKDANAYNF
550 560 570 580 590 600
IMALPQQFDT LVGEGGGQMS GGQKQRVAIA RALIRNPKIL LLDMATSALD NESEARVQEA
610 620 630 640 650 660
LNKIQHGHTI ISVAHRLSTV RAADVIIGFE HGVAVERGTH EELLERKGVY FMLVTLQSQG
670 680 690 700 710 720
DNAHKETSIM GKDATEGGTL ERTFSRGSYR DSLRASIRQR SKSQLSLLTH DPPLAVADHK
730 740 750 760 770 780
SSYKDSKDND VLVEEVEPAP VRRILKYNIP EWHYILVGSL SAAINGAVTP IYSLLFSQLL
790 800 810 820 830 840
GTFSLLDKEQ QRSEIHSMCL FFVILGCVSI FTQFLQGYTF AKSGELLTKR LRKFGFKAML
850 860 870 880 890 900
GQDIGWFDDL RNNPGVLTTR LATDASQVQG ATGSQVGMMV NSFTNIIAAL LIAFFFSWKL
910 920 930 940 950 960
SLIITIFFPF LALSGAVQTK MLTGFASQDK QALEKAGQIT SEALSNIRTV AGIGVEGRFI
970 980 990 1000 1010 1020
KAFEVELQTS YKTAVRKANI YGLCFAFSQG IAFLANSAAY RYGGYLIAYE GLGFSHVFRV
1030 1040 1050 1060 1070 1080
VSSVALSATA VGRTFSYTPS YAKAKISAAR FFQLLDRKPP INVYSEAGEK WDNFQGKIDF
1090 1100 1110 1120 1130 1140
IDCKFTYPSR PDIQVLNGLS VSVNPGQTLA FVGSSGCGKS TSIQLLERFY DPDQGTVMID
1150 1160 1170 1180 1190 1200
GHDSKKVNIQ FLRSNIGIVS QEPVLFDCSI MDNIKYGDNT KEISVERAIA AAKQAQLHDF
1210 1220 1230 1240 1250 1260
VMSLPEKYET NVGIQGSQLS RGEKQRIAIA RAIVRDPKIL LLDEATSALD TESEKTVQTA
1270 1280 1290 1300 1310 1320
LDKAREGRTC IVIAHRLSTI QNSDIIAVVS QGVVIEKGTH EKLMAQKGAY YKLVITGAPI
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