P21447

PR
Gene name
Abcb1a
Protein name
ATP-dependent translocase ABCB1
Names
ATP-binding cassette sub-family B member 1A, MDR1A, Multidrug resistance protein 1A, Multidrug resistance protein 3, P-glycoprotein 3, Phospholipid transporter ABCB1
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:18671
EC number
7.6.2.1: Linked to the hydrolysis of a nucleoside triphosphate
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

619-705 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

41 structures for P21447

Entry ID Method Resolution Chain Position Source
3G5U X-ray 380 A A/B 1-1276 PDB
3G60 X-ray 440 A A/B 1-1276 PDB
3G61 X-ray 435 A A/B 1-1276 PDB
4KSB X-ray 380 A A 1-1276 PDB
4KSC X-ray 400 A A 1-1276 PDB
4KSD X-ray 410 A A 1-1276 PDB
4LSG X-ray 380 A A/B 1-1276 PDB
4M1M X-ray 380 A A/B 1-1276 PDB
4M2S X-ray 440 A A/B 1-1276 PDB
4M2T X-ray 435 A A/B 1-1276 PDB
4Q9H X-ray 340 A A 1-1276 PDB
4Q9I X-ray 378 A A 1-1276 PDB
4Q9J X-ray 360 A A 1-1276 PDB
4Q9K X-ray 380 A A 1-1276 PDB
4Q9L X-ray 380 A A 1-1276 PDB
4XWK X-ray 350 A A 1-1276 PDB
5KO2 X-ray 330 A A/B 1-1276 PDB
5KOY X-ray 385 A A/B 1-1276 PDB
5KPD X-ray 335 A A/B 1-1276 PDB
5KPI X-ray 401 A A/B 1-1276 PDB
5KPJ X-ray 350 A A 1-1276 PDB
6GDI EM 790 A A 1-1276 PDB
6Q81 EM 790 A A 1-1276 PDB
6UJN X-ray 398 A A 1-1276 PDB
6UJP X-ray 398 A A 1-1276 PDB
6UJR X-ray 410 A A 1-1276 PDB
6UJS X-ray 417 A A 1-1276 PDB
6UJT X-ray 417 A A 1-1276 PDB
6UJW X-ray 415 A A 1-1276 PDB
7OTG EM 540 A A 1-1276 PDB
7OTI EM 420 A A 1-1276 PDB
7ZK4 EM 260 A A 1-1276 PDB
7ZK5 EM 260 A A 1-1276 PDB
7ZK6 EM 310 A A 1-1276 PDB
7ZK7 EM 320 A A 1-1276 PDB
7ZK8 EM 300 A A 1-1271 PDB
7ZK9 EM 430 A A 1-1260 PDB
7ZKA EM 290 A A 1-1276 PDB
7ZKB EM 470 A A 1-1276 PDB
8AVY EM 290 A A 1-1276 PDB
AF-P21447-F1 Predicted AlphaFoldDB

51 variants for P21447

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3411747078 16 S>P No EVA
rs3388728908 58 I>L No EVA
rs3388736122 73 D>V No EVA
rs3388748966 88 S>G No EVA
rs31417886 88 S>N No EVA
rs244105348 91 M>I No EVA
rs217202515 95 D>N No EVA
rs31419904 131 F>L No EVA
rs3388743361 155 E>V No EVA
rs3388746714 165 G>R No EVA
rs3388743009 177 K>I No EVA
rs3388743367 195 T>A No EVA
rs3388739351 226 G>D No EVA
rs240310159 363 K>N No EVA
rs254265652 444 D>E No EVA
rs265821827 446 M>V No EVA
rs864273043 505 A>P No EVA
rs864303343 529 G>R No EVA
rs3388743414 561 S>R No EVA
rs3388740913 604 E>* No EVA
rs228638731 609 D>E No EVA
rs3388728920 614 E>D No EVA
rs3388749022 739 G>D No EVA
rs262661371 740 P>S No EVA
rs1134323936 754 L>V No EVA
rs1134894857 755 F>Y No EVA
rs229978426 757 I>V No EVA
rs222494891 789 F>L No EVA
rs3395246473 791 S>T No EVA
rs3388743420 827 S>Y No EVA
rs3388746786 832 I>F No EVA
rs3388746750 882 D>E No EVA
rs3388746739 895 E>G No EVA
rs3388743387 912 F>L No EVA
rs238566954 927 A>S No EVA
rs256545593 961 T>A No EVA
rs230481900 998 T>K No EVA
rs3388736152 1007 I>T No EVA
rs260713322 1011 T>I No EVA
rs3388739355 1018 S>R No EVA
rs3388739365 1021 G>A No EVA
rs3388733055 1036 V>D No EVA
rs232731033 1037 V>M No EVA
rs251200996 1045 S>N No EVA
rs3388735770 1092 L>P No EVA
rs31418766 1108 Q>H No EVA
rs3388743371 1133 S>R No EVA
rs3388733036 1143 R>G No EVA
rs3388739466 1230 L>M No EVA
rs3388740932 1247 V>I No EVA
rs215635890 1271 A>T No EVA

No associated diseases with P21447

8 regional properties for P21447

Type Name Position InterPro Accession
domain ABC transporter-like, ATP-binding domain 388 - 624 IPR003439-1
domain ABC transporter-like, ATP-binding domain 1031 - 1269 IPR003439-2
domain AAA+ ATPase domain 415 - 607 IPR003593-1
domain AAA+ ATPase domain 1058 - 1246 IPR003593-2
domain ABC transporter type 1, transmembrane domain 50 - 353 IPR011527-1
domain ABC transporter type 1, transmembrane domain 708 - 996 IPR011527-2
conserved_site ABC transporter-like, conserved site 527 - 541 IPR017871-1
conserved_site ABC transporter-like, conserved site 1172 - 1186 IPR017871-2

Functions

Description
EC Number 7.6.2.1 Linked to the hydrolysis of a nucleoside triphosphate
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
  • Apical cell membrane
  • Cytoplasm
  • ABCB1 localization is influenced by C1orf115 expression levels (plasma membrane versus cytoplasm)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

8 GO annotations of cellular component

Name Definition
apical plasma membrane The region of the plasma membrane located at the apical end of the cell.
brush border membrane The portion of the plasma membrane surrounding the brush border.
cell surface The external part of the cell wall and/or plasma membrane.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
intercellular canaliculus An extremely narrow tubular channel located between adjacent cells. An instance of this is the secretory canaliculi occurring between adjacent parietal cells in the gastric mucosa of vertebrates.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

13 GO annotations of molecular function

Name Definition
ABC-type xenobiotic transporter activity Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATPase-coupled transmembrane transporter activity Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source.
carboxylic acid transmembrane transporter activity Enables the transfer of carboxylic acids from one side of a membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-).
ceramide floppase activity Catalysis of the movement of ceramide from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP.
efflux transmembrane transporter activity Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane.
floppase activity Catalysis of the movement of a lipid from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP.
phosphatidylcholine floppase activity Catalysis of the movement of phosphatidylcholine from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP.
phosphatidylethanolamine flippase activity Catalysis of the movement of phosphatidylethanolamine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP.
transmembrane transporter activity Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
ubiquitin protein ligase binding Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins.
xenobiotic transmembrane transporter activity Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.

52 GO annotations of biological process

Name Definition
brain development The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
carboxylic acid transmembrane transport The process in which carboxylic acid is transported across a membrane.
cellular hyperosmotic salinity response Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
cellular response to alkaloid Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active.
cellular response to antibiotic Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.
cellular response to borneol Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a borneol stimulus.
cellular response to dexamethasone stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus.
cellular response to estradiol stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
cellular response to external biotic stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things.
cellular response to L-glutamate Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-glutamate(1-) stimulus.
cellular response to lipopolysaccharide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
cellular response to mycotoxin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycotoxin stimulus. A mycotoxin is a toxic chemical substance produced by fungi.
cellular response to tumor necrosis factor Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
ceramide translocation The movement of a ceramide molecule from one leaflet of a membrane bilayer to the opposite leaflet.
circadian rhythm Any biological process in an organism that recurs with a regularity of approximately 24 hours.
daunorubicin transport The directed movement of daunorubicin, an anthracycline antibiotic produced by Streptomyces coeruleorubidus or S. peucetius and used as an antineoplastic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
establishment of blood-brain barrier Establishment of the barrier between the blood and the brain. The cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier.
establishment of blood-retinal barrier Establishment of the barrier between the blood and the retina. The blood-retinal barrier is located at two levels, forming an outer barrier in the retinal pigment epithelium and an inner barrier in the endothelial membrane of the retinal vessels. Both these membranes have tight junctions of the 'nonleaky' type.
export across plasma membrane The directed movement of some substance from inside of a cell, across the plasma membrane and into the extracellular region.
G2/M transition of mitotic cell cycle The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.
hormone transport The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
intestinal absorption Any process in which nutrients are taken up from the contents of the intestine.
lactation The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young.
maintenance of blood-brain barrier Maintaining the structure and function of the blood-brain barrier, thus ensuring specific regulated transport of substances (e.g. macromolecules, small molecules, ions) into the brain, and out of the brain into the blood circulation.
negative regulation of cell death Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
phospholipid translocation The movement of a phospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet.
placenta development The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.
positive regulation of anion channel activity Any process that activates or increases the frequency, rate or extent of anion channel activity.
positive regulation of establishment of Sertoli cell barrier Any process that activates or increases the frequency, rate or extent of establishment of Sertoli cell barrier.
positive regulation of response to drug Any process that activates or increases the frequency, rate or extent of response to drug.
protein localization to bicellular tight junction A process in which a protein is transported to, or maintained in, a location within a bicellular tight junction.
regulation of chloride transport Any process that modulates the frequency, rate or extent of chloride transport.
regulation of intestinal absorption Any process that modulates the frequency, rate or extent of intestinal absorption.
regulation of response to osmotic stress Any process that modulates the rate or extent of the response to osmotic stress.
response to antineoplastic agent Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antineoplastic agent stimulus. An antineoplastic agent is a substance that inhibits or prevents the proliferation of neoplasms.
response to cadmium ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
response to codeine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a codeine stimulus.
response to cyclosporin A Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclosporin A stimulus.
response to glucagon Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus.
response to glycoside Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoside stimulus.
response to hypoxia Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
response to morphine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure.
response to quercetin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a quercetin stimulus.
response to thyroxine A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroxine stimulus.
response to vitamin A Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin A stimulus.
response to vitamin D Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus.
response to xenobiotic stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
stem cell proliferation The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
terpenoid transport The directed movement of terpenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Terpenoids are a class of compounds characterized by an isoprenoid chemical structure and include derivatives with various functional groups.
transepithelial transport The directed movement of a substance from one side of an epithelium to the other.
xenobiotic detoxification by transmembrane export across the plasma membrane A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell.
xenobiotic transport across blood-brain barrier The directed movement of a xenobiotic through the blood-brain barrier.

10 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O95342 ABCB11 Bile salt export pump Homo sapiens (Human) PR
P08183 ABCB1 ATP-dependent translocase ABCB1 Homo sapiens (Human) PR
P06795 Abcb1b ATP-dependent translocase ABCB1 Mus musculus (Mouse) PR
P21440 Abcb4 Phosphatidylcholine translocator ABCB4 Mus musculus (Mouse) PR
Q9QY30 Abcb11 Bile salt export pump Mus musculus (Mouse) PR
Q9DC29 Abcb6 ATP-binding cassette sub-family B member 6 Mus musculus (Mouse) PR
O70127 Abcb11 Bile salt export pump Rattus norvegicus (Rat) PR
Q8H1R4 ABCI10 ABC transporter I family member 10 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LJX0 ABCB19 ABC transporter B family member 19 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZR72 ABCB1 ABC transporter B family member 1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MELEEDLKGR ADKNFSKMGK KSKKEKKEKK PAVSVLTMFR YAGWLDRLYM LVGTLAAIIH
70 80 90 100 110 120
GVALPLMMLI FGDMTDSFAS VGNVSKNSTN MSEADKRAMF AKLEEEMTTY AYYYTGIGAG
130 140 150 160 170 180
VLIVAYIQVS FWCLAAGRQI HKIRQKFFHA IMNQEIGWFD VHDVGELNTR LTDDVSKINE
190 200 210 220 230 240
GIGDKIGMFF QAMATFFGGF IIGFTRGWKL TLVILAISPV LGLSAGIWAK ILSSFTDKEL
250 260 270 280 290 300
HAYAKAGAVA EEVLAAIRTV IAFGGQKKEL ERYNNNLEEA KRLGIKKAIT ANISMGAAFL
310 320 330 340 350 360
LIYASYALAF WYGTSLVISK EYSIGQVLTV FFSVLIGAFS VGQASPNIEA FANARGAAYE
370 380 390 400 410 420
VFKIIDNKPS IDSFSKSGHK PDNIQGNLEF KNIHFSYPSR KEVQILKGLN LKVKSGQTVA
430 440 450 460 470 480
LVGNSGCGKS TTVQLMQRLY DPLDGMVSID GQDIRTINVR YLREIIGVVS QEPVLFATTI
490 500 510 520 530 540
AENIRYGRED VTMDEIEKAV KEANAYDFIM KLPHQFDTLV GERGAQLSGG QKQRIAIARA
550 560 570 580 590 600
LVRNPKILLL DEATSALDTE SEAVVQAALD KAREGRTTIV IAHRLSTVRN ADVIAGFDGG
610 620 630 640 650 660
VIVEQGNHDE LMREKGIYFK LVMTQTAGNE IELGNEACKS KDEIDNLDMS SKDSGSSLIR
670 680 690 700 710 720
RRSTRKSICG PHDQDRKLST KEALDEDVPP ASFWRILKLN STEWPYFVVG IFCAIINGGL
730 740 750 760 770 780
QPAFSVIFSK VVGVFTNGGP PETQRQNSNL FSLLFLILGI ISFITFFLQG FTFGKAGEIL
790 800 810 820 830 840
TKRLRYMVFK SMLRQDVSWF DDPKNTTGAL TTRLANDAAQ VKGATGSRLA VIFQNIANLG
850 860 870 880 890 900
TGIIISLIYG WQLTLLLLAI VPIIAIAGVV EMKMLSGQAL KDKKELEGSG KIATEAIENF
910 920 930 940 950 960
RTVVSLTREQ KFETMYAQSL QIPYRNAMKK AHVFGITFSF TQAMMYFSYA ACFRFGAYLV
970 980 990 1000 1010 1020
TQQLMTFENV LLVFSAIVFG AMAVGQVSSF APDYAKATVS ASHIIRIIEK TPEIDSYSTQ
1030 1040 1050 1060 1070 1080
GLKPNMLEGN VQFSGVVFNY PTRPSIPVLQ GLSLEVKKGQ TLALVGSSGC GKSTVVQLLE
1090 1100 1110 1120 1130 1140
RFYDPMAGSV FLDGKEIKQL NVQWLRAQLG IVSQEPILFD CSIAENIAYG DNSRVVSYEE
1150 1160 1170 1180 1190 1200
IVRAAKEANI HQFIDSLPDK YNTRVGDKGT QLSGGQKQRI AIARALVRQP HILLLDEATS
1210 1220 1230 1240 1250 1260
ALDTESEKVV QEALDKAREG RTCIVIAHRL STIQNADLIV VIQNGKVKEH GTHQQLLAQK
1270
GIYFSMVSVQ AGAKRS