Q5RKI8

PR
Gene name
Abcb8
Protein name
Mitochondrial potassium channel ATP-binding subunit
Names
ATP-binding cassette sub-family B member 8, mitochondrial, ABCB8, Mitochondrial sulfonylurea-receptor, MITOSUR
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:362302
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

3-138 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5RKI8

Entry ID Method Resolution Chain Position Source
AF-Q5RKI8-F1 Predicted AlphaFoldDB

No variants for Q5RKI8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5RKI8

No associated diseases with Q5RKI8

4 regional properties for Q5RKI8

Type Name Position InterPro Accession
domain ABC transporter-like, ATP-binding domain 454 - 691 IPR003439
domain AAA+ ATPase domain 481 - 668 IPR003593
domain ABC transporter type 1, transmembrane domain 131 - 419 IPR011527
conserved_site ABC transporter-like, conserved site 594 - 608 IPR017871

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion inner membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial ATP-gated potassium channel complex A protein-containing complex that is capable of the ATP-dependent diffusion of a potassium ion across the mitochondrial inner membrane.
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial membrane Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.

3 GO annotations of molecular function

Name Definition
ABC-type transporter activity Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATPase-coupled transmembrane transporter activity Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source.

4 GO annotations of biological process

Name Definition
cell volume homeostasis Any process involved in maintaining the steady state of a cell's volume. The cell's volume refers to the three-dimensional space occupied by a cell.
mitochondrial potassium ion transmembrane transport The process in which a potassium ion is transported across a mitochondrial membrane, into or out of the mitochondrion.
potassium ion transmembrane transport A process in which a potassium ion is transported from one side of a membrane to the other.
transmembrane transport The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O70595 Abcb6 ATP-binding cassette sub-family B member 6 Rattus norvegicus (Rat) PR
O70127 Abcb11 Bile salt export pump Rattus norvegicus (Rat) PR
B2GUP8 abcb8 Mitochondrial potassium channel ATP-binding subunit Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MLVHLFRVGI RGGPVPRWSL QSLRFQTFSA ARSSDDQFSS CLLRAVAQLR SQLRAHLPRS
70 80 90 100 110 120
PPASHRSTSA WCWVGGTLVV PAVLWQHPRF CLIALCEAKG SPPAQPTRAR ELRFKWKLFW
130 140 150 160 170 180
HFLHPHLLAL GLAIVLALGA ALVNVQIPLL LGQLVEIVAK YTREHVGSFV SESRRLSIQL
190 200 210 220 230 240
LLLYGVQGLL TFGYLVLLSH MGERMAMDMR KALFSSLLRQ DIAFFDAKKT GQLVSRLTTD
250 260 270 280 290 300
VQEFKSSFKL VISQGLRSST QVIGSLMTLS ILSPRLTLML AVVTPALMGV GTLMGSGLRK
310 320 330 340 350 360
LSRQCQEQIA RATGVADEAL GSVRTVRAFA MEKREEERYQ AELESCCCKA EELGRGIALF
370 380 390 400 410 420
QGLSNIAFNC MVLGTLFIGG SLVAGQQLKG GDLMSFLVAS QTVQRSMASL SVLFGQVVRG
430 440 450 460 470 480
LSAGARVFEY MSLSPVIPLT GGYSIPSKDL RGSITFQNVS FSYPCRPGFN VLKNFTLKLP
490 500 510 520 530 540
PGKIVALVGQ SGGGKTTVAS LLERFYDPTA GVVTLDGHDL RTLDPSWLRG QVIGFISQEP
550 560 570 580 590 600
VLFATTIMEN IRFGKLDASD EEVYTAARKA NAHEFISSFP DGYSTVVGER GTTLSGGQKQ
610 620 630 640 650 660
RLAIARALIK RPTVLILDEA TSALDAESER IVQEALDRAS AGRTVLVIAH RLSTVRAAHS
670 680 690 700 710
IIVMANGQVC EAGTHEELLQ KGGLYAELIR RQALDASLPS APPAEKPEDH RSCQ