B2GUP8

PR
Gene name
abcb8
Protein name
Mitochondrial potassium channel ATP-binding subunit
Names
ATP-binding cassette sub-family B member 8, mitochondrial, ABCB8, Mitochondrial sulfonylurea-receptor, MITOSUR
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KEGG Pathway
xtr:100158634
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

51-127 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B2GUP8

Entry ID Method Resolution Chain Position Source
AF-B2GUP8-F1 Predicted AlphaFoldDB

No variants for B2GUP8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B2GUP8

No associated diseases with B2GUP8

4 regional properties for B2GUP8

Type Name Position InterPro Accession
domain ABC transporter-like, ATP-binding domain 442 - 679 IPR003439
domain AAA+ ATPase domain 469 - 656 IPR003593
domain ABC transporter type 1, transmembrane domain 121 - 409 IPR011527
conserved_site ABC transporter-like, conserved site 582 - 596 IPR017871

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion inner membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
mitochondrial ATP-gated potassium channel complex A protein-containing complex that is capable of the ATP-dependent diffusion of a potassium ion across the mitochondrial inner membrane.
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

2 GO annotations of molecular function

Name Definition
ABC-type transporter activity Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

1 GO annotations of biological process

Name Definition
potassium ion transmembrane transport A process in which a potassium ion is transported from one side of a membrane to the other.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5RKI8 Abcb8 Mitochondrial potassium channel ATP-binding subunit Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MLFHFLQAGL RQCRPPARLV GLETGLSGAR GPSLPATLAN YSRLRNACRP PWRSPWKPVK
70 80 90 100 110 120
KGKLLAVLLG PAVLGVGVRA ARCQVELIAP PLIVPQGARP EPEFNWAEFW KLLRPQLIAL
130 140 150 160 170 180
LTAVLLAFGA ALLNIRIPLM LGELVNVVSR YTREHAGNYL QEVQGPALKL LCLYGAQGLL
190 200 210 220 230 240
TCGYIVLLSR VGERVAGSMR KSLFFSLLRQ DVAFFDAEKT GLLVNRLTSD VQEFKSSFKQ
250 260 270 280 290 300
VISQGLRSLT QTVGCFLSLY YISPKLTGLL LVVMPVLVGS GALIGSFLRK LSRRAQEQVA
310 320 330 340 350 360
RATGLADEAL GNVRTVKAFA MESREMELYS AEVDKSSGQN EVLGVGIAVF QGLSNVVLNC
370 380 390 400 410 420
IVLGTIFAGG SLMSSKELSA GELMSFLVAS QTVQRSMANM SVLFGQVVRG LSAGGRVFEF
430 440 450 460 470 480
MSLEPTIPLS GGFKLPVLRG EIHFKDVSFS YPTRPGHEVL RSFDLRIPHG KTVALVGQSG
490 500 510 520 530 540
GGKSTVAALL ERFYDPTEGA VQLDGVDIRI LDPSWLRGEV IGFINQEPVL FGTTIIENIR
550 560 570 580 590 600
FGRPDATDAE VHEAAIQANA DSFIRSFPEG YNTMLGERGV TLSGGQKQRV AIARALLKDP
610 620 630 640 650 660
KILILDEATS ALDTESERAV QVALDRARSG RTVLVIAHRL STISEADFIV VLSKGQVAEF
670 680
GTHQDLLRRG GLYADLIRRQ NQESQEAQ