Q9Z1G4
PR
Gene name |
Atp6v0a1 (Atp6n1) |
Protein name |
V-type proton ATPase 116 kDa subunit a 1 |
Names |
V-ATPase 116 kDa subunit a 1, Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit, Vacuolar adenosine triphosphatase subunit Ac116, Vacuolar proton pump subunit 1, Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:11975 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9Z1G4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9Z1G4-F1 | Predicted | AlphaFoldDB |
46 variants for Q9Z1G4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389200547 | 43 | D>E | No | EVA | |
| rs3389200559 | 43 | D>G | No | EVA | |
| rs3389201824 | 44 | V>M | No | EVA | |
| rs3402868708 | 100 | N>S | No | EVA | |
| rs3402696369 | 101 | F>L | No | EVA | |
| rs3389205695 | 119 | K>M | No | EVA | |
| rs3389173968 | 121 | N>Y | No | EVA | |
| rs3389207197 | 180 | G>D | No | EVA | |
| rs3389207166 | 182 | I>F | No | EVA | |
| rs3389205698 | 191 | E>K | No | EVA | |
| 194 | L>F | No | |||
| rs3389138230 | 197 | V>M | No | EVA | |
| rs3389197092 | 252 | Y>N | No | EVA | |
| rs3402795783 | 283 | E>A | No | EVA | |
| rs3389138180 | 320 | D>H | No | EVA | |
| rs3389205762 | 333 | P>H | No | EVA | |
| rs3389173908 | 336 | D>E | No | EVA | |
| rs3389178167 | 336 | D>H | No | EVA | |
| rs3389190927 | 448 | S>N | No | EVA | |
| rs3389205728 | 482 | F>V | No | EVA | |
| rs3389207178 | 505 | S>R | No | EVA | |
| rs3389178187 | 508 | L>I | No | EVA | |
| rs3389201998 | 509 | Q>H | No | EVA | |
| rs3389211589 | 545 | M>K | No | EVA | |
| rs3389178235 | 551 | L>P | No | EVA | |
| rs3389200481 | 552 | G>V | No | EVA | |
| rs3389173943 | 553 | I>T | No | EVA | |
| rs3389200502 | 556 | M>L | No | EVA | |
| rs3389200568 | 557 | L>P | No | EVA | |
| rs3389200529 | 560 | V>F | No | EVA | |
| rs3389200529 | 560 | V>I | No | EVA | |
| rs3389138144 | 564 | L>R | No | EVA | |
| rs3389204489 | 606 | D>N | No | EVA | |
| rs3402697014 | 609 | S>H | No | EVA | |
| rs3389173967 | 621 | I>L | No | EVA | |
| rs3389200551 | 622 | N>Y | No | EVA | |
| rs3389217816 | 629 | P>S | No | EVA | |
| rs3389201994 | 633 | N>I | No | EVA | |
| rs3389211646 | 650 | V>M | No | EVA | |
| rs3389173906 | 653 | L>F | No | EVA | |
| rs3389204438 | 661 | F>I | No | EVA | |
| rs3389204438 | 661 | F>L | No | EVA | |
| rs864282156 | 664 | L>R | No | EVA | |
| rs27089404 | 670 | Y>H | No | EVA | |
| rs3389217793 | 696 | E>* | No | EVA | |
| rs3389214024 | 698 | I>F | No | EVA |
No associated diseases with Q9Z1G4
No regional properties for Q9Z1G4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9Z1G4 | |||
Functions
16 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| clathrin-coated vesicle membrane | The lipid bilayer surrounding a clathrin-coated vesicle. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| integral component of synaptic vesicle membrane | The component of the synaptic vesicle membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| intracellular membrane-bounded organelle | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. |
| intracellular organelle | Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. |
| melanosome | A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| nuclear speck | A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. |
| perinuclear region of cytoplasm | Cytoplasm situated near, or occurring around, the nucleus. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| synaptic vesicle | A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane. |
| vacuolar proton-transporting V-type ATPase complex | A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen. |
| vacuolar proton-transporting V-type ATPase, V0 domain | The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATPase binding | Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP. |
| proton-transporting ATPase activity, rotational mechanism | Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| regulation of macroautophagy | Any process that modulates the frequency, rate or extent of macroautophagy. |
| toxin transport | The directed movement of a toxin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| vacuolar acidification | Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion. |
16 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P32563 | VPH1 | V-type proton ATPase subunit a, vacuolar isoform | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| O97681 | ATP6V0A2 | V-type proton ATPase 116 kDa subunit a 2 | Bos taurus (Bovine) | PR |
| Q29466 | ATP6V0A1 | V-type proton ATPase 116 kDa subunit a 1 | Bos taurus (Bovine) | PR |
| Q9I8D0 | ATP6V0A1 | V-type proton ATPase 116 kDa subunit a 1 | Gallus gallus (Chicken) | PR |
| Q13488 | TCIRG1 | V-type proton ATPase 116 kDa subunit a 3 | Homo sapiens (Human) | PR |
| Q9HBG4 | ATP6V0A4 | V-type proton ATPase 116 kDa subunit a 4 | Homo sapiens (Human) | PR |
| Q9Y487 | ATP6V0A2 | V-type proton ATPase 116 kDa subunit a 2 | Homo sapiens (Human) | PR |
| Q93050 | ATP6V0A1 | V-type proton ATPase 116 kDa subunit a 1 | Homo sapiens (Human) | PR |
| Q920R6 | Atp6v0a4 | V-type proton ATPase 116 kDa subunit a 4 | Mus musculus (Mouse) | PR |
| P15920 | Atp6v0a2 | V-type proton ATPase 116 kDa subunit a 2 | Mus musculus (Mouse) | PR |
| P25286 | Atp6v0a1 | V-type proton ATPase 116 kDa subunit a 1 | Rattus norvegicus (Rat) | PR |
| P30628 | unc-32 | V-type proton ATPase 116 kDa subunit a 1 | Caenorhabditis elegans | PR |
| Q8RWZ7 | VHA-a1 | V-type proton ATPase subunit a1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SJT7 | VHA-a2 | V-type proton ATPase subunit a2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8W4S4 | VHA-a3 | V-type proton ATPase subunit a3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| A1A5G6 | atp6v0a1 | V-type proton ATPase 116 kDa subunit a 1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGELFRSEEM | TLAQLFLQSE | AAYCCVSELG | ELGKVQFRDL | NPDVNVFQRK | FVNEVRRCEE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| MDRKLRFVEK | EIRKANIPIM | DTGENPEVPF | PRDMIDLEAN | FEKIENELKE | INTNQEALKR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NFLELTELKF | ILRKTQQFFD | EAELHHQQMA | DPDLLEESSS | LLEPNEMGRG | APLRLGFVAG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VINRERIPTF | ERMLWRVCRG | NVFLRQAEIE | NPLEDPVTGD | YVHKSVFIIF | FQGDQLKNRV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KKICEGFRAS | LYPCPETPQE | RKEMASGVNT | RIDDLQMVLN | QTEDHRQRVL | QAAAKNIRVW |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FIKVRKMKAI | YHTLNLCNID | VTQKCLIAEV | WCPVTDLDSI | QFALRRGTEH | SGSTVPSILN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RMQTNQTPPT | YNKTNKFTHG | FQNIVDAYGI | GTYREINPAP | YTVITFPFLF | AVMFGDFGHG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ILMTLFAVWM | VLRESRILSQ | KHENEMFSMV | FSGRYIILLM | GLFSIYTGLI | YNDCFSKSLN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| IFGSSWSVRP | MFTQGNWTEE | TLLGSSVLQL | NPAIPGVFGG | PYPFGIDPIW | NIATNKLTFL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| NSFKMKMSVI | LGIIHMLFGV | SLSLFNHIYF | KKPLNIYFGF | IPEIIFMSSL | FGYLVILIFY |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KWTAYDAHSS | RNAPSLLIHF | INMFLFSYPE | SGNAMLYSGQ | KGIQCFLIVV | AMLCVPWMLL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| FKPLILRHQY | LRKKHLGTLN | FGGIRVGNGP | TEEDAEIIQH | DQLSTHSEDA | EEFDFGDTMV |
| 730 | 740 | 750 | 760 | 770 | 780 |
| HQAIHTIEYC | LGCISNTASY | LRLWALSLAH | AQLSEVLWTM | VIHIGLHVRS | LAGGLGLFFI |
| 790 | 800 | 810 | 820 | 830 | |
| FAAFATLTVA | ILLIMEGLSA | FLHALRLHWV | EFQNKFYTGT | GFKFLPFSFE | HIREGKFDE |