Q920R6
PR
Gene name |
Atp6v0a4 (Atp6n1b) |
Protein name |
V-type proton ATPase 116 kDa subunit a 4 |
Names |
V-ATPase 116 kDa isoform a 4, V-type proton ATPase 116 kDa subunit a isoform 4, Vacuolar proton translocating ATPase 116 kDa subunit a isoform 4, Vacuolar proton translocating ATPase 116 kDa subunit a kidney isoform |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:140494 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q920R6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q920R6-F1 | Predicted | AlphaFoldDB |
46 variants for Q920R6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388791072 | 9 | E>* | No | EVA | |
| rs3388809805 | 10 | M>V | No | EVA | |
| rs3388806515 | 91 | R>W | No | EVA | |
| rs3388806486 | 93 | M>L | No | EVA | |
| rs3396653011 | 135 | Q>L | No | EVA | |
| rs3396716309 | 136 | D>G | No | EVA | |
| rs3388815904 | 153 | T>I | No | EVA | |
| rs47125959 | 161 | T>A | No | EVA | |
| rs3388812844 | 210 | D>Y | No | EVA | |
| rs3388809817 | 220 | N>K | No | EVA | |
| rs3388825068 | 251 | E>K | No | EVA | |
| rs3388828650 | 292 | W>R | No | EVA | |
| rs3388815896 | 309 | L>Q | No | EVA | |
| rs3396670006 | 312 | C>F | No | EVA | |
| rs3388823182 | 318 | Q>* | No | EVA | |
| rs3396492268 | 319 | Q>E | No | EVA | |
| rs3388809754 | 324 | E>K | No | EVA | |
| rs220819603 | 351 | I>V | No | EVA | |
| rs3388816531 | 362 | D>N | No | EVA | |
| rs3388815932 | 366 | F>I | No | EVA | |
| rs3388825076 | 368 | R>K | No | EVA | |
| rs3388809786 | 372 | F>I | No | EVA | |
| rs3396716342 | 392 | N>S | No | EVA | |
| rs3388817844 | 408 | M>I | No | EVA | |
| rs3388823194 | 425 | M>L | No | EVA | |
| rs3388822115 | 467 | N>Y | No | EVA | |
| rs3388809764 | 468 | D>G | No | EVA | |
| rs3388809793 | 522 | I>F | No | EVA | |
| rs3388823148 | 523 | D>E | No | EVA | |
| rs216680762 | 550 | A>V | No | EVA | |
| rs3388824381 | 571 | N>Y | No | EVA | |
| rs3388806538 | 578 | P>S | No | EVA | |
| rs260824859 | 649 | V>L | No | EVA | |
| rs3388815920 | 664 | A>T | No | EVA | |
| rs3396720269 | 678 | E>V | No | EVA | |
| rs50582078 | 681 | V>L | No | EVA | |
| rs3413074056 | 682 | E>D | No | EVA | |
| rs3396250307 | 683 | G>R | No | EVA | |
| rs225201366 | 702 | G>D | No | EVA | |
| rs242943001 | 702 | G>S | No | EVA | |
| rs3388802334 | 754 | M>L | No | EVA | |
| rs1132229897 | 788 | V>I | No | EVA | |
| rs3396668955 | 803 | W>* | No | EVA | |
| rs3396715514 | 809 | K>* | No | EVA | |
| rs3396580538 | 809 | K>M | No | EVA | |
| rs3388789827 | 813 | G>E | No | EVA |
No associated diseases with Q920R6
No regional properties for Q920R6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q920R6 | |||
Functions
10 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical part of cell | The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue. |
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| basolateral plasma membrane | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| brush border | The dense covering of microvilli on the apical surface of an epithelial cell in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell. |
| brush border membrane | The portion of the plasma membrane surrounding the brush border. |
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| vacuolar proton-transporting V-type ATPase complex | A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen. |
| vacuolar proton-transporting V-type ATPase, V0 domain | The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATPase binding | Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP. |
| P-type proton-exporting transporter activity | Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out). These transporters use a phosphorylative mechanism, which have a phosphorylated intermediate state during the ion transport cycle. |
| proton-transporting ATPase activity, rotational mechanism | Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| ossification | The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance. |
| proton transmembrane transport | The directed movement of a proton across a membrane. |
| regulation of pH | Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. |
| renal tubular secretion | The elimination of substances from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. Substances that are secreted include organic anions, ammonia, potassium and drugs. |
| sensory perception of sound | The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound. |
| vacuolar acidification | Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion. |
16 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P32563 | VPH1 | V-type proton ATPase subunit a, vacuolar isoform | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q29466 | ATP6V0A1 | V-type proton ATPase 116 kDa subunit a 1 | Bos taurus (Bovine) | PR |
| O97681 | ATP6V0A2 | V-type proton ATPase 116 kDa subunit a 2 | Bos taurus (Bovine) | PR |
| Q9I8D0 | ATP6V0A1 | V-type proton ATPase 116 kDa subunit a 1 | Gallus gallus (Chicken) | PR |
| Q13488 | TCIRG1 | V-type proton ATPase 116 kDa subunit a 3 | Homo sapiens (Human) | PR |
| Q93050 | ATP6V0A1 | V-type proton ATPase 116 kDa subunit a 1 | Homo sapiens (Human) | PR |
| Q9Y487 | ATP6V0A2 | V-type proton ATPase 116 kDa subunit a 2 | Homo sapiens (Human) | PR |
| Q9HBG4 | ATP6V0A4 | V-type proton ATPase 116 kDa subunit a 4 | Homo sapiens (Human) | PR |
| P15920 | Atp6v0a2 | V-type proton ATPase 116 kDa subunit a 2 | Mus musculus (Mouse) | PR |
| Q9Z1G4 | Atp6v0a1 | V-type proton ATPase 116 kDa subunit a 1 | Mus musculus (Mouse) | PR |
| P25286 | Atp6v0a1 | V-type proton ATPase 116 kDa subunit a 1 | Rattus norvegicus (Rat) | PR |
| P30628 | unc-32 | V-type proton ATPase 116 kDa subunit a 1 | Caenorhabditis elegans | PR |
| Q8RWZ7 | VHA-a1 | V-type proton ATPase subunit a1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8W4S4 | VHA-a3 | V-type proton ATPase subunit a3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SJT7 | VHA-a2 | V-type proton ATPase subunit a2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| A1A5G6 | atp6v0a1 | V-type proton ATPase 116 kDa subunit a 1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASVFRSEEM | CLSQVFLQVE | AAYCCVAELG | ELGLVQFKDL | NANVNSFQRK | FVNEVRRCES |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LERILRFLED | EMQNEILIQV | PEKDAETPLP | REMITLETTL | EKLEGELQEA | NQSHQALKKS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FLELTELKYL | LKKTQDFFET | ETNLGEDFFV | EDTSGLLELR | TIPAFMTGKL | GFTAGVINRE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RMASFERLLW | RVCRGNVYLK | FSEMDTLLED | PVTKEEIKKN | IFIIFYQGEQ | LRLKIKKICD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GFRATIYPCP | EHAAERREML | TSVNVRLEDL | ITVITQTESH | RQRLLQEAAA | NWHSWVIKVQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KMKAVYHVLN | MCNIDVTQQC | IIAEIWFPVA | DTRHIKKALE | QGMELSGSSM | IPIMTEVETK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TDPPTFNRTN | KFTAGFQNIV | DAYGVGSYRE | INPAPYTIIT | FPFLFAVMFG | DCGHGMVMLM |
| 430 | 440 | 450 | 460 | 470 | 480 |
| AALWMVLNER | HLLAQKSTNE | MWNIFFNGRY | LILLMGIFSI | YTGLIYNDCF | SKSFNIFGSS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| WSVQPMFRNG | TWNTHIVENS | PYLQLDPAIP | GVYSGNPYPF | GIDPIWNLAS | NKLTFLNSYK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| MKMSVILGIA | HMIFGVILSL | FNHIYFRRTL | NIILQFIPEM | IFMLSLFGYL | VFMIIFKWCR |
| 610 | 620 | 630 | 640 | 650 | 660 |
| YDAHTSRKAP | SILIHFIGMF | LFDYDDSSNA | PLYGHQQEVQ | TFFVIIALVS | VPWMLLIKPF |
| 670 | 680 | 690 | 700 | 710 | 720 |
| VLRAKHQKSQ | LQSFTIHEDA | VEGDHSGHSS | KKTAGAHGMK | DGHEEEFNFG | DIFVHQAIHT |
| 730 | 740 | 750 | 760 | 770 | 780 |
| IEYCLGCISN | TASYLRLWAL | SLAHAELSEV | LWTMVMSIGL | RLQGWAGLVG | VFIIFAVFAV |
| 790 | 800 | 810 | 820 | 830 | |
| LTVAILLVME | GLSAFLHALR | LHWVEFQNKF | YEGAGSKFSP | FSFKHVLEGT | AEE |