Q8W4S4
PR
Gene name |
VHA-a3 (At4g39080, F19H22.180) |
Protein name |
V-type proton ATPase subunit a3 |
Names |
V-ATPase subunit a3, V-type proton ATPase 95 kDa subunit a isoform 3, V-ATPase 95 kDa isoform a3, Vacuolar H(+)-ATPase subunit a isoform 3, Vacuolar proton pump subunit a3, Vacuolar proton translocating ATPase 95 kDa subunit a isoform 3 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G39080 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8W4S4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8W4S4-F1 | Predicted | AlphaFoldDB |
23 variants for Q8W4S4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH02978637 | 11 | C>F | No | 1000Genomes | |
| tmp_4_18209571_A_T | 20 | E>V | No | 1000Genomes | |
| tmp_4_18210244_A_G | 86 | K>R | No | 1000Genomes | |
| ENSVATH00559301 | 89 | V>I | No | 1000Genomes | |
| ENSVATH12495175 | 90 | P>L | No | 1000Genomes | |
| ENSVATH02978643 | 101 | I>F | No | 1000Genomes | |
| ENSVATH14359607 | 124 | N>S | No | 1000Genomes | |
| tmp_4_18210461_G_A | 129 | R>H | No | 1000Genomes | |
| ENSVATH00559302 | 180 | E>D | No | 1000Genomes | |
| tmp_4_18210983_A_C | 181 | K>T | No | 1000Genomes | |
| tmp_4_18211494_C_T | 248 | S>F | No | 1000Genomes | |
| ENSVATH12495221 | 301 | Q>H | No | 1000Genomes | |
| ENSVATH14359638 | 302 | R>C | No | 1000Genomes | |
| tmp_4_18212151_C_T | 321 | R>C | No | 1000Genomes | |
| ENSVATH06851704 | 324 | K>N | No | 1000Genomes | |
| ENSVATH00559304 | 357 | Q>E | No | 1000Genomes | |
| tmp_4_18212452_C_T | 383 | S>L | No | 1000Genomes | |
| tmp_4_18213095_A_G | 474 | M>V | No | 1000Genomes | |
| tmp_4_18213152_C_T | 493 | P>S | No | 1000Genomes | |
| tmp_4_18213780_A_G | 624 | M>V | No | 1000Genomes | |
| ENSVATH14359643 | 647 | A>G | No | 1000Genomes | |
| tmp_4_18214166_A_G | 690 | N>D | No | 1000Genomes | |
| ENSVATH12495258 | 695 | H>R | No | 1000Genomes |
No associated diseases with Q8W4S4
No regional properties for Q8W4S4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8W4S4 | |||
11 GO annotations of cellular component
| Name | Definition |
|---|---|
| chloroplast | A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. |
| chloroplast envelope | The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plant-type vacuole | A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana. |
| plant-type vacuole membrane | The lipid bilayer surrounding a vacuole that retains the same shape regardless of cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this component is found in Arabidopsis thaliana. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| vacuolar membrane | The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell. |
| vacuolar proton-transporting V-type ATPase complex | A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen. |
| vacuolar proton-transporting V-type ATPase, V0 domain | The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane. |
| vacuole | A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATPase binding | Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP. |
| nutrient reservoir activity | Functions in the storage of nutritious substrates. |
| proton-transporting ATPase activity, rotational mechanism | Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. |
| pyrophosphate hydrolysis-driven proton transmembrane transporter activity | Enables the transmembrane transport of one proton (H+), driven by the hydrolysis of pyrophosphate, and generating a proton motive force. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| proton motive force-driven ATP synthesis | The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. |
| sequestering of zinc ion | The process of binding or confining zinc ions such that they are separated from other components of a biological system. |
| vacuolar acidification | Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion. |
| vacuolar proton-transporting V-type ATPase complex assembly | The aggregation, arrangement and bonding together of a vacuolar proton-transporting V-type ATPase complex, proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across the vacuolar membrane. |
| vacuolar sequestering | The process of transporting a substance into, and confining within, a vacuole. |
16 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P32563 | VPH1 | V-type proton ATPase subunit a, vacuolar isoform | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| O97681 | ATP6V0A2 | V-type proton ATPase 116 kDa subunit a 2 | Bos taurus (Bovine) | PR |
| Q29466 | ATP6V0A1 | V-type proton ATPase 116 kDa subunit a 1 | Bos taurus (Bovine) | PR |
| Q9I8D0 | ATP6V0A1 | V-type proton ATPase 116 kDa subunit a 1 | Gallus gallus (Chicken) | PR |
| Q9HBG4 | ATP6V0A4 | V-type proton ATPase 116 kDa subunit a 4 | Homo sapiens (Human) | PR |
| Q9Y487 | ATP6V0A2 | V-type proton ATPase 116 kDa subunit a 2 | Homo sapiens (Human) | PR |
| Q13488 | TCIRG1 | V-type proton ATPase 116 kDa subunit a 3 | Homo sapiens (Human) | PR |
| Q93050 | ATP6V0A1 | V-type proton ATPase 116 kDa subunit a 1 | Homo sapiens (Human) | PR |
| Q920R6 | Atp6v0a4 | V-type proton ATPase 116 kDa subunit a 4 | Mus musculus (Mouse) | PR |
| P15920 | Atp6v0a2 | V-type proton ATPase 116 kDa subunit a 2 | Mus musculus (Mouse) | PR |
| Q9Z1G4 | Atp6v0a1 | V-type proton ATPase 116 kDa subunit a 1 | Mus musculus (Mouse) | PR |
| P25286 | Atp6v0a1 | V-type proton ATPase 116 kDa subunit a 1 | Rattus norvegicus (Rat) | PR |
| P30628 | unc-32 | V-type proton ATPase 116 kDa subunit a 1 | Caenorhabditis elegans | PR |
| Q8RWZ7 | VHA-a1 | V-type proton ATPase subunit a1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SJT7 | VHA-a2 | V-type proton ATPase subunit a2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| A1A5G6 | atp6v0a1 | V-type proton ATPase 116 kDa subunit a 1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAESGGGGGC | CPPMDLMRSE | TMQLVQLIVP | MESAHLTVSY | LGDLGLVQFK | DLNSEKSPFQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RTYAAQIKRC | GEMARKIRFF | RDQMSKAGVP | AKEMQGKEND | IDLDDVEVKL | GELEAELVEI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NANNDKLQRS | YNELMEYKLV | LQKAGEFFSS | AHRSAADQQR | ETESQQAGED | LLESPLLQEE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KSIDSTKQVK | LGFLTGLVPR | EKSMVFERIL | FRATRGNIFI | RQTVIEEPVI | DPNSGEKAEK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NVFVVFYSGE | RAKSKILKIC | EAFGANRYPF | SEDLGRQAQM | ITEVSGRLSE | LKTTIDAGLG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QRNILLQTIG | DKFELWNLKV | RKEKAIYHTL | NMLSLDVTKK | CLVAEGWSPV | FASREIQDAL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QRAAVDSNSQ | VGSIFQVLRT | KESPPTYFRT | NKFTSAIQEI | VDAYGVAKYQ | EANPGVFTIV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TFPFLFAVMF | GDWGHGICIL | LATMYLILKE | KKLASQKLGD | IMEMAFGGRY | VILMMSLFSI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| YTGLIYNEFF | SIPFPLFAPS | AYDCRDVSCS | EATTIGLIKV | RDTYPFGLDP | VWHGSRSELP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| FLNSLKMKMS | ILLGVSQMNL | GIIMSYFNAR | FFKSSVNIWF | QFIPQMIFLN | SLFGYLSVLI |
| 610 | 620 | 630 | 640 | 650 | 660 |
| IIKWCTGSQA | DLYHVMIYMF | LSPMDELGEN | QLFPHQKTLQ | LVLLFLALVS | VPCMLLPKPF |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ILKKQHEARH | QGQAYAPLDE | TDESLHVETN | GGGSHGHEEF | EFSEIFVHQL | IHTIEFVLGA |
| 730 | 740 | 750 | 760 | 770 | 780 |
| VSNTASYLRL | WALSLAHSEL | SSVFYEKVLL | LAWGYNNPLI | LIVGVLVFIF | ATVGVLLVME |
| 790 | 800 | 810 | 820 | ||
| TLSAFLHALR | LHWVEFQNKF | YEGDGYKFAP | FTFIFTANED | E |