Q29466
PR
Gene name |
ATP6V0A1 (ATP6N1, VPP1) |
Protein name |
V-type proton ATPase 116 kDa subunit a 1 |
Names |
V-ATPase 116 kDa subunit a 1, Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit, Vacuolar adenosine triphosphatase subunit Ac116, Vacuolar proton pump subunit 1, Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:286768 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for Q29466
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 6XBW | EM | 337 A | a | 1-838 | PDB |
| 6XBY | EM | 379 A | a | 1-838 | PDB |
| 7KHR | EM | 362 A | a | 1-838 | PDB |
| AF-Q29466-F1 | Predicted | AlphaFoldDB |
No variants for Q29466
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q29466 | |||||
No associated diseases with Q29466
No regional properties for Q29466
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q29466 | |||
Functions
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| clathrin-coated vesicle membrane | The lipid bilayer surrounding a clathrin-coated vesicle. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| melanosome | A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| synaptic vesicle membrane | The lipid bilayer surrounding a synaptic vesicle. |
| vacuolar proton-transporting V-type ATPase complex | A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen. |
| vacuolar proton-transporting V-type ATPase, V0 domain | The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATPase binding | Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP. |
| proton-transporting ATPase activity, rotational mechanism | Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| pH reduction | Any process that reduces the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion. |
| proton transmembrane transport | The directed movement of a proton across a membrane. |
| vacuolar acidification | Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion. |
16 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P32563 | VPH1 | V-type proton ATPase subunit a, vacuolar isoform | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| O97681 | ATP6V0A2 | V-type proton ATPase 116 kDa subunit a 2 | Bos taurus (Bovine) | PR |
| Q9I8D0 | ATP6V0A1 | V-type proton ATPase 116 kDa subunit a 1 | Gallus gallus (Chicken) | PR |
| Q13488 | TCIRG1 | V-type proton ATPase 116 kDa subunit a 3 | Homo sapiens (Human) | PR |
| Q9HBG4 | ATP6V0A4 | V-type proton ATPase 116 kDa subunit a 4 | Homo sapiens (Human) | PR |
| Q9Y487 | ATP6V0A2 | V-type proton ATPase 116 kDa subunit a 2 | Homo sapiens (Human) | PR |
| Q93050 | ATP6V0A1 | V-type proton ATPase 116 kDa subunit a 1 | Homo sapiens (Human) | PR |
| Q920R6 | Atp6v0a4 | V-type proton ATPase 116 kDa subunit a 4 | Mus musculus (Mouse) | PR |
| P15920 | Atp6v0a2 | V-type proton ATPase 116 kDa subunit a 2 | Mus musculus (Mouse) | PR |
| Q9Z1G4 | Atp6v0a1 | V-type proton ATPase 116 kDa subunit a 1 | Mus musculus (Mouse) | PR |
| P25286 | Atp6v0a1 | V-type proton ATPase 116 kDa subunit a 1 | Rattus norvegicus (Rat) | PR |
| P30628 | unc-32 | V-type proton ATPase 116 kDa subunit a 1 | Caenorhabditis elegans | PR |
| Q8RWZ7 | VHA-a1 | V-type proton ATPase subunit a1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SJT7 | VHA-a2 | V-type proton ATPase subunit a2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8W4S4 | VHA-a3 | V-type proton ATPase subunit a3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| A1A5G6 | atp6v0a1 | V-type proton ATPase 116 kDa subunit a 1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGELFRSEEM | TLAQLFLQSE | AAYCCVSELG | ELGKVQFRDL | NPDVNVFQRK | FVNEVRRCEE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| MDRKLRFVEK | EIRKANIPIM | DTGENPEVPF | PRDMIDLEAN | FEKIENELKE | INTNQEALKR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NFLELTELKF | ILRKTQQFFD | EMADPDLLEE | SSSLLEPSEM | GRGTPLRLGF | VAGVINRERI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PTFERMLWRV | CRGNVFLRQA | EIENPLEDPV | TGDYVHKSVF | IIFFQGDQLK | NRVKKICEGF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RASLYPCPET | PQERKEMASG | VNTRIDDLQM | VLNQTEDHRQ | RVLQAAAKNI | RVWFIKVRKM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KAIYHTLNLC | NIDVTQKCLI | AEVWCPVTDL | DSIQFALRRG | TEHSGSTVPS | ILNRMQTNQT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PPTYNKTNKF | TYGFQNIVDA | YGIGTYREIN | PAPYTIITFP | FLFAVMFGDL | GHGILMTLFA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VWMVLKESRI | LSQKNENEMF | STIFSGRYII | LLMGVFSIYT | GLIYNDCFSK | SLNIFGSSWS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VRPMFDIYNW | TEETLRGNPV | LQLNPAVTGV | FGGPYPFGID | PIWNIATNKL | TFLNSFKMKM |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SVILGIIHML | FGVSLSLFNH | TYFKKPLNIY | FGFIPEIIFM | TSLFGYLVIL | IFYKWTAYNA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KTSEKAPSLL | IHFINMFLFS | YGDSGNSMLY | SGQKGIQCFL | VVVALLCVPW | MLLFKPLVLR |
| 670 | 680 | 690 | 700 | 710 | 720 |
| RQYLRRKHLG | TLNFGGIRVG | NGPTEEDAEI | IQHDQLSTHS | EDAEEPTEDE | VFDFGDTMVH |
| 730 | 740 | 750 | 760 | 770 | 780 |
| QAIHTIEYCL | GCISNTASYL | RLWALSLAHA | QLSEVLWTMV | IHIGLKVKSL | AGGLALFFIF |
| 790 | 800 | 810 | 820 | 830 | |
| AAFATLTVAI | LLIMEGLSAF | LHALRLHWVE | FQNKFYSGTG | FKFLPFSFEH | IREGKFDD |