P25286

PR
Gene name
Atp6v0a1 (Atp6n1, Vpp1)
Protein name
V-type proton ATPase 116 kDa subunit a 1
Names
V-ATPase 116 kDa subunit a 1, Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit, Vacuolar adenosine triphosphatase subunit Ac116, Vacuolar proton pump subunit 1, Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:29757
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

47-195 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

14 structures for P25286

Entry ID Method Resolution Chain Position Source
6VQ6 EM 390 A a 1-838 PDB
6VQ7 EM 400 A a 1-838 PDB
6VQ8 EM 390 A a 1-838 PDB
6VQC EM 380 A a 1-838 PDB
6VQG EM 420 A a 1-838 PDB
6VQH EM 440 A a 1-838 PDB
6VQI EM 430 A a 1-838 PDB
6VQJ EM 570 A a 1-838 PDB
6VQK EM 570 A a 1-838 PDB
7UZF EM 380 A a 1-838 PDB
7UZG EM 370 A a 1-838 PDB
7UZH EM 380 A a 1-838 PDB
7UZI EM 390 A a 1-838 PDB
AF-P25286-F1 Predicted AlphaFoldDB

No variants for P25286

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P25286

No associated diseases with P25286

1 regional properties for P25286

Type Name Position InterPro Accession
domain Tubulin/FtsZ, 2-layer sandwich domain 37 - 182 IPR018316

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Multi-pass membrane protein
  • Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein
  • Melanosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

13 GO annotations of cellular component

Name Definition
anchoring junction A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
clathrin-coated vesicle membrane The lipid bilayer surrounding a clathrin-coated vesicle.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
integral component of synaptic vesicle membrane The component of the synaptic vesicle membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
intracellular organelle Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
melanosome A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
synaptic vesicle A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
terminal bouton Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it.
vacuolar proton-transporting V-type ATPase complex A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen.
vacuolar proton-transporting V-type ATPase, V0 domain The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane.

2 GO annotations of molecular function

Name Definition
ATPase binding Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP.
proton-transporting ATPase activity, rotational mechanism Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism.

3 GO annotations of biological process

Name Definition
regulation of macroautophagy Any process that modulates the frequency, rate or extent of macroautophagy.
toxin transport The directed movement of a toxin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
vacuolar acidification Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion.

16 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P32563 VPH1 V-type proton ATPase subunit a, vacuolar isoform Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
O97681 ATP6V0A2 V-type proton ATPase 116 kDa subunit a 2 Bos taurus (Bovine) PR
Q29466 ATP6V0A1 V-type proton ATPase 116 kDa subunit a 1 Bos taurus (Bovine) PR
Q9I8D0 ATP6V0A1 V-type proton ATPase 116 kDa subunit a 1 Gallus gallus (Chicken) PR
Q13488 TCIRG1 V-type proton ATPase 116 kDa subunit a 3 Homo sapiens (Human) PR
Q9HBG4 ATP6V0A4 V-type proton ATPase 116 kDa subunit a 4 Homo sapiens (Human) PR
Q9Y487 ATP6V0A2 V-type proton ATPase 116 kDa subunit a 2 Homo sapiens (Human) PR
Q93050 ATP6V0A1 V-type proton ATPase 116 kDa subunit a 1 Homo sapiens (Human) PR
Q920R6 Atp6v0a4 V-type proton ATPase 116 kDa subunit a 4 Mus musculus (Mouse) PR
P15920 Atp6v0a2 V-type proton ATPase 116 kDa subunit a 2 Mus musculus (Mouse) PR
Q9Z1G4 Atp6v0a1 V-type proton ATPase 116 kDa subunit a 1 Mus musculus (Mouse) PR
P30628 unc-32 V-type proton ATPase 116 kDa subunit a 1 Caenorhabditis elegans PR
Q8RWZ7 VHA-a1 V-type proton ATPase subunit a1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SJT7 VHA-a2 V-type proton ATPase subunit a2 Arabidopsis thaliana (Mouse-ear cress) PR
Q8W4S4 VHA-a3 V-type proton ATPase subunit a3 Arabidopsis thaliana (Mouse-ear cress) PR
A1A5G6 atp6v0a1 V-type proton ATPase 116 kDa subunit a 1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MGELFRSEEM TLAQLFLQSE AAYCCVSELE ELGKVQFRDL NPDVNVFQRK FVNEVRRCEE
70 80 90 100 110 120
MDRKLRFVEK EIRKANIPIM DTGENPEVPF PRDMIDLEAN FEKIENELKE INTNQEALKR
130 140 150 160 170 180
NFLELTELKF ILRKTQQFFD EMADPDLLEE SSSLLEPNEM GRGAPLRLGF VAGVINRERI
190 200 210 220 230 240
PTFERMLWRV CRGNVFLRQA EIENPLEDPV TGDYVHKSVF IIFFQGDQLK NRVKKICEGF
250 260 270 280 290 300
RASLYPCPET PQERKEMASG VNTRIDDLQM VLNQTEDHRQ RVLQAAAKNI RVWFIKVRKM
310 320 330 340 350 360
KAIYHTLNLC NIDVTQKCLI AEVWCPVTDL DSIQFALRRG TEHSGSTVPS ILNRMQTNQT
370 380 390 400 410 420
PPTYNKTNKF THGFQNIVDA YGIGTYREIN PAPYTVITFP FLFAVMFGDF GHGILMTLFA
430 440 450 460 470 480
VWMVLRESRI LSQKNENEMF SMVFSGRYII LLMGLFSIYT GLIYNDCFSK SLNIFGSSWS
490 500 510 520 530 540
VRPMFTIGNW TEETLLGSSV LQLNPAIPGV FGGPYPFGID PIWNIATNKL TFLNSFKMKM
550 560 570 580 590 600
SVILGIIHML FGVSLSLFNH IYFKKPLNIY FGFIPEIIFM SSLFGYLVIL IFYKWTAYDA
610 620 630 640 650 660
HSSRNAPSLL IHFINMFLFS YPESGNAMLY SGQKGIQCFL IVVAMLCVPW MLLFKPLILR
670 680 690 700 710 720
HQYLRKKHLG TLNFGGIRVG NGPTEEDAEI IQHDQLSTHS EDAEEPTEDE VFDFGDTMVH
730 740 750 760 770 780
QAIHTIEYCL GCISNTASYL RLWALSLAHA QLSEVLWTMV IHIGLHVRSL AGGLGLFFIF
790 800 810 820 830
AAFATLTVAI LLIMEGLSAF LHALRLHWVE FQNKFYTGTG FKFLPFSFEH IREGKFDE