Q9I8D0

PR
Gene name
ATP6V0A1
Protein name
V-type proton ATPase 116 kDa subunit a 1
Names
V-ATPase 116 kDa subunit a 1, Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:395474
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

112-194 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9I8D0

Entry ID Method Resolution Chain Position Source
AF-Q9I8D0-F1 Predicted AlphaFoldDB

No variants for Q9I8D0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9I8D0

No associated diseases with Q9I8D0

2 regional properties for Q9I8D0

Type Name Position InterPro Accession
domain Ubiquitin E2 variant, N-terminal 2 - 145 IPR008883
domain Steadiness box (SB) domain 317 - 391 IPR017916

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Multi-pass membrane protein
  • Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein
  • Melanosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

8 GO annotations of cellular component

Name Definition
anchoring junction A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
clathrin-coated vesicle membrane The lipid bilayer surrounding a clathrin-coated vesicle.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
melanosome A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
synaptic vesicle membrane The lipid bilayer surrounding a synaptic vesicle.
vacuolar proton-transporting V-type ATPase complex A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen.
vacuolar proton-transporting V-type ATPase, V0 domain The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane.

2 GO annotations of molecular function

Name Definition
ATPase binding Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP.
proton-transporting ATPase activity, rotational mechanism Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism.

1 GO annotations of biological process

Name Definition
vacuolar acidification Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion.

16 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P32563 VPH1 V-type proton ATPase subunit a, vacuolar isoform Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
O97681 ATP6V0A2 V-type proton ATPase 116 kDa subunit a 2 Bos taurus (Bovine) PR
Q29466 ATP6V0A1 V-type proton ATPase 116 kDa subunit a 1 Bos taurus (Bovine) PR
Q13488 TCIRG1 V-type proton ATPase 116 kDa subunit a 3 Homo sapiens (Human) PR
Q9HBG4 ATP6V0A4 V-type proton ATPase 116 kDa subunit a 4 Homo sapiens (Human) PR
Q9Y487 ATP6V0A2 V-type proton ATPase 116 kDa subunit a 2 Homo sapiens (Human) PR
Q93050 ATP6V0A1 V-type proton ATPase 116 kDa subunit a 1 Homo sapiens (Human) PR
Q920R6 Atp6v0a4 V-type proton ATPase 116 kDa subunit a 4 Mus musculus (Mouse) PR
P15920 Atp6v0a2 V-type proton ATPase 116 kDa subunit a 2 Mus musculus (Mouse) PR
Q9Z1G4 Atp6v0a1 V-type proton ATPase 116 kDa subunit a 1 Mus musculus (Mouse) PR
P25286 Atp6v0a1 V-type proton ATPase 116 kDa subunit a 1 Rattus norvegicus (Rat) PR
P30628 unc-32 V-type proton ATPase 116 kDa subunit a 1 Caenorhabditis elegans PR
Q8RWZ7 VHA-a1 V-type proton ATPase subunit a1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SJT7 VHA-a2 V-type proton ATPase subunit a2 Arabidopsis thaliana (Mouse-ear cress) PR
Q8W4S4 VHA-a3 V-type proton ATPase subunit a3 Arabidopsis thaliana (Mouse-ear cress) PR
A1A5G6 atp6v0a1 V-type proton ATPase 116 kDa subunit a 1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MGELFRSEEM TLAQLFLQSE AAYCCVSELG ELGKVQFRDL NPDVNVFQRK FVNEVRRCEE
70 80 90 100 110 120
MDRKLRFVEK EIKKANIPIM DTGENPEVPF PRDMIDLEAN FEKIENELKE INTNQEALKR
130 140 150 160 170 180
NFLELTELKF ILRKTQQFFD EMADPDLLEE SSSLLEPSEM GRGAPLRLGF VAGVINRERI
190 200 210 220 230 240
PTFERMLWRV CRGNVFLRQA EIENPLEDPV TGDYVHKSVF IIFFQGDQLK NRVKKICEGF
250 260 270 280 290 300
RASLYPCPET PQERKEMASG VNTRIDDLQM VLNQTEDHRQ RVLQAAAKNI RVWFIKVRKM
310 320 330 340 350 360
KAIYHTLNLC NIDVTQKCLS AEVWCPVADL DSIQFALRRG TEHSGSTVPS ILNRMQTNQT
370 380 390 400 410 420
PPTYNKTNKF TCGFQNIVDA YGIGTYREIN PAPYTIITFP FLFAVMFGDF GHGILMTLIA
430 440 450 460 470 480
IWMVLRESRI LSQKSDNEMF STVFSGRYII LLMGLFSTYT GLIYNDCFSK SLNMFGSSWS
490 500 510 520 530 540
VRPMFSKANW SDELLKTTPL LQLDPAEAGV FGGPYPFGID PIWNIANNKL AFLNSFKMKM
550 560 570 580 590 600
SVILGIIHML FGVMLSLLNH IYFKKPLNIY LGFIPEMIFM SSLFGYLVIL IFYKWTAYDA
610 620 630 640 650 660
HTSKEAPSPL IHFINMFLFS YGDTSNKMLY RGQKGIQCFL VVVALLCVPW MLVAKPLVLR
670 680 690 700 710 720
HQYLRRKHLG THNFGGIRVG NGPTEEDAEI IQHDQLSTHS EEGEEPTEDE VFDFADTVVY
730 740 750 760 770 780
QAIHTIEYCL GCISNTASYL RLWALSLAHA QLSEVLWTMV IHTGLSVRSL AGGFGLVFIF
790 800 810 820 830
AAFATLTVAI LLVMEGLSAF LHALRLHWIE FQNKFYTGTG FKFLPFSFDP IREGKFDD