Q8RWZ7

PR
Gene name
VHA-a1
Protein name
V-type proton ATPase subunit a1
Names
V-ATPase subunit a1, V-type proton ATPase 95 kDa subunit a isoform 1, V-ATPase 95 kDa isoform a1, Vacuolar H(+)-ATPase subunit a isoform 1, Vacuolar proton pump subunit a1, Vacuolar proton translocating ATPase 95 kDa subunit a isoform 1
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT2G28520
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

129-209 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8RWZ7

Entry ID Method Resolution Chain Position Source
AF-Q8RWZ7-F1 Predicted AlphaFoldDB

24 variants for Q8RWZ7

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH14564811 33 R>P No 1000Genomes
ENSVATH13451094 121 S>N No 1000Genomes
ENSVATH13451105 125 R>Q No 1000Genomes
tmp_2_12211708_T_A 148 S>R No 1000Genomes
tmp_2_12211771_T_G 169 F>L No 1000Genomes
tmp_2_12211796_C_A 178 Q>K No 1000Genomes
ENSVATH05614683 184 H>L No 1000Genomes
ENSVATH05614684 187 Q>K No 1000Genomes
ENSVATH01915902 200 D>E No 1000Genomes
tmp_2_12211956_C_A 202 L>I No 1000Genomes
tmp_2_12212012_C_G 220 N>K No 1000Genomes
tmp_2_12212197_A_G 255 I>V No 1000Genomes
tmp_2_12212252_C_T 273 T>I No 1000Genomes
ENSVATH13451109 281 R>S No 1000Genomes
tmp_2_12212587_A_C 314 N>T No 1000Genomes
tmp_2_12212967_T_G 374 F>C No 1000Genomes
tmp_2_12213428_G_C 441 G>A No 1000Genomes
tmp_2_12213467_C_T 454 T>M No 1000Genomes
tmp_2_12213913_A_T 463 M>L No 1000Genomes
tmp_2_12214039_G_T 505 D>Y No 1000Genomes
tmp_2_12214173_A_T 513 T>S No 1000Genomes
tmp_2_12214759_C_G 644 L>V No 1000Genomes
tmp_2_12214983_C_T 691 A>V No 1000Genomes
ENSVATH00252551 818 I>S No 1000Genomes

No associated diseases with Q8RWZ7

3 regional properties for Q8RWZ7

Type Name Position InterPro Accession
domain Target SNARE coiled-coil homology domain 195 - 287 IPR000727
domain Syntaxin, N-terminal domain 33 - 235 IPR006011
conserved_site Syntaxin/epimorphin, conserved site 206 - 246 IPR006012

Functions

Description
EC Number
Subcellular Localization
  • Vacuole membrane ; Multi-pass membrane protein
  • Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

9 GO annotations of cellular component

Name Definition
endosome A vacuole to which materials ingested by endocytosis are delivered.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
trans-Golgi network The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.
trans-Golgi network membrane The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network.
trans-Golgi network transport vesicle membrane The lipid bilayer surrounding a vesicle transporting substances between the trans-Golgi network and other parts of the cell.
vacuolar proton-transporting V-type ATPase complex A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen.
vacuolar proton-transporting V-type ATPase, V0 domain The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane.
vacuole A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.

2 GO annotations of molecular function

Name Definition
ATPase binding Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP.
proton-transporting ATPase activity, rotational mechanism Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism.

2 GO annotations of biological process

Name Definition
proton-transporting V-type ATPase complex assembly The aggregation, arrangement and bonding together of a proton-transporting V-type ATPase complex, proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient.
vacuolar acidification Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion.

16 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P32563 VPH1 V-type proton ATPase subunit a, vacuolar isoform Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
O97681 ATP6V0A2 V-type proton ATPase 116 kDa subunit a 2 Bos taurus (Bovine) PR
Q29466 ATP6V0A1 V-type proton ATPase 116 kDa subunit a 1 Bos taurus (Bovine) PR
Q9I8D0 ATP6V0A1 V-type proton ATPase 116 kDa subunit a 1 Gallus gallus (Chicken) PR
Q9HBG4 ATP6V0A4 V-type proton ATPase 116 kDa subunit a 4 Homo sapiens (Human) PR
Q9Y487 ATP6V0A2 V-type proton ATPase 116 kDa subunit a 2 Homo sapiens (Human) PR
Q13488 TCIRG1 V-type proton ATPase 116 kDa subunit a 3 Homo sapiens (Human) PR
Q93050 ATP6V0A1 V-type proton ATPase 116 kDa subunit a 1 Homo sapiens (Human) PR
Q920R6 Atp6v0a4 V-type proton ATPase 116 kDa subunit a 4 Mus musculus (Mouse) PR
P15920 Atp6v0a2 V-type proton ATPase 116 kDa subunit a 2 Mus musculus (Mouse) PR
Q9Z1G4 Atp6v0a1 V-type proton ATPase 116 kDa subunit a 1 Mus musculus (Mouse) PR
P25286 Atp6v0a1 V-type proton ATPase 116 kDa subunit a 1 Rattus norvegicus (Rat) PR
P30628 unc-32 V-type proton ATPase 116 kDa subunit a 1 Caenorhabditis elegans PR
Q8W4S4 VHA-a3 V-type proton ATPase subunit a3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SJT7 VHA-a2 V-type proton ATPase subunit a2 Arabidopsis thaliana (Mouse-ear cress) PR
A1A5G6 atp6v0a1 V-type proton ATPase 116 kDa subunit a 1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MEEFLDKLPQ MDLMRSEKMT LVQLIIPVES AHRSITYLGE LGLLQFRDLN ADKSPFQRTF
70 80 90 100 110 120
ANQVKRCGEM SRKLRFFKDQ IDKAGLRCSP RLEIEPDIAL GDLERQLADH EHEVLEMNSN
130 140 150 160 170 180
SEKLRQTYNE LLEFKIVLEK ASGFLVSSNT HAIGEEIELH ESTYSNNGFI ETASLLEQEM
190 200 210 220 230 240
NPGHSNQSGL RFISGIINKD KLLKFERMLF RATRGNMLFN QTTSDEEIMD PSTSEMVEKV
250 260 270 280 290 300
VFVVFFSGEQ ARTKILKICE AFGANCYPVP EDTTKQRQLT REVLSRLSDL EATLDAGTRH
310 320 330 340 350 360
RNNALNSVGY SLTNWITTVR REKAVYDTLN MLNFDVTKKC LVGEGWCPTF AKTQIHEVLQ
370 380 390 400 410 420
RATFDSSSQV GVIFHVMQAV ESPPTYFRTN KLTNAFQEII DAYGVARYQE ANPAVYSVVT
430 440 450 460 470 480
YPFLFAVMFG DWGHGLCLLL GALYLLARER KLSTQKLGSF MEMLFGGRYV ILLMALFSIY
490 500 510 520 530 540
CGLIYNEFFS VPFHIFGGSA YKCRDTTCSD AYTVGLIKYR DPYPFGVDPS WRGSRTELPY
550 560 570 580 590 600
LNSLKMKMSI LLGIAQMNLG LILSFFNARF FGSSLDIRYQ FIPQMIFLNS LFGYLSLLII
610 620 630 640 650 660
IKWCTGSQAD LYHVMIYMFL SPTEELGENE LFWGQRPLQI VLLLLAFIAV PWMLFPKPFA
670 680 690 700 710 720
LRKIHMERFQ GRTYGVLVSS EVDLDVEPDS ARGGGHHEEE FNFSEIFVHQ LIHSIEFVLG
730 740 750 760 770 780
SVSNTASYLR LWALSLAHSE LSTVFYEKVL LLAWGYENIL IRLIGVAVFA FATAFILLMM
790 800 810
ETLSAFLHAL RLHWVEFMGK FFNGDGYKFK PFSFALI