Q9VKN7

PR
Gene name
aurB
Protein name
Aurora kinase B
Names
IPL1/Aurora-like protein kinase, Serine/threonine-protein kinase Ial, Serine/threonine-protein kinase aurora-B
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG6620
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-79 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

195-216 (Activation loop from InterPro)

Target domain

53-305 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q9VKN7

Entry ID Method Resolution Chain Position Source
AF-Q9VKN7-F1 Predicted AlphaFoldDB

No variants for Q9VKN7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9VKN7

No associated diseases with Q9VKN7

3 regional properties for Q9VKN7

Type Name Position InterPro Accession
domain Protein kinase domain 53 - 305 IPR000719
active_site Serine/threonine-protein kinase, active site 174 - 186 IPR008271
binding_site Protein kinase, ATP binding site 59 - 82 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Chromosome
  • Cytoplasm, cytoskeleton
  • Midbody
  • Meiotic and mitotic chromosomes
  • During each division, relocates to the midbody microtubules
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

11 GO annotations of cellular component

Name Definition
chromosome passenger complex A eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger complex coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain-containing protein Survivin, Aurora kinase, INCENP and Borealin.
chromosome, centromeric region The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
condensed chromosome, centromeric region The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
kinetochore A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
meiotic spindle midzone The area in the center of the meiotic spindle where the spindle microtubules from opposite poles overlap.
midbody A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
spindle The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.
spindle microtubule Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole.
spindle midzone The area in the center of the spindle where the spindle microtubules from opposite poles overlap.
spindle pole centrosome A centrosome from which one pole of a mitotic or meiotic spindle is organized.

7 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
histone kinase activity (H3-S28 specific) Catalysis of the transfer of a phosphate group to the serine-28 residue of histone H3.
histone serine kinase activity Catalysis of the transfer of a phosphate group to a serine residue of a histone.
metal ion binding Binding to a metal ion.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine/threonine/tyrosine kinase activity Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

14 GO annotations of biological process

Name Definition
chromatin organization The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.
chromosome condensation The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.
female germ-line stem cell asymmetric division The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes.
meiotic cell cycle Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
midbody abscission The process by which the midbody, the cytoplasmic bridge that connects the two prospective daughter cells, is severed at the end of mitotic cytokinesis, resulting in two separate daughter cells.
mitotic chromosome condensation The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells.
mitotic cytokinesis A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
mitotic sister chromatid segregation The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.
mitotic spindle assembly checkpoint signaling A signal transduction process that contributes to a mitotic cell cycle spindle assembly checkpoint, that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle.
mitotic spindle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.
positive regulation of cytokinesis Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells.
post-translational protein modification The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of cytokinesis Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells.

15 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P38991 IPL1 Spindle assembly checkpoint kinase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q7YRC6 AURKB Aurora kinase B Bos taurus (Bovine) PR
Q2TA06 AURKA Aurora kinase A Bos taurus (Bovine) PR
O14965 AURKA Aurora kinase A Homo sapiens (Human) PR
Q9UQB9 AURKC Aurora kinase C Homo sapiens (Human) PR
Q96GD4 AURKB Aurora kinase B Homo sapiens (Human) PR
O70126 Aurkb Aurora kinase B Mus musculus (Mouse) PR
O88445 Aurkc Aurora kinase C Mus musculus (Mouse) PR
P97477 Aurka Aurora kinase A Mus musculus (Mouse) PR
A5GFW1 AURKA Aurora kinase A Sus scrofa (Pig) PR
Q9N0X0 AURKB Aurora kinase B Sus scrofa (Pig) PR
O55099 Aurkb Aurora kinase B Rattus norvegicus (Rat) PR
O01427 air-2 Aurora/IPL1-related protein kinase 2 Caenorhabditis elegans PR
A4IGM9 aurkb Aurora kinase B Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q6NW76 aurkb Aurora kinase B Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MTLSRAKHAN RNHLPHLLAK VPEEHQEPIK NMCLKMMSHD AYGQPYDWSP RDFEMGAHLG
70 80 90 100 110 120
RGKFGRVYLA RERHSHYLVA MKVMFKEELR KGCVQRQVLR EIEIQSRLKH PHILRLLTWF
130 140 150 160 170 180
HDESRIYLAL EIASEGELFK HLRGAPNHRF DEPRSAKYTY QVANALNYCH LNNVIHRDLK
190 200 210 220 230 240
PENILLTSTD DLKLADFGWS AHTPNNKRRT LCGTLDYLPP EMVDGNSYDD SVDQWCLGIL
250 260 270 280 290 300
CYEFVVGCPP FESNSTESTY SKIRRMEISY PSHLSKGCKE LIGGLLRKES KGRITLVDVM
310 320
THYWVKAGMA ERELQLQKRE RGKENTARN