AiPD: Autoinhibited Protein Database

Q9UQB9

Gene name	AURKC (AIE2, AIK3, AIRK3, ARK3, STK13)
Protein name	Aurora kinase C
Names	Aurora 3, Aurora/IPL1-related kinase 3, ARK-3, Aurora-related kinase 3, Aurora/IPL1/Eg2 protein 2, Serine/threonine-protein kinase 13, Serine/threonine-protein kinase aurora-C
Species	Homo sapiens (Human)
KEGG Pathway	hsa:6795
EC number	2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-69 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-69 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

183-204 (Activation loop from InterPro)

Target domain	43-293 (Protein kinase domain)
Relief mechanism
Assay

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

3 structures for Q9UQB9

Entry ID	Method	Resolution	Chain	Position	Source
6GR8	X-ray	175 A	A	36-305	PDB
6GR9	X-ray	225 A	A	36-305	PDB
AF-Q9UQB9-F1	Predicted				AlphaFoldDB

263 variants for Q9UQB9

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
RCV002536856 RCV000825037 RCV000779270 rs749123022	35	M>missing	Infertility associated with multi-tailed spermatozoa and excessive DNA [ClinVar]	Yes	ClinVar dbSNP
RCV000725720 rs397515619 RCV000006686	49	L>missing	Infertility associated with multi-tailed spermatozoa and excessive DNA [ClinVar]	Yes	ClinVar dbSNP
CA10652260 RCV000314950 rs886054645	62	L>F	Infertility associated with multi-tailed spermatozoa and excessive DNA [ClinVar]	Yes	ClinGen ClinVar TOPMed dbSNP gnomAD
rs2087499420 RCV001130263	70	A>G	Infertility associated with multi-tailed spermatozoa and excessive DNA [ClinVar]	Yes	ClinVar dbSNP
CA9695903 rs61736320 RCV001130264	79	I>V	Infertility associated with multi-tailed spermatozoa and excessive DNA [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV001130975 rs2087531534	219	K>T	Infertility associated with multi-tailed spermatozoa and excessive DNA [ClinVar]	Yes	ClinVar dbSNP
RCV000006687 rs121908654 CA118124	229	C>Y	Infertility associated with multi-tailed spermatozoa and excessive DNA [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
rs761881153 RCV001130977 CA9696034	230	Y>C	Infertility associated with multi-tailed spermatozoa and excessive DNA [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs55658999 RCV001449804 RCV002286429 CA9696044	248	Y>*	Male infertility with spermatogenesis disorder Infertility associated with multi-tailed spermatozoa and excessive DNA [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV001133931 rs763668016 CA9696060	260	L>P	Infertility associated with multi-tailed spermatozoa and excessive DNA [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
CA407688588 rs1201425479	2	S>G		No	ClinGen TOPMed
rs1366855265 CA407688592	2	S>I		No	ClinGen TOPMed gnomAD
CA9695814 rs553335951	4	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1472508163 CA407688602	4	P>S		No	ClinGen gnomAD
CA9695816 rs141765733	5	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9695817 rs754714440	5	R>T		No	ClinGen ExAC gnomAD
CA310421908 rs914607463	9	Q>H		No	ClinGen TOPMed gnomAD
CA310421906 rs990631555	9	Q>P		No	ClinGen TOPMed gnomAD
CA310421912 rs969884455	11	G>S		No	ClinGen Ensembl
CA9695818 rs765267337	11	G>V		No	ClinGen ExAC TOPMed gnomAD
rs1278468838 CA407688652	13	A>S		No	ClinGen TOPMed gnomAD
CA407688660 rs1379841117	14	Q>*		No	ClinGen TOPMed gnomAD
rs975373769 CA310421918	14	Q>H		No	ClinGen TOPMed
CA407688673 rs1257760488	16	A>E		No	ClinGen gnomAD
rs182340558 CA9695819	16	A>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1462038055 CA407688679	17	G>D		No	ClinGen TOPMed gnomAD
CA407688676 rs1332248030	17	G>S		No	ClinGen TOPMed
CA9695821 rs777213018	18	E>K		No	ClinGen ExAC TOPMed gnomAD
CA310422168 rs200296015	20	L>S		No	ClinGen 1000Genomes
rs780948811 CA9695847	22	T>K		No	ClinGen ExAC gnomAD
rs750014683 CA9695848	23	A>T		No	ClinGen ExAC gnomAD
rs756534884 CA9695849	24	N>H		No	ClinGen ExAC gnomAD
rs1568483618 CA407688747	25	Q>L		No	ClinGen Ensembl
rs749827114 CA9695853	26	T>I		No	ClinGen ExAC gnomAD
TCGA novel	27	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1425006689 CA407688768	28	Q>H		No	ClinGen gnomAD
rs1413970158 CA407688766	28	Q>R		No	ClinGen gnomAD
rs1287521082 CA407688776	29	Q>H		No	ClinGen TOPMed
TCGA novel	30	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9695855 rs200712786	31	S>N		No	ClinGen ExAC TOPMed gnomAD
rs748307098 CA9695857	32	S>I		No	ClinGen ExAC TOPMed gnomAD
rs748307098 CA407688794	32	S>N		No	ClinGen ExAC TOPMed gnomAD
rs1466497645 CA407688803	33	P>Q		No	ClinGen gnomAD
rs1398755756 CA407688808	34	A>G		No	ClinGen gnomAD
rs772011888 CA9695858	35	M>L		No	ClinGen ExAC TOPMed gnomAD
rs772011888 CA407688811	35	M>V		No	ClinGen ExAC TOPMed gnomAD
CA9695882 rs146186252	36	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA310422235 rs866773092	36	R>W		No	ClinGen Ensembl
CA9695884 rs768412496	37	R>C		No	ClinGen ExAC gnomAD
CA9695883 rs768412496	37	R>S		No	ClinGen ExAC gnomAD
CA9695885 rs761609075	38	L>R		No	ClinGen ExAC gnomAD
rs767068148 CA9695886	39	T>A		No	ClinGen ExAC TOPMed gnomAD
rs749836915 CA9695887	43	F>L		No	ClinGen ExAC gnomAD
CA9695889 rs766182833	47	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs137858773 COSM289991 CA9695890	47	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA gnomAD
CA407688904 rs1421580444	48	P>R		No	ClinGen gnomAD
VAR_040385	52	G>E	a lung adenocarcinoma sample; somatic mutation [UniProt]	No	UniProt
CA407688935 rs1429809007	53	K>R		No	ClinGen gnomAD
rs377720871 CA9695891	54	F>L		No	ClinGen ESP ExAC gnomAD
CA310422248 rs369744086	56	N>I		No	ClinGen ESP TOPMed
CA407688962 rs1279516603	57	V>L		No	ClinGen gnomAD
CA310422250 rs967893025	58	Y>S		No	ClinGen Ensembl
COSM3835922 CA407688985 rs1218090649	61	R>W	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1222795282 CA407688993	62	L>P		No	ClinGen TOPMed gnomAD
CA9695894 rs758760516	65	S>G		No	ClinGen ExAC gnomAD
rs778334991 CA9695895	65	S>R		No	ClinGen ExAC TOPMed gnomAD
rs757312038 CA9695897	68	I>T		No	ClinGen ExAC TOPMed gnomAD
CA407689038 rs1156888282	69	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA407689053 rs1406222128	71	L>P		No	ClinGen gnomAD
rs746052199 CA9695899	73	V>I		No	ClinGen ExAC gnomAD
CA9695900 rs768463930	74	L>P		No	ClinGen ExAC
CA9695902 rs748122744	76	K>N		No	ClinGen ExAC gnomAD
CA407689099 rs1302597906	78	Q>L		No	ClinGen gnomAD
rs148631645 CA9695904	79	I>T		No	ClinGen ESP ExAC gnomAD
CA407689149 rs1406598635	83	G>E		No	ClinGen TOPMed
rs1291567225 CA407689158	84	L>V		No	ClinGen gnomAD
CA310422271 rs774920331	86	H>Y		No	ClinGen TOPMed gnomAD
TCGA novel	87	Q>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1179694544 CA407689248	90	R>Q		No	ClinGen TOPMed
CA407689245 rs1382593516	90	R>W		No	ClinGen TOPMed
CA310422272 COSM1712984 rs938334932	91	E>K	Variant assessed as Somatic; 0.0 impact. skin [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs765945753 COSM1305183 CA9695907	93	E>Q	urinary_tract [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA407689326 rs1212779545	96	A>T		No	ClinGen TOPMed
TCGA novel	97	H>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA407689354 rs1459445379	98	L>V		No	ClinGen gnomAD
rs1177291522 CA407689363	99	Q>*		No	ClinGen gnomAD
TCGA novel	100	H>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA407689486 rs202030166	102	N>D		No	ClinGen ExAC gnomAD
CA9695934 rs202030166	102	N>H		No	ClinGen ExAC gnomAD
CA9695935 rs370357811	102	N>S		No	ClinGen ESP ExAC gnomAD
rs767588611 CA9695936	103	I>S		No	ClinGen ExAC gnomAD
rs1398810905 CA407689517	104	L>R		No	ClinGen gnomAD
rs756195705 COSM266071 CA9695938	105	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA9695939 rs45555141	105	R>H		No	ClinGen ExAC
rs1202265691 CA407689550	107	Y>*		No	ClinGen gnomAD
CA310422356 rs1039212821	107	Y>F		No	ClinGen TOPMed gnomAD
TCGA novel	107	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9695941 rs758149112	108	N>D		No	ClinGen ExAC gnomAD
CA310422358 rs45623632	109	Y>C		No	ClinGen Ensembl
CA407689581 rs1485365631	110	F>C		No	ClinGen gnomAD
TCGA novel	110	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA407689578 rs1437633992 COSM3423268	110	F>V	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs199855150 CA9695943	111	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs777649755 CA9695942	111	H>Y		No	ClinGen ExAC gnomAD
rs1318062881 CA407689598	112	D>N		No	ClinGen Ensembl
CA9695944 rs771054259	113	A>P		No	ClinGen ExAC TOPMed gnomAD
rs1053349926 CA310422363	114	R>C		No	ClinGen TOPMed
rs1051922045 CA310422365	114	R>H		No	ClinGen TOPMed gnomAD
CA407689627 rs1051922045	114	R>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs547639001 CA9695946	115	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9695945 rs781258727	115	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs769321124 CA9695947	116	V>L		No	ClinGen ExAC gnomAD
rs1373163298 CA407689657	117	Y>C		No	ClinGen gnomAD
rs762620183 CA9695949	120	L>V		No	ClinGen ExAC
rs1431458756 CA407689695	121	E>*		No	ClinGen TOPMed
rs768917128 CA9695950	122	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA9695951 rs774633250	123	A>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA407689724 rs774633250	123	A>V		No	ClinGen ExAC gnomAD
CA9695952 rs762160840	124	P>S		No	ClinGen ExAC TOPMed gnomAD
rs768071401 CA9695953	125	R>S		No	ClinGen ExAC gnomAD
rs564437807 CA9695955	130	K>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs748043145 CA310422377	132	L>P		No	ClinGen Ensembl
CA407689849 rs1341328356	134	K>Q		No	ClinGen gnomAD
rs549736371 CA9695958	136	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9695960 rs779269368	138	L>*		No	ClinGen ExAC TOPMed gnomAD
rs779269368 CA9695959	138	L>S		No	ClinGen ExAC TOPMed gnomAD
rs1255301204 CA407689906	138	L>V		No	ClinGen TOPMed
rs1288469202 CA407689925	139	D>G		No	ClinGen gnomAD
CA9695961 COSM1318245 rs757093824	142	R>C	Variant assessed as Somatic; 0.0 impact. haematopoietic_and_lymphoid_tissue [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
COSM193672 CA9695962 rs781321656	142	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1301622606 CA407689975	143	T>I		No	ClinGen TOPMed
rs1200987353 CA407689989	144	A>V		No	ClinGen gnomAD
rs45503793 CA407689997	145	T>K		No	ClinGen ExAC TOPMed gnomAD
rs45503793 CA9695963 COSM3693112	145	T>M	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs747748648 CA9695986	147	I>T		No	ClinGen ExAC TOPMed gnomAD
CA9695985 rs778566668	147	I>V		No	ClinGen ExAC
VAR_040386	148	E>Q	a lung squamous cell carcinoma sample; somatic mutation [UniProt]	No	UniProt
TCGA novel	150	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA407690659 rs1262554782	152	D>V		No	ClinGen TOPMed
CA407690683 rs1191840164	154	L>P		No	ClinGen TOPMed
TCGA novel	155	T>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA407690687 rs1313709159	155	T>S		No	ClinGen gnomAD
CA407690706 rs1234928803	156	Y>C		No	ClinGen gnomAD
rs747326825 CA407690702	156	Y>D		No	ClinGen ExAC gnomAD
CA9695989 rs747326825	156	Y>H		No	ClinGen ExAC gnomAD
CA310422578 rs147955649	157	C>F		No	ClinGen ESP
CA9695990 rs771521821	158	H>R		No	ClinGen ExAC TOPMed gnomAD
rs1433221592 CA407690755	159	D>E		No	ClinGen gnomAD
CA407690745 rs1568484491	159	D>N		No	ClinGen Ensembl
rs1177453339 CA407690759	160	K>Q		No	ClinGen gnomAD
rs1220569605 CA407690853	166	D>V		No	ClinGen TOPMed
CA407690867 rs776978723	167	I>N		No	ClinGen ExAC TOPMed gnomAD
CA9695991 rs776978723	167	I>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	171	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA407690934 rs1316809304	172	L>P		No	ClinGen TOPMed
rs886295358 CA310422589	173	L>V		No	ClinGen Ensembl
TCGA novel	175	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA407690974 rs1568484519	176	F>S		No	ClinGen Ensembl
rs765370411 CA9695993	178	G>S		No	ClinGen ExAC gnomAD
rs1599974638 CA407691009	179	E>K		No	ClinGen Ensembl
rs1599974643 CA407691032	180	V>M		No	ClinGen Ensembl
CA9695994 rs775879982	181	K>M		No	ClinGen ExAC TOPMed gnomAD
rs369113656 CA9695995	183	A>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs369113656 CA9695996	183	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	185	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA407691214 rs1599974695	188	S>A		No	ClinGen Ensembl
rs766389749 CA9695999	188	S>C		No	ClinGen ExAC gnomAD
rs766389749 CA407691218	188	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA407691258 rs1462408257	190	H>L		No	ClinGen TOPMed
rs753676680 CA9696000	191	T>I		No	ClinGen ExAC gnomAD
CA9696002 rs778336053	192	P>L		No	ClinGen ExAC TOPMed gnomAD
rs778336053 CA407691304	192	P>R		No	ClinGen ExAC TOPMed gnomAD
CA9696001 rs754504724	192	P>S		No	ClinGen ExAC gnomAD
rs1292898721 CA407691332	193	S>C		No	ClinGen gnomAD
TCGA novel	194	L>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA310426735 rs200042694	197	K>N		No	ClinGen Ensembl
CA9696018 rs766038899	199	M>T		No	ClinGen ExAC gnomAD
rs1460179537 CA407692517	199	M>V		No	ClinGen TOPMed
CA310426738 rs937634821	200	C>Y		No	ClinGen TOPMed
TCGA novel	202	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9696019 rs753784986	203	L>P		No	ClinGen ExAC TOPMed gnomAD
rs752259384 CA9696022	207	P>L		No	ClinGen ExAC TOPMed gnomAD
CA407692745 rs1192298496	209	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA9696025 rs751129243	210	M>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1217468905 CA407692778	210	M>T		No	ClinGen gnomAD
CA9696024 rs777518471	210	M>V		No	ClinGen ExAC TOPMed gnomAD
rs1195267369 CA407692812	211	I>M		No	ClinGen TOPMed
CA9696026 rs757665503	211	I>T		No	ClinGen ExAC gnomAD
CA9696027 rs781355971	213	G>E		No	ClinGen ExAC gnomAD
CA407692846 rs1568484991	213	G>R		No	ClinGen Ensembl
CA310426746 rs377697885	215	T>I		No	ClinGen TOPMed gnomAD
rs560403104 CA9696029	216	Y>*		No	ClinGen ExAC gnomAD
rs1380978382 CA407692910	217	D>Y		No	ClinGen gnomAD
CA9696030 rs780694228	219	K>N		No	ClinGen ExAC gnomAD
TCGA novel	221	D>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA310426753 rs199933542	221	D>Y		No	ClinGen 1000Genomes
CA407693040 rs1429695197	225	I>T		No	ClinGen TOPMed gnomAD
CA407693058 rs1373044469	227	V>M		No	ClinGen gnomAD
TCGA novel	228	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9696036 rs776475472	235	G>R		No	ClinGen ExAC TOPMed gnomAD
CA9696037 rs759308943	235	G>V		No	ClinGen ExAC gnomAD
rs1222681629 CA407693176	236	Y>C		No	ClinGen gnomAD
CA407693170 rs1487799721	236	Y>H		No	ClinGen TOPMed gnomAD
CA9696038 rs765203245	237	P>S		No	ClinGen ExAC gnomAD
rs149157434 CA310426760	241	S>N		No	ClinGen ESP
CA407693253 rs762552612	242	A>P		No	ClinGen ExAC TOPMed gnomAD
CA9696040 rs762552612	242	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
VAR_040387	244	H>Q	a lung adenocarcinoma sample; somatic mutation [UniProt]	No	UniProt
CA407693285 rs1471193063	244	H>R		No	ClinGen gnomAD
CA9696041 rs763466275 COSM1396969	244	H>Y	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA310426765 rs1032362379	247	T>I		No	ClinGen TOPMed gnomAD
CA9696043 rs758885205	248	Y>*		No	ClinGen ExAC gnomAD
CA9696045 rs780990641	250	R>C		No	ClinGen ExAC TOPMed gnomAD
rs534798496 CA9696046	250	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA407693466 rs1190287357	254	V>I		No	ClinGen gnomAD
rs45527835 CA310426807	255	D>Y		No	ClinGen Ensembl
CA9696059 rs147392532	257	R>K		No	ClinGen 1000Genomes ExAC gnomAD
CA9696058 rs147392532	257	R>M		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	263	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9696063 rs767327431	263	P>L		No	ClinGen ExAC gnomAD
CA310426813 rs867452462	263	P>T		No	ClinGen Ensembl
TCGA novel	264	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA407693595 rs1326341552	264	L>V		No	ClinGen gnomAD
rs750070354 CA9696064	265	G>R		No	ClinGen ExAC gnomAD
rs756579497 CA9696065	266	A>P		No	ClinGen ExAC gnomAD
TCGA novel	266	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9696067 rs765491946	267	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs574255112 CA9696066	267	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1157230144 CA407693636	268	D>E		No	ClinGen gnomAD
TCGA novel	271	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA407693688 rs1259306834	272	R>T		No	ClinGen gnomAD
rs1599977438 CA407693737	276	Y>D		No	ClinGen Ensembl
CA407693750 rs936825828	277	Q>E		No	ClinGen TOPMed gnomAD
CA310426820 rs936825828	277	Q>K		No	ClinGen TOPMed gnomAD
CA407693774 rs1437359871	278	P>L		No	ClinGen TOPMed gnomAD
rs755502739 CA9696069	280	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1360082157 CA407693832	283	P>A		No	ClinGen TOPMed
rs201199082 CA9696071	286	Q>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs200445619 CA9696072	286	Q>R		No	ClinGen 1000Genomes ExAC gnomAD
CA9696073 rs777999940	287	I>N		No	ClinGen ExAC gnomAD
CA9696074 rs747182848	288	L>R		No	ClinGen ExAC gnomAD
CA9696076 rs769593496 CA9696075	290	H>Q		No	ClinGen ExAC gnomAD
CA407693915 rs1186906245	290	H>Y		No	ClinGen gnomAD
rs1004381778 CA310426830	291	P>L		No	ClinGen Ensembl
CA407693946 rs1166086375	292	W>*		No	ClinGen TOPMed gnomAD
CA9696078 rs749109023	293	V>L		No	ClinGen ExAC gnomAD
TCGA novel	294	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs768538793 CA9696079	295	A>D		No	ClinGen ExAC TOPMed gnomAD
rs768538793 CA407693985	295	A>G		No	ClinGen ExAC TOPMed gnomAD
rs1183811631 CA407693993	296	H>Y		No	ClinGen TOPMed
CA407694017 rs1373200287	298	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA407694016 rs1373200287	298	R>G		No	ClinGen TOPMed gnomAD
rs575228273 CA9696081 COSM1396977	298	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA9696082 rs544419764	299	R>T		No	ClinGen 1000Genomes ExAC gnomAD
CA310426837 rs377167746	301	L>M		No	ClinGen ESP TOPMed gnomAD
rs766124268 CA407694055	302	P>A		No	ClinGen ExAC gnomAD
rs766124268 CA9696085	302	P>S		No	ClinGen ExAC gnomAD
rs1352742293 CA407694074	304	C>R		No	ClinGen gnomAD
rs754213322 CA9696086	305	A>S		No	ClinGen ExAC gnomAD
CA9696087 rs560887013	305	A>V		No	ClinGen 1000Genomes ExAC gnomAD
rs765699626 CA9696088	307	M>V		No	ClinGen ExAC gnomAD
rs753203548 CA9696089	308	A>T		No	ClinGen ExAC gnomAD
CA310426843 rs868453657	309	S>F		No	ClinGen Ensembl

1 associated diseases with Q9UQB9

[MIM: 243060]: Spermatogenic failure 5 (SPGF5)

An infertility disorder caused by spermatogenesis defects. Semen from affected men show close to 100% morphologically abnormal multiflagellar spermatozoa with low motility, oversized irregular heads, and abnormal midpiece and acrosome. {ECO:0000269|PubMed:17435757, ECO:0000269|PubMed:21733974}. Note=The disease is caused by variants affecting the gene represented in this entry.

Without disease ID

An infertility disorder caused by spermatogenesis defects. Semen from affected men show close to 100% morphologically abnormal multiflagellar spermatozoa with low motility, oversized irregular heads, and abnormal midpiece and acrosome. {ECO:0000269|PubMed:17435757, ECO:0000269|PubMed:21733974}. Note=The disease is caused by variants affecting the gene represented in this entry.

3 regional properties for Q9UQB9

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	43 - 293	IPR000719
active_site	Serine/threonine-protein kinase, active site	162 - 174	IPR008271
binding_site	Protein kinase, ATP binding site	49 - 72	IPR017441

Functions

		Description
EC Number	2.7.11.1	Protein-serine/threonine kinases
Subcellular Localization	Nucleus Chromosome Chromosome, centromere Cytoplasm, cytoskeleton, spindle	Distributes in the condensed chromosomes during prophase to metaphase After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remains in the midbody during cytokinesis
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

10 GO annotations of cellular component

Name	Definition
chromosome passenger complex	A eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger complex coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain-containing protein Survivin, Aurora kinase, INCENP and Borealin.
chromosome, centromeric region	The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
condensed chromosome	A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
midbody	A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
spindle	The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.
spindle microtubule	Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole.
spindle midzone	The area in the center of the spindle where the spindle microtubules from opposite poles overlap.
spindle pole centrosome	A centrosome from which one pole of a mitotic or meiotic spindle is organized.

5 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
histone serine kinase activity	Catalysis of the transfer of a phosphate group to a serine residue of a histone.
protein kinase activity	Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine/tyrosine kinase activity	Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

11 GO annotations of biological process

Name	Definition
attachment of spindle microtubules to kinetochore	The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex.
cell division	The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
histone modification	The covalent alteration of one or more amino acid residues within a histone protein.
meiotic cell cycle	Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
mitotic spindle midzone assembly	The cell cycle process in which the aggregation, arrangement and bonding together of a set of components forms the spindle midzone.
mitotic spindle organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.
oocyte development	The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.
positive regulation of cytokinesis	Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells.
protein phosphorylation	The process of introducing a phosphate group on to a protein.
regulation of cytokinesis	Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells.
spermatogenesis	The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.

15 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P38991	IPL1	Spindle assembly checkpoint kinase	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q7YRC6	AURKB	Aurora kinase B	Bos taurus (Bovine)	PR
Q2TA06	AURKA	Aurora kinase A	Bos taurus (Bovine)	PR
Q9VKN7	aurB	Aurora kinase B	Drosophila melanogaster (Fruit fly)	PR
Q96GD4	AURKB	Aurora kinase B	Homo sapiens (Human)	PR
O14965	AURKA	Aurora kinase A	Homo sapiens (Human)	PR
O70126	Aurkb	Aurora kinase B	Mus musculus (Mouse)	PR
P97477	Aurka	Aurora kinase A	Mus musculus (Mouse)	PR
O88445	Aurkc	Aurora kinase C	Mus musculus (Mouse)	PR
Q9N0X0	AURKB	Aurora kinase B	Sus scrofa (Pig)	PR
A5GFW1	AURKA	Aurora kinase A	Sus scrofa (Pig)	PR
O55099	Aurkb	Aurora kinase B	Rattus norvegicus (Rat)	PR
O01427	air-2	Aurora/IPL1-related protein kinase 2	Caenorhabditis elegans	PR
A4IGM9	aurkb	Aurora kinase B	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q6NW76	aurkb	Aurora kinase B	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MSSPRAVVQL	GKAQPAGEEL	ATANQTAQQP	SSPAMRRLTV	DDFEIGRPLG	KGKFGNVYLA
70	80	90	100	110	120
RLKESHFIVA	LKVLFKSQIE	KEGLEHQLRR	EIEIQAHLQH	PNILRLYNYF	HDARRVYLIL
130	140	150	160	170	180
EYAPRGELYK	ELQKSEKLDE	QRTATIIEEL	ADALTYCHDK	KVIHRDIKPE	NLLLGFRGEV
190	200	210	220	230	240
KIADFGWSVH	TPSLRRKTMC	GTLDYLPPEM	IEGRTYDEKV	DLWCIGVLCY	ELLVGYPPFE
250	260	270	280	290	300
SASHSETYRR	ILKVDVRFPL	SMPLGARDLI	SRLLRYQPLE	RLPLAQILKH	PWVQAHSRRV

LPPCAQMAS