O01427
Gene name |
air-2 |
Protein name |
Aurora/IPL1-related protein kinase 2 |
Names |
Serine/threonine-protein kinase aurora-B |
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_B0207.4 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
170-191 (Activation loop from InterPro)
Target domain |
30-280 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for O01427
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O01427-F1 | Predicted | AlphaFoldDB |
No variants for O01427
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O01427 | |||||
No associated diseases with O01427
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
10 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromosome passenger complex | A eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger complex coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain-containing protein Survivin, Aurora kinase, INCENP and Borealin. |
| condensed chromosome | A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure. |
| condensed nuclear chromosome | A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| microtubule cytoskeleton | The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins. |
| midbody | A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis. |
| spindle | The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart. |
| spindle microtubule | Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole. |
| spindle midzone | The area in the center of the spindle where the spindle microtubules from opposite poles overlap. |
| spindle pole centrosome | A centrosome from which one pole of a mitotic or meiotic spindle is organized. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATPase binding | Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP. |
| histone serine kinase activity | Catalysis of the transfer of a phosphate group to a serine residue of a histone. |
| kinesin binding | Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation. |
| protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
17 GO annotations of biological process
| Name | Definition |
|---|---|
| chromatin organization | The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA. |
| chromosome condensation | The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells. |
| chromosome segregation | The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. |
| establishment of protein localization | The directed movement of a protein to a specific location. |
| meiotic spindle midzone assembly | The formation of the spindle midzone, the area in the center of the spindle where the spindle microtubules from opposite poles overlap, as a part of the process of meiosis. |
| mitotic cell cycle | Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. |
| mitotic cytokinesis | A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells. |
| mitotic spindle midzone assembly | The cell cycle process in which the aggregation, arrangement and bonding together of a set of components forms the spindle midzone. |
| mitotic spindle organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle. |
| peptidyl-serine phosphorylation | The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. |
| peptidyl-threonine phosphorylation | The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. |
| positive regulation of mitotic cell cycle spindle assembly checkpoint | Any process that increases the rate, frequency, or extent of the mitotic cell cycle spindle assembly checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle. |
| positive regulation of mitotic sister chromatid separation | Any process that activates or increases the frequency, rate or extent of mitotic sister chromatid separation. |
| protein autophosphorylation | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of actomyosin contractile ring contraction | Any process that modulates the frequency, rate or extent of contraction of the actomyosin ring involved in cytokinesis that takes place as part of a cell cycle. |
| regulation of cytokinesis | Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells. |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P38991 | IPL1 | Spindle assembly checkpoint kinase | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q2TA06 | AURKA | Aurora kinase A | Bos taurus (Bovine) | PR |
| Q7YRC6 | AURKB | Aurora kinase B | Bos taurus (Bovine) | PR |
| Q9VKN7 | aurB | Aurora kinase B | Drosophila melanogaster (Fruit fly) | PR |
| O14965 | AURKA | Aurora kinase A | Homo sapiens (Human) | PR |
| Q9UQB9 | AURKC | Aurora kinase C | Homo sapiens (Human) | PR |
| Q96GD4 | AURKB | Aurora kinase B | Homo sapiens (Human) | PR |
| O70126 | Aurkb | Aurora kinase B | Mus musculus (Mouse) | PR |
| O88445 | Aurkc | Aurora kinase C | Mus musculus (Mouse) | PR |
| P97477 | Aurka | Aurora kinase A | Mus musculus (Mouse) | PR |
| A5GFW1 | AURKA | Aurora kinase A | Sus scrofa (Pig) | PR |
| Q9N0X0 | AURKB | Aurora kinase B | Sus scrofa (Pig) | PR |
| O55099 | Aurkb | Aurora kinase B | Rattus norvegicus (Rat) | PR |
| A4IGM9 | aurkb | Aurora kinase B | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q6NW76 | aurkb | Aurora kinase B | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MENKPPVINL | PEKETVNTPQ | KGGKFTINDF | EIGRPLGKGK | FGSVYLARTK | TGHFHVAIKV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LFKSQLISGG | VEHQLEREIE | IQSHLNHPNI | IKLYTYFWDA | KKIYLVLEYA | PGGEMYKQLT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VSKRFSEPTA | AKYMYEIADA | LSYCHRKNVI | HRDIKPENLL | IGSQGELKIG | DFGWSVHAPS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NKRQTMCGTM | DYLPPEMVNG | ADHSDAVDLW | AIGVLCYEFL | VGKPPFEHED | QSKTYAAIKA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ARFTYPDSVK | KGARDLIGRL | LVVDPKARCT | LEQVKEHYWI | QGMMEAKIRA | EKQQKIEKEA |
| SLRNH |