P97477

PR
Gene name
Aurka
Protein name
Aurora kinase A
Names
Aurora 2, Aurora/IPL1-related kinase 1, ARK-1, Aurora-related kinase 1, Ipl1- and aurora-related kinase 1, Serine/threonine-protein kinase 15, Serine/threonine-protein kinase 6, Serine/threonine-protein kinase Ayk1, Serine/threonine-protein kinase aurora-A
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:20878
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-135 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

9 structures for P97477

Entry ID Method Resolution Chain Position Source
3D14 X-ray 190 A A 116-381 PDB
3D15 X-ray 230 A A 116-381 PDB
3D2I X-ray 290 A A 116-381 PDB
3D2K X-ray 250 A A 116-381 PDB
3DAJ X-ray 200 A A 116-381 PDB
3DJ5 X-ray 180 A A 116-381 PDB
3DJ6 X-ray 170 A A 116-381 PDB
3DJ7 X-ray 280 A A 116-381 PDB
AF-P97477-F1 Predicted AlphaFoldDB

19 variants for P97477

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388614831 39 S>N No EVA
rs3388615849 41 G>D No EVA
rs3388617039 44 Q>H No EVA
rs3388608448 108 L>F No EVA
rs3388612771 119 W>L No EVA
rs3388614809 125 D>G No EVA
rs3388615857 187 L>R No EVA
rs3388605115 194 A>P No EVA
rs3388612759 214 Q>H No EVA
rs3388615853 214 Q>P No EVA
rs3388611668 216 L>I No EVA
rs3388613788 230 E>D No EVA
rs3388612813 238 C>* No EVA
rs3388617023 270 V>L No EVA
rs3392672503 314 L>RVCLERRHPH* No EVA
rs3388614783 348 R>M No EVA
rs3388600486 364 T>A No EVA
rs3388615915 379 S>Y No EVA
rs3388600495 391 T>I No EVA

No associated diseases with P97477

3 regional properties for P97477

Type Name Position InterPro Accession
domain Protein kinase domain 124 - 374 IPR000719
active_site Serine/threonine-protein kinase, active site 243 - 255 IPR008271
binding_site Protein kinase, ATP binding site 130 - 153 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
  • Cytoplasm, cytoskeleton, spindle pole
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole
  • Cell projection, neuron projection
  • Cell projection, cilium
  • Cytoplasm, cytoskeleton, cilium basal body
  • Basolateral cell membrane
  • Localizes on centrosomes in interphase cells and at each spindle pole in mitosis (PubMed:9245792)
  • Associates with both the pericentriolar material (PCM) and centrioles (By similarity)
  • Colocalized with SIRT2 at centrosome (By similarity)
  • Detected at the neurite hillock in developing neurons (PubMed:19668197)
  • The localization to the spindle poles is regulated by AAAS (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

21 GO annotations of cellular component

Name Definition
axon hillock Portion of the neuronal cell soma from which the axon originates.
centriole A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle.
centrosome A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
chromosome passenger complex A eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger complex coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain-containing protein Survivin, Aurora kinase, INCENP and Borealin.
ciliary basal body A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
germinal vesicle The enlarged, fluid filled nucleus of a primary oocyte, the development of which is suspended in prophase I of the first meiotic division between embryohood and sexual maturity.
meiotic spindle A spindle that forms as part of meiosis. Several proteins, such as budding yeast Spo21p, fission yeast Spo2 and Spo13, and C. elegans mei-1, localize specifically to the meiotic spindle and are absent from the mitotic spindle.
microtubule cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
microtubule organizing center An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.
mitotic spindle A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules.
mitotic spindle pole Either of the ends of a mitotic spindle, a spindle that forms as part of mitosis, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.
pronucleus The nucleus of either the ovum or the spermatozoon following fertilization. Thus, in the fertilized ovum, there are two pronuclei, one originating from the ovum, the other from the spermatozoon that brought about fertilization; they approach each other, but do not fuse until just before the first cleavage, when each pronucleus loses its membrane to release its contents.
spindle The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.
spindle microtubule Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole.
spindle midzone The area in the center of the spindle where the spindle microtubules from opposite poles overlap.
spindle pole Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.
spindle pole centrosome A centrosome from which one pole of a mitotic or meiotic spindle is organized.

8 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
histone serine kinase activity Catalysis of the transfer of a phosphate group to a serine residue of a histone.
protein heterodimerization activity Binding to a nonidentical protein to form a heterodimer.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein kinase binding Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
ubiquitin protein ligase binding Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins.

29 GO annotations of biological process

Name Definition
anterior/posterior axis specification The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
apoptotic process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
centrosome cycle The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle.
centrosome localization Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell.
cilium disassembly A cellular process that results in the breakdown of a cilium.
liver regeneration The regrowth of lost or destroyed liver.
meiotic cell cycle Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
meiotic spindle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle.
microtubule cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
mitotic cell cycle Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
mitotic centrosome separation Separation of duplicated centrosome components at the beginning of mitosis. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle.
mitotic spindle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.
negative regulation of apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
negative regulation of gene expression Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
negative regulation of protein binding Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.
neuron projection extension Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
peptidyl-serine phosphorylation The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
positive regulation of mitochondrial fission Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments.
positive regulation of oocyte maturation Any process that activates or increases the frequency, rate or extent of oocyte maturation.
positive regulation of proteasomal ubiquitin-dependent protein catabolic process Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
proteasome-mediated ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
protein localization to centrosome A process in which a protein is transported to, or maintained at, the centrosome.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of cytokinesis Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells.
regulation of protein stability Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.
response to wounding Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
spindle assembly involved in female meiosis I The aggregation, arrangement and bonding together of a set of components to form the spindle during meiosis I of a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster.
spindle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart.

15 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P38991 IPL1 Spindle assembly checkpoint kinase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q7YRC6 AURKB Aurora kinase B Bos taurus (Bovine) PR
Q2TA06 AURKA Aurora kinase A Bos taurus (Bovine) PR
Q9VKN7 aurB Aurora kinase B Drosophila melanogaster (Fruit fly) PR
Q96GD4 AURKB Aurora kinase B Homo sapiens (Human) PR
Q9UQB9 AURKC Aurora kinase C Homo sapiens (Human) PR
O14965 AURKA Aurora kinase A Homo sapiens (Human) PR
O88445 Aurkc Aurora kinase C Mus musculus (Mouse) PR
O70126 Aurkb Aurora kinase B Mus musculus (Mouse) PR
Q9N0X0 AURKB Aurora kinase B Sus scrofa (Pig) PR
A5GFW1 AURKA Aurora kinase A Sus scrofa (Pig) PR
O55099 Aurkb Aurora kinase B Rattus norvegicus (Rat) PR
O01427 air-2 Aurora/IPL1-related protein kinase 2 Caenorhabditis elegans PR
A4IGM9 aurkb Aurora kinase B Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q6NW76 aurkb Aurora kinase B Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MDRCKENCVS RPVKTTVPFG PKRVLVTEQI PSQNLGSASS GQAQRVLCPS NSQRVPSQAQ
70 80 90 100 110 120
KLGAGQKPAP KQLPAASVPR PVSRLNNPQK NEQPAASGND SEKEQASLQK TEDTKKRQWT
130 140 150 160 170 180
LEDFDIGRPL GKGKFGNVYL ARERQSKFIL ALKVLFKTQL EKANVEHQLR REVEIQSHLR
190 200 210 220 230 240
HPNILRLYGY FHDATRVYLI LEYAPLGTVY RELQKLSKFD EQRTATYITE LANALSYCHS
250 260 270 280 290 300
KRVIHRDIKP ENLLLGSNGE LKIADFGWSV HAPSSRRTTM CGTLDYLPPE MIEGRMHDEK
310 320 330 340 350 360
VDLWSLGVLC YEFLVGMPPF EAHTYQETYR RISRVEFTFP DFVTEGARDL ISRLLKHNAS
370 380 390
QRLTLAEVLE HPWIKANSSK PPTGHTSKEP TSKSS