Q6NW76

PR
Gene name
aurkb (stka)
Protein name
Aurora kinase B
Names
Serine/threonine kinase A, Serine/threonine-protein kinase 12, Serine/threonine-protein kinase aurora-B
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-76 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

193-214 (Activation loop from InterPro)

Target domain

53-303 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q6NW76

Entry ID Method Resolution Chain Position Source
AF-Q6NW76-F1 Predicted AlphaFoldDB

No variants for Q6NW76

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6NW76

No associated diseases with Q6NW76

3 regional properties for Q6NW76

Type Name Position InterPro Accession
domain Protein kinase domain 53 - 303 IPR000719
active_site Serine/threonine-protein kinase, active site 172 - 184 IPR008271
binding_site Protein kinase, ATP binding site 59 - 82 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Nucleus
  • Chromosome
  • Chromosome, centromere
  • Cytoplasm, cytoskeleton, spindle
  • Midbody
  • Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis
  • Localization (and probably targeting of the CPC) to the inner centromere occurs predominantly in regions with overlapping mitosis-specific histone phosphorylations H3pT3 and H2ApT12
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

8 GO annotations of cellular component

Name Definition
chromosome passenger complex A eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger complex coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain-containing protein Survivin, Aurora kinase, INCENP and Borealin.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
kinetochore A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
midbody A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
spindle microtubule Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole.
spindle midzone The area in the center of the spindle where the spindle microtubules from opposite poles overlap.
spindle pole centrosome A centrosome from which one pole of a mitotic or meiotic spindle is organized.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
histone kinase activity (H3-S28 specific) Catalysis of the transfer of a phosphate group to the serine-28 residue of histone H3.
histone serine kinase activity Catalysis of the transfer of a phosphate group to a serine residue of a histone.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

19 GO annotations of biological process

Name Definition
abscission The controlled shedding of a body part.
cellular response to UV Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
chromosome segregation The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
cleavage furrow formation Generation of the cleavage furrow, a shallow groove in the cell surface near the old metaphase plate that marks the site of cytokinesis. This process includes the recruitment and localized activation of signals such as RhoA at the site of the future furrow to ensure that furrowing initiates at the correct site in the cell.
microtubule cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
mitotic cytokinesis A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
mitotic cytokinesis checkpoint signaling A signaling process that contributes to a mitotic cell cycle checkpoint that detects a defect in cytokinesis and prevents further rounds of nuclear division until cytokinesis is completed.
mitotic spindle assembly checkpoint signaling A signal transduction process that contributes to a mitotic cell cycle spindle assembly checkpoint, that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle.
mitotic spindle midzone assembly The cell cycle process in which the aggregation, arrangement and bonding together of a set of components forms the spindle midzone.
mitotic spindle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.
negative regulation of B cell apoptotic process Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell apoptotic process.
negative regulation of cytokinesis Any process that stops, prevents, or reduces the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
positive regulation of cytokinesis Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells.
positive regulation of mitotic sister chromatid segregation Any process that starts or increases the frequency, rate or extent of sister chromatid segregation during mitosis.
post-translational protein modification The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome.
protein localization to kinetochore Any process in which a protein is transported to, or maintained at, the kinetochore.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of cytokinesis Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells.

15 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P38991 IPL1 Spindle assembly checkpoint kinase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q2TA06 AURKA Aurora kinase A Bos taurus (Bovine) PR
Q7YRC6 AURKB Aurora kinase B Bos taurus (Bovine) PR
Q9VKN7 aurB Aurora kinase B Drosophila melanogaster (Fruit fly) PR
O14965 AURKA Aurora kinase A Homo sapiens (Human) PR
Q9UQB9 AURKC Aurora kinase C Homo sapiens (Human) PR
Q96GD4 AURKB Aurora kinase B Homo sapiens (Human) PR
P97477 Aurka Aurora kinase A Mus musculus (Mouse) PR
O70126 Aurkb Aurora kinase B Mus musculus (Mouse) PR
O88445 Aurkc Aurora kinase C Mus musculus (Mouse) PR
A5GFW1 AURKA Aurora kinase A Sus scrofa (Pig) PR
Q9N0X0 AURKB Aurora kinase B Sus scrofa (Pig) PR
O55099 Aurkb Aurora kinase B Rattus norvegicus (Rat) PR
O01427 air-2 Aurora/IPL1-related protein kinase 2 Caenorhabditis elegans PR
A4IGM9 aurkb Aurora kinase B Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MQNKENREPR VQQTPSAGVG PLRVEMNPDT HAVSGPGRVP VKSNSKVLSI DDFDIGRPLG
70 80 90 100 110 120
KGKFGNVYLA RERKLKVVIA LKVLFKSQMV KEGVEHQLRR EIEIQSHLRH PNILRFYNYF
130 140 150 160 170 180
HDDTRVFLIL EYAPRGEMYK ELQRYGRFDD QRTATYMEEV SDALQYCHEK KVIHRDIKPE
190 200 210 220 230 240
NLLLGYRGEL KIADFGWSVH APSLRRRTMC GTLDYLPPEM IEGHSHDEKV DLWSIGVLCY
250 260 270 280 290 300
ECLVGNPPFE TASHAETYKR ITKVDLQFPK LVSEGARDLI SKLLRHSPSM RLPLRSVMEH
310
PWVKANSRRV LPPVCSSEPH