A5GFW1

PR
Gene name
AURKA
Protein name
Aurora kinase A
Names
Aurora 2, Aurora/IPL1-related kinase 1, ARK-1, Aurora-related kinase 1, Ipl1- and aurora-related kinase 1, Serine/threonine-protein kinase 15, Serine/threonine-protein kinase 6, Serine/threonine-protein kinase Ayk1, Serine/threonine-protein kinase aurora-A
Species
Sus scrofa (Pig)
KEGG Pathway
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-143 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

273-294 (Activation loop from InterPro)

Target domain

133-383 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for A5GFW1

Entry ID Method Resolution Chain Position Source
AF-A5GFW1-F1 Predicted AlphaFoldDB

9 variants for A5GFW1

Variant ID(s) Position Change Description Diseaes Association Provenance
rs321932500 36 L>P No EVA
rs790708856 38 S>T No EVA
rs342865287 39 A>T No EVA
rs334418838 61 T>M No EVA
rs713130120 114 A>V No EVA
rs333023738 115 A>V No EVA
rs697222811 276 G>R No EVA
rs698254211 349 P>T No EVA
rs705717771 402 P>H No EVA

No associated diseases with A5GFW1

4 regional properties for A5GFW1

Type Name Position InterPro Accession
domain Protein kinase domain 133 - 383 IPR000719
active_site Serine/threonine-protein kinase, active site 252 - 264 IPR008271
binding_site Protein kinase, ATP binding site 139 - 162 IPR017441
domain Aurora kinase A 127 - 384 IPR030611

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
  • Cytoplasm, cytoskeleton, spindle pole
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole
  • Cell projection, neuron projection
  • Cell projection, cilium
  • Cytoplasm, cytoskeleton, cilium basal body
  • Basolateral cell membrane
  • Detected at the neurite hillock in developing neurons
  • Localizes at the centrosome in mitotic cells from early prophase until telophase, but also localizes to the spindle pole MTs from prophase to anaphase
  • Moves to the midbody during both telophase and cytokinesis
  • Associates with both the pericentriolar material (PCM) and centrioles
  • Colocalized with SIRT2 at centrosome
  • The localization to the spindle poles is regulated by AAAS (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

10 GO annotations of cellular component

Name Definition
centriole A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle.
centrosome A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
chromosome passenger complex A eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger complex coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain-containing protein Survivin, Aurora kinase, INCENP and Borealin.
ciliary basal body A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
mitotic spindle pole Either of the ends of a mitotic spindle, a spindle that forms as part of mitosis, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.
neuron projection A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
spindle microtubule Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole.
spindle midzone The area in the center of the spindle where the spindle microtubules from opposite poles overlap.
spindle pole centrosome A centrosome from which one pole of a mitotic or meiotic spindle is organized.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
histone serine kinase activity Catalysis of the transfer of a phosphate group to a serine residue of a histone.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.

9 GO annotations of biological process

Name Definition
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
cilium disassembly A cellular process that results in the breakdown of a cilium.
meiotic spindle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle.
mitotic centrosome separation Separation of duplicated centrosome components at the beginning of mitosis. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle.
mitotic spindle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.
positive regulation of meiotic cell cycle process involved in oocyte maturation Any process that activates or increases the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation.
positive regulation of translation Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of cytokinesis Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells.

15 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P38991 IPL1 Spindle assembly checkpoint kinase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q7YRC6 AURKB Aurora kinase B Bos taurus (Bovine) PR
Q2TA06 AURKA Aurora kinase A Bos taurus (Bovine) PR
Q9VKN7 aurB Aurora kinase B Drosophila melanogaster (Fruit fly) PR
Q96GD4 AURKB Aurora kinase B Homo sapiens (Human) PR
Q9UQB9 AURKC Aurora kinase C Homo sapiens (Human) PR
O14965 AURKA Aurora kinase A Homo sapiens (Human) PR
O70126 Aurkb Aurora kinase B Mus musculus (Mouse) PR
O88445 Aurkc Aurora kinase C Mus musculus (Mouse) PR
P97477 Aurka Aurora kinase A Mus musculus (Mouse) PR
Q9N0X0 AURKB Aurora kinase B Sus scrofa (Pig) PR
O55099 Aurkb Aurora kinase B Rattus norvegicus (Rat) PR
O01427 air-2 Aurora/IPL1-related protein kinase 2 Caenorhabditis elegans PR
A4IGM9 aurkb Aurora kinase B Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q6NW76 aurkb Aurora kinase B Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MDKCKENCIS GLKTTVPPGD GPKRVPVTQH FPAQHLPSAN SGQAQRVLCP SNSSQRLPSH
70 80 90 100 110 120
TQKLVSSHKP VQNLKQKQSQ ATSGPRPVSR PLSNTQQSEQ PQPAAPGNNP EKEAASKQKN
130 140 150 160 170 180
EESKKRQWAL EDFEIGRPLG KGKFGNVYLA REKQSKFILA LKVLFKTQLE KAGVEHQLRR
190 200 210 220 230 240
EVEIQSHLRH PNILRLYGYF HDATRVYLIL EYAPLGAVYR ELQKLSKFDE QRTATYITEL
250 260 270 280 290 300
ANALSYCHSK RVIHRDIKPE NLLLGSAGEL KIADFGWSVH APSSRRTTLC GTLDYLPPEM
310 320 330 340 350 360
IEGRMHDEKV DLWSLGVLCY EFLVGKPPFE ANTYQETYKR ISRVEFTFPD FVPEGARDLI
370 380 390 400
SRLLKHNPSH RPTLKEVLEH PWITANSKPA SSHKKESTSK QP