AiPD: Autoinhibited Protein Database

Q96GD4

Gene name	AURKB
Protein name	Aurora kinase B
Names	Aurora 1, Aurora- and IPL1-like midbody-associated protein 1, AIM-1, Aurora/IPL1-related kinase 2, ARK-2, Aurora-related kinase 2, STK-1, Serine/threonine-protein kinase 12, Serine/threonine-protein kinase 5, Serine/threonine-protein kinase aurora-B
Species	Homo sapiens (Human)
KEGG Pathway	hsa:9212
EC number	2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-151 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-151 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for Q96GD4

Entry ID	Method	Resolution	Chain	Position	Source
4AF3	X-ray	275 A	A	55-344	PDB
AF-Q96GD4-F1	Predicted				AlphaFoldDB

293 variants for Q96GD4

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA397985833 RCV000791307 rs1597343914	283	R>C	NK-cell enteropathy [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
CA8371674 rs773262332	2	A>V		No	ClinGen ExAC gnomAD
rs1395424704 CA397992686	3	Q>*		No	ClinGen gnomAD
TCGA novel	4	K>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	5	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8371672 rs779961970	6	N>I		No	ClinGen ExAC gnomAD
CA8371671 rs779961970	6	N>S		No	ClinGen ExAC gnomAD
CA287554682 rs779961970	6	N>T		No	ClinGen ExAC gnomAD
rs1387585682 CA397992639	7	S>A		No	ClinGen TOPMed gnomAD
CA287554662 rs745736983	8	Y>*		No	ClinGen ExAC gnomAD
rs142567548 CA8371670	8	Y>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA397992619 rs148452780	9	P>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA8371668 rs148452780	9	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA397992621 rs148452780	9	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs956825869 CA287554659	9	P>S		No	ClinGen Ensembl
rs947477963 CA287554651	12	Y>H		No	ClinGen TOPMed
rs756682338 CA8371667	13	G>C		No	ClinGen ExAC gnomAD
CA8371666 rs753550850	15	Q>*		No	ClinGen ExAC gnomAD
rs1597357177 CA397992557	15	Q>H		No	ClinGen Ensembl
rs1567578803 CA397992561	15	Q>L		No	ClinGen Ensembl
CA8371665 rs763789172	16	T>M		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	17	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA397991817 rs1597351595	18	P>L		No	ClinGen Ensembl
TCGA novel	19	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1298220077 CA397991794	19	S>F		No	ClinGen gnomAD
TCGA novel	19	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8371633 rs774168747	22	S>N		No	ClinGen ExAC TOPMed gnomAD
CA8371632 rs770844551	23	T>I		No	ClinGen ExAC TOPMed
CA397991744 rs1471615513	23	T>P		No	ClinGen TOPMed
rs749239345 CA8371630	24	L>V		No	ClinGen ExAC gnomAD
RCV001197552 rs1391275763 CA397991707	25	P>L		No	ClinGen ClinVar TOPMed dbSNP
rs924562298 CA287553490	27	R>*		No	ClinGen TOPMed gnomAD
CA397991685 rs924562298	27	R>G		No	ClinGen TOPMed gnomAD
rs370931710 CA397991684	27	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs370931710 CA397991683	27	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
COSM986231 COSM986230 CA8371629 rs370931710	27	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs769224760 CA8371628	29	L>P		No	ClinGen ExAC gnomAD
CA397991626 rs780771169	30	R>P		No	ClinGen ExAC TOPMed gnomAD
COSM1387622 CA8371626 COSM1387621 rs780771169	30	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA8371627 rs747826611	30	R>W		No	ClinGen ExAC TOPMed gnomAD
CA397991581 rs754633475	32	E>K		No	ClinGen ExAC TOPMed gnomAD
rs754633475 CA8371625	32	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs1272390478 CA397991538	33	P>T		No	ClinGen TOPMed gnomAD
CA8371624 rs144573311	34	V>I		No	ClinGen ESP ExAC
rs758885283 CA8371622	35	T>I		No	ClinGen ExAC gnomAD
rs758885283 CA8371623	35	T>S		No	ClinGen ExAC gnomAD
rs1362101464 CA397991436	36	P>S		No	ClinGen TOPMed
CA8371621 rs377496373	37	S>P		No	ClinGen ESP ExAC gnomAD
CA287553476 rs1010792978	38	A>T		No	ClinGen TOPMed gnomAD
rs1274318904 CA397991404	38	A>V		No	ClinGen TOPMed
CA397991389 rs1198016157	39	L>F		No	ClinGen TOPMed
CA8371620 rs765439455	39	L>P		No	ClinGen ExAC TOPMed gnomAD
rs761936670 CA8371619	40	V>G		No	ClinGen ExAC gnomAD
rs1306744788 CA397991372	41	L>F		No	ClinGen gnomAD
CA397991327 rs1172359320	42	M>I		No	ClinGen TOPMed gnomAD
rs764267429 CA8371617	42	M>T		No	ClinGen ExAC gnomAD
CA8371618 rs753945703	42	M>V		No	ClinGen ExAC TOPMed gnomAD
CA8371616 rs760951381	43	S>N		No	ClinGen ExAC gnomAD
CA8371615 rs529657077	44	R>C		No	ClinGen 1000Genomes ExAC gnomAD
CA8371614 rs201438176	44	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA287553456 rs1033492004	45	S>Y		No	ClinGen TOPMed
CA8371613 rs373303324	46	N>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs1249647161 CA397991224	46	N>S		No	ClinGen gnomAD
CA397991151 rs1442898027	50	T>A		No	ClinGen gnomAD
rs548042738 CA8371612	51	A>S		No	ClinGen ExAC TOPMed gnomAD
rs548042738 CA8371611	51	A>T		No	ClinGen ExAC TOPMed gnomAD
CA8371589 rs55878091 VAR_040383	52	A>V		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA397991034 rs1331070591	53	P>R		No	ClinGen TOPMed
rs372199124 CA8371587	57	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	57	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs74385486 CA8371586	58	M>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA397990972 rs1373405985	58	M>T		No	ClinGen gnomAD
CA8371584 rs199981964	61	S>G		No	ClinGen 1000Genomes ExAC gnomAD
rs368707663 CA8371583	63	G>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA287553361 rs967208121	63	G>R		No	ClinGen TOPMed
rs752882057 CA8371580	66	D>E		No	ClinGen ExAC gnomAD
rs756175507 CA8371581	66	D>N		No	ClinGen ExAC TOPMed gnomAD
rs767826491 CA8371579	67	I>F		No	ClinGen ExAC gnomAD
CA8371577 rs146036524	69	T>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs146036524 CA8371578	69	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
COSM1640912 rs767082154 COSM1640913 CA8371549	70	R>Q	stomach [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA8371550 rs141907099	70	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA397990618 rs1307369422	71	H>R		No	ClinGen gnomAD
CA397990620 rs1371205455	71	H>Y		No	ClinGen gnomAD
rs759268563 CA8371548	72	F>L		No	ClinGen ExAC
CA8371546 rs771442246	73	T>I		No	ClinGen ExAC gnomAD
rs763420999 CA8371545	74	I>T		No	ClinGen ExAC TOPMed gnomAD
rs1217804024 CA397990594	74	I>V		No	ClinGen gnomAD
CA287553229 rs1030051590	76	D>E		No	ClinGen Ensembl
rs1422636488 CA397990521	79	I>L		No	ClinGen TOPMed gnomAD
CA8371544 rs569477433	79	I>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8371543 rs752234429	81	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA287553208 rs1016005962	81	R>H		No	ClinGen TOPMed gnomAD
CA397990472 rs1567573394	83	L>P		No	ClinGen Ensembl
rs1479941422 CA397990460	84	G>D		No	ClinGen gnomAD
rs754558313 CA8371539	91	V>L		No	ClinGen ExAC TOPMed gnomAD
rs754558313 CA287553192	91	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs758519714 CA8371537	92	Y>C		No	ClinGen ExAC gnomAD
CA8371538 rs780305148	92	Y>H		No	ClinGen ExAC gnomAD
CA397990325 rs1273614816	94	A>V		No	ClinGen TOPMed
CA397990319 rs1287767783	95	R>G		No	ClinGen gnomAD
CA8371536 rs184713921	95	R>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs777418552 CA8371535	96	E>D		No	ClinGen ExAC gnomAD
CA397990261 COSM3773352 COSM3773351 rs1465361269	99	S>N	pancreas [Cosmic]	No	ClinGen cosmic curated gnomAD
CA8371534 rs756093765	99	S>R		No	ClinGen ExAC gnomAD
VAR_027970 rs3027254 CA287553162	100	H>Q		No	ClinGen UniProt Ensembl dbSNP
rs150216235 CA8371532	103	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA397990187 rs1410672341	104	A>V		No	ClinGen gnomAD
CA397990173 rs1424983703	105	L>P		No	ClinGen TOPMed gnomAD
CA287553139 rs937138967	108	L>F		No	ClinGen TOPMed gnomAD
CA8371529 rs766172470	111	S>Y		No	ClinGen ExAC gnomAD
rs1330076383 CA397990109	113	I>K		No	ClinGen gnomAD
rs1330076383 CA397990108	113	I>T		No	ClinGen gnomAD
rs148364684 CA8371528	114	E>D		No	ClinGen 1000Genomes ExAC gnomAD
rs765462146 CA8371525	117	G>C		No	ClinGen ExAC gnomAD
CA8371523 rs777080470	119	E>*		No	ClinGen ExAC TOPMed
rs777080470 CA397990031	119	E>Q		No	ClinGen ExAC TOPMed
rs1376766144 CA397989979	123	R>C		No	ClinGen gnomAD
COSM279089 CA397989977 rs1322292985	123	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA397989966 rs1470035595	124	R>K		No	ClinGen TOPMed
TCGA novel	127	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8371491 rs778477607	133	H>Q		No	ClinGen ExAC gnomAD
CA397989845 rs1166178184	133	H>R		No	ClinGen gnomAD
rs756899404 CA8371490	136	N>D		No	ClinGen ExAC gnomAD
rs754259507 CA8371489	137	I>L		No	ClinGen ExAC gnomAD
rs754259507 CA287552917	137	I>V		No	ClinGen ExAC gnomAD
COSM986224 COSM986225 CA8371487 rs761178783	139	R>C	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs753106886 CA8371486	139	R>H		No	ClinGen ExAC gnomAD
CA8371485 rs767662913	142	N>H		No	ClinGen ExAC TOPMed gnomAD
rs1482688018 CA397989381	142	N>S		No	ClinGen gnomAD
rs148133660 CA397989301	147	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8371483 rs774454455	147	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA8371484 rs148133660 COSM166451	147	R>W	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs761715349 CA8371482	149	R>S		No	ClinGen ExAC gnomAD
CA397989266 rs1218829707	150	I>F		No	ClinGen gnomAD
CA397989244 rs1162727792	151	Y>C		No	ClinGen TOPMed
rs763251744 CA8371481	152	L>S		No	ClinGen ExAC TOPMed gnomAD
rs1336269033 CA397989195	155	E>D		No	ClinGen gnomAD
rs147097910 CA8371480	157	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1416551145 CA397989139	158	P>H		No	ClinGen TOPMed gnomAD
rs1416551145 CA397989136	158	P>R		No	ClinGen TOPMed gnomAD
rs531140672 CA287552881	159	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs746973523 CA8371478	159	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA
rs746973523 CA397989114	159	R>L		No	ClinGen ExAC
rs745673717	159	R>P	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs531140672 CA8371479	159	R>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs772022668 CA8371475	160	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA8371474 rs745437215	160	G>V		No	ClinGen ExAC gnomAD
CA8371473 rs778473673	162	L>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	166	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8371471 rs141770478	167	Q>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA397988950 rs556060247	167	Q>H		No	ClinGen TOPMed
rs778145484 CA8371470	171	T>I		No	ClinGen ExAC TOPMed gnomAD
CA8371468 rs199630207	174	E>K		No	ClinGen ExAC TOPMed gnomAD
rs199630207 CA8371467	174	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA8371466 rs139322514	176	R>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs751644642 CA8371465	176	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA8371464 rs563853963	177	T>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
VAR_040384 rs55871613 CA8371463	179	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen UniProt ExAC NCI-TCGA dbSNP gnomAD
rs369799875 CA287552633	181	M>T		No	ClinGen ESP TOPMed
CA287552629 rs1024089548	183	E>K		No	ClinGen TOPMed gnomAD
rs747492163 CA8371431	184	L>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA287552611 rs993921967	185	A>T		No	ClinGen Ensembl
CA397987394 rs1555528819	187	A>P		No	ClinGen Ensembl
rs1344814938 CA397987383	188	L>V		No	ClinGen gnomAD
rs780753505 CA397987365	189	M>R		No	ClinGen ExAC TOPMed gnomAD
rs780753505 CA8371430	189	M>T		No	ClinGen ExAC TOPMed gnomAD
CA8371429 rs758942421	190	Y>*		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	192	H>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1345373862 CA397987257	194	K>N		No	ClinGen TOPMed
CA8371427 rs757425325	194	K>R		No	ClinGen ExAC TOPMed gnomAD
rs757425325 CA8371426	194	K>T		No	ClinGen ExAC TOPMed gnomAD
rs1364985233 CA397987251	195	K>E		No	ClinGen gnomAD
rs1456213387 CA397987237	195	K>N		No	ClinGen TOPMed gnomAD
CA397987222 rs1301272425	196	V>A		No	ClinGen gnomAD
CA287552578 rs1036419971	201	I>L		No	ClinGen Ensembl
TCGA novel	202	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs146905713 CA287552572	204	E>D		No	ClinGen ESP
CA397987051 rs1371011578	205	N>I		No	ClinGen gnomAD
CA397986972 rs1236404954	210	L>F		No	ClinGen TOPMed
CA8371423 rs149651741 RCV001197551 CA287552569	212	G>R		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1597347314 CA397986904	213	E>V		No	ClinGen Ensembl
rs1206885296 CA397986845	217	A>S		No	ClinGen TOPMed
rs1191377562 CA397986791	220	G>S		No	ClinGen TOPMed gnomAD
rs1597347270 CA397986766	222	S>A		No	ClinGen Ensembl
rs1479839130 CA397986742	224	H>Q		No	ClinGen gnomAD
rs766373871 CA8371421	225	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA397986446 rs1362686724	233	M>T		No	ClinGen TOPMed gnomAD
CA8371392 rs746401290	233	M>V		No	ClinGen ExAC gnomAD
CA397986394 rs1416479957	236	T>I		No	ClinGen TOPMed gnomAD
CA397986397 rs1416479957	236	T>N		No	ClinGen TOPMed gnomAD
CA287552181 rs371084440	238	D>Y		No	ClinGen ESP TOPMed gnomAD
rs1461095881 CA397986342	241	P>S		No	ClinGen gnomAD
rs1014338139 CA287552180	243	E>A		No	ClinGen Ensembl
TCGA novel	246	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs771314452 CA8371390	247	G>E		No	ClinGen ExAC TOPMed gnomAD
CA8371389 COSM3821086 rs749454960 COSM3821087	248	R>C	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
COSM3403399 rs777705809 COSM3403398 CA8371388	248	R>H	central_nervous_system [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1195973827 CA397986236	249	M>R		No	ClinGen gnomAD
CA8371387 rs756369265	249	M>V		No	ClinGen ExAC TOPMed gnomAD
CA8371385 rs779852896	252	E>G		No	ClinGen ExAC gnomAD
CA287552169 rs1037161645	255	D>H		No	ClinGen Ensembl
CA8371384 rs547667789	256	L>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs750194641 CA8371383	259	I>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs765259156 CA8371382	261	V>M		No	ClinGen ExAC gnomAD
CA397986034 rs1352124464	264	Y>C		No	ClinGen gnomAD
CA397986038 rs1458939205	264	Y>H		No	ClinGen gnomAD
CA397986002 rs1242900493	266	L>P		No	ClinGen TOPMed
CA8371380 rs377723203 CA8371381	268	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs377723203 CA8371379	268	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1444417079 CA397985979	269	G>R		No	ClinGen gnomAD
CA287552118 rs964708710	272	P>S		No	ClinGen TOPMed
rs888095238 CA287552115	273	F>L		No	ClinGen Ensembl
CA8371374 rs774578753	274	E>K		No	ClinGen ExAC gnomAD
TCGA novel	276	A>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8371372 rs749704838	278	H>R		No	ClinGen ExAC gnomAD
rs771529944 CA8371373	278	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs565442198 CA8371369 CA8371370	279	N>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8371371 rs532696717	279	N>S		No	ClinGen 1000Genomes ExAC gnomAD
rs921141395 CA287552094	280	E>D		No	ClinGen Ensembl
CA8371366 rs1466818032	280	E>K		No	ClinGen TOPMed
rs1357061315 CA397985858	281	T>A		No	ClinGen gnomAD
CA8371365 rs755160237	282	Y>F		No	ClinGen ExAC TOPMed gnomAD
rs1597343904 CA397985828	283	R>H		No	ClinGen Ensembl
rs140224531 CA8371364	284	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
COSM986222 COSM986223 rs866443565 CA287552090	284	R>H	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA397985813 rs866443565	284	R>L		No	ClinGen TOPMed gnomAD
CA397985811 rs1388038760	285	I>V		No	ClinGen gnomAD
rs764223601 CA8371362	286	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1437061929	288	V>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA397985702 rs1436349390	290	L>P		No	ClinGen TOPMed gnomAD
CA397985660 rs1262064135	293	P>H		No	ClinGen TOPMed gnomAD
rs1262064135 CA397985656	293	P>L		No	ClinGen TOPMed gnomAD
rs767082017 CA8371340	293	P>S		No	ClinGen ExAC TOPMed gnomAD
rs773593110 CA8371336	294	A>D		No	ClinGen ExAC gnomAD
CA8371338 rs151173438 COSM309397	294	A>S	lung [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs151173438 CA8371337 COSM986221 COSM986220	294	A>T	endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA8371335 rs773593110	294	A>V		No	ClinGen ExAC gnomAD
rs1240362644 CA397985640	295	S>A		No	ClinGen gnomAD
rs1335610811 CA397985634	295	S>F		No	ClinGen gnomAD
rs1454860641 CA397985631	296	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs768656332 CA8371331 COSM1387617 COSM1387618 CA8371332	298	M>I	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1059476 CA397985600	298	M>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
VAR_027971 rs1059476 CA8371333	298	M>T		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA397985576 rs1468316832	299	G>E		No	ClinGen gnomAD
CA287551966 rs987905457	301	Q>H		No	ClinGen TOPMed
CA8371330 rs760974257	301	Q>K		No	ClinGen ExAC gnomAD
rs775624172 CA8371329	302	D>G		No	ClinGen ExAC TOPMed gnomAD
CA8371328 rs772308526	303	L>F		No	ClinGen ExAC gnomAD
CA8371327 rs749106198	303	L>R		No	ClinGen ExAC TOPMed gnomAD
CA8371326 rs146334050	304	I>T		No	ClinGen 1000Genomes ExAC gnomAD
rs1189382796 CA397985522	304	I>V		No	ClinGen gnomAD
CA397985452 rs1567567792	309	R>S		No	ClinGen Ensembl
CA397985449 rs1438848669	310	H>D		No	ClinGen TOPMed
rs1465901154 CA397985425	311	N>S		No	ClinGen gnomAD
rs1465901154 CA397985427	311	N>T		No	ClinGen gnomAD
rs748036368 CA8371324	312	P>L		No	ClinGen ExAC gnomAD
CA8371323 rs144169786	313	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1031633247 CA287551961	313	S>P		No	ClinGen TOPMed
rs779610702 CA8371320	315	R>Q		No	ClinGen ExAC gnomAD
CA8371321 rs548720084	315	R>W		No	ClinGen ExAC TOPMed gnomAD
rs758063733 CA8371319	317	P>A		No	ClinGen ExAC TOPMed gnomAD
rs758063733 CA397985357	317	P>S		No	ClinGen ExAC TOPMed gnomAD
CA397985341 rs1450678505	318	L>P		No	ClinGen gnomAD
CA397985320 rs1319055091	320	Q>P		No	ClinGen gnomAD
CA397985319 rs1319055091	320	Q>R		No	ClinGen gnomAD
rs1597342831 CA397985302	321	V>G		No	ClinGen Ensembl
rs765528752 CA8371316	323	A>T		No	ClinGen ExAC gnomAD
CA397985269 rs1597342789	324	H>P		No	ClinGen Ensembl
CA8371314 rs148715809	325	P>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs148715809 CA8371313	325	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8371310 rs369229594	328	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs773142037 CA8371308	328	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs369229594 CA8371309	328	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs769668225 CA8371307	329	A>S		No	ClinGen ExAC gnomAD
rs573707475 CA287551905	329	A>V		No	ClinGen 1000Genomes gnomAD
CA8371305 rs781331723	330	N>D		No	ClinGen ExAC gnomAD
rs1597342659 CA397985196	330	N>T		No	ClinGen Ensembl
CA397985175 rs746570349	332	R>G		No	ClinGen ExAC TOPMed gnomAD
rs879004728 CA397985170	332	R>L		No	ClinGen TOPMed gnomAD
rs879004728 CA397985171	332	R>P		No	ClinGen TOPMed gnomAD
rs879004728 CA287551900	332	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs746570349 CA8371303	332	R>W		No	ClinGen ExAC TOPMed gnomAD
CA397985155 rs1597342598	334	V>G		No	ClinGen Ensembl
rs758002006 CA8371301	336	P>S		No	ClinGen ExAC TOPMed gnomAD
CA8371299 rs779280853	338	S>F		No	ClinGen ExAC gnomAD
CA397985130 rs1304933044	339	A>D		No	ClinGen gnomAD
CA287551889 rs926096865	340	L>R		No	ClinGen Ensembl
CA287551887 rs267605101	341	Q>*		No	ClinGen Ensembl
CA397985120 rs1261323776	341	Q>P		No	ClinGen gnomAD
CA8371296 rs201709756	344	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8371295 COSM1387613 COSM1387614 rs201709756	344	A>T	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1161457774 CA397985098	345	A>R		No	ClinGen TOPMed gnomAD

1 associated diseases with Q96GD4

Without disease ID

3 regional properties for Q96GD4

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	77 - 327	IPR000719
active_site	Serine/threonine-protein kinase, active site	196 - 208	IPR008271
binding_site	Protein kinase, ATP binding site	83 - 106	IPR017441

Functions

		Description
EC Number	2.7.11.1	Protein-serine/threonine kinases
Subcellular Localization	Nucleus Chromosome Chromosome, centromere Chromosome, centromere, kinetochore Cytoplasm, cytoskeleton, spindle Midbody	Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis (PubMed:20929775) Colocalized with gamma tubulin in the midbody (PubMed:17726514) Proper localization of the active, Thr-232-phosphorylated form during metaphase may be dependent upon interaction with SPDYC (PubMed:20605920) Colocalized with SIRT2 during cytokinesis with the midbody (PubMed:17726514) Localization (and probably targeting of the CPC) to the inner centromere occurs predominantly in regions with overlapping mitosis-specific histone phosphorylations H3pT3 and H2ApT12 (PubMed:20929775)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

15 GO annotations of cellular component

Name	Definition
chromocenter	A region in which centric, heterochromatic portions from more than one chromosomes form a compact structure.
chromosome passenger complex	A eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger complex coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain-containing protein Survivin, Aurora kinase, INCENP and Borealin.
condensed chromosome, centromeric region	The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
kinetochore	A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
microtubule cytoskeleton	The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
midbody	A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
mitotic spindle midzone	The area in the center of the anaphase spindle consisting of microtubules, microtubule bundling factors and kinesin motors where the spindle microtubules from opposite poles overlap in an antiparallel manner.
mitotic spindle pole	Either of the ends of a mitotic spindle, a spindle that forms as part of mitosis, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
spindle	The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.
spindle microtubule	Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole.
spindle midzone	The area in the center of the spindle where the spindle microtubules from opposite poles overlap.
spindle pole centrosome	A centrosome from which one pole of a mitotic or meiotic spindle is organized.

6 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
histone serine kinase activity	Catalysis of the transfer of a phosphate group to a serine residue of a histone.
kinase binding	Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine/threonine/tyrosine kinase activity	Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

36 GO annotations of biological process

Name	Definition
abscission	The controlled shedding of a body part.
aging	A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
attachment of spindle microtubules to kinetochore	The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex.
cell population proliferation	The multiplication or reproduction of cells, resulting in the expansion of a cell population.
cellular response to UV	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
cleavage furrow formation	Generation of the cleavage furrow, a shallow groove in the cell surface near the old metaphase plate that marks the site of cytokinesis. This process includes the recruitment and localized activation of signals such as RhoA at the site of the future furrow to ensure that furrowing initiates at the correct site in the cell.
histone modification	The covalent alteration of one or more amino acid residues within a histone protein.
mitotic cell cycle	Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
mitotic cytokinesis	A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
mitotic cytokinesis checkpoint signaling	A signaling process that contributes to a mitotic cell cycle checkpoint that detects a defect in cytokinesis and prevents further rounds of nuclear division until cytokinesis is completed.
mitotic spindle assembly checkpoint signaling	A signal transduction process that contributes to a mitotic cell cycle spindle assembly checkpoint, that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle.
mitotic spindle midzone assembly	The cell cycle process in which the aggregation, arrangement and bonding together of a set of components forms the spindle midzone.
mitotic spindle organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.
negative regulation of B cell apoptotic process	Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell apoptotic process.
negative regulation of cytokinesis	Any process that stops, prevents, or reduces the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells.
negative regulation of protein binding	Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.
negative regulation of transcription by RNA polymerase II	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
positive regulation of attachment of mitotic spindle microtubules to kinetochore	Any process that activates or increases the frequency, rate or extent of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation.
positive regulation of cytokinesis	Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells.
positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore	Any process that activates or increases the frequency, rate or extent of lateral attachment of mitotic spindle microtubules to kinetochore.
positive regulation of mitotic cell cycle spindle assembly checkpoint	Any process that increases the rate, frequency, or extent of the mitotic cell cycle spindle assembly checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle.
positive regulation of mitotic cytokinesis	Any process that activates or increases the frequency, rate or extent of mitotic cytokinesis.
positive regulation of mitotic sister chromatid segregation	Any process that starts or increases the frequency, rate or extent of sister chromatid segregation during mitosis.
positive regulation of mitotic sister chromatid separation	Any process that activates or increases the frequency, rate or extent of mitotic sister chromatid separation.
positive regulation of protein phosphorylation	Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
positive regulation of telomerase activity	Any process that activates or increases the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
positive regulation of telomere capping	Any process that activates or increases the frequency, rate or extent of telomere capping.
positive regulation of telomere maintenance via telomerase	Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase.
post-translational protein modification	The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome.
protein autophosphorylation	The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
protein localization to kinetochore	Any process in which a protein is transported to, or maintained at, the kinetochore.
protein phosphorylation	The process of introducing a phosphate group on to a protein.
regulation of chromosome segregation	Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets.
regulation of cytokinesis	Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells.
regulation of signal transduction by p53 class mediator	Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator.
spindle organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart.

15 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P38991	IPL1	Spindle assembly checkpoint kinase	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q2TA06	AURKA	Aurora kinase A	Bos taurus (Bovine)	PR
Q7YRC6	AURKB	Aurora kinase B	Bos taurus (Bovine)	PR
Q9VKN7	aurB	Aurora kinase B	Drosophila melanogaster (Fruit fly)	PR
Q9UQB9	AURKC	Aurora kinase C	Homo sapiens (Human)	PR
O14965	AURKA	Aurora kinase A	Homo sapiens (Human)	PR
P97477	Aurka	Aurora kinase A	Mus musculus (Mouse)	PR
O88445	Aurkc	Aurora kinase C	Mus musculus (Mouse)	PR
O70126	Aurkb	Aurora kinase B	Mus musculus (Mouse)	PR
A5GFW1	AURKA	Aurora kinase A	Sus scrofa (Pig)	PR
Q9N0X0	AURKB	Aurora kinase B	Sus scrofa (Pig)	PR
O55099	Aurkb	Aurora kinase B	Rattus norvegicus (Rat)	PR
O01427	air-2	Aurora/IPL1-related protein kinase 2	Caenorhabditis elegans	PR
A4IGM9	aurkb	Aurora kinase B	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q6NW76	aurkb	Aurora kinase B	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MAQKENSYPW	PYGRQTAPSG	LSTLPQRVLR	KEPVTPSALV	LMSRSNVQPT	AAPGQKVMEN
70	80	90	100	110	120
SSGTPDILTR	HFTIDDFEIG	RPLGKGKFGN	VYLAREKKSH	FIVALKVLFK	SQIEKEGVEH
130	140	150	160	170	180
QLRREIEIQA	HLHHPNILRL	YNYFYDRRRI	YLILEYAPRG	ELYKELQKSC	TFDEQRTATI
190	200	210	220	230	240
MEELADALMY	CHGKKVIHRD	IKPENLLLGL	KGELKIADFG	WSVHAPSLRR	KTMCGTLDYL
250	260	270	280	290	300
PPEMIEGRMH	NEKVDLWCIG	VLCYELLVGN	PPFESASHNE	TYRRIVKVDL	KFPASVPMGA
310	320	330	340
QDLISKLLRH	NPSERLPLAQ	VSAHPWVRAN	SRRVLPPSAL	QSVA