O88445
PR
Gene name |
Aurkc (Aie1, Aik3, Airk3, Ark3, Stk13) |
Protein name |
Aurora kinase C |
Names |
Aurora 3, Aurora/IPL1-related kinase 3, ARK-3, Aurora-related kinase 3, Aurora/IPL1/Eg2 protein 1, Serine/threonine-protein kinase 13, Serine/threonine-protein kinase aurora-C |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:20871 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O88445
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O88445-F1 | Predicted | AlphaFoldDB |
29 variants for O88445
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs585118864 | 10 | H>R | No | EVA | |
| rs3397620742 | 13 | I>S | No | EVA | |
| rs3388881691 | 20 | R>C | No | EVA | |
| rs3388873054 | 29 | R>C | No | EVA | |
| rs108002113 | 34 | R>G | No | EVA | |
| rs3412911176 | 34 | R>P | No | EVA | |
| rs3397528649 | 46 | V>F | No | EVA | |
| rs108167585 | 48 | F>S | No | EVA | |
| rs108846394 | 53 | E>D | No | EVA | |
| rs3388877281 | 55 | E>K | No | EVA | |
| rs108170789 | 62 | R>C | No | EVA | |
| rs1132020431 | 62 | R>L | No | EVA | |
| rs578915695 | 74 | R>P | No | EVA | |
| rs3397207367 | 102 | Y>* | No | EVA | |
| rs1133671733 | 112 | D>A | No | EVA | |
| rs1133000003 | 115 | R>H | No | EVA | |
| rs582541712 | 121 | Q>R | No | EVA | |
| rs3388871200 | 122 | E>D | No | EVA | |
| rs1132056011 | 137 | H>Q | No | EVA | |
| rs3397666593 | 164 | T>P | No | EVA | |
| rs3388878950 | 165 | P>L | No | EVA | |
| rs3388858006 | 186 | Q>R | No | EVA | |
| rs3388877233 | 203 | Y>C | No | EVA | |
| rs3388880036 | 215 | S>R | No | EVA | |
| rs3388866217 | 218 | S>R | No | EVA | |
| rs3388873100 | 237 | A>S | No | EVA | |
| rs3388857972 | 241 | D>V | No | EVA | |
| rs3388862059 | 252 | S>L | No | EVA | |
| rs3397665373 | 277 | C>C | No | EVA |
No associated diseases with O88445
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
11 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromosome | A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. |
| chromosome passenger complex | A eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger complex coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain-containing protein Survivin, Aurora kinase, INCENP and Borealin. |
| chromosome, centromeric region | The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. |
| condensed chromosome | A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| meiotic spindle midzone | The area in the center of the meiotic spindle where the spindle microtubules from opposite poles overlap. |
| midbody | A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| spindle microtubule | Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole. |
| spindle midzone | The area in the center of the spindle where the spindle microtubules from opposite poles overlap. |
| spindle pole centrosome | A centrosome from which one pole of a mitotic or meiotic spindle is organized. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| histone serine kinase activity | Catalysis of the transfer of a phosphate group to a serine residue of a histone. |
| protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| meiotic cell cycle | Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions. |
| mitotic spindle organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle. |
| oocyte development | The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. |
| protein autophosphorylation | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of cytokinesis | Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells. |
| spermatogenesis | The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. |
| spindle midzone assembly | The cell cycle process in which aggregation, arrangement and bonding together of a set of components to form the spindle midzone. The spindle midzone is the area in the center of the spindle where the spindle microtubules from opposite poles overlap. |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P38991 | IPL1 | Spindle assembly checkpoint kinase | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q7YRC6 | AURKB | Aurora kinase B | Bos taurus (Bovine) | PR |
| Q2TA06 | AURKA | Aurora kinase A | Bos taurus (Bovine) | PR |
| Q9VKN7 | aurB | Aurora kinase B | Drosophila melanogaster (Fruit fly) | PR |
| O14965 | AURKA | Aurora kinase A | Homo sapiens (Human) | PR |
| Q96GD4 | AURKB | Aurora kinase B | Homo sapiens (Human) | PR |
| Q9UQB9 | AURKC | Aurora kinase C | Homo sapiens (Human) | PR |
| O70126 | Aurkb | Aurora kinase B | Mus musculus (Mouse) | PR |
| P97477 | Aurka | Aurora kinase A | Mus musculus (Mouse) | PR |
| Q9N0X0 | AURKB | Aurora kinase B | Sus scrofa (Pig) | PR |
| A5GFW1 | AURKA | Aurora kinase A | Sus scrofa (Pig) | PR |
| O55099 | Aurkb | Aurora kinase B | Rattus norvegicus (Rat) | PR |
| O01427 | air-2 | Aurora/IPL1-related protein kinase 2 | Caenorhabditis elegans | PR |
| A4IGM9 | aurkb | Aurora kinase B | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q6NW76 | aurkb | Aurora kinase B | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEPSTSTRKH | FTINDFEIGR | PLGRGKFGRV | YLARLKENHF | IVALKVLFKS | EIEKEGLEHQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LRREVEIQAH | LQHRNILRLY | NYFYDDTRIY | LILEYAPGGE | LYKELQRHQK | LDQQRTATII |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QELSDALTYC | HEKKVIHRDI | KPENLLLGLN | GEVKISDFGW | SVHTPSLRRK | TMCGTLDYLP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PEMIAQKPYN | EMVDLWCIGV | LCYELLVGKP | PFESSTSSET | YRRIRQVDFK | FPSSVPAGAQ |
| 250 | 260 | 270 | |||
| DLISKLLRYH | PSERLSLAQV | LKHPWVREHS | RRVLPC |