P38991
Gene name |
IPL1 (YPL209C) |
Protein name |
Spindle assembly checkpoint kinase |
Names |
Aurora kinase, Increase-in-ploidy protein 1 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YPL209C |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
244-266 (Activation loop from InterPro)
Target domain |
104-355 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for P38991
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P38991-F1 | Predicted | AlphaFoldDB |
3 variants for P38991
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s16-157381 | 71 | S>N | No | SGRP | |
| s16-156559 | 345 | R>P | No | SGRP | |
| s16-156517 | 359 | K>M | No | SGRP |
No associated diseases with P38991
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
9 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromosome passenger complex | A eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger complex coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain-containing protein Survivin, Aurora kinase, INCENP and Borealin. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| kinetochore | A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. |
| kinetochore microtubule | Any of the spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic or meiotic chromosome segregation. |
| microtubule | Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| spindle | The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart. |
| spindle microtubule | Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole. |
| spindle midzone | The area in the center of the spindle where the spindle microtubules from opposite poles overlap. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| histone serine kinase activity | Catalysis of the transfer of a phosphate group to a serine residue of a histone. |
| protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
16 GO annotations of biological process
| Name | Definition |
|---|---|
| attachment of spindle microtubules to kinetochore | The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex. |
| attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation | The cell cycle process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex contributing to meiotic chromosome segregation. |
| chromosome segregation | The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. |
| homologous chromosome segregation | The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets. |
| meiotic sister chromatid segregation | The cell cycle process in which sister chromatids are organized and then physically separated and randomly apportioned to two sets during the second division of the meiotic cell cycle. |
| mitotic DNA integrity checkpoint signaling | A signaling process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA during mitosis. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction. |
| mitotic spindle disassembly | The controlled breakdown of the spindle during a mitotic cell cycle. |
| mitotic spindle organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle. |
| negative regulation of protein import into nucleus during spindle assembly checkpoint | Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus, and that occurs as a response to the mitotic cell cycle spindle assembly checkpoint. In S. cerevisiae, this process involves inhibition of the karyopherin/importin Kap121p (also known as Pse1p), which acts as the specific nuclear import receptor for several proteins, including Glc7p. Glc7p functions in opposition to key spindle assembly checkpoint protein Aurora kinase (Ipl1p). |
| peptidyl-serine phosphorylation | The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. |
| peptidyl-threonine phosphorylation | The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. |
| positive regulation of mitotic cell cycle spindle assembly checkpoint | Any process that increases the rate, frequency, or extent of the mitotic cell cycle spindle assembly checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle. |
| regulation of cytokinesis | Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells. |
| regulation of mitotic cell cycle spindle assembly checkpoint | Any process that modulates the rate, frequency, or extent of the mitotic cell cycle spindle assembly checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle. |
| regulation of mitotic spindle assembly | Any process that modulates the frequency, rate or extent of mitotic spindle assembly. |
| sister chromatid biorientation | The cell cycle process in which sister chromatids establish stable attachments to microtubules emanating from opposite spindle poles. |
14 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2TA06 | AURKA | Aurora kinase A | Bos taurus (Bovine) | PR |
| Q9VKN7 | aurB | Aurora kinase B | Drosophila melanogaster (Fruit fly) | PR |
| Q9UQB9 | AURKC | Aurora kinase C | Homo sapiens (Human) | PR |
| Q96GD4 | AURKB | Aurora kinase B | Homo sapiens (Human) | PR |
| O14965 | AURKA | Aurora kinase A | Homo sapiens (Human) | PR |
| O88445 | Aurkc | Aurora kinase C | Mus musculus (Mouse) | PR |
| O70126 | Aurkb | Aurora kinase B | Mus musculus (Mouse) | PR |
| P97477 | Aurka | Aurora kinase A | Mus musculus (Mouse) | PR |
| Q9N0X0 | AURKB | Aurora kinase B | Sus scrofa (Pig) | PR |
| A5GFW1 | AURKA | Aurora kinase A | Sus scrofa (Pig) | PR |
| O55099 | Aurkb | Aurora kinase B | Rattus norvegicus (Rat) | PR |
| O01427 | air-2 | Aurora/IPL1-related protein kinase 2 | Caenorhabditis elegans | PR |
| A4IGM9 | aurkb | Aurora kinase B | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q6NW76 | aurkb | Aurora kinase B | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MQRNSLVNIK | LNANSPSKKT | TTRPNTSRIN | KPWRISHSPQ | QRNPNSKIPS | PVREKLNRLP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VNNKKFLDME | SSKIPSPIRK | ATSSKMIHEN | KKLPKFKSLS | LDDFELGKKL | GKGKFGKVYC |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VRHRSTGYIC | ALKVMEKEEI | IKYNLQKQFR | REVEIQTSLN | HPNLTKSYGY | FHDEKRVYLL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MEYLVNGEMY | KLLRLHGPFN | DILASDYIYQ | IANALDYMHK | KNIIHRDIKP | ENILIGFNNV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IKLTDFGWSI | INPPENRRKT | VCGTIDYLSP | EMVESREYDH | TIDAWALGVL | AFELLTGAPP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FEEEMKDTTY | KRIAALDIKM | PSNISQDAQD | LILKLLKYDP | KDRMRLGDVK | MHPWILRNKP |
| FWENKRL |