AiPD: Autoinhibited Protein Database

O14965

Gene name	AURKA
Protein name	Aurora kinase A
Names	Aurora 2, Aurora/IPL1-related kinase 1, ARK-1, Aurora-related kinase 1, Breast tumor-amplified kinase, Ipl1- and aurora-related kinase 1, Serine/threonine-protein kinase 15, Serine/threonine-protein kinase 6, Serine/threonine-protein kinase Ayk1, Serine/threonine-protein kinase aurora-A
Species	Homo sapiens (Human)
KEGG Pathway	hsa:6790
EC number	2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-152 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-152 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

273-294 (Activation loop from InterPro)

Target domain	133-383 (Protein kinase domain)
Relief mechanism
Assay

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

184 structures for O14965

Entry ID	Method	Resolution	Chain	Position	Source
1MQ4	X-ray	190 A	A	125-391	PDB
1MUO	X-ray	290 A	A	107-403	PDB
1OL5	X-ray	250 A	A	122-403	PDB
1OL6	X-ray	300 A	A	122-403	PDB
1OL7	X-ray	275 A	A	122-403	PDB
2BMC	X-ray	260 A	A/B/C/D/E/F	100-403	PDB
2C6D	X-ray	220 A	A	124-398	PDB
2C6E	X-ray	210 A	A/B	123-401	PDB
2DWB	X-ray	250 A	A	122-403	PDB
2J4Z	X-ray	200 A	A/B	100-403	PDB
2J50	X-ray	300 A	A/B	126-403	PDB
2NP8	X-ray	225 A	A	125-391	PDB
2W1C	X-ray	324 A	A	122-389	PDB
2W1D	X-ray	297 A	A	122-389	PDB
2W1E	X-ray	293 A	A	122-389	PDB
2W1F	X-ray	285 A	A	122-389	PDB
2W1G	X-ray	271 A	A	122-389	PDB
2WQE	X-ray	250 A	A	127-388	PDB
2WTV	X-ray	240 A	A/B/C/D	122-403	PDB
2WTW	X-ray	330 A	A	122-403	PDB
2X6D	X-ray	280 A	A	122-403	PDB
2X6E	X-ray	335 A	A	122-403	PDB
2X81	X-ray	291 A	A	126-391	PDB
2XNE	X-ray	280 A	A	122-392	PDB
2XNG	X-ray	260 A	A	122-403	PDB
2XRU	X-ray	290 A	A	126-403	PDB
3COH	X-ray	270 A	A/B	124-391	PDB
3E5A	X-ray	230 A	A	125-391	PDB
3EFW	X-ray	229 A	A/B	125-391	PDB
3FDN	X-ray	190 A	A	123-401	PDB
3H0Y	X-ray	250 A	A	124-391	PDB
3H0Z	X-ray	292 A	A/B/C	124-391	PDB
3H10	X-ray	220 A	A/B/D	124-391	PDB
3HA6	X-ray	236 A	A	125-391	PDB
3K5U	X-ray	235 A	A	123-401	PDB
3LAU	X-ray	210 A	A	125-399	PDB
3M11	X-ray	275 A	A	123-401	PDB
3MYG	X-ray	240 A	A	125-391	PDB
3NRM	X-ray	305 A	A	126-403	PDB
3O50	X-ray	200 A	A/B	125-391	PDB
3O51	X-ray	320 A	A	125-391	PDB
3P9J	X-ray	280 A	A	125-391	PDB
3QBN	X-ray	350 A	A	124-403	PDB
3R21	X-ray	290 A	A	126-391	PDB
3R22	X-ray	290 A	A	126-391	PDB
3UNZ	X-ray	280 A	A/B	123-401	PDB
3UO4	X-ray	245 A	A	123-401	PDB
3UO5	X-ray	270 A	A	123-401	PDB
3UO6	X-ray	280 A	A/B	123-401	PDB
3UOD	X-ray	250 A	A	123-401	PDB
3UOH	X-ray	280 A	A/B	123-401	PDB
3UOJ	X-ray	290 A	A/B	123-401	PDB
3UOK	X-ray	295 A	A/B	123-401	PDB
3UOL	X-ray	240 A	A/B	123-401	PDB
3UP2	X-ray	230 A	A	123-401	PDB
3UP7	X-ray	305 A	A	123-401	PDB
3VAP	X-ray	266 A	A	125-391	PDB
3W10	X-ray	270 A	A	126-403	PDB
3W16	X-ray	280 A	A	126-403	PDB
3W18	X-ray	250 A	A/B	126-403	PDB
3W2C	X-ray	245 A	A/C/E/G	128-388	PDB
4B0G	X-ray	250 A	A	122-403	PDB
4BN1	X-ray	250 A	A	122-403	PDB
4BYI	X-ray	260 A	A	122-403	PDB
4BYJ	X-ray	275 A	A	122-403	PDB
4C3P	X-ray	269 A	A/D	122-403	PDB
4C3R	X-ray	279 A	A	122-403	PDB
4CEG	X-ray	210 A	A	122-403	PDB
4DEA	X-ray	245 A	A	123-401	PDB
4DEB	X-ray	305 A	A	123-401	PDB
4DED	X-ray	305 A	A	123-401	PDB
4DEE	X-ray	230 A	A	123-401	PDB
4DHF	X-ray	280 A	A/B	126-391	PDB
4J8M	X-ray	185 A	A	123-401	PDB
4J8N	X-ray	314 A	A/B/C/D	123-401	PDB
4JAI	X-ray	320 A	A	122-396	PDB
4JAJ	X-ray	270 A	A	122-396	PDB
4JBO	X-ray	249 A	A	123-401	PDB
4JBP	X-ray	245 A	A	123-401	PDB
4JBQ	X-ray	230 A	A	123-401	PDB
4O0S	X-ray	250 A	A	122-403	PDB
4O0U	X-ray	260 A	A	122-403	PDB
4O0W	X-ray	260 A	A	122-403	PDB
4PRJ	X-ray	280 A	A	124-391	PDB
4UYN	X-ray	190 A	A	125-399	PDB
4UZD	X-ray	320 A	A/B	125-399	PDB
4UZH	X-ray	200 A	A	125-399	PDB
4ZS0	X-ray	300 A	A	122-403	PDB
4ZTQ	X-ray	280 A	A	122-403	PDB
4ZTR	X-ray	285 A	A	122-403	PDB
4ZTS	X-ray	290 A	A	122-403	PDB
5AAD	X-ray	310 A	A	122-403	PDB
5AAE	X-ray	311 A	A	122-403	PDB
5AAF	X-ray	278 A	A	122-403	PDB
5AAG	X-ray	285 A	A	122-403	PDB
5DN3	X-ray	205 A	A	125-391	PDB
5DNR	X-ray	195 A	A	125-391	PDB
5DOS	X-ray	298 A	A	126-390	PDB
5DPV	X-ray	229 A	A	126-390	PDB
5DR2	X-ray	246 A	A	128-390	PDB
5DR6	X-ray	253 A	A	126-390	PDB
5DR9	X-ray	247 A	A	126-390	PDB
5DRD	X-ray	213 A	A	126-390	PDB
5DT0	X-ray	215 A	A	126-390	PDB
5DT3	X-ray	233 A	A	126-390	PDB
5DT4	X-ray	286 A	A	126-390	PDB
5EW9	X-ray	218 A	A	123-390	PDB
5G15	X-ray	206 A	A	122-403	PDB
5G1X	X-ray	172 A	A	122-403	PDB
5L8J	X-ray	168 A	A	122-403	PDB
5L8K	X-ray	179 A	A	122-403	PDB
5L8L	X-ray	167 A	A	122-403	PDB
5LXM	X-ray	208 A	A	122-403	PDB
5OBJ	X-ray	290 A	A	125-391	PDB
5OBR	X-ray	262 A	A	125-391	PDB
5ODT	X-ray	202 A	A	122-403	PDB
5ONE	X-ray	260 A	A	122-403	PDB
5ORL	X-ray	169 A	A	127-391	PDB
5ORN	X-ray	219 A	A	127-391	PDB
5ORO	X-ray	212 A	A	127-391	PDB
5ORP	X-ray	219 A	A	127-391	PDB
5ORR	X-ray	209 A	A	127-391	PDB
5ORS	X-ray	198 A	A	127-391	PDB
5ORT	X-ray	256 A	A	127-391	PDB
5ORV	X-ray	188 A	A	127-391	PDB
5ORW	X-ray	200 A	A	127-391	PDB
5ORX	X-ray	188 A	A	127-391	PDB
5ORY	X-ray	199 A	A	127-391	PDB
5ORZ	X-ray	192 A	A	127-391	PDB
5OS0	X-ray	174 A	A	127-391	PDB
5OS1	X-ray	190 A	A	127-391	PDB
5OS2	X-ray	192 A	A	127-391	PDB
5OS3	X-ray	181 A	A	127-391	PDB
5OS4	X-ray	188 A	A	127-391	PDB
5OS5	X-ray	174 A	A	125-392	PDB
5OS6	X-ray	220 A	A	127-391	PDB
5OSD	X-ray	199 A	A	125-391	PDB
5OSE	X-ray	190 A	A	127-391	PDB
5OSF	X-ray	189 A	A	127-391	PDB
5ZAN	X-ray	285 A	A	123-403	PDB
6C2R	X-ray	196 A	A	125-391	PDB
6C2T	X-ray	173 A	A	125-391	PDB
6C83	X-ray	255 A	A/B	122-403	PDB
6CPE	X-ray	245 A	A	122-403	PDB
6CPF	X-ray	230 A	A	122-403	PDB
6CPG	X-ray	280 A	A/D	122-403	PDB
6GRA	X-ray	260 A	A	122-403	PDB
6HJJ	X-ray	213 A	A	122-403	PDB
6HJK	X-ray	240 A	A	122-403	PDB
6I2U	X-ray	250 A	A	122-403	PDB
6R49	X-ray	221 A	A	122-403	PDB
6R4A	X-ray	194 A	A	122-403	PDB
6R4B	X-ray	215 A	A	122-403	PDB
6R4C	X-ray	204 A	A	122-403	PDB
6R4D	X-ray	201 A	A	122-403	PDB
6VPG	X-ray	264 A	A	117-389	PDB
6VPH	X-ray	214 A	A	117-389	PDB
6VPI	X-ray	200 A	A	117-389	PDB
6VPJ	X-ray	210 A	A	117-389	PDB
6VPL	X-ray	186 A	A/B	117-389	PDB
6VPM	X-ray	158 A	A/B	117-389	PDB
6XKA	X-ray	265 A	A	117-389	PDB
6Z4Y	X-ray	225 A	A	122-403	PDB
7AYH	X-ray	280 A	A	122-403	PDB
7AYI	X-ray	286 A	A	122-403	PDB
7FIC	X-ray	232 A	A	127-391	PDB
7O2V	X-ray	310 A	A	116-403	PDB
7ZTL	X-ray	190 A	A	122-403	PDB
8C14	X-ray	193 A	A	125-391	PDB
8C15	X-ray	241 A	A	126-388	PDB
8C1D	X-ray	212 A	A	126-388	PDB
8C1E	X-ray	280 A	A	125-391	PDB
8C1F	X-ray	192 A	A	126-388	PDB
8C1G	X-ray	196 A	A	126-388	PDB
8C1H	X-ray	223 A	A	126-388	PDB
8C1I	X-ray	281 A	A	126-388	PDB
8C1K	X-ray	243 A	A	126-390	PDB
8C1M	X-ray	284 A	A	125-391	PDB
8GUW	X-ray	270 A	A/B/C	123-403	PDB
8JF4	X-ray	289 A	A	127-389	PDB
8JMX	X-ray	295 A	A	127-389	PDB
8SSO	X-ray	197 A	A/D	122-403	PDB
8SSP	X-ray	260 A	A	122-403	PDB
AF-O14965-F1	Predicted				AlphaFoldDB

246 variants for O14965

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA118383 RCV001723547 RCV000007021 VAR_030841 rs2273535	31	F>I	Colon cancer, susceptibility to [ClinVar]	Yes	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1455074519 RCV000984118 CA409697381	346	F>L	Multiple myeloma [ClinVar]	Yes	ClinGen ClinVar TOPMed dbSNP
rs1372816386 CA409394996	2	D>E		No	ClinGen gnomAD
CA9917548 rs745894289	3	R>L		No	ClinGen ExAC TOPMed gnomAD
rs745894289 CA9917547	3	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA409394990 rs1439588568	4	S>A		No	ClinGen gnomAD
CA409394985 rs1319672869	5	K>E		No	ClinGen TOPMed gnomAD
rs779031598 CA9917546	7	N>T		No	ClinGen ExAC gnomAD
rs1381110341 CA409394943	10	S>L		No	ClinGen TOPMed
VAR_030840 rs6069717 CA316162535	11	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen UniProt Ensembl NCI-TCGA dbSNP
CA9917544 rs749521329	12	P>L		No	ClinGen ExAC gnomAD
rs1441802471 CA409394930	13	V>F		No	ClinGen TOPMed
CA316162505 rs767872675	14	K>*		No	ClinGen ExAC gnomAD
CA9917540 rs767872675	14	K>E		No	ClinGen ExAC gnomAD
rs6064386 CA316162499	14	K>N		No	ClinGen Ensembl
CA9917541 rs767872675	14	K>Q		No	ClinGen ExAC gnomAD
CA9917509 rs373331431	17	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs748414317 CA9917510	17	A>P		No	ClinGen ExAC gnomAD
CA409699675 rs373331431	17	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA409699664 rs1475776989	19	V>A		No	ClinGen gnomAD
CA409699653 rs1422893955	21	G>D		No	ClinGen gnomAD
rs188825988 CA9917507	24	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs779597046 CA9917506	24	R>H		No	ClinGen ExAC TOPMed gnomAD
CA316745522 CA409699620 rs750077869	27	V>L		No	ClinGen ExAC TOPMed gnomAD
CA9917504 rs750077869	27	V>M		No	ClinGen ExAC TOPMed gnomAD
CA409699594 rs2273535	31	F>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA409699593 rs2273535	31	F>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1338142196 CA409699585	32	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs145616804 CA316745521	34	Q>H		No	ClinGen ESP TOPMed
CA9917502 rs753618383	34	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA9917501 rs763948949	36	P>L		No	ClinGen ExAC gnomAD
rs1211313151 CA409699557	36	P>S		No	ClinGen TOPMed
rs1313879008 CA409699551	37	L>S		No	ClinGen TOPMed gnomAD
rs1315333827 CA409699541	39	V>I		No	ClinGen gnomAD
rs1357703858 CA409699531	40	N>S		No	ClinGen gnomAD
CA409699525 rs1196676729	41	S>C		No	ClinGen TOPMed
CA316745520 rs556861777	42	G>D		No	ClinGen gnomAD
rs769961096 CA9917495	46	R>P		No	ClinGen ExAC TOPMed gnomAD
CA9917496 rs769961096	46	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs763087319 CA9917497	46	R>W		No	ClinGen ExAC gnomAD
rs781474634 CA9917494	49	C>G		No	ClinGen ExAC gnomAD
rs781474634 CA9917493	49	C>R		No	ClinGen ExAC gnomAD
rs1181783760 CA409699476	49	C>Y		No	ClinGen TOPMed
rs34572020 CA9917491 VAR_041127	50	P>L		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA9917492 rs769051409	50	P>S		No	ClinGen ExAC gnomAD
CA409699461 rs1397339267	52	N>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	52	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9917489 rs375420005	56	R>C	Variant assessed as Somatic; 0.0001386 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs749883403 CA9917488	56	R>H		No	ClinGen ExAC TOPMed gnomAD
rs375420005 CA9917490	56	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
VAR_030842 CA9917486 rs1047972	57	I>V	increased kinase activity [UniProt]	No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs753518238 CA9917485	60	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA409699401 rs1255617961	61	A>E		No	ClinGen gnomAD
CA9917483 rs373634582	63	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs1475407765 CA409699373	65	V>A		No	ClinGen gnomAD
rs1294435614 CA409699377	65	V>I		No	ClinGen gnomAD
CA409699366 rs1281596637	66	S>C		No	ClinGen gnomAD
TCGA novel	68	H>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA316745518 rs761965396	69	K>R		No	ClinGen TOPMed
rs767515238 CA9917480	70	P>L		No	ClinGen ExAC TOPMed gnomAD
rs568356248 CA9917478	72	Q>R		No	ClinGen ExAC gnomAD
CA316745517 rs971358516	73	N>K		No	ClinGen Ensembl
rs769911074 CA9917477	74	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs1163949591 CA409699304	75	K>N		No	ClinGen gnomAD
CA316745516 rs1015357020	75	K>Q		No	ClinGen Ensembl
rs1403493502 CA409699291	77	K>R		No	ClinGen gnomAD
CA409699286 rs1318153493	78	Q>E		No	ClinGen TOPMed
CA409699264 rs1177507344	81	A>T		No	ClinGen TOPMed gnomAD
rs45533839 CA9917474	84	V>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA409699242 rs1479887662	84	V>L		No	ClinGen TOPMed
CA409699237 rs1468523581	85	P>S		No	ClinGen gnomAD
rs1221521216 CA409699219	88	V>I		No	ClinGen gnomAD
CA409699208 rs1320396487	89	S>F		No	ClinGen gnomAD
CA409699202 rs1258775616	90	R>S		No	ClinGen TOPMed
rs1376513260 CA409699204	90	R>T		No	ClinGen gnomAD
rs1420463153 CA409699184	93	N>S		No	ClinGen TOPMed gnomAD
rs952233187 CA316745515	95	T>I		No	ClinGen Ensembl
CA409699172 rs1600707681	95	T>P		No	ClinGen Ensembl
CA9917470 rs746371874	98	S>G		No	ClinGen ExAC TOPMed gnomAD
rs369728775 CA9917469	98	S>R		No	ClinGen ESP ExAC gnomAD
TCGA novel	100	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA409699125 rs1371585869	101	P>L		No	ClinGen TOPMed
TCGA novel	101	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs748900943 CA9917467	103	P>L		No	ClinGen ExAC gnomAD
TCGA novel	103	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
VAR_061745 rs2230743 CA9917466	104	S>L		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
TCGA novel	105	A>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1022155570 CA316745318	107	E>D		No	ClinGen TOPMed gnomAD
rs1396388179 CA409699074	108	N>S		No	ClinGen gnomAD
rs747814875 CA9917446	112	E>D		No	ClinGen ExAC TOPMed gnomAD
CA409699040 rs1201702309	113	E>Q		No	ClinGen TOPMed
rs45455492 CA316745316	114	L>Q		No	ClinGen Ensembl
rs1463162917 CA409699029	115	A>T		No	ClinGen gnomAD
rs1354633707 CA409699018	116	S>L		No	ClinGen gnomAD
rs1477781531 CA409699005	118	Q>R		No	ClinGen TOPMed gnomAD
TCGA novel	120	N>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1218471999 CA409698977	122	E>Q		No	ClinGen Ensembl
CA409698967 rs1385155907	123	S>*		No	ClinGen gnomAD
CA9917444 rs754759581	123	S>T		No	ClinGen ExAC TOPMed gnomAD
CA9917443 rs751452141	124	K>E		No	ClinGen ExAC gnomAD
TCGA novel	126	R>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1456483466 CA409698931	126	R>S		No	ClinGen gnomAD
CA409698926 rs1289758251	127	Q>R		No	ClinGen TOPMed
CA9917422 rs777846199	129	A>V		No	ClinGen ExAC
CA409698897 rs1260570180	131	E>G		No	ClinGen TOPMed
TCGA novel	132	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9917421 rs756121188	137	R>C		No	ClinGen ExAC TOPMed gnomAD
rs756121188 CA409698856	137	R>G		No	ClinGen ExAC TOPMed gnomAD
rs752948413 CA9917420	137	R>H		No	ClinGen ExAC TOPMed gnomAD
CA409698838 rs879169420	140	G>A		No	ClinGen gnomAD
CA316745193 rs879169420	140	G>D		No	ClinGen gnomAD
CA409698826 rs1308043779	142	G>*		No	ClinGen gnomAD
CA409698796 rs1372582799	146	N>S		No	ClinGen gnomAD
rs1052598989 CA316745192	149	L>F		No	ClinGen Ensembl
CA409698777 rs1387877998	149	L>M		No	ClinGen gnomAD
CA9917418 rs759659726	150	A>T		No	ClinGen ExAC gnomAD
rs1161897792 CA409698759	152	E>Q		No	ClinGen gnomAD
rs751997979 CA9917417	154	Q>R		No	ClinGen ExAC gnomAD
VAR_041128	155	S>R	a colorectal adenocarcinoma sample; somatic mutation; reduces interaction with TPX2 [UniProt]	No	UniProt
rs766650881 CA9917416	158	I>V		No	ClinGen ExAC gnomAD
rs1197614826 CA409698687	162	K>T		No	ClinGen gnomAD
CA9917413 rs769430412	167	A>T		No	ClinGen ExAC gnomAD
CA409698649 rs1205976211	167	A>V		No	ClinGen TOPMed
rs1265162322 CA409698621	171	K>N		No	ClinGen gnomAD
rs370497957 CA9917411 CA409698613	173	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
VAR_041129	174	V>M	a metastatic melanoma sample; somatic mutation; constitutively enhanced kinase activity [UniProt]	No	UniProt
rs746609481 CA9917409	176	H>R		No	ClinGen ExAC TOPMed gnomAD
rs948288770 CA316745190	178	L>R		No	ClinGen Ensembl
CA316745189 rs45520831	179	R>K		No	ClinGen Ensembl
TCGA novel	185	Q>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9917407 rs771707391	189	R>L		No	ClinGen ExAC gnomAD
rs779964295 CA9917408	189	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA316745053 rs972022489	197	Y>C		No	ClinGen TOPMed
rs1414079445 CA409698441	197	Y>H		No	ClinGen gnomAD
CA409698442 rs1414079445	197	Y>N		No	ClinGen gnomAD
rs762388330 CA9917394	198	G>D		No	ClinGen ExAC gnomAD
CA316745052 rs45483697	198	G>S		No	ClinGen Ensembl
CA409698412 rs1478111934	201	H>R		No	ClinGen gnomAD
rs776320107 CA9917393	201	H>Y		No	ClinGen ExAC gnomAD
rs1304208982 CA409698337	212	Y>C		No	ClinGen gnomAD
rs972895205 CA409698329	213	A>G		No	ClinGen TOPMed gnomAD
rs972895205 CA316745051	213	A>V		No	ClinGen TOPMed gnomAD
rs771934480 CA9917389	215	L>P		No	ClinGen ExAC gnomAD
rs771934480 CA9917390	215	L>R		No	ClinGen ExAC gnomAD
CA409698292 rs1198722160	220	R>G		No	ClinGen gnomAD
CA409698276 rs1303904133	222	L>V		No	ClinGen TOPMed
CA409698270 rs1217224639	223	Q>E		No	ClinGen gnomAD
rs1217224639 CA409698271	223	Q>K		No	ClinGen gnomAD
rs774110467 CA9917387	224	K>Q		No	ClinGen ExAC gnomAD
CA409698251 rs1285105507	225	L>R		No	ClinGen gnomAD
CA316745049 rs369713348	230	E>K		No	ClinGen ESP TOPMed gnomAD
CA316745047 rs1015771390	234	A>T		No	ClinGen Ensembl
CA9917382 rs747256704	235	T>I		No	ClinGen ExAC gnomAD
CA9917381 rs747256704	235	T>N		No	ClinGen ExAC gnomAD
rs373550419 CA9917369	249	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA9917368 rs373550419	249	S>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA9917367 rs369218936	251	R>T		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	256	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs773064040 CA9917364	257	I>V		No	ClinGen ExAC
CA409698020 rs1221358724	258	K>E		No	ClinGen gnomAD
rs866281286 CA316744231	258	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA409698017 rs1246719056	258	K>T		No	ClinGen gnomAD
rs1202687188 CA409697958	267	A>S		No	ClinGen TOPMed
rs768810063 CA9917363	267	A>V		No	ClinGen ExAC gnomAD
CA9917362 rs747008066	268	G>E		No	ClinGen ExAC gnomAD
CA409697944 rs1486433364	269	E>D		No	ClinGen TOPMed
rs925746484 CA316744230	269	E>V		No	ClinGen TOPMed
rs1353170280 CA409697869	280	H>R		No	ClinGen gnomAD
CA9917360 rs543625235	282	P>L		No	ClinGen 1000Genomes ExAC gnomAD
rs577939422 CA316744229	285	R>K		No	ClinGen 1000Genomes
CA316743835 rs772720875	287	T>I		No	ClinGen Ensembl
CA409697811 rs1173273550	288	T>A		No	ClinGen gnomAD
rs560948705 CA9917339	291	G>A		No	ClinGen 1000Genomes ExAC gnomAD
CA409697778 rs1194907010	293	L>P		No	ClinGen gnomAD
rs779238744 CA9917338	294	D>Y		No	ClinGen ExAC gnomAD
rs1483666546 CA409697754	297	P>S		No	ClinGen gnomAD
CA409697747 rs1255490947	298	P>L		No	ClinGen gnomAD
rs371787863 CA9917336	301	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA9917335 rs756649666	304	R>G		No	ClinGen ExAC TOPMed gnomAD
rs753238269 CA9917333	304	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA9917334 rs756649666	304	R>W		No	ClinGen ExAC TOPMed gnomAD
CA9917332 rs780584099	305	M>I		No	ClinGen ExAC TOPMed gnomAD
CA9917331 rs751240542 CA9917330	307	D>E		No	ClinGen ExAC gnomAD
CA9917329 rs765964564	308	E>K		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	314	S>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA409697627 rs1377907944	315	L>P		No	ClinGen gnomAD
CA316743832 rs978663717	320	Y>C		No	ClinGen Ensembl
CA9917328 rs762567231	322	F>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	323	L>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA316743831 rs1046125726	323	L>S		No	ClinGen TOPMed gnomAD
CA316743830 rs11539196	325	G>W		No	ClinGen Ensembl
CA409697554 rs1341455664	326	K>N		No	ClinGen TOPMed gnomAD
CA316743829 rs928987283	327	P>T		No	ClinGen TOPMed
CA409697532 rs1172047718	330	E>Q		No	ClinGen gnomAD
rs1354503122 CA409697525	331	A>T		No	ClinGen TOPMed
CA9917326 rs765075405	333	T>I		No	ClinGen ExAC TOPMed
CA9917325 rs761713577	336	E>G		No	ClinGen ExAC TOPMed gnomAD
rs1255724180 CA409697468	339	K>E		No	ClinGen gnomAD
TCGA novel	339	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1181878456 CA409697458	340	R>T		No	ClinGen gnomAD
CA9917323 rs772280719	342	S>*		No	ClinGen ExAC gnomAD
rs200181472 CA9917320	343	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA9917321 rs774552788	343	R>W		No	ClinGen ExAC TOPMed gnomAD
CA316743805 rs1055017499	344	V>A		No	ClinGen TOPMed
rs748492974 CA9917299	347	T>I		No	ClinGen ExAC gnomAD
CA316743804 rs45557632	348	F>L		No	ClinGen gnomAD
rs1195985945 CA409697370	348	F>S		No	ClinGen TOPMed
rs1301620722 CA409697361	350	D>N		No	ClinGen gnomAD
CA9917297 rs201356620	354	E>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs747506381 CA9917296	355	G>E		No	ClinGen ExAC gnomAD
TCGA novel	356	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1432466899 CA409697310	357	R>S		No	ClinGen gnomAD
rs1199513104 CA409697312	357	R>T		No	ClinGen gnomAD
rs757867582 CA9917294	358	D>E		No	ClinGen ExAC gnomAD
rs1488445064 CA409697286	361	S>A		No	ClinGen gnomAD
rs1284841822 CA409697282	362	R>G		No	ClinGen gnomAD
rs1346546758 CA409697262	365	K>E		No	ClinGen gnomAD
CA316743802 rs192771776	366	H>Y		No	ClinGen 1000Genomes TOPMed gnomAD
CA316743801 rs368251182	367	N>D		No	ClinGen ESP TOPMed gnomAD
CA409697236 rs1345363855	368	P>L		No	ClinGen gnomAD
rs756839520 CA9917291	369	S>R		No	ClinGen ExAC gnomAD
rs33923703 VAR_041130 CA9917290	373	M>V		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA316743798 rs897978091	375	R>T		No	ClinGen Ensembl
rs1185841172 CA409697179	377	V>I		No	ClinGen gnomAD
CA409697166 rs1442832751	379	E>Q		No	ClinGen TOPMed
CA9917288 rs146034224	381	P>L		No	ClinGen ESP ExAC gnomAD
TCGA novel	381	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA409697127 rs918964104	384	T>I		No	ClinGen TOPMed gnomAD
CA316743796 rs918964104	384	T>R		No	ClinGen TOPMed gnomAD
CA9917285 rs763051712	386	N>H		No	ClinGen ExAC gnomAD
CA409697114 rs1290167761	386	N>K		No	ClinGen TOPMed
rs536637669 CA9917284	387	S>P		No	ClinGen 1000Genomes ExAC gnomAD
CA316743795 rs376893456	391	S>T		No	ClinGen Ensembl
rs761905670 CA9917280	392	N>D		No	ClinGen ExAC TOPMed gnomAD
rs761905670 CA9917281	392	N>Y		No	ClinGen ExAC TOPMed gnomAD
rs56018429 CA316743794	394	Q>*		No	ClinGen gnomAD
TCGA novel	395	N>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs113451501 CA9917278	395	N>S		No	ClinGen ExAC gnomAD
CA9917276 rs775906971	398	S>L		No	ClinGen ExAC gnomAD
CA9917277 rs747528451	398	S>T		No	ClinGen ExAC gnomAD
rs771512723 CA9917275	400	S>T		No	ClinGen ExAC gnomAD
CA409697020 rs1428893706	401	K>E		No	ClinGen TOPMed gnomAD
CA9917274 rs745433550	402	Q>*		No	ClinGen ExAC gnomAD
CA316743793 rs1037323685	402	Q>H		No	ClinGen TOPMed gnomAD
rs778256805 CA9917273	402	Q>P		No	ClinGen ExAC gnomAD
rs1454252955 CA409697004	403	S>C		No	ClinGen TOPMed

No associated diseases with O14965

4 regional properties for O14965

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	133 - 383	IPR000719
active_site	Serine/threonine-protein kinase, active site	252 - 264	IPR008271
binding_site	Protein kinase, ATP binding site	139 - 162	IPR017441
domain	Aurora kinase A	127 - 384	IPR030611

Functions

		Description
EC Number	2.7.11.1	Protein-serine/threonine kinases
Subcellular Localization	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle pole Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cell projection, neuron projection Cell projection, cilium Cytoplasm, cytoskeleton, cilium basal body Basolateral cell membrane	Detected at the neurite hillock in developing neurons (By similarity) Localizes at the centrosome in mitotic cells from early prophase until telophase, but also localizes to the spindle pole MTs from prophase to anaphase (PubMed:17229885, PubMed:21225229, PubMed:9606188) Colocalized with SIRT2 at centrosome (PubMed:22014574) Moves to the midbody during both telophase and cytokinesis (PubMed:17726514) Associates with both the pericentriolar material (PCM) and centrioles (PubMed:22014574) The localization to the spindle poles is regulated by AAAS (PubMed:26246606)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

20 GO annotations of cellular component

Name	Definition
axon hillock	Portion of the neuronal cell soma from which the axon originates.
centriole	A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle.
centrosome	A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
chromosome passenger complex	A eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger complex coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain-containing protein Survivin, Aurora kinase, INCENP and Borealin.
ciliary basal body	A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
germinal vesicle	The enlarged, fluid filled nucleus of a primary oocyte, the development of which is suspended in prophase I of the first meiotic division between embryohood and sexual maturity.
meiotic spindle	A spindle that forms as part of meiosis. Several proteins, such as budding yeast Spo21p, fission yeast Spo2 and Spo13, and C. elegans mei-1, localize specifically to the meiotic spindle and are absent from the mitotic spindle.
microtubule	Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
microtubule cytoskeleton	The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
midbody	A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
mitotic spindle	A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules.
mitotic spindle pole	Either of the ends of a mitotic spindle, a spindle that forms as part of mitosis, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear region of cytoplasm	Cytoplasm situated near, or occurring around, the nucleus.
pronucleus	The nucleus of either the ovum or the spermatozoon following fertilization. Thus, in the fertilized ovum, there are two pronuclei, one originating from the ovum, the other from the spermatozoon that brought about fertilization; they approach each other, but do not fuse until just before the first cleavage, when each pronucleus loses its membrane to release its contents.
spindle	The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.
spindle midzone	The area in the center of the spindle where the spindle microtubules from opposite poles overlap.
spindle pole centrosome	A centrosome from which one pole of a mitotic or meiotic spindle is organized.

10 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
histone serine kinase activity	Catalysis of the transfer of a phosphate group to a serine residue of a histone.
molecular function activator activity	A molecular function regulator that activates or increases the activity of its target via non-covalent binding that does not result in covalent modification to the target.
protein heterodimerization activity	Binding to a nonidentical protein to form a heterodimer.
protein kinase activity	Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein kinase binding	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine/threonine/tyrosine kinase activity	Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
ubiquitin protein ligase binding	Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins.

31 GO annotations of biological process

Name	Definition
anterior/posterior axis specification	The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
apoptotic process	A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
cell division	The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
centrosome localization	Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell.
cilium disassembly	A cellular process that results in the breakdown of a cilium.
G2/M transition of mitotic cell cycle	The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.
liver regeneration	The regrowth of lost or destroyed liver.
mitotic cell cycle	Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
mitotic centrosome separation	Separation of duplicated centrosome components at the beginning of mitosis. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle.
mitotic spindle organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.
negative regulation of apoptotic process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
negative regulation of gene expression	Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
negative regulation of protein binding	Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.
neuron projection extension	Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
peptidyl-serine phosphorylation	The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
positive regulation of mitochondrial fission	Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments.
positive regulation of mitotic nuclear division	Any process that activates or increases the frequency, rate or extent of mitosis.
positive regulation of oocyte maturation	Any process that activates or increases the frequency, rate or extent of oocyte maturation.
positive regulation of proteasomal ubiquitin-dependent protein catabolic process	Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
proteasome-mediated ubiquitin-dependent protein catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
protein autophosphorylation	The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
protein localization to centrosome	A process in which a protein is transported to, or maintained at, the centrosome.
protein phosphorylation	The process of introducing a phosphate group on to a protein.
regulation of centrosome cycle	Any process that modulates the frequency, rate or extent of the centrosome cycle, the processes of centrosome duplication and separation.
regulation of cytokinesis	Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells.
regulation of G2/M transition of mitotic cell cycle	Any signalling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle.
regulation of protein stability	Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.
regulation of signal transduction by p53 class mediator	Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator.
response to wounding	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
spindle assembly involved in female meiosis I	The aggregation, arrangement and bonding together of a set of components to form the spindle during meiosis I of a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster.
spindle organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart.

15 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P38991	IPL1	Spindle assembly checkpoint kinase	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q7YRC6	AURKB	Aurora kinase B	Bos taurus (Bovine)	PR
Q2TA06	AURKA	Aurora kinase A	Bos taurus (Bovine)	PR
Q9VKN7	aurB	Aurora kinase B	Drosophila melanogaster (Fruit fly)	PR
Q9UQB9	AURKC	Aurora kinase C	Homo sapiens (Human)	PR
Q96GD4	AURKB	Aurora kinase B	Homo sapiens (Human)	PR
O70126	Aurkb	Aurora kinase B	Mus musculus (Mouse)	PR
O88445	Aurkc	Aurora kinase C	Mus musculus (Mouse)	PR
P97477	Aurka	Aurora kinase A	Mus musculus (Mouse)	PR
Q9N0X0	AURKB	Aurora kinase B	Sus scrofa (Pig)	PR
A5GFW1	AURKA	Aurora kinase A	Sus scrofa (Pig)	PR
O55099	Aurkb	Aurora kinase B	Rattus norvegicus (Rat)	PR
O01427	air-2	Aurora/IPL1-related protein kinase 2	Caenorhabditis elegans	PR
A4IGM9	aurkb	Aurora kinase B	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q6NW76	aurkb	Aurora kinase B	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MDRSKENCIS	GPVKATAPVG	GPKRVLVTQQ	FPCQNPLPVN	SGQAQRVLCP	SNSSQRIPLQ
70	80	90	100	110	120
AQKLVSSHKP	VQNQKQKQLQ	ATSVPHPVSR	PLNNTQKSKQ	PLPSAPENNP	EEELASKQKN
130	140	150	160	170	180
EESKKRQWAL	EDFEIGRPLG	KGKFGNVYLA	REKQSKFILA	LKVLFKAQLE	KAGVEHQLRR
190	200	210	220	230	240
EVEIQSHLRH	PNILRLYGYF	HDATRVYLIL	EYAPLGTVYR	ELQKLSKFDE	QRTATYITEL
250	260	270	280	290	300
ANALSYCHSK	RVIHRDIKPE	NLLLGSAGEL	KIADFGWSVH	APSSRRTTLC	GTLDYLPPEM
310	320	330	340	350	360
IEGRMHDEKV	DLWSLGVLCY	EFLVGKPPFE	ANTYQETYKR	ISRVEFTFPD	FVTEGARDLI
370	380	390	400
SRLLKHNPSQ	RPMLREVLEH	PWITANSSKP	SNCQNKESAS	KQS