Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q9SV13

Entry ID Method Resolution Chain Position Source
AF-Q9SV13-F1 Predicted AlphaFoldDB

34 variants for Q9SV13

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_3_19255649_T_G 10 Q>P No 1000Genomes
ENSVATH06297514 15 L>F No 1000Genomes
tmp_3_19255573_C_G 35 Q>H No 1000Genomes
ENSVATH14421798 108 N>K No 1000Genomes
tmp_3_19255175_C_T 127 V>M No 1000Genomes
ENSVATH08154033 153 E>D No 1000Genomes
tmp_3_19255079_C_A 159 D>Y No 1000Genomes
tmp_3_19255037_A_G 173 F>L No 1000Genomes
ENSVATH12716460 218 F>C No 1000Genomes
ENSVATH08154030 221 K>I No 1000Genomes
tmp_3_19253928_G_A 261 T>I No 1000Genomes
tmp_3_19253676_G_T 265 S>R No 1000Genomes
tmp_3_19253677_C_G 265 S>T No 1000Genomes
tmp_3_19253659_A_G 271 F>S No 1000Genomes
tmp_3_19253588_C_T 295 A>T No 1000Genomes
ENSVATH06297459 317 D>H No 1000Genomes
ENSVATH06297458 334 I>M No 1000Genomes
ENSVATH00415216 344 V>I No 1000Genomes
tmp_3_19252641_A_C 412 F>V No 1000Genomes
tmp_3_19252638_T_A 413 T>S No 1000Genomes
tmp_3_19252626_G_C 417 L>V No 1000Genomes
tmp_3_19252551_C_T 442 D>N No 1000Genomes
ENSVATH06297445 444 Q>E No 1000Genomes
tmp_3_19252294_T_C 482 I>M No 1000Genomes
tmp_3_19252236_T_C 502 I>V No 1000Genomes
ENSVATH14421775 529 D>N No 1000Genomes
ENSVATH14421764 541 R>C No 1000Genomes
ENSVATH06297438 567 I>L No 1000Genomes
ENSVATH00415207 573 V>A No 1000Genomes
ENSVATH00415206 585 V>E No 1000Genomes
ENSVATH12716410 591 I>T No 1000Genomes
tmp_3_19251783_C_G 593 R>S No 1000Genomes
ENSVATH06297435 640 M>T No 1000Genomes
ENSVATH14421761 652 N>T No 1000Genomes

No associated diseases with Q9SV13

3 regional properties for Q9SV13

Type Name Position InterPro Accession
domain STAS domain 513 - 637 IPR002645
domain SLC26A/SulP transporter domain 82 - 462 IPR011547
conserved_site Sulphate anion transporter, conserved site 111 - 132 IPR018045

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

3 GO annotations of molecular function

Name Definition
secondary active sulfate transmembrane transporter activity Enables the secondary active transfer of sulfate from one side of a membrane to the other. Secondary active transport is the transfer of a solute across a membrane, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.
sulfate transmembrane transporter activity Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other.
symporter activity Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.

1 GO annotations of biological process

Name Definition
sulfate transport The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

15 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A6QNW6 SLC26A8 Testis anion transporter 1 Bos taurus (Bovine) PR
P50443 SLC26A2 Sulfate transporter Homo sapiens (Human) PR
Q86WA9 SLC26A11 Sodium-independent sulfate anion transporter Homo sapiens (Human) PR
Q8TE54 SLC26A7 Anion exchange transporter Homo sapiens (Human) PR
Q96RN1 SLC26A8 Testis anion transporter 1 Homo sapiens (Human) PR
P58743 SLC26A5 Prestin Homo sapiens (Human) PR
Q99NH7 Slc26a5 Prestin Mus musculus (Mouse) PR
Q9R155 Slc26a4 Pendrin Mus musculus (Mouse) PR
Q9WVC8 Slc26a3 Chloride anion exchanger Mus musculus (Mouse) PR
Q8R0C3 Slc26a8 Testis anion transporter 1 Mus musculus (Mouse) PR
Q924C9 Slc26a3 Chloride anion exchanger Rattus norvegicus (Rat) PR
Q9EPH0 Slc26a5 Prestin Rattus norvegicus (Rat) PR
Q02920 Early nodulin-70 Glycine max (Soybean) (Glycine hispida) PR
Q9FY46 SULTR4;1 Sulfate transporter 4.1, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
Q8GYH8 SULTR4;2 Probable sulfate transporter 4.2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MGTEDYTFPQ GAEELHRRHH TVEAPQPQPF LKSLQYSVKE TLFPDDPFRQ FKNQNASRKF
70 80 90 100 110 120
VLGLKYFLPI FEWAPRYNLK FFKSDLIAGI TIASLAIPQG ISYAKLANLP PILGLYSSFV
130 140 150 160 170 180
PPLVYAVLGS SRDLAVGTVA VASLLTGAML SKEVDAEKDP KLYLHLAFTA TFFAGVLEAS
190 200 210 220 230 240
LGIFRLGFIV DFLSHATIVG FMGGAATVVS LQQLKGIFGL KHFTDSTDVI SVMRSVFSQT
250 260 270 280 290 300
HEWRWESGVL GCGFLFFLLS TRYFSIKKPK FFWVAAMAPL TSVILGSLLV YFTHAERHGV
310 320 330 340 350 360
QVIGDLKKGL NPLSGSDLIF TSPYMSTAVK TGLITGIIAL AEGVAVGRSF AMFKNYNIDG
370 380 390 400 410 420
NKEMIAFGMM NIVGSFTSCY LTTGPFSRSA VNYNAGCKTA MSNIVMAIAV MFTLLFLTPL
430 440 450 460 470 480
FHYTPLVVLS AIIISAMLGL IDYQAAIHLW KVDKFDFLVC MSAYVGVVFG SVEIGLVVAV
490 500 510 520 530 540
AISIARLLLF VSRPKTAVKG NIPNSMIYRN TEQYPSSRTV PGILILEIDA PIYFANASYL
550 560 570 580 590 600
RERIIRWIDE EEERVKQSGE SSLQYIILDM SAVGNIDTSG ISMMVEIKKV IDRRALKLVL
610 620 630 640 650
SNPKGEVVKK LTRSKFIGDH LGKEWMFLTV GEAVEACSYM LHTFKTEPAS KNEPWNNV