Q99NH7
PR
Gene name |
Slc26a5 (Pres) |
Protein name |
Prestin |
Names |
Solute carrier family 26 member 5 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:80979 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q99NH7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q99NH7-F1 | Predicted | AlphaFoldDB |
28 variants for Q99NH7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388752379 | 7 | N>S | No | EVA | |
| rs3388749517 | 45 | K>R | No | EVA | |
| rs3388743626 | 107 | V>M | No | EVA | |
| rs3388745920 | 172 | D>E | No | EVA | |
| rs3388745739 | 212 | G>D | No | EVA | |
| rs3388731310 | 235 | K>* | No | EVA | |
| rs3388735655 | 244 | V>L | No | EVA | |
| rs3410368956 | 324 | G>W | No | EVA | |
| rs3388752355 | 331 | P>L | No | EVA | |
| rs3388752311 | 336 | F>Y | No | EVA | |
| rs3388749599 | 369 | V>F | No | EVA | |
| rs3388743152 | 372 | N>S | No | EVA | |
| rs3395085458 | 402 | V>PS* | No | EVA | |
| rs3394698181 | 451 | M>L | No | EVA | |
| rs3395220914 | 460 | F>* | No | EVA | |
| rs3395334775 | 460 | F>Q | No | EVA | |
| rs3395220906 | 468 | E>* | No | EVA | |
| rs3388744011 | 562 | V>L | No | EVA | |
| rs31966593 | 587 | V>M | No | EVA | |
| rs240271851 | 597 | A>S | No | EVA | |
| rs3388741486 | 607 | P>S | No | EVA | |
| rs256145366 | 614 | V>I | No | EVA | |
| rs3388745685 | 622 | K>E | No | EVA | |
| rs3388741501 | 684 | V>M | No | EVA | |
| rs1134427090 | 726 | A>V | No | EVA | |
| rs254219068 | 727 | S>P | No | EVA | |
| rs229436252 | 728 | L>P | No | EVA | |
| rs1132513584 | 739 | P>S | No | EVA |
No associated diseases with Q99NH7
Functions
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| basolateral plasma membrane | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| lateral plasma membrane | The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells. |
| lateral wall of outer hair cell | The lateral wall of an outer hair cell (OHC) is a unique trilaminate composite consisting of the plasma membrane, an underlying cytoskeletal network containing an actin-spectrin cortical lattice, and an adjacent system of circumferential lamellar organelles known as the subsurface cisternae. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| bicarbonate transmembrane transporter activity | Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-. |
| chloride transmembrane transporter activity | Enables the transfer of chloride ions from one side of a membrane to the other. |
| identical protein binding | Binding to an identical protein or proteins. |
| oxalate transmembrane transporter activity | Enables the transfer of oxalate from one side of a membrane to the other. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals. |
| secondary active sulfate transmembrane transporter activity | Enables the secondary active transfer of sulfate from one side of a membrane to the other. Secondary active transport is the transfer of a solute across a membrane, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. |
| spectrin binding | Binding to spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers. |
| sulfate transmembrane transporter activity | Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other. |
18 GO annotations of biological process
| Name | Definition |
|---|---|
| anion transmembrane transport | The process in which an anion is transported across a membrane. |
| chloride transmembrane transport | The process in which chloride is transported across a membrane. |
| cochlea development | The progression of the cochlea over time from its formation to the mature structure. The cochlea is the snail-shaped portion of the inner ear that is responsible for the detection of sound. |
| fructose transmembrane transport | The directed movement of fructose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey. |
| ion transmembrane transport | A process in which an ion is transported across a membrane. |
| negative regulation of ion transmembrane transport | Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. |
| positive regulation of cell motility | Any process that activates or increases the frequency, rate or extent of cell motility. |
| positive regulation of cell size | Any process that increases cell size. |
| regulation of cell shape | Any process that modulates the surface configuration of a cell. |
| regulation of membrane potential | Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. |
| response to auditory stimulus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auditory stimulus. |
| response to ischemia | Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply. |
| response to potassium ion | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus. |
| response to salicylic acid | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salicylic acid stimulus. |
| response to salt | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus. |
| response to thyroid hormone | A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus. |
| response to xenobiotic stimulus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. |
| sensory perception of sound | The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound. |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A6QNW6 | SLC26A8 | Testis anion transporter 1 | Bos taurus (Bovine) | PR |
| P50443 | SLC26A2 | Sulfate transporter | Homo sapiens (Human) | PR |
| Q8TE54 | SLC26A7 | Anion exchange transporter | Homo sapiens (Human) | PR |
| Q86WA9 | SLC26A11 | Sodium-independent sulfate anion transporter | Homo sapiens (Human) | PR |
| Q96RN1 | SLC26A8 | Testis anion transporter 1 | Homo sapiens (Human) | PR |
| P58743 | SLC26A5 | Prestin | Homo sapiens (Human) | PR |
| Q9R155 | Slc26a4 | Pendrin | Mus musculus (Mouse) | PR |
| Q9WVC8 | Slc26a3 | Chloride anion exchanger | Mus musculus (Mouse) | PR |
| Q8R0C3 | Slc26a8 | Testis anion transporter 1 | Mus musculus (Mouse) | PR |
| Q924C9 | Slc26a3 | Chloride anion exchanger | Rattus norvegicus (Rat) | PR |
| Q9EPH0 | Slc26a5 | Prestin | Rattus norvegicus (Rat) | PR |
| Q02920 | Early nodulin-70 | Glycine max (Soybean) (Glycine hispida) | PR | |
| Q9FY46 | SULTR4;1 | Sulfate transporter 4.1, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SV13 | SULTR3;1 | Sulfate transporter 3.1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8GYH8 | SULTR4;2 | Probable sulfate transporter 4.2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDHAEENEIP | AETQRYYVER | PIFSHPVLQE | RLHVKDKVTE | SIGDKLKQAF | TCTPKKIRNI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IYMFLPITKW | LPAYKFKEYV | LGDLVSGIST | GVLQLPQGLA | FAMLAAVPPV | FGLYSSFYPV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IMYCFFGTSR | HISIGPFAVI | SLMIGGVAVR | LVPDDIVIPG | GVNATNGTEA | RDALRVKVAM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SVTLLSGIIQ | FCLGVCRFGF | VAIYLTEPLV | RGFTTAAAVH | VFTSMLKYLF | GVKTKRYSGI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FSVVYSTVAV | LQNVKNLNVC | SLGVGLMVFG | LLLGGKEFNE | RFKEKLPAPI | PLEFFAVVMG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TGISAGFNLH | ESYSVDVVGT | LPLGLLPPAN | PDTSLFHLVY | VDAIAIAIVG | FSVTISMAKT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LANKHGYQVD | GNQELIALGI | CNSIGSLFQT | FSISCSLSRS | LVQEGTGGKT | QLAGCLASLM |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ILLVILATGF | LFESLPQAVL | SAIVIVNLKG | MFMQFSDLPF | FWRTSKIELT | IWLTTFVSSL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| FLGLDYGLIT | AVIIALLTVI | YRTQSPSYKV | LGQLPDTDVY | IDIDAYEEVK | EIPGIKIFQI |
| 550 | 560 | 570 | 580 | 590 | 600 |
| NAPIYYANSD | LYSSALKRKT | GVNPALIMGA | RRKAMRKYAK | EVGNANVANA | TVVKVDAEVD |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GENATKPEEE | DDEVKFPPIV | IKTTFPEELQ | RFLPQGENVH | TVILDFTQVN | FVDSVGVKTL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| AGIVKEYGDV | GIYVYLAGCS | PQVVNDLTRN | NFFENPALKE | LLFHSIHDAV | LGSQVREAMA |
| 730 | 740 | ||||
| EQEATASLPQ | EDMEPNATPT | TPEA |