AiPD: Autoinhibited Protein Database

Gene name	Slc26a4 (Pds)
Protein name	Pendrin
Names	Sodium-independent chloride/iodide transporter, Solute carrier family 26 member 4
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:23985
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

5-84 (Predicted disordered autoinhibitory region) PR

5-84 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
7WK1	EM	325 A	A/B	1-780	PDB
7WK7	EM	349 A	A/B	1-780	PDB
7WL2	EM	325 A	A/B	1-780	PDB
7WL7	EM	351 A	A/B	1-780	PDB
7WL8	EM	340 A	A/B	1-780	PDB
7WL9	EM	378 A	A/B	1-780	PDB
7WLA	EM	376 A	A/B	1-780	PDB
7WLB	EM	410 A	A/B	1-780	PDB
7WLE	EM	362 A	A/B	1-780	PDB
8HZN	EM	325 A	A/B	1-780	PDB
AF-Q9R155-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs264545196	65	V>I	No	EVA
rs3389243177	123	P>L	No	EVA
rs251373153	168	G>R	No	EVA
rs3389204166	226	A>V	No	EVA
rs107752849	264	I>V	No	EVA
rs3389235228	273	I>V	No	EVA
rs3389237822	292	F>I	No	EVA
rs3403238383	326	G>S	No	EVA
rs3389222232	334	G>E	No	EVA
rs3389210682	347	S>T	No	EVA
rs3389250127	350	L>*	No	EVA
rs3389250132	370	V>L	No	EVA
rs37181502	422	V>M	No	EVA
rs3389245941	488	M>V	No	EVA
rs3389229027	578	Y>*	No	EVA
rs226477703	608	I>V	No	EVA
rs3389228974	615	F>I	No	EVA
rs3389231108	615	F>L	No	EVA
rs3389210648	634	I>N	No	EVA
rs3389167551	669	D>Y	No	EVA
rs3389222245	736	R>I	No	EVA
rs217848809	738	G>S	No	EVA
rs3389233867	749	I>E	No	EVA
rs3389235196	750	R>W	No	EVA
rs36982362	766	E>G	No	EVA
rs3389210658	767	E>*	No	EVA
rs3389210658	767	E>K	No	EVA

Type	Name	Position	InterPro Accession
domain	Alpha crystallin/Hsp20 domain	67 - 180	IPR002068

		Description
EC Number
Subcellular Localization	Apical cell membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein	Localizes to the apical brush border of cells in the cortical collecting ducts of the kidney
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
apical plasma membrane	The region of the plasma membrane located at the apical end of the cell.
brush border membrane	The portion of the plasma membrane surrounding the brush border.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
integral component of plasma membrane	The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

Name	Definition
anion transmembrane transporter activity	Enables the transfer of a negatively charged ion from one side of a membrane to the other.
bicarbonate transmembrane transporter activity	Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-.
chloride transmembrane transporter activity	Enables the transfer of chloride ions from one side of a membrane to the other.
iodide transmembrane transporter activity	Enables the transfer of iodide ions from one side of a membrane to the other.
oxalate transmembrane transporter activity	Enables the transfer of oxalate from one side of a membrane to the other. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals.
secondary active sulfate transmembrane transporter activity	Enables the secondary active transfer of sulfate from one side of a membrane to the other. Secondary active transport is the transfer of a solute across a membrane, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.
sulfate transmembrane transporter activity	Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other.

Name	Definition
animal organ morphogenesis	Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
inorganic anion transport	The directed movement of inorganic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage.
regulation of pH	Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell.
regulation of protein localization	Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
A6QNW6	SLC26A8	Testis anion transporter 1	Bos taurus (Bovine)	PR
P50443	SLC26A2	Sulfate transporter	Homo sapiens (Human)	PR
P58743	SLC26A5	Prestin	Homo sapiens (Human)	PR
Q8TE54	SLC26A7	Anion exchange transporter	Homo sapiens (Human)	PR
Q86WA9	SLC26A11	Sodium-independent sulfate anion transporter	Homo sapiens (Human)	PR
Q96RN1	SLC26A8	Testis anion transporter 1	Homo sapiens (Human)	PR
Q99NH7	Slc26a5	Prestin	Mus musculus (Mouse)	PR
Q9WVC8	Slc26a3	Chloride anion exchanger	Mus musculus (Mouse)	PR
Q8R0C3	Slc26a8	Testis anion transporter 1	Mus musculus (Mouse)	PR
Q924C9	Slc26a3	Chloride anion exchanger	Rattus norvegicus (Rat)	PR
Q9EPH0	Slc26a5	Prestin	Rattus norvegicus (Rat)	PR
Q02920		Early nodulin-70	Glycine max (Soybean) (Glycine hispida)	PR
Q9FY46	SULTR4;1	Sulfate transporter 4.1, chloroplastic	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SV13	SULTR3;1	Sulfate transporter 3.1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8GYH8	SULTR4;2	Probable sulfate transporter 4.2	Arabidopsis thaliana (Mouse-ear cress)	PR