AiPD: Autoinhibited Protein Database

Gene name	Slc26a8
Protein name	Testis anion transporter 1
Names	Anion exchange transporter, Solute carrier family 26 member 8
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:224661
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-81 (Predicted disordered autoinhibitory region) PR

1-81 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8R0C3-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389448884	18	P>S	No	EVA
rs3389442415	19	F>I	No	EVA
rs3389449945	90	L>H	No	EVA
rs3389454038	127	A>V	No	EVA
rs3389361270	147	G>C	No	EVA
rs3389416584	156	M>K	No	EVA
rs3389454013	157	I>F	No	EVA
rs3389446366	167	N>Y	No	EVA
rs3389448874	172	L>*	No	EVA
rs3389449988	243	M>L	No	EVA
rs3389448851	292	N>I	No	EVA
rs3389407390	319	L>F	No	EVA
rs3389464945	319	L>R	No	EVA
rs3389396389	356	V>A	No	EVA
rs3389449918	395	G>R	No	EVA
rs3412880423	400	L>F	No	EVA
rs3389407400	417	T>A	No	EVA
rs3389426931	450	N>K	No	EVA
rs3389460099	463	N>K	No	EVA
rs3407560329	500	L>R	No	EVA
rs3407627839	500	L>V	No	EVA
rs3389442358	502	V>I	No	EVA
rs3389449915	533	T>P	No	EVA
rs3389454024	562	F>L	No	EVA
rs3389449803	567	H>Q	No	EVA
rs3389396352	575	E>*	No	EVA
rs3389426915	621	V>I	No	EVA
rs3407895252	639	I>T	No	EVA
rs3407476155	643	Y>*	No	EVA
rs3389442344	650	S>C	No	EVA
rs3389447295	665	T>S	No	EVA
rs3389439177	668	R>K	No	EVA
rs3389463479	672	Q>H	No	EVA
rs3389446323	673	S>I	No	EVA
rs3389416662	674	Y>*	No	EVA
rs3389440874	680	A>S	No	EVA
rs3389463470	696	E>*	No	EVA
rs3389426876	909	P>S	No	EVA
rs3413117730	913	L>Q	No	EVA
rs3389407443	990	R>I	No	EVA

Type	Name	Position	InterPro Accession
domain	Alpha crystallin/Hsp20 domain	74 - 185	IPR002068
domain	Heat shock protein beta-8, alpha-crystallin domain (ACD)	80 - 170	IPR042790

		Description
EC Number
Subcellular Localization	Membrane ; Multi-pass membrane protein	Located at the annulus ring structure within the sperm cell
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
integral component of plasma membrane	The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
bicarbonate transmembrane transporter activity	Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-.
chloride channel activity	Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
chloride transmembrane transporter activity	Enables the transfer of chloride ions from one side of a membrane to the other.
oxalate transmembrane transporter activity	Enables the transfer of oxalate from one side of a membrane to the other. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals.
sulfate transmembrane transporter activity	Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other.

Name	Definition
anion transport	The directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
chloride transport	The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
flagellated sperm motility	The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm.
meiotic cell cycle	Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
oxalate transport	The directed movement of oxalate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals.
sperm capacitation	A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium.
sulfate transport	The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
A6QNW6	SLC26A8	Testis anion transporter 1	Bos taurus (Bovine)	PR
P50443	SLC26A2	Sulfate transporter	Homo sapiens (Human)	PR
P58743	SLC26A5	Prestin	Homo sapiens (Human)	PR
Q8TE54	SLC26A7	Anion exchange transporter	Homo sapiens (Human)	PR
Q86WA9	SLC26A11	Sodium-independent sulfate anion transporter	Homo sapiens (Human)	PR
Q96RN1	SLC26A8	Testis anion transporter 1	Homo sapiens (Human)	PR
Q9WVC8	Slc26a3	Chloride anion exchanger	Mus musculus (Mouse)	PR
Q9R155	Slc26a4	Pendrin	Mus musculus (Mouse)	PR
Q99NH7	Slc26a5	Prestin	Mus musculus (Mouse)	PR
Q924C9	Slc26a3	Chloride anion exchanger	Rattus norvegicus (Rat)	PR
Q9EPH0	Slc26a5	Prestin	Rattus norvegicus (Rat)	PR
Q02920		Early nodulin-70	Glycine max (Soybean) (Glycine hispida)	PR
Q9SV13	SULTR3;1	Sulfate transporter 3.1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9FY46	SULTR4;1	Sulfate transporter 4.1, chloroplastic	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8GYH8	SULTR4;2	Probable sulfate transporter 4.2	Arabidopsis thaliana (Mouse-ear cress)	PR