Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q9SKN6

Entry ID Method Resolution Chain Position Source
AF-Q9SKN6-F1 Predicted AlphaFoldDB

53 variants for Q9SKN6

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_2_12103676_A_G 2 N>S No 1000Genomes
ENSVATH01913779 10 E>K No 1000Genomes
ENSVATH05612374 12 F>L No 1000Genomes
tmp_2_12103715_T_G 15 L>R No 1000Genomes
tmp_2_12103733_A_G 21 D>G No 1000Genomes
ENSVATH01913780 24 V>F No 1000Genomes
ENSVATH00252265 28 N>T No 1000Genomes
ENSVATH05612376 55 P>A No 1000Genomes
ENSVATH05612377 62 L>* No 1000Genomes
ENSVATH05612378 65 E>K No 1000Genomes
tmp_2_12103869_C_G 66 F>L No 1000Genomes
ENSVATH14563807 81 I>V No 1000Genomes
ENSVATH14563808 82 L>F No 1000Genomes
tmp_2_12105574_C_T 93 T>I No 1000Genomes
tmp_2_12105606_T_C 104 S>P No 1000Genomes
ENSVATH00252269 110 L>S No 1000Genomes
ENSVATH14563811 111 S>C No 1000Genomes
tmp_2_12105684_G_T 130 G>* No 1000Genomes
ENSVATH00252270 131 D>N No 1000Genomes
ENSVATH00252271 135 A>V No 1000Genomes
tmp_2_12105703_T_A 136 F>Y No 1000Genomes
ENSVATH00252272 151 L>P No 1000Genomes
tmp_2_12105750_A_G 152 R>G No 1000Genomes
ENSVATH05612405 156 L>F No 1000Genomes
tmp_2_12105766_A_T 157 K>I No 1000Genomes
ENSVATH05612406 159 F>Y No 1000Genomes
ENSVATH00252273 162 E>G No 1000Genomes
ENSVATH13446596 169 P>L No 1000Genomes
ENSVATH05612408 170 D>H No 1000Genomes
ENSVATH01913802 174 S>F No 1000Genomes
tmp_2_12105820_C_T 175 S>F No 1000Genomes
ENSVATH05612409 178 S>F No 1000Genomes
tmp_2_12105831_G_A 179 A>T No 1000Genomes
ENSVATH05612410 183 R>G No 1000Genomes
ENSVATH13446598 185 K>Q No 1000Genomes
ENSVATH01913803 185 K>R No 1000Genomes
ENSVATH05612411 195 H>L No 1000Genomes
ENSVATH05612412 197 E>K No 1000Genomes
ENSVATH01913805 203 Q>L No 1000Genomes
ENSVATH01913805 203 Q>P No 1000Genomes
ENSVATH01913806 206 E>K No 1000Genomes
ENSVATH05612413 213 T>I No 1000Genomes
tmp_2_12105958_G_A 221 R>H No 1000Genomes
ENSVATH14563813 226 R>H No 1000Genomes
ENSVATH13446599 244 H>Y No 1000Genomes
ENSVATH00252275 263 D>N No 1000Genomes
ENSVATH14563814 268 R>H No 1000Genomes
tmp_2_12106114_G_A 273 G>E No 1000Genomes
ENSVATH14563815 274 P>R No 1000Genomes
tmp_2_12106140_A_C 282 N>H No 1000Genomes
ENSVATH13446601 284 G>V No 1000Genomes
tmp_2_12106150_G_A 285 R>K No 1000Genomes
ENSVATH05612416 288 S>T No 1000Genomes

No associated diseases with Q9SKN6

1 regional properties for Q9SKN6

Type Name Position InterPro Accession
domain Zinc finger, GATA-type 187 - 249 IPR000679

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
DNA-binding transcription factor activity A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
sequence-specific DNA binding Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.

18 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P23769 GATA2 Endothelial transcription factor GATA-2 Homo sapiens (Human) PR
O09100 Gata2 Endothelial transcription factor GATA-2 Mus musculus (Mouse) PR
Q942A1 RR4 Two-component response regulator ORR4 Oryza sativa subsp japonica (Rice) PR
Q6H468 RR11 Two-component response regulator ORR11 Oryza sativa subsp japonica (Rice) PR
Q0PVB3 RR7 Two-component response regulator ORR7 Oryza sativa subsp japonica (Rice) PR
Q7Y0W5 EHD1 Two-component response regulator ORR30 Oryza sativa subsp japonica (Rice) PR
Q9ZWS9 ARR3 Two-component response regulator ARR3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FXD6 ARR11 Two-component response regulator ARR11 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SB04 ARR5 Two-component response regulator ARR5 Arabidopsis thaliana (Mouse-ear cress) PR
O80366 ARR9 Two-component response regulator ARR9 Arabidopsis thaliana (Mouse-ear cress) PR
Q6LA43 APRR2 Two-component response regulator-like APRR2 Arabidopsis thaliana (Mouse-ear cress) PR
Q93WK5 APRR7 Two-component response regulator-like APRR7 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FJ16 APRR4 Putative two-component response regulator-like APRR4 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LVG4 APRR3 Two-component response regulator-like APRR3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LKL2 APRR1 Two-component response regulator-like APRR1 Arabidopsis thaliana (Mouse-ear cress) PR
O65515 GATA7 GATA transcription factor 7 Arabidopsis thaliana (Mouse-ear cress) PR
Q8L4M6 GATA3 GATA transcription factor 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LT45 GATA29 GATA transcription factor 29 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MNNDLWLPEE DFKGLPDNFL DNLVDPTNDV SVEDIETGDD EGDWDAKFQK LVPPPLDELM
70 80 90 100 110 120
SLSYEFTCNG QRVQVQKHVP ILKQSSSSEV FSTVDNSPPN VKVSKLLQSL SPVSVLKNTN
130 140 150 160 170 180
GSGSPQNPNG DQKLAFLVKG IRSKRKRPTL LRVTFLKSFL LEMSQQFAPD ESESSEISAL
190 200 210 220 230 240
KKRKKNKSRR LKCTHCETTT TPQWREGPNG RKTLCNACGI RFRSGRLVLE YRPAASPTFI
250 260 270 280 290
PTVHSNLHKK IIYMRMKDND QFDTRKIRAE TSGPETRSRL RNFGRPMSYG Q