Q6LA43
PR
Gene name |
APRR2 (TOC2, At4g18020, T6K21.200) |
Protein name |
Two-component response regulator-like APRR2 |
Names |
Pseudo-response regulator 2, TOC2 protein |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G18020 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6LA43
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6LA43-F1 | Predicted | AlphaFoldDB |
95 variants for Q6LA43
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_4_10006645_T_A | 13 | N>I | No | 1000Genomes | |
| ENSVATH06710422 | 16 | K>Q | No | 1000Genomes | |
| ENSVATH06710421 | 20 | V>A | No | 1000Genomes | |
| tmp_4_10006607_C_A | 26 | G>C | No | 1000Genomes | |
| tmp_4_10006606_C_A | 26 | G>V | No | 1000Genomes | |
| ENSVATH14243468 | 28 | D>E | No | 1000Genomes | |
| ENSVATH06710419 | 30 | D>G | No | 1000Genomes | |
| ENSVATH02870720 | 31 | G>E | No | 1000Genomes | |
| tmp_4_10006589_C_T | 32 | D>N | No | 1000Genomes | |
| tmp_4_10006571_C_T | 38 | E>K | No | 1000Genomes | |
| tmp_4_10006551_T_A | 44 | E>D | No | 1000Genomes | |
| tmp_4_10006552_T_A | 44 | E>V | No | 1000Genomes | |
| tmp_4_10006550_A_C | 45 | S>A | No | 1000Genomes | |
| tmp_4_10006017_C_A | 62 | A>S | No | 1000Genomes | |
| tmp_4_10005995_C_T | 69 | S>N | No | 1000Genomes | |
| tmp_4_10005990_G_C | 71 | H>D | No | 1000Genomes | |
| tmp_4_10005981_T_C | 74 | I>V | No | 1000Genomes | |
| ENSVATH14243453 | 77 | V>G | No | 1000Genomes | |
| ENSVATH06710409 | 88 | F>L | No | 1000Genomes | |
| tmp_4_10005931_C_G | 90 | E>D | No | 1000Genomes | |
| ENSVATH00518636 | 109 | T>S | No | 1000Genomes | |
| tmp_4_10005765_T_A | 114 | I>L | No | 1000Genomes | |
| tmp_4_10005761_G_A | 115 | A>V | No | 1000Genomes | |
| tmp_4_10005507_A_T | 144 | N>K | No | 1000Genomes | |
| tmp_4_10005487_G_A | 151 | S>L | No | 1000Genomes | |
| tmp_4_10005484_A_G | 152 | I>T | No | 1000Genomes | |
| ENSVATH00518632 | 152 | I>V | No | 1000Genomes | |
| ENSVATH14243450 | 156 | P>S | No | 1000Genomes | |
| tmp_4_10005458_C_T | 161 | V>I | No | 1000Genomes | |
| tmp_4_10005426_C_T | 171 | M>I | No | 1000Genomes | |
| ENSVATH00518627 | 174 | E>D | No | 1000Genomes | |
| tmp_4_10005365_G_C | 192 | L>V | No | 1000Genomes | |
| tmp_4_10005340_A_G | 200 | I>T | No | 1000Genomes | |
| tmp_4_10005316_T_G | 208 | N>T | No | 1000Genomes | |
| ENSVATH11960379 | 211 | T>I | No | 1000Genomes | |
| ENSVATH11960378 | 222 | I>V | No | 1000Genomes | |
| tmp_4_10005267_T_G | 224 | E>D | No | 1000Genomes | |
| ENSVATH11960377 | 237 | D>G | No | 1000Genomes | |
| ENSVATH02870706 | 247 | G>E | No | 1000Genomes | |
| tmp_4_10005190_T_C | 250 | E>G | No | 1000Genomes | |
| ENSVATH14243449 | 253 | E>K | No | 1000Genomes | |
| tmp_4_10005166_C_A | 258 | G>V | No | 1000Genomes | |
| ENSVATH06710401 | 267 | S>L | No | 1000Genomes | |
| tmp_4_10005134_C_G | 269 | D>H | No | 1000Genomes | |
| ENSVATH00518626 | 276 | E>G | No | 1000Genomes | |
| tmp_4_10005088_G_A | 284 | S>F | No | 1000Genomes | |
| tmp_4_10005086_C_T | 285 | G>R | No | 1000Genomes | |
| tmp_4_10005085_C_A | 285 | G>V | No | 1000Genomes | |
| tmp_4_10005074_C_T | 289 | V>M | No | 1000Genomes | |
| tmp_4_10005061_T_C | 293 | K>R | No | 1000Genomes | |
| tmp_4_10005055_C_T | 295 | S>N | No | 1000Genomes | |
| tmp_4_10004855_G_C | 334 | T>S | No | 1000Genomes | |
| ENSVATH06710388 | 358 | D>E | No | 1000Genomes | |
| ENSVATH06710387 | 359 | D>E | No | 1000Genomes | |
| ENSVATH14243448 | 360 | H>N | No | 1000Genomes | |
| ENSVATH00518620 | 374 | N>S | No | 1000Genomes | |
| tmp_4_10004636_T_C | 379 | N>S | No | 1000Genomes | |
| ENSVATH00518619 | 380 | V>A | No | 1000Genomes | |
| ENSVATH00518619 | 380 | V>D | No | 1000Genomes | |
| ENSVATH00518619 | 380 | V>G | No | 1000Genomes | |
| ENSVATH06710386 | 385 | H>Y | No | 1000Genomes | |
| tmp_4_10004573_T_A | 400 | Y>F | No | 1000Genomes | |
| tmp_4_10004570_G_A | 401 | P>L | No | 1000Genomes | |
| ENSVATH06710385 | 401 | P>S | No | 1000Genomes | |
| ENSVATH00518617 | 408 | L>V | No | 1000Genomes | |
| ENSVATH06710383 | 410 | P>S | No | 1000Genomes | |
| ENSVATH02870689 | 420 | P>S | No | 1000Genomes | |
| tmp_4_10004508_A_T | 422 | W>R | No | 1000Genomes | |
| ENSVATH06710382 | 429 | P>T | No | 1000Genomes | |
| ENSVATH00518611 | 432 | S>N | No | 1000Genomes | |
| tmp_4_10004268_G_T | 432 | S>R | No | 1000Genomes | |
| ENSVATH06710376 | 434 | N>T | No | 1000Genomes | |
| ENSVATH06710377 | 434 | N>Y | No | 1000Genomes | |
| tmp_4_10004249_G_A | 439 | P>S | No | 1000Genomes | |
| ENSVATH02870674 | 441 | G>R | No | 1000Genomes | |
| ENSVATH06710375 | 449 | I>V | No | 1000Genomes | |
| tmp_4_10004216_T_A | 450 | T>S | No | 1000Genomes | |
| ENSVATH02870671 | 456 | A>G | No | 1000Genomes | |
| ENSVATH06710371 | 456 | A>P | No | 1000Genomes | |
| ENSVATH06710371 | 456 | A>T | No | 1000Genomes | |
| tmp_4_10004082_C_A | 458 | G>V | No | 1000Genomes | |
| tmp_4_10004070_G_A | 462 | P>L | No | 1000Genomes | |
| ENSVATH00518609 | 462 | P>S | No | 1000Genomes | |
| ENSVATH14243419 | 466 | E>A | No | 1000Genomes | |
| tmp_4_10004055_G_C | 467 | T>S | No | 1000Genomes | |
| tmp_4_10004043_A_G | 471 | I>T | No | 1000Genomes | |
| ENSVATH00518608 | 473 | P>R | No | 1000Genomes | |
| ENSVATH02870670 | 475 | S>T | No | 1000Genomes | |
| ENSVATH11960326 | 486 | V>I | No | 1000Genomes | |
| ENSVATH11960316 | 507 | E>D | No | 1000Genomes | |
| tmp_4_10003805_G_A | 514 | T>M | No | 1000Genomes | |
| ENSVATH14243416 | 515 | R>H | No | 1000Genomes | |
| ENSVATH06710366 | 525 | S>A | No | 1000Genomes | |
| tmp_4_10003770_A_G | 526 | C>R | No | 1000Genomes | |
| ENSVATH00518603 | 530 | G>S | No | 1000Genomes |
No associated diseases with Q6LA43
1 regional properties for Q6LA43
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | GPCR, rhodopsin-like, 7TM | 40 - 440 | IPR017452 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription factor activity | A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. |
| transcription cis-regulatory region binding | Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| phosphorelay signal transduction system | A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. |
| positive regulation of DNA-templated transcription | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
18 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P23769 | GATA2 | Endothelial transcription factor GATA-2 | Homo sapiens (Human) | PR |
| O09100 | Gata2 | Endothelial transcription factor GATA-2 | Mus musculus (Mouse) | PR |
| Q942A1 | RR4 | Two-component response regulator ORR4 | Oryza sativa subsp japonica (Rice) | PR |
| Q6H468 | RR11 | Two-component response regulator ORR11 | Oryza sativa subsp japonica (Rice) | PR |
| Q0PVB3 | RR7 | Two-component response regulator ORR7 | Oryza sativa subsp japonica (Rice) | PR |
| Q7Y0W5 | EHD1 | Two-component response regulator ORR30 | Oryza sativa subsp japonica (Rice) | PR |
| Q9ZWS9 | ARR3 | Two-component response regulator ARR3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FXD6 | ARR11 | Two-component response regulator ARR11 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SKN6 | GATA13 | Putative GATA transcription factor 13 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LT45 | GATA29 | GATA transcription factor 29 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SB04 | ARR5 | Two-component response regulator ARR5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O80366 | ARR9 | Two-component response regulator ARR9 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8L4M6 | GATA3 | GATA transcription factor 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O65515 | GATA7 | GATA transcription factor 7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q93WK5 | APRR7 | Two-component response regulator-like APRR7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FJ16 | APRR4 | Putative two-component response regulator-like APRR4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LVG4 | APRR3 | Two-component response regulator-like APRR3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LKL2 | APRR1 | Two-component response regulator-like APRR1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVITANDLSK | WENFPKGLKV | LLLLNGCDSD | GDGSSAAETR | SELESMDYIV | TTFTDETEAL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SAVVKNPESF | HIAIVEVNMS | AESESFKFLE | AAKDVLPTIM | ISTDHCITTT | MKCIALGAVE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FLQKPLSPEK | LKNIWQHVVH | KAFNDGGSNV | SISLKPVKES | VVSMLHLETD | MTIEEKDPAP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| STPQLKQDSR | LLDGDCQENI | NFSMENVNSS | TEKDNMEDHQ | DIGESKSVDT | TNRKLDDDKV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VVKEERGDSE | KEEEGETGDL | ISEKTDSVDI | HKKEDETKPI | NKSSGIKNVS | GNKTSRKKVD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| WTPELHKKFV | QAVEQLGVDQ | AIPSRILELM | KVGTLTRHNV | ASHLQKFRQH | RKNILPKDDH |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NHRWIQSREN | HRPNQRNYNV | FQQQHRPVMA | YPVWGLPGVY | PPGAIPPLWP | PPLQSIGQPP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PWHWKPPYPT | VSGNAWGCPV | GPPVTGSYIT | PSNTTAGGFQ | YPNGAETGFK | IMPASQPDEE |
| 490 | 500 | 510 | 520 | 530 | |
| MLDQVVKEAI | SKPWLPLPLG | LKPPSAESVL | AELTRQGISA | VPSSSCLING | SHRLR |