Q9LKL2
PR
Gene name |
APRR1 (AIP1, TOC1, At5g61380, MFB13.16) |
Protein name |
Two-component response regulator-like APRR1 |
Names |
ABI3-interacting protein 1, Pseudo-response regulator 1, Timing of CAB expression 1 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G61380 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9LKL2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9LKL2-F1 | Predicted | AlphaFoldDB |
56 variants for Q9LKL2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_5_24675657_G_A | 40 | E>K | No | 1000Genomes | |
| tmp_5_24676127_G_A | 91 | D>N | No | 1000Genomes | |
| tmp_5_24676300_A_T | 103 | Q>L | No | 1000Genomes | |
| ENSVATH14643917 | 118 | A>T | No | 1000Genomes | |
| tmp_5_24676598_G_T | 152 | L>F | No | 1000Genomes | |
| ENSVATH07461007 | 165 | D>N | No | 1000Genomes | |
| tmp_5_24676737_G_A | 199 | E>K | No | 1000Genomes | |
| tmp_5_24676851_G_A | 209 | A>T | No | 1000Genomes | |
| tmp_5_24676893_T_A | 223 | S>T | No | 1000Genomes | |
| tmp_5_24676942_C_T | 239 | S>F | No | 1000Genomes | |
| ENSVATH12892323 | 244 | M>I | No | 1000Genomes | |
| ENSVATH03461053 | 245 | K>N | No | 1000Genomes | |
| ENSVATH07461010 | 251 | A>T | No | 1000Genomes | |
| ENSVATH07461011 | 255 | S>L | No | 1000Genomes | |
| tmp_5_24677096_A_C | 259 | K>N | No | 1000Genomes | |
| ENSVATH12892346 | 259 | K>R | No | 1000Genomes | |
| tmp_5_24677187_G_A | 290 | D>N | No | 1000Genomes | |
| tmp_5_24677205_C_T | 296 | H>Y | No | 1000Genomes | |
| tmp_5_24677218_G_T | 300 | G>V | No | 1000Genomes | |
| ENSVATH03461054 | 306 | Q>E | No | 1000Genomes | |
| ENSVATH07461012 | 307 | V>M | No | 1000Genomes | |
| tmp_5_24677270_A_C | 317 | K>N | No | 1000Genomes | |
| tmp_5_24677287_C_G | 323 | T>R | No | 1000Genomes | |
| tmp_5_24677337_A_G | 340 | N>D | No | 1000Genomes | |
| ENSVATH14643920 | 345 | H>Y | No | 1000Genomes | |
| ENSVATH07461013 | 349 | R>G | No | 1000Genomes | |
| ENSVATH03461056 | 357 | V>M | No | 1000Genomes | |
| tmp_5_24677392_T_G | 358 | V>G | No | 1000Genomes | |
| tmp_5_24677395_C_G | 359 | A>G | No | 1000Genomes | |
| ENSVATH07461014 | 362 | G>R | No | 1000Genomes | |
| ENSVATH03461057 | 369 | A>V | No | 1000Genomes | |
| tmp_5_24677431_G_A | 371 | R>K | No | 1000Genomes | |
| tmp_5_24677443_C_T | 375 | T>I | No | 1000Genomes | |
| ENSVATH07461016 | 377 | Q>L | No | 1000Genomes | |
| ENSVATH07461017 | 378 | Y>F | No | 1000Genomes | |
| tmp_5_24677476_A_G | 386 | Q>R | No | 1000Genomes | |
| ENSVATH07461018 | 387 | N>K | No | 1000Genomes | |
| ENSVATH12892349 | 388 | G>D | No | 1000Genomes | |
| tmp_5_24677484_G_A | 389 | A>T | No | 1000Genomes | |
| ENSVATH07461019 | 402 | P>L | No | 1000Genomes | |
| ENSVATH12892350 | 406 | E>K | No | 1000Genomes | |
| tmp_5_24677544_G_T | 409 | G>C | No | 1000Genomes | |
| tmp_5_24677568_A_G | 417 | M>V | No | 1000Genomes | |
| ENSVATH00746426 | 442 | N>D | No | 1000Genomes | |
| tmp_5_24677671_T_A | 451 | V>D | No | 1000Genomes | |
| ENSVATH12892351 | 456 | M>L | No | 1000Genomes | |
| tmp_5_24677707_T_C | 463 | M>T | No | 1000Genomes | |
| ENSVATH07461020 | 465 | Q>P | No | 1000Genomes | |
| ENSVATH03461058 | 485 | P>S | No | 1000Genomes | |
| tmp_5_24677846_G_A | 509 | M>I | No | 1000Genomes | |
| ENSVATH07461021 | 510 | V>I | No | 1000Genomes | |
| ENSVATH07461022 | 516 | P>L | No | 1000Genomes | |
| ENSVATH00746428 | 523 | N>D | No | 1000Genomes | |
| ENSVATH00746429 | 545 | N>S | No | 1000Genomes | |
| ENSVATH07461023 | 568 | V>I | No | 1000Genomes | |
| ENSVATH03461059 | 619 | T>R | No | 1000Genomes |
No associated diseases with Q9LKL2
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA-binding transcription factor activity | A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| circadian rhythm | Any biological process in an organism that recurs with a regularity of approximately 24 hours. |
| circumnutation | The organismal movement by which the tip of a plant organ follows a spiral pattern as a consequence of growth. |
| cytokinin-activated signaling pathway | The series of molecular signals generated by the binding of a cytokinin to a receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| DNA-templated transcription | The synthesis of an RNA transcript from a DNA template. |
| flower development | The process whose specific outcome is the progression of the flower over time, from its formation to the mature structure. The flower is the reproductive structure in a plant, and its development begins with the transition of the vegetative or inflorescence meristem into a floral meristem. |
| negative regulation of gene expression | Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| phosphorelay signal transduction system | A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. |
| regulation of DNA-templated transcription | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| regulation of gene expression | Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
18 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P23769 | GATA2 | Endothelial transcription factor GATA-2 | Homo sapiens (Human) | PR |
| O09100 | Gata2 | Endothelial transcription factor GATA-2 | Mus musculus (Mouse) | PR |
| Q942A1 | RR4 | Two-component response regulator ORR4 | Oryza sativa subsp japonica (Rice) | PR |
| Q6H468 | RR11 | Two-component response regulator ORR11 | Oryza sativa subsp japonica (Rice) | PR |
| Q0PVB3 | RR7 | Two-component response regulator ORR7 | Oryza sativa subsp japonica (Rice) | PR |
| Q7Y0W5 | EHD1 | Two-component response regulator ORR30 | Oryza sativa subsp japonica (Rice) | PR |
| Q9SKN6 | GATA13 | Putative GATA transcription factor 13 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LT45 | GATA29 | GATA transcription factor 29 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q6LA43 | APRR2 | Two-component response regulator-like APRR2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8L4M6 | GATA3 | GATA transcription factor 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O65515 | GATA7 | GATA transcription factor 7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O80366 | ARR9 | Two-component response regulator ARR9 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q93WK5 | APRR7 | Two-component response regulator-like APRR7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FJ16 | APRR4 | Putative two-component response regulator-like APRR4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FXD6 | ARR11 | Two-component response regulator ARR11 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SB04 | ARR5 | Two-component response regulator ARR5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZWS9 | ARR3 | Two-component response regulator ARR3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LVG4 | APRR3 | Two-component response regulator-like APRR3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDLNGECKGG | DGFIDRSRVR | ILLCDNDSTS | LGEVFTLLSE | CSYQVTAVKS | ARQVIDALNA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EGPDIDIILA | EIDLPMAKGM | KMLRYITRDK | DLRRIPVIMM | SRQDEVPVVV | KCLKLGAADY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LVKPLRTNEL | LNLWTHMWRR | RRMLGLAEKN | MLSYDFDLVG | SDQSDPNTNS | TNLFSDDTDD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RSLRSTNPQR | GNLSHQENEW | SVATAPVHAR | DGGLGADGTA | TSSLAVTAIE | PPLDHLAGSH |
| 250 | 260 | 270 | 280 | 290 | 300 |
| HEPMKRNSNP | AQFSSAPKKS | RLKIGESSAF | FTYVKSTVLR | TNGQDPPLVD | GNGSLHLHRG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LAEKFQVVAS | EGINNTKQAR | RATPKSTVLR | TNGQDPPLVN | GNGSHHLHRG | AAEKFQVVAS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EGINNTKQAH | RSRGTEQYHS | QGETLQNGAS | YPHSLERSRT | LPTSMESHGR | NYQEGNMNIP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QVAMNRSKDS | SQVDGSGFSA | PNAYPYYMHG | VMNQVMMQSA | AMMPQYGHQI | PHCQPNHPNG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| MTGYPYYHHP | MNTSLQHSQM | SLQNGQMSMV | HHSWSPAGNP | PSNEVRVNKL | DRREEALLKF |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RRKRNQRCFD | KKIRYVNRKR | LAERRPRVKG | QFVRKMNGVN | VDLNGQPDSA | DYDDEEEEEE |
| 610 | |||||
| EEEEENRDSS | PQDDALGT |