Q9SFB8
PR
Gene name |
PIP5K6 (At3g07960, F17A17.30) |
Protein name |
Phosphatidylinositol 4-phosphate 5-kinase 6 |
Names |
AtPIP5K6, 1-phosphatidylinositol 4-phosphate kinase 6, Diphosphoinositide kinase 6, PtdIns(4)P-5-kinase 6 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G07960 |
EC number |
2.7.1.68: Phosphotransferases with an alcohol group as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9SFB8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9SFB8-F1 | Predicted | AlphaFoldDB |
15 variants for Q9SFB8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_3_2535326_A_G | 18 | E>G | No | 1000Genomes | |
| ENSVATH10549334 | 132 | L>S | No | 1000Genomes | |
| ENSVATH10549385 | 233 | V>M | No | 1000Genomes | |
| tmp_3_2536066_G_C | 239 | R>T | No | 1000Genomes | |
| tmp_3_2536168_G_A | 273 | R>K | No | 1000Genomes | |
| ENSVATH02122604 | 275 | V>I | No | 1000Genomes | |
| tmp_3_2536188_A_T | 280 | S>C | No | 1000Genomes | |
| ENSVATH05792949 | 325 | G>S | No | 1000Genomes | |
| ENSVATH02122608 | 439 | R>H | No | 1000Genomes | |
| tmp_3_2537164_G_C | 496 | M>I | No | 1000Genomes | |
| ENSVATH02122614 | 585 | I>F | No | 1000Genomes | |
| ENSVATH05792961 | 586 | K>R | No | 1000Genomes | |
| ENSVATH05792962 | 591 | P>L | No | 1000Genomes | |
| ENSVATH02122624 | 603 | E>D | No | 1000Genomes | |
| tmp_3_2538084_C_G | 714 | D>E | No | 1000Genomes |
No associated diseases with Q9SFB8
8 regional properties for Q9SFB8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Phosphatidylinositol-4-phosphate 5-kinase, core | 321 - 712 | IPR002498 |
| repeat | MORN repeat | 30 - 54 | IPR003409-1 |
| repeat | MORN repeat | 53 - 76 | IPR003409-2 |
| repeat | MORN repeat | 76 - 99 | IPR003409-3 |
| repeat | MORN repeat | 99 - 122 | IPR003409-4 |
| repeat | MORN repeat | 122 - 143 | IPR003409-5 |
| repeat | MORN repeat | 145 - 169 | IPR003409-6 |
| repeat | MORN repeat | 168 - 191 | IPR003409-7 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.1.68 | Phosphotransferases with an alcohol group as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| pollen tube | A tubular cell projection that is part of a pollen tube cell and extends from a pollen grain. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| 1-phosphatidylinositol-4-phosphate 5-kinase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H(+). |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| clathrin-dependent endocytosis | An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles. |
| phosphatidylinositol phosphate biosynthetic process | The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate. |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q0P5F7 | PIP4K2C | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma | Bos taurus (Bovine) | PR |
| Q17QS4 | PIP5KL1 | Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 | Bos taurus (Bovine) | PR |
| Q8TBX8 | PIP4K2C | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma | Homo sapiens (Human) | PR |
| P78356 | PIP4K2B | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | Homo sapiens (Human) | PR |
| Q5T9C9 | PIP5KL1 | Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 | Homo sapiens (Human) | PR |
| Q99755 | PIP5K1A | Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha | Homo sapiens (Human) | PR |
| Q80XI4 | Pip4k2b | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | Mus musculus (Mouse) | PR |
| Q91XU3 | Pip4k2c | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma | Mus musculus (Mouse) | PR |
| Q6U7H8 | Pip5kl1 | Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 | Mus musculus (Mouse) | PR |
| O88370 | Pip4k2c | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma | Rattus norvegicus (Rat) | PR |
| O48709 | PIP5K3 | Phosphatidylinositol 4-phosphate 5-kinase 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q56YP2 | PIP5K1 | Phosphatidylinositol 4-phosphate 5-kinase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8L796 | PIP5K2 | Phosphatidylinositol 4-phosphate 5-kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q6GL14 | pip4k2c | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q6IQE1 | pip4k2c | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSVAHADDAD | DYSRPTGESY | HAEKALPSGD | FYTGQWRDNL | PHGHGKYLWT | DGCMYVGDWH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RGKTMGKGRF | SWPSGATYEG | DFKNGYMDGK | GTYIDSSGDL | YRGSWVMNLR | HGQGTKSYVN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GDCYDGEWRR | GLQDGHGRYQ | WKNENHYIGQ | WKNGLMNGNG | TMIWSNGNRY | DGSWEDGAPK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GNGTFRWSDG | SFYVGVWSKD | PKEQNGTYYP | STSSGNFDWQ | PQQVFYVDLS | ECVVCTCQRI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PVLPSQKMPV | WYGASEQSSS | GNRTKNSERP | RRRSVDGRVS | NGEMELRSNG | SGYLQVDDNA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ESTRSSLGPL | RIQPAKKQGQ | TISKGHKNYE | LMLNLQLGIR | HSVGRPAPAT | SLDLKASAFD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PKEKLWTKFP | SEGSKYTPPH | QSCEFKWKDY | CPVVFRTLRK | LFSVDAADYM | LSICGNDALR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ELSSPGKSGS | FFYLTNDDRY | MIKTMKKAET | KVLIRMLPAY | YNHVRACENT | LVTKFFGLHC |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VKLTGTAQKK | VRFVIMGNLF | CTGHSIHRRF | DLKGSSHGRL | TTKPESEIDP | NTTLKDLDLN |
| 550 | 560 | 570 | 580 | 590 | 600 |
| FAFRLQKNWF | QEFCRQVDRD | CEFLEQERIM | DYSLLVGLHF | REAAIKDSAT | PTSGARTPTG |
| 610 | 620 | 630 | 640 | 650 | 660 |
| NSETRLSRAE | MDRFLLDASK | LASIKLGINM | PARVERTARR | SDCENQLVGD | PTGEFYDVIV |
| 670 | 680 | 690 | 700 | 710 | |
| YFGIIDILQD | YDISKKLEHA | YKSMQYDPTS | ISAVDPKQYS | RRFRDFIFRV | FVEDA |