Q17QS4
PR
Gene name |
PIP5KL1 |
Protein name |
Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 |
Names |
PI(4)P 5-kinase-like protein 1, PtdIns(4)P-5-kinase-like protein 1 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:523736 |
EC number |
2.7.1.68: Phosphotransferases with an alcohol group as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q17QS4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q17QS4-F1 | Predicted | AlphaFoldDB |
192 variants for Q17QS4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs445621445 | 11 | I>L | No | EVA | |
| rs470110579 | 15 | S>P | No | EVA | |
| rs449864318 | 17 | E>A | No | EVA | |
| rs480976235 | 19 | G>A | No | EVA | |
| rs460991021 | 22 | A>P | No | EVA | |
| rs459724991 | 25 | S>* | No | EVA | |
| rs479737467 | 25 | S>P | No | EVA | |
| rs439623206 | 28 | G>D | No | EVA | |
| rs477727870 | 29 | H>N | No | EVA | |
| rs464066318 | 29 | H>P | No | EVA | |
| rs443945153 | 36 | L>R | No | EVA | |
| rs455151036 | 37 | R>Q | No | EVA | |
| rs440923076 | 40 | Q>P | No | EVA | |
| rs472318481 | 41 | C>G | No | EVA | |
| rs452070475 | 42 | R>P | No | EVA | |
| rs469803670 | 44 | G>V | No | EVA | |
| rs436265719 | 46 | F>L | No | EVA | |
| rs456236138 | 46 | F>Y | No | EVA | |
| rs467372466 | 47 | E>G | No | EVA | |
| rs447426854 | 49 | G>C | No | EVA | |
| rs446021018 | 51 | G>W | No | EVA | |
| rs477397942 | 52 | H>N | No | EVA | |
| rs463774454 | 52 | H>P | No | EVA | |
| rs443918186 | 53 | E>G | No | EVA | |
| rs481747472 | 55 | H>P | No | EVA | |
| rs461529504 | 55 | H>Q | No | EVA | |
| rs441484810 | 57 | V>A | No | EVA | |
| rs441484810 | 57 | V>G | No | EVA | |
| rs472327266 | 60 | L>V | No | EVA | |
| rs452065610 | 61 | M>R | No | EVA | |
| rs438494310 | 63 | A>G | No | EVA | |
| rs476172476 | 66 | W>C | No | EVA | |
| rs455996653 | 67 | A>S | No | EVA | |
| rs436228926 | 68 | A>T | No | EVA | |
| rs467537728 | 70 | Q>P | No | EVA | |
| rs137088876 | 71 | V>G | No | EVA | |
| rs465169513 | 73 | M>I | No | EVA | |
| rs433815934 | 73 | M>T | No | EVA | |
| rs446055337 | 74 | D>G | No | EVA | |
| rs477562128 | 75 | H>L | No | EVA | |
| rs470158308 | 76 | P>L | No | EVA | |
| rs479615333 | 84 | E>D | No | EVA | |
| rs469825372 | 96 | G>S | No | EVA | |
| rs450873198 | 96 | G>V | No | EVA | |
| rs461965626 | 98 | E>G | No | EVA | |
| rs482155594 | 98 | E>Q | No | EVA | |
| rs442037822 | 99 | L>R | No | EVA | |
| rs480143318 | 100 | G>S | No | EVA | |
| rs439889776 | 101 | T>A | No | EVA | |
| rs439889776 | 101 | T>P | No | EVA | |
| rs457550469 | 102 | L>M | No | EVA | |
| rs443322576 | 102 | L>W | No | EVA | |
| rs474733647 | 103 | A>V | No | EVA | |
| rs454501590 | 104 | G>D | No | EVA | |
| rs465788765 | 107 | F>L | No | EVA | |
| rs449829288 | 110 | L>P | No | EVA | |
| rs449829288 | 110 | L>R | No | EVA | |
| rs482116788 | 113 | S>P | No | EVA | |
| rs468555126 | 114 | L>V | No | EVA | |
| rs479818358 | 115 | G>W | No | EVA | |
| rs459759963 | 116 | L>R | No | EVA | |
| rs439860720 | 120 | D>A | No | EVA | |
| rs439860720 | 120 | D>V | No | EVA | |
| rs477724608 | 121 | Y>H | No | EVA | |
| rs463936475 | 123 | A>P | No | EVA | |
| rs452110995 | 131 | Y>S | No | EVA | |
| rs432238726 | 133 | Q>H | No | EVA | |
| rs476357582 | 134 | F>V | No | EVA | |
| rs456174714 | 136 | S>R | No | EVA | |
| rs436102474 | 142 | A>D | No | EVA | |
| rs467597848 | 143 | S>I | No | EVA | |
| rs479218904 | 150 | Q>H | No | EVA | |
| rs447892450 | 150 | Q>P | No | EVA | |
| rs465411589 | 151 | R>G | No | EVA | |
| rs444867025 | 152 | F>L | No | EVA | |
| rs482550662 | 156 | T>P | No | EVA | |
| rs482550662 | 156 | T>S | No | EVA | |
| rs442447467 | 157 | L>R | No | EVA | |
| rs462365093 | 157 | L>V | No | EVA | |
| rs460406845 | 159 | S>N | No | EVA | |
| rs440303142 | 162 | V>A | No | EVA | |
| rs440303142 | 162 | V>G | No | EVA | |
| rs471579747 | 164 | A>T | No | EVA | |
| rs456528241 | 168 | H>L | No | EVA | |
| rs476742381 | 168 | H>N | No | EVA | |
| rs456528241 | 168 | H>P | No | EVA | |
| rs436348502 | 169 | L>Q | No | EVA | |
| rs467755447 | 170 | P>T | No | EVA | |
| rs454373078 | 173 | V>E | No | EVA | |
| rs434296385 | 174 | H>P | No | EVA | |
| rs465374839 | 174 | H>Q | No | EVA | |
| rs445434989 | 175 | H>P | No | EVA | |
| rs482514939 | 175 | H>Q | No | EVA | |
| rs468951877 | 176 | L>P | No | EVA | |
| rs876549870 | 179 | H>P | No | EVA | |
| rs448886280 | 179 | H>Q | No | EVA | |
| rs480206536 | 180 | P>T | No | EVA | |
| rs460121839 | 182 | S>* | No | EVA | |
| rs876114691 | 187 | V>G | No | EVA | |
| rs462384997 | 190 | V>G | No | EVA | |
| rs442325021 | 195 | V>G | No | EVA | |
| rs482245293 | 201 | K>* | No | EVA | |
| rs462178766 | 202 | Y>C | No | EVA | |
| rs462178766 | 202 | Y>S | No | EVA | |
| rs448662716 | 204 | I>N | No | EVA | |
| rs459924299 | 205 | V>A | No | EVA | |
| rs480179856 | 205 | V>I | No | EVA | |
| rs439876512 | 210 | F>S | No | EVA | |
| rs470454675 | 227 | V>G | No | EVA | |
| rs481630778 | 231 | V>G | No | EVA | |
| rs478543883 | 252 | K>* | No | EVA | |
| rs478543883 | 252 | K>E | No | EVA | |
| rs458363819 | 253 | T>S | No | EVA | |
| rs438405039 | 257 | G>R | No | EVA | |
| rs480310985 | 265 | R>G | No | EVA | |
| rs440279900 | 271 | T>P | No | EVA | |
| rs471601308 | 274 | L>P | No | EVA | |
| rs458998863 | 279 | V>I | No | EVA | |
| rs446740700 | 309 | S>P | No | EVA | |
| rs478131388 | 311 | R>* | No | EVA | |
| rs478131388 | 311 | R>G | No | EVA | |
| rs464344802 | 311 | R>P | No | EVA | |
| rs450642846 | 312 | G>V | No | EVA | |
| rs482068764 | 313 | A>E | No | EVA | |
| rs462968204 | 315 | S>R | No | EVA | |
| rs442931148 | 318 | E>G | No | EVA | |
| rs480396088 | 320 | G>E | No | EVA | |
| rs460407805 | 325 | R>P | No | EVA | |
| rs440651459 | 328 | P>A | No | EVA | |
| rs451877271 | 329 | D>E | No | EVA | |
| rs471945925 | 329 | D>G | No | EVA | |
| rs471945925 | 329 | D>V | No | EVA | |
| rs444544559 | 331 | P>S | No | EVA | |
| rs476064568 | 332 | N>I | No | EVA | |
| rs435302325 | 333 | A>D | No | EVA | |
| rs466551628 | 335 | H>P | No | EVA | |
| rs452966335 | 336 | I>L | No | EVA | |
| rs464408401 | 338 | D>A | No | EVA | |
| rs482044588 | 340 | P>Q | No | EVA | |
| rs468421342 | 341 | E>G | No | EVA | |
| rs449271154 | 343 | R>L | No | EVA | |
| rs460368857 | 344 | Y>H | No | EVA | |
| rs446849383 | 345 | F>S | No | EVA | |
| rs458335581 | 349 | V>G | No | EVA | |
| rs462383899 | 350 | D>A | No | EVA | |
| rs475984910 | 350 | D>H | No | EVA | |
| rs441729691 | 351 | L>P | No | EVA | |
| rs473141238 | 352 | T>A | No | EVA | |
| rs473141238 | 352 | T>P | No | EVA | |
| rs453025907 | 353 | T>P | No | EVA | |
| rs470618879 | 355 | Y>* | No | EVA | |
| rs457147990 | 356 | G>W | No | EVA | |
| rs448311784 | 359 | K>T | No | EVA | |
| rs466856741 | 362 | E>* | No | EVA | |
| rs446910678 | 362 | E>G | No | EVA | |
| rs477979578 | 363 | Q>E | No | EVA | |
| rs458172704 | 363 | Q>H | No | EVA | |
| rs451077484 | 366 | K>* | No | EVA | |
| rs451077484 | 366 | K>Q | No | EVA | |
| rs482611018 | 367 | T>M | No | EVA | |
| rs462319590 | 369 | R>P | No | EVA | |
| rs442193688 | 372 | G>A | No | EVA | |
| rs459404618 | 374 | T>P | No | EVA | |
| rs470553594 | 377 | T>N | No | EVA | |
| rs439351950 | 377 | T>P | No | EVA | |
| rs437072757 | 379 | S>R | No | EVA | |
| rs454682498 | 380 | P>R | No | EVA | |
| rs474975933 | 380 | P>T | No | EVA | |
| rs434506303 | 383 | Y>S | No | EVA | |
| rs433302927 | 386 | R>G | No | EVA | |
| rs464513585 | 386 | R>P | No | EVA | |
| rs450917372 | 387 | L>I | No | EVA | |
| rs482278206 | 387 | L>P | No | EVA | |
| rs468859098 | 388 | C>R | No | EVA | |
| rs448813611 | 389 | Q>L | No | EVA | |
| rs448813611 | 389 | Q>P | No | EVA | |
| rs479980114 | 390 | W>G | No | EVA | |
| rs479980114 | 390 | W>R | No | EVA | |
| rs459965455 | 391 | V>G | No | EVA | |
| rs439315086 | 392 | E>A | No | EVA | |
| rs439315086 | 392 | E>G | No | EVA | |
| rs463315884 | 393 | A>G | No | EVA | |
| rs477181124 | 393 | A>S | No | EVA | |
| rs474620599 | 394 | H>D | No | EVA | |
| rs454643825 | 394 | H>P | No | EVA | |
| rs441095272 | 395 | T>P | No | EVA | |
| rs452231361 | 396 | E>* | No | EVA | |
| rs433269616 | 396 | E>G | No | EVA | |
| rs437150334 | 397 | E>C | No | EVA | |
| rs464617198 | 397 | E>G | No | EVA | |
| rs457377041 | 397 | E>L | No | EVA | |
| rs464617198 | 397 | E>R | No | EVA |
No associated diseases with Q17QS4
1 regional properties for Q17QS4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Phosphatidylinositol-4-phosphate 5-kinase, core | 38 - 396 | IPR002498 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.1.68 | Phosphotransferases with an alcohol group as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell projection | A prolongation or process extending from a cell, e.g. a flagellum or axon. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| 1-phosphatidylinositol-4-phosphate 5-kinase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H(+). |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of cell migration | Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration. |
| negative regulation of mitochondrial membrane potential | Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or extent of a mitochondrial membrane potential, the electric potential existing across any mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. |
| negative regulation of protein phosphorylation | Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein. |
| phosphatidylinositol phosphate biosynthetic process | The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate. |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
| positive regulation of apoptotic process | Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q0P5F7 | PIP4K2C | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma | Bos taurus (Bovine) | PR |
| Q8TBX8 | PIP4K2C | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma | Homo sapiens (Human) | PR |
| Q99755 | PIP5K1A | Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha | Homo sapiens (Human) | PR |
| P78356 | PIP4K2B | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | Homo sapiens (Human) | PR |
| Q5T9C9 | PIP5KL1 | Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 | Homo sapiens (Human) | PR |
| Q91XU3 | Pip4k2c | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma | Mus musculus (Mouse) | PR |
| Q80XI4 | Pip4k2b | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | Mus musculus (Mouse) | PR |
| Q6U7H8 | Pip5kl1 | Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 | Mus musculus (Mouse) | PR |
| O88370 | Pip4k2c | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma | Rattus norvegicus (Rat) | PR |
| O48709 | PIP5K3 | Phosphatidylinositol 4-phosphate 5-kinase 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q56YP2 | PIP5K1 | Phosphatidylinositol 4-phosphate 5-kinase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SFB8 | PIP5K6 | Phosphatidylinositol 4-phosphate 5-kinase 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8L796 | PIP5K2 | Phosphatidylinositol 4-phosphate 5-kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q6GL14 | pip4k2c | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q6IQE1 | pip4k2c | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAAPSPGPRE | ILAPSPEAGR | RAAASSSGHR | GLLWRLRDKQ | CRLGLFEIGP | GHELHQVMCL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| MQAGLWAATQ | VSMDHPPTGL | PTEEDFSEVL | TQVHEGFELG | TLAGPVFARL | RRSLGLAEED |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YQAALGPSRP | YLQFLSTSKS | KASFFLSHDQ | RFFLKTLRSR | EVQALLAHLP | RYVHHLQRHP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HSLLARVLGV | HSLRVARGKK | KYFIVMQSVF | YPAGRISERY | DIKGCEVSRW | VEPAPEGSVL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VLVLKDLNFQ | GKTINLGPQR | SWFLRQMELD | TAFLRELNVL | DYSLLMAFQR | LHEDERGPGS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SLIFRTARSI | RGAQSAEESG | AQNRRLLPDA | PNALHIVDGP | EHRYFLGLVD | LTTVYGLRKR |
| 370 | 380 | 390 | |||
| LEQLWKTLRY | PGRTFSTVSP | ACYARRLCQW | VEAHTE |