Q0P5F7

PR
Gene name
PIP4K2C (PIP5K2C)
Protein name
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
Names
Phosphatidylinositol 5-phosphate 4-kinase type II gamma, PI(5)P 4-kinase type II gamma, PIP4KII-gamma
Species
Bos taurus (Bovine)
KEGG Pathway
bta:540005
EC number
2.7.1.149: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-59 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q0P5F7

Entry ID Method Resolution Chain Position Source
AF-Q0P5F7-F1 Predicted AlphaFoldDB

88 variants for Q0P5F7

Variant ID(s) Position Change Description Diseaes Association Provenance
rs432011719 3 S>C No EVA
rs465087037 4 S>P No EVA
rs456259665 7 P>T No EVA
rs437581367 9 T>P No EVA
rs467385313 10 A>G No EVA
rs449166555 11 V>E No EVA
rs478951711 14 A>E No EVA
rs466564570 15 T>A No EVA
rs445015993 15 T>R No EVA
rs477834420 17 A>V No EVA
rs723408002 18 P>S No EVA
rs483063896 19 G>R No EVA
rs443068574 22 F>C No EVA
rs472888210 23 G>D No EVA
rs439004169 24 F>I No EVA
rs439004169 24 F>L No EVA
rs456222972 25 A>G No EVA
rs472025222 25 A>P No EVA
rs437735675 26 S>A No EVA
rs437735675 26 S>P No EVA
rs455256733 27 K>Q No EVA
rs433835519 28 T>N No EVA
rs466728046 29 K>Q No EVA
rs477795753 31 K>N No EVA
rs469055752 32 H>Q No EVA
rs450119930 33 F>L No EVA
rs483194479 34 V>L No EVA
rs461314243 35 Q>R No EVA
rs449207946 39 K>N No EVA
rs479085925 40 V>E No EVA
rs479085925 40 V>G No EVA
rs460828020 41 F>S No EVA
rs439169557 43 A>G No EVA
rs471990183 45 D>H No EVA
rs463155102 50 V>G No EVA
rs444077448 53 W>C No EVA
rs132731515 55 V>G No EVA
rs473920381 57 H>N No EVA
rs455673887 75 D>H No EVA
rs437791028 87 H>P No EVA
rs439443283 130 P>S No EVA
rs442007420 170 H>P No EVA
rs449037720 225 S>Y No EVA
rs435590563 243 M>I No EVA
rs457303520 244 D>V No EVA
rs475775518 265 K>Q No EVA
rs439778271 269 D>H No EVA
rs451504931 272 F>V No EVA
rs433586970 274 V>L No EVA
rs455352557 278 I>T No EVA
rs473788021 286 G>S No EVA
rs444184271 291 I>F No EVA
rs471992036 296 P>S No EVA
rs460810065 298 E>G No EVA
rs438993858 298 E>Q No EVA
rs110427991 301 P>L No EVA
rs449480241 313 C>F No EVA
rs461402083 314 G>V No EVA
rs465252231 322 V>G No EVA
rs432969221 326 G>C No EVA
rs444994699 330 E>A No EVA
rs455541547 335 Y>C No EVA
rs455541547 335 Y>S No EVA
rs467375683 336 I>L No EVA
rs456249495 336 I>M No EVA
rs437542318 336 I>T No EVA
rs471454343 337 H>P No EVA
rs438465858 338 S>F No EVA
rs438465858 338 S>Y No EVA
rs472775711 339 H>R No EVA
rs443156235 340 R>G No EVA
rs461570831 340 R>P No EVA
rs461570831 340 R>Q No EVA
rs443560273 342 L>P No EVA
rs447685516 344 P>S No EVA
rs478806470 345 G>E No EVA
rs437605450 346 E>D No EVA
rs467639556 346 E>G No EVA
rs456161552 347 F>V No EVA
rs464943788 348 E>D No EVA
rs432106312 350 F>L No EVA
rs453735632 351 I>F No EVA
rs453735632 351 I>L No EVA
rs472847822 353 V>A No EVA
rs452712126 367 V>E No EVA
rs452712126 367 V>G No EVA
rs435057344 369 F>C No EVA
rs435057344 369 F>S No EVA

No associated diseases with Q0P5F7

No regional properties for Q0P5F7

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q0P5F7

Functions

Description
EC Number 2.7.1.149 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
  • Endoplasmic reticulum
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
autophagosome A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
1-phosphatidylinositol-4-phosphate 5-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H(+).
1-phosphatidylinositol-5-phosphate 4-kinase activity Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
identical protein binding Binding to an identical protein or proteins.

6 GO annotations of biological process

Name Definition
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity Any process that decreases the frequency, rate or extent of the catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
negative regulation of insulin receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.
phosphatidylinositol phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
positive regulation of autophagosome assembly Any process that activates or increases the frequency, rate or extent of autophagic vacuole assembly.

15 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q17QS4 PIP5KL1 Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 Bos taurus (Bovine) PR
Q99755 PIP5K1A Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha Homo sapiens (Human) PR
P78356 PIP4K2B Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens (Human) PR
Q5T9C9 PIP5KL1 Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 Homo sapiens (Human) PR
Q8TBX8 PIP4K2C Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma Homo sapiens (Human) PR
Q6U7H8 Pip5kl1 Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 Mus musculus (Mouse) PR
Q80XI4 Pip4k2b Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Mus musculus (Mouse) PR
Q91XU3 Pip4k2c Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma Mus musculus (Mouse) PR
O88370 Pip4k2c Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma Rattus norvegicus (Rat) PR
O48709 PIP5K3 Phosphatidylinositol 4-phosphate 5-kinase 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q56YP2 PIP5K1 Phosphatidylinositol 4-phosphate 5-kinase 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SFB8 PIP5K6 Phosphatidylinositol 4-phosphate 5-kinase 6 Arabidopsis thaliana (Mouse-ear cress) PR
Q8L796 PIP5K2 Phosphatidylinositol 4-phosphate 5-kinase 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q6GL14 pip4k2c Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q6IQE1 pip4k2c Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MASSSVPPTA VPAATAAPGA GFGFASKTKK KHFVQQKVKV FRAADPLVGV FLWGVAHSIN
70 80 90 100 110 120
ELSQVPPPVM LLPDDFKASS KIKVNNHLFH RENLPSHFKF KEYCPQVFRN LRDRFGIDDQ
130 140 150 160 170 180
DYLVSLTRSP PTESEGSDGR FLISYDRTLV IKEVSSEDIA DMHSNLSNYH QYIVKCHGNT
190 200 210 220 230 240
LLPQFLGMYR VSVDSEDSYM LVMRNMFSHR LPVHRKYDLK GSLVSREASD KEKVKELPTL
250 260 270 280 290 300
KDMDFLNKNQ KVYIGEEEKK VFLEKLKRDV EFLVQLKIMD YSLLLGIHDI IRGSEPEEDG
310 320 330 340 350 360
PVREEESEGD GDCGLTGPPA PVGSYGTSPE GIGGYIHSHR PLGPGEFESF IDVYAIRSAE
370 380 390 400 410 420
GAPQKEVYFM GLIDILTQYD AKKKAAHAAK TVKHGAGAEI STVHPEQYAK RFLDFITNIF
A