Q80XI4
PR
Gene name |
Pip4k2b |
Protein name |
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta |
Names |
1-phosphatidylinositol 5-phosphate 4-kinase 2-beta, Diphosphoinositide kinase 2-beta, Phosphatidylinositol 5-phosphate 4-kinase type II beta, PI(5)P 4-kinase type II beta, PIP4KII-beta, PtdIns(5)P-4-kinase isoform 2-beta |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:108083 |
EC number |
2.7.1.149: Phosphotransferases with an alcohol group as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q80XI4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q80XI4-F1 | Predicted | AlphaFoldDB |
15 variants for Q80XI4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389197200 | 111 | G>D | No | EVA | |
| rs3389201413 | 123 | R>H | No | EVA | |
| rs3389168350 | 130 | D>E | No | EVA | |
| rs3389197379 | 131 | S>* | No | EVA | |
| rs3389185653 | 131 | S>R | No | EVA | |
| rs3389191350 | 149 | I>N | No | EVA | |
| rs3389191322 | 175 | H>D | No | EVA | |
| rs3389133264 | 178 | T>I | No | EVA | |
| rs3389197174 | 185 | G>V | No | EVA | |
| rs3389172087 | 186 | M>I | No | EVA | |
| rs3389168407 | 200 | V>I | No | EVA | |
| rs3389197166 | 308 | E>V | No | EVA | |
| rs3389172094 | 309 | N>S | No | EVA | |
| rs3389197854 | 318 | C>Y | No | EVA | |
| rs3389194073 | 327 | P>S | No | EVA |
No associated diseases with Q80XI4
1 regional properties for Q80XI4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Phosphatidylinositol-4-phosphate 5-kinase, core | 38 - 416 | IPR002498 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.1.149 | Phosphotransferases with an alcohol group as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| autophagosome | A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy. |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| 1-phosphatidylinositol-4-phosphate 5-kinase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H(+). |
| 1-phosphatidylinositol-5-phosphate 4-kinase activity | Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| GTP binding | Binding to GTP, guanosine triphosphate. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process | The chemical reactions and pathways resulting in the formation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. |
| autophagosome-lysosome fusion | The process in which autophagosomes, double-membraned vesicles containing cytoplasmic material, fuse with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bounded structures (autophagic bodies) appear in the vacuole. Fusion provides an acidic environment and digestive function to the interior of the autophagosome. |
| negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity | Any process that decreases the frequency, rate or extent of the catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. |
| negative regulation of insulin receptor signaling pathway | Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling. |
| phosphatidylinositol metabolic process | The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. |
| phosphatidylinositol phosphate biosynthetic process | The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate. |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
| positive regulation of autophagosome assembly | Any process that activates or increases the frequency, rate or extent of autophagic vacuole assembly. |
| regulation of autophagy | Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q17QS4 | PIP5KL1 | Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 | Bos taurus (Bovine) | PR |
| Q0P5F7 | PIP4K2C | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma | Bos taurus (Bovine) | PR |
| Q99755 | PIP5K1A | Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha | Homo sapiens (Human) | PR |
| Q5T9C9 | PIP5KL1 | Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 | Homo sapiens (Human) | PR |
| Q8TBX8 | PIP4K2C | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma | Homo sapiens (Human) | PR |
| P78356 | PIP4K2B | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | Homo sapiens (Human) | PR |
| Q91XU3 | Pip4k2c | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma | Mus musculus (Mouse) | PR |
| Q6U7H8 | Pip5kl1 | Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 | Mus musculus (Mouse) | PR |
| O88370 | Pip4k2c | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma | Rattus norvegicus (Rat) | PR |
| O48709 | PIP5K3 | Phosphatidylinositol 4-phosphate 5-kinase 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q56YP2 | PIP5K1 | Phosphatidylinositol 4-phosphate 5-kinase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SFB8 | PIP5K6 | Phosphatidylinositol 4-phosphate 5-kinase 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8L796 | PIP5K2 | Phosphatidylinositol 4-phosphate 5-kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q6GL14 | pip4k2c | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q6IQE1 | pip4k2c | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSNCTSTTA | VAVAPLSASK | TKTKKKHFVC | QKVKLFRASE | PILSVLMWGV | NHTINELSNV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PVPVMLMPDD | FKAYSKIKVD | NHLFNKENLP | SRFKFKEYCP | MVFRNLRERF | GIDDQDYQNS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VTRSAPINSD | SQGRCGTRFL | TTYDRRFVIK | TVSSEDVAEM | HNILKKYHQF | IVECHGNTLL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PQFLGMYRLT | VDGVETYMVV | TRNVFSHRLT | VHRKYDLKGS | TVAREASDKE | KAKDLPTFKD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NDFLNEGQKL | HVGEESKKNF | LEKLKRDVEF | LAQLKIMDYS | LLVGIHDVDR | AEQEEMEVEE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RAEEEECEND | GVGGSLLCSY | GTPPDSPGNL | LSFPRFFGPG | EFDPSVDVYA | MKSHESAPKK |
| 370 | 380 | 390 | 400 | 410 | |
| EVYFMAIIDI | LTPYDAKKKA | AHAAKTVKHG | AGAEISTVNP | EQYSKRFNEF | MSNILT |