Q8L796

PR
Gene name
PIP5K2 (At1g77740, T32E8.7)
Protein name
Phosphatidylinositol 4-phosphate 5-kinase 2
Names
AtPIP5K2, 1-phosphatidylinositol 4-phosphate kinase 2, Diphosphoinositide kinase 2, PtdIns(4)P-5-kinase 2
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G77740
EC number
2.7.1.68: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

603-685 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8L796

Entry ID Method Resolution Chain Position Source
AF-Q8L796-F1 Predicted AlphaFoldDB

38 variants for Q8L796

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_1_29220644_C_T 5 P>S No 1000Genomes
ENSVATH05163126 11 E>K No 1000Genomes
tmp_1_29220670_A_T 13 E>D No 1000Genomes
ENSVATH05163127 18 V>G No 1000Genomes
ENSVATH05163130 26 L>F No 1000Genomes
ENSVATH05163129 26 L>V No 1000Genomes
ENSVATH05163131 28 K>R No 1000Genomes
ENSVATH13828314 30 R>Q No 1000Genomes
ENSVATH13828315 41 D>G No 1000Genomes
ENSVATH01550622 75 P>L No 1000Genomes
ENSVATH05163139 148 G>S No 1000Genomes
tmp_1_29221130_A_G 167 R>G No 1000Genomes
ENSVATH00146620 192 M>T No 1000Genomes
ENSVATH05163140 203 N>Y No 1000Genomes
ENSVATH13828317 227 G>V No 1000Genomes
ENSVATH05163142 232 S>N No 1000Genomes
ENSVATH05163143 235 F>L No 1000Genomes
tmp_1_29221348_T_G 239 D>E No 1000Genomes
tmp_1_29221412_A_G 261 I>V No 1000Genomes
ENSVATH00146623 270 T>S No 1000Genomes
tmp_1_29221464_G_A 278 S>N No 1000Genomes
ENSVATH13828318 313 E>K No 1000Genomes
ENSVATH13828319 314 A>T No 1000Genomes
ENSVATH01550627 321 R>M No 1000Genomes
ENSVATH05163146 326 K>N No 1000Genomes
ENSVATH14488871 338 C>W No 1000Genomes
ENSVATH05163151 382 K>Q No 1000Genomes
ENSVATH00146626 384 S>G No 1000Genomes
tmp_1_29222158_A_G 444 D>G No 1000Genomes
ENSVATH05163154 445 A>T No 1000Genomes
ENSVATH01550637 514 Q>P No 1000Genomes
ENSVATH05163163 565 N>S No 1000Genomes
tmp_1_29223116_G_C 625 K>N No 1000Genomes
tmp_1_29223115_A_G 625 K>R No 1000Genomes
ENSVATH13828338 675 R>K No 1000Genomes
tmp_1_29223629_A_T 678 Y>F No 1000Genomes
ENSVATH13828340 689 Q>H No 1000Genomes
tmp_1_29223697_T_G 701 F>V No 1000Genomes

No associated diseases with Q8L796

8 regional properties for Q8L796

Type Name Position InterPro Accession
domain Phosphatidylinositol-4-phosphate 5-kinase, core 351 - 751 IPR002498
repeat MORN repeat 80 - 104 IPR003409-1
repeat MORN repeat 103 - 126 IPR003409-2
repeat MORN repeat 126 - 150 IPR003409-3
repeat MORN repeat 149 - 172 IPR003409-4
repeat MORN repeat 172 - 195 IPR003409-5
repeat MORN repeat 195 - 219 IPR003409-6
repeat MORN repeat 218 - 241 IPR003409-7

Functions

Description
EC Number 2.7.1.68 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
  • Cell membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
1-phosphatidylinositol-3-phosphate 5-kinase activity Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H(+).
1-phosphatidylinositol-4-phosphate 5-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H(+).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

5 GO annotations of biological process

Name Definition
developmental process involved in reproduction A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring.
lateral root formation The process that gives rise to a lateral root. This process pertains to the initial formation of a structure from unspecified parts. A lateral root primordium represents an organized group of cells derived from the root pericycle that will differentiate into a new root, as opposed to the initiation of the main root from the embryo proper.
phosphatidylinositol phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
positive gravitropism The orientation of plant parts towards gravity.

15 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q0P5F7 PIP4K2C Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma Bos taurus (Bovine) PR
Q17QS4 PIP5KL1 Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 Bos taurus (Bovine) PR
P78356 PIP4K2B Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens (Human) PR
Q5T9C9 PIP5KL1 Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 Homo sapiens (Human) PR
Q8TBX8 PIP4K2C Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma Homo sapiens (Human) PR
Q99755 PIP5K1A Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha Homo sapiens (Human) PR
Q6U7H8 Pip5kl1 Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 Mus musculus (Mouse) PR
Q80XI4 Pip4k2b Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Mus musculus (Mouse) PR
Q91XU3 Pip4k2c Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma Mus musculus (Mouse) PR
O88370 Pip4k2c Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma Rattus norvegicus (Rat) PR
O48709 PIP5K3 Phosphatidylinositol 4-phosphate 5-kinase 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q56YP2 PIP5K1 Phosphatidylinositol 4-phosphate 5-kinase 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SFB8 PIP5K6 Phosphatidylinositol 4-phosphate 5-kinase 6 Arabidopsis thaliana (Mouse-ear cress) PR
Q6GL14 pip4k2c Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q6IQE1 pip4k2c Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MMREPLVSEE EEEEATEVLL VEKTKLCKRR GDEEKTEERR DDLLLLALTP MVRSKSQGTT
70 80 90 100 110 120
RRVTPTPPPV DVEKPLPNGD LYMGTFSGGF PNGSGKYLWK DGCMYEGEWK RGKASGKGKF
130 140 150 160 170 180
SWPSGATYEG EFKSGRMEGS GTFVGVDGDT YRGSWVADRK QGHGQKRYAN GDYYEGTWRR
190 200 210 220 230 240
NLQDGRGRYV WMNGNQYTGE WRNGVICGKG VLAWPNGNRY EGQWENGVPK GSGVFTWADG
250 260 270 280 290 300
SSWIGSWNES SNLMRNFFDG IEKNELIVAT RKRSSVDSGA GSLTGEKIFP RICIWESDGE
310 320 330 340 350 360
AGDITCDIVD NVEASVIYRD RISIDKDGFR QFRKNPCCFS GEAKKPGETI SKGHKKYDLM
370 380 390 400 410 420
LNLQHGIRYS VGKHASVVRD LKQSDFDPSE KFWTRFPPEG SKTTPPHLSV DFRWKDYCPL
430 440 450 460 470 480
VFRRLRELFT VDPADYMLAI CGNDALRELS SPGKSGSFFY LTQDDRFMIK TVKKSEVKVL
490 500 510 520 530 540
LRMLPSYYKH VCQYENTLVT RFYGVHCIKP VGGQKTRFIV MGNLFCSEYR IQRRFDLKGS
550 560 570 580 590 600
SHGRYTSKPE GEIDETTTLK DLDLNFAFRL QRNWYQELMT QIKRDCEFLE AERIMDYSLL
610 620 630 640 650 660
VGVHFRDDNT GDKMGLSPFV LRSGKIESYQ SEKFMRGCRF LEAELQDMDR ILAGRKPLIR
670 680 690 700 710 720
LGANMPARAE RMARRSDYDQ YSSGGTNYQS HGEVYEVVLY FGIIDILQDY DISKKIEHAY
730 740 750
KSLQADPASI SAVDPKLYSR RFRDFISRIF IEDG