Q99755
PR
Gene name |
PIP5K1A |
Protein name |
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha |
Names |
PIP5K1-alpha, PtdIns(4)P-5-kinase 1 alpha, 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha, Phosphatidylinositol 4-phosphate 5-kinase type I alpha, PIP5KIalpha |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:8394 |
EC number |
2.7.1.68: Phosphotransferases with an alcohol group as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q99755
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q99755-F1 | Predicted | AlphaFoldDB |
354 variants for Q99755
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs1389588176 CA341910581 |
4 | A>V | No |
ClinGen gnomAD |
|
|
rs757909566 CA341910613 |
6 | S>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA1087149 rs757909566 |
6 | S>Y | No |
ClinGen ExAC gnomAD |
|
|
rs146472749 CA1087151 |
7 | G>A | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs765203580 CA1087150 |
7 | G>R | No |
ClinGen ExAC |
|
|
rs758497457 CA1087152 |
8 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs747867472 CA1087154 |
9 | S>* | No |
ClinGen ExAC gnomAD |
|
|
rs1011266712 CA29505782 |
11 | S>L | No |
ClinGen TOPMed gnomAD |
|
|
rs1280371198 CA341910816 |
15 | S>* | No |
ClinGen gnomAD |
|
|
CA341910803 rs1217129145 |
15 | S>A | No |
ClinGen gnomAD |
|
|
CA1087156 rs777602849 |
16 | S>F | No |
ClinGen ExAC gnomAD |
|
|
CA341910913 rs1203613440 |
19 | P>L | No |
ClinGen gnomAD |
|
|
rs143477505 CA1087159 |
20 | A>V | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs745417143 CA1087160 |
21 | V>I | No |
ClinGen ExAC gnomAD |
|
|
rs771559819 CA341910979 |
22 | P>A | No |
ClinGen ExAC gnomAD |
|
|
CA341910995 rs1171019290 |
22 | P>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs771559819 CA1087161 |
22 | P>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA1087162 rs775222396 |
23 | S>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1087164 rs764552843 |
24 | C>R | No |
ClinGen ExAC gnomAD |
|
|
CA29505837 rs140435966 |
25 | T>I | No |
ClinGen ESP TOPMed |
|
|
rs1160632500 CA341911119 |
26 | L>S | No |
ClinGen gnomAD |
|
|
CA1087167 rs183368936 |
27 | S>F | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1437798168 CA341917366 |
30 | A>V | No |
ClinGen TOPMed |
|
|
CA341917375 rs1257452370 |
31 | S>A | No |
ClinGen gnomAD |
|
|
rs771475886 CA1087214 |
36 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA341917437 rs771475886 |
36 | P>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA341917465 rs1329695141 |
38 | A>T | No |
ClinGen TOPMed |
|
|
rs1278671845 CA341917845 |
41 | V>I | No |
ClinGen TOPMed |
|
|
rs1220499618 CA341917868 |
42 | L>F | No |
ClinGen TOPMed |
|
|
CA29529428 rs796608225 |
44 | A>S | No |
ClinGen Ensembl |
|
|
rs894274287 CA29529443 |
46 | Q>* | No |
ClinGen TOPMed |
|
|
rs760095699 CA1087235 |
47 | D>V | No |
ClinGen ExAC gnomAD |
|
|
rs1336049208 CA341917936 |
48 | S>F | No |
ClinGen gnomAD |
|
|
CA1087238 rs199497446 |
49 | Y>* | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs201886237 CA1087236 |
49 | Y>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA341917972 rs1462540188 |
51 | S>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
| TCGA novel | 52 | L>= | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs370166597 CA1087260 |
53 | V>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs766268525 CA1087262 |
56 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1213811665 CA341918197 |
59 | M>I | No |
ClinGen gnomAD |
|
|
CA341918180 rs1322990463 |
59 | M>L | No |
ClinGen gnomAD |
|
| TCGA novel | 60 | P>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1558272703 CA341918219 |
61 | I>M | No |
ClinGen Ensembl |
|
|
CA1087264 rs759523740 |
62 | K>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA341918261 rs1210317038 |
64 | I>T | No |
ClinGen gnomAD |
|
|
CA1087266 rs752209854 |
67 | R>T | No |
ClinGen ExAC gnomAD |
|
|
rs755582526 CA1087267 |
68 | S>G | No |
ClinGen ExAC gnomAD |
|
|
rs373842118 CA1087268 |
68 | S>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA341918332 rs1476215546 |
70 | D>A | No |
ClinGen gnomAD |
|
|
CA29531842 rs915680088 |
74 | E>G | No |
ClinGen Ensembl |
|
|
rs199964115 CA29531844 |
77 | Y>* | No |
ClinGen Ensembl |
|
| TCGA novel | 84 | A>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1570940089 CA341919763 |
84 | A>V | No |
ClinGen Ensembl |
|
| TCGA novel | 85 | L>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1174425342 CA341919904 |
90 | Q>R | No |
ClinGen gnomAD |
|
| TCGA novel | 94 | T>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA341920078 rs1200271456 |
98 | G>R | No |
ClinGen TOPMed |
|
|
rs1411195632 CA341920111 |
99 | S>N | No |
ClinGen gnomAD |
|
|
CA341920186 rs1279749049 |
101 | S>N | No |
ClinGen gnomAD |
|
|
rs1342696083 CA341920227 |
102 | T>I | No |
ClinGen TOPMed |
|
|
rs775302806 CA1087284 |
103 | K>T | No |
ClinGen ExAC gnomAD |
|
|
rs587682988 CA29535696 |
104 | P>L | No |
ClinGen 1000Genomes |
|
|
rs763482724 CA1087286 |
106 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA341920368 rs1348431747 |
106 | R>H | No |
ClinGen gnomAD |
|
|
rs1273867285 CA341920472 |
110 | M>V | No |
ClinGen TOPMed |
|
|
CA1087289 rs764903695 |
112 | D>H | No |
ClinGen ExAC gnomAD |
|
|
rs750724768 CA1087290 |
113 | F>S | No |
ClinGen ExAC gnomAD |
|
|
rs779784493 CA29535784 |
115 | V>M | No |
ClinGen Ensembl |
|
|
rs1332278204 CA341920706 |
116 | V>L | No |
ClinGen TOPMed |
|
|
CA1087291 rs758707233 |
118 | S>T | No |
ClinGen ExAC TOPMed |
|
|
CA1087292 rs780521602 |
120 | F>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs752756497 CA1087315 |
125 | G>R | No |
ClinGen ExAC gnomAD |
|
|
CA341921252 rs1394830220 |
134 | Y>H | No |
ClinGen gnomAD |
|
|
CA1087318 rs778057101 |
135 | N>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs778057101 CA1087317 |
135 | N>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA341921283 rs1328057988 |
135 | N>K | No |
ClinGen gnomAD |
|
|
rs771233592 CA1087319 |
135 | N>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA341921292 rs1480323915 |
136 | D>G | No |
ClinGen TOPMed gnomAD |
|
|
rs746855603 CA1087321 |
138 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA341921498 rs1311808402 |
145 | V>A | No |
ClinGen TOPMed |
|
|
rs769285963 CA1087325 |
148 | R>H | No |
ClinGen ExAC gnomAD |
|
|
CA1087327 rs762488256 |
151 | R>W | No |
ClinGen ExAC gnomAD |
|
|
CA29536465 rs143805959 |
156 | I>V | No |
ClinGen ESP |
|
|
rs774538039 CA1087329 |
157 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
rs766074475 CA1087328 |
157 | R>W | No |
ClinGen ExAC gnomAD |
|
|
CA1087330 COSM106616 rs146767366 |
158 | P>L | skin [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
CA1087332 rs753241257 |
159 | D>N | No |
ClinGen ExAC gnomAD |
|
|
CA1087333 rs753241257 |
159 | D>Y | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 161 | Y>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1382637005 CA341921839 |
161 | Y>C | No |
ClinGen gnomAD |
|
|
rs764247872 CA1087334 |
161 | Y>H | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 162 | L>= | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1281752951 CA341922513 |
163 | Y>C | No |
ClinGen gnomAD |
|
|
rs369780167 CA1087357 COSM1262225 |
169 | P>L | Variant assessed as Somatic; 4.663e-05 impact. oesophagus [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs369780167 CA341922596 |
169 | P>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs757374502 CA1087356 |
169 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1423547472 CA341922615 |
171 | I>V | No |
ClinGen TOPMed |
|
|
CA1087360 rs758656460 |
174 | C>Y | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 175 | S>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 185 | V>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA1087363 rs587643022 |
187 | S>G | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
| TCGA novel | 192 | I>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1392199192 CA341922969 |
192 | I>V | No |
ClinGen gnomAD |
|
|
CA341922984 rs1335188386 |
193 | I>V | No |
ClinGen TOPMed |
|
|
rs1383402826 CA341923153 |
206 | K>Q | No |
ClinGen TOPMed |
|
|
CA341923223 rs1292227762 |
211 | Y>* | No |
ClinGen TOPMed |
|
|
CA1087391 rs779867805 |
216 | N>S | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 217 | Q>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1475489460 CA341923523 |
219 | P>R | No |
ClinGen TOPMed |
|
|
CA29537871 rs1003261676 |
222 | L>S | No |
ClinGen TOPMed |
|
|
CA341923660 rs1570956026 |
224 | P>L | No |
ClinGen Ensembl |
|
|
rs1048925301 CA29537872 |
227 | Y>F | No |
ClinGen gnomAD |
|
|
CA1087395 rs762356101 |
231 | C>Y | No |
ClinGen ExAC gnomAD |
|
|
CA341923841 rs1222838342 |
233 | Q>* | No |
ClinGen TOPMed |
|
|
rs770221352 CA1087397 |
234 | A>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs770221352 CA1087396 |
234 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1087398 rs763022795 |
234 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs1463214866 CA341923935 |
237 | K>R | No |
ClinGen gnomAD |
|
|
rs766529574 CA1087399 |
240 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA1087400 rs751766379 |
242 | V>M | No |
ClinGen ExAC gnomAD |
|
|
CA1087401 rs759819974 |
244 | M>T | No |
ClinGen ExAC |
|
| TCGA novel | 249 | P>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs377064939 CA29537953 |
251 | S>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP NCI-TCGA TOPMed gnomAD |
|
rs377064939 CA341924249 |
251 | S>W | No |
ClinGen ESP TOPMed gnomAD |
|
|
CA1087402 rs587618751 |
255 | H>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
| TCGA novel | 255 | H>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs587680327 CA1087403 |
256 | I>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA1087405 rs778722548 |
257 | K>E | No |
ClinGen ExAC gnomAD |
|
|
CA341924452 rs1233511641 |
261 | K>E | No |
ClinGen gnomAD |
|
|
rs779780000 CA1087408 |
265 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
rs1314880365 CA341924588 |
267 | R>W | No |
ClinGen TOPMed gnomAD |
|
|
rs754640579 CA1087410 |
268 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
CA1087409 rs746632430 |
268 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs781567276 CA1087411 |
274 | R>G | No |
ClinGen ExAC |
|
|
CA1087412 rs748489655 |
274 | R>Q | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 277 | P>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA341924807 rs1352387736 |
279 | P>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
rs749850177 CA1087415 |
282 | K>N | No |
ClinGen ExAC gnomAD |
|
|
rs1165884119 CA341924871 |
283 | D>E | No |
ClinGen gnomAD |
|
|
rs1371904495 CA341924875 |
284 | L>V | No |
ClinGen TOPMed |
|
|
CA341924886 rs1380989777 |
285 | D>N | No |
ClinGen TOPMed gnomAD |
|
|
CA1087416 rs770993079 |
288 | Q>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1161771106 CA341924971 |
289 | D>E | No |
ClinGen gnomAD |
|
|
rs1314998906 CA341924959 |
289 | D>G | No |
ClinGen gnomAD |
|
|
CA341924988 rs1346235154 |
290 | I>T | No |
ClinGen gnomAD |
|
|
rs587717250 CA1087417 |
291 | P>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA |
|
CA341925025 rs759781472 |
292 | D>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1087418 rs759781472 |
292 | D>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1087420 rs767663810 |
295 | F>S | No |
ClinGen ExAC TOPMed gnomAD |
|
| rs756244757 | 296 | L>F | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
| rs756244757 | 296 | L>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1570957266 CA341925154 |
297 | D>E | No |
ClinGen Ensembl |
|
|
CA341925197 rs374846839 |
299 | D>A | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA341925178 rs1287302815 |
299 | D>N | No |
ClinGen gnomAD |
|
|
CA1087421 rs374846839 |
299 | D>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA341925225 rs1483393459 |
300 | M>T | No |
ClinGen TOPMed |
|
|
rs1225220689 CA341925212 |
300 | M>V | No |
ClinGen TOPMed gnomAD |
|
|
rs758849500 CA29538062 |
301 | Y>* | No |
ClinGen Ensembl |
|
|
rs761527729 CA1087422 |
302 | N>S | No |
ClinGen ExAC gnomAD |
|
|
rs1282434679 CA341925356 |
304 | L>F | No |
ClinGen gnomAD |
|
| TCGA novel | 304 | L>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA1087425 rs183966255 |
307 | T>I | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs145572106 CA29538077 |
309 | Q>H | No |
ClinGen ESP gnomAD |
|
|
rs1242484794 CA341925531 |
310 | R>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs1570957692 CA341925582 |
311 | D>E | No |
ClinGen Ensembl |
|
| TCGA novel | 311 | D>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 316 | Q>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA341926694 rs1397385437 |
323 | Y>C | No |
ClinGen gnomAD |
|
|
rs1570969495 CA341926738 |
324 | S>I | No |
ClinGen Ensembl |
|
| TCGA novel | 326 | L>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1281790611 CA341926829 |
328 | S>T | No |
ClinGen TOPMed |
|
|
CA1087445 rs766446469 |
329 | I>V | No |
ClinGen ExAC TOPMed |
|
|
CA1087447 rs754456936 |
331 | N>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs61751621 CA1087448 |
332 | I>T | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs587729901 CA1087450 |
333 | D>G | No |
ClinGen 1000Genomes ExAC gnomAD |
|
| TCGA novel | 333 | D>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1158439875 CA341927653 |
334 | H>Y | No |
ClinGen TOPMed |
|
|
rs985420378 CA29539480 |
337 | R>* | No |
ClinGen gnomAD |
|
|
rs985420378 CA341927711 |
337 | R>G | No |
ClinGen gnomAD |
|
|
rs141668904 CA1087451 |
337 | R>P | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs141668904 CA29539490 |
337 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1180079290 CA341927782 |
339 | P>L | No |
ClinGen TOPMed |
|
|
rs1273921227 CA341927768 |
339 | P>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs746446850 CA1087455 |
341 | S>N | No |
ClinGen ExAC |
|
|
rs772042441 COSM398521 CA1087456 |
341 | S>R | lung [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
CA341927860 rs1255300622 |
342 | S>N | No |
ClinGen gnomAD |
|
| TCGA novel | 345 | Q>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1193060839 CA341927957 |
346 | Y>C | No |
ClinGen gnomAD |
|
|
rs962167295 CA29539523 |
346 | Y>H | No |
ClinGen TOPMed gnomAD |
|
|
CA1087457 rs780225134 |
347 | S>L | No |
ClinGen ExAC gnomAD |
|
|
CA341928051 rs1168022300 |
349 | D>G | No |
ClinGen gnomAD |
|
|
rs1476079648 CA341928029 |
349 | D>N | No |
ClinGen TOPMed gnomAD |
|
|
CA341928073 rs1416622412 |
350 | T>N | No |
ClinGen gnomAD |
|
|
rs747179720 CA1087458 |
351 | R>* | No |
ClinGen ExAC gnomAD |
|
|
rs769026009 CA1087459 |
353 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1087462 rs368254946 |
354 | A>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1215805107 CA341928161 |
355 | P>R | No |
ClinGen TOPMed |
|
|
rs759583481 CA1087465 |
356 | Q>* | No |
ClinGen ExAC TOPMed gnomAD |
|
| rs757546289 | 356 | Q>P | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1382778122 CA341928391 |
365 | E>* | No |
ClinGen TOPMed |
|
|
CA341928425 rs1275360280 |
366 | S>A | No |
ClinGen gnomAD |
|
| TCGA novel | 368 | Q>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1202555114 CA341928542 |
370 | E>A | No |
ClinGen gnomAD |
|
|
rs1335880667 CA341928563 |
371 | A>S | No |
ClinGen TOPMed gnomAD |
|
|
CA341928552 rs1335880667 |
371 | A>T | No |
ClinGen TOPMed gnomAD |
|
|
rs933715329 CA29539608 |
372 | R>* | No |
ClinGen TOPMed |
|
|
rs933715329 CA341928580 |
372 | R>G | No |
ClinGen TOPMed |
|
|
CA1087467 rs766905114 |
372 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
rs917226973 CA29539623 |
373 | R>Q | No |
ClinGen TOPMed gnomAD |
|
|
CA1087468 rs752299839 |
373 | R>W | No |
ClinGen ExAC gnomAD |
|
|
rs1193197347 CA341928637 |
375 | G>R | No |
ClinGen gnomAD |
|
|
rs760271474 CA1087469 |
376 | T>A | No |
ClinGen ExAC gnomAD |
|
|
rs763740355 CA341928683 |
377 | M>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1404681528 CA341928685 |
377 | M>T | No |
ClinGen TOPMed |
|
|
rs763740355 CA1087470 |
377 | M>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1177374514 CA341928743 |
379 | T>A | No |
ClinGen TOPMed gnomAD |
|
|
rs1177374514 CA341928742 |
379 | T>P | No |
ClinGen TOPMed gnomAD |
|
|
rs1447445559 CA341928798 |
381 | D>E | No |
ClinGen TOPMed |
|
|
CA341928806 rs754145025 |
382 | H>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs754145025 CA1087471 |
382 | H>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA341929078 rs1183192132 |
383 | M>R | No |
ClinGen TOPMed |
|
|
rs748351425 CA1087502 |
389 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs368478257 CA1087501 |
389 | R>W | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1455543251 CA341929215 |
391 | S>R | No |
ClinGen gnomAD |
|
|
rs587652042 CA1087503 |
394 | E>K | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1045534805 CA29540630 |
395 | R>S | No |
ClinGen TOPMed |
|
|
CA341929312 rs1570980717 |
396 | L>I | No |
ClinGen Ensembl |
|
|
rs1378269733 CA341929462 |
405 | I>V | No |
ClinGen gnomAD |
|
|
rs898847926 CA29541353 |
413 | K>N | No |
ClinGen TOPMed |
|
|
rs1232292734 CA341930545 |
417 | H>R | No |
ClinGen gnomAD |
|
|
rs1231195477 CA341930585 |
419 | W>* | No |
ClinGen Ensembl |
|
|
rs1231195477 CA341930592 |
419 | W>C | No |
ClinGen Ensembl |
|
|
CA29541378 rs953792929 |
425 | D>E | No |
ClinGen TOPMed gnomAD |
|
|
CA29541371 rs748387772 |
425 | D>N | No |
ClinGen TOPMed gnomAD |
|
|
CA341930721 rs1222053991 |
426 | G>R | No |
ClinGen gnomAD |
|
|
rs769345973 CA1087550 |
428 | T>A | No |
ClinGen ExAC |
|
|
CA1087551 rs777191309 |
428 | T>S | No |
ClinGen ExAC gnomAD |
|
|
rs1417741813 CA341931083 |
430 | S>L | No |
ClinGen gnomAD |
|
|
CA29542123 rs920118931 |
431 | V>A | No |
ClinGen Ensembl |
|
|
rs1160946193 CA341931115 |
432 | H>L | No |
ClinGen gnomAD |
|
|
rs587773647 CA1087552 |
433 | R>C | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
COSM895740 rs1433513533 CA341931152 |
433 | R>H | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
rs1310548825 CA341931160 |
434 | P>S | No |
ClinGen gnomAD |
|
|
CA1087554 rs774818450 |
435 | G>S | No |
ClinGen ExAC gnomAD |
|
|
CA1087557 rs776135660 |
438 | A>G | No |
ClinGen ExAC gnomAD |
|
|
CA1087556 rs772649098 |
438 | A>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA341931274 rs772649098 |
438 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs764210000 CA1087559 |
439 | E>Q | No |
ClinGen ExAC gnomAD |
|
|
CA1087561 rs762052509 |
440 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
rs1327470594 CA341931370 |
440 | R>W | No |
ClinGen TOPMed |
|
|
rs1444188031 CA341931439 |
442 | Q>R | No |
ClinGen TOPMed |
|
|
CA1087562 rs765446519 |
443 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs368324834 CA1087563 |
443 | R>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs765446519 CA341931469 |
443 | R>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA29542188 rs944396523 |
445 | M>L | No |
ClinGen Ensembl |
|
|
CA341931547 rs1232569120 |
446 | C>S | No |
ClinGen gnomAD |
|
|
rs752651579 CA1087566 |
449 | V>A | No |
ClinGen ExAC gnomAD |
|
|
CA341931693 rs1426663465 |
452 | K>N | No |
ClinGen gnomAD |
|
|
CA1087568 rs777290314 |
453 | I>M | No |
ClinGen ExAC gnomAD |
|
|
rs751125575 CA29542217 |
454 | P>T | No |
ClinGen Ensembl |
|
|
rs767279975 CA1087582 |
458 | S>P | No |
ClinGen ExAC |
|
|
CA341932895 rs1431348953 |
461 | K>N | No |
ClinGen TOPMed gnomAD |
|
|
CA1087584 rs756039919 |
463 | F>Y | No |
ClinGen ExAC gnomAD |
|
|
rs1057071633 CA29544039 |
464 | R>P | No |
ClinGen TOPMed |
|
|
rs1057071633 CA341932951 |
464 | R>Q | No |
ClinGen TOPMed |
|
|
rs763944215 COSM1688515 CA1087585 |
464 | R>W | Variant assessed as Somatic; 0.0 impact. skin breast [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
CA1087586 rs367565944 |
465 | S>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA1087587 rs756814723 |
466 | G>V | No |
ClinGen ExAC gnomAD |
|
|
CA341933025 rs1558300731 |
467 | S>L | No |
ClinGen Ensembl |
|
|
rs201156474 CA1087588 |
467 | S>P | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA1087589 rs745492896 |
469 | F>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1087591 rs143418421 |
471 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1360030623 CA341933074 COSM895742 |
471 | R>W | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA TOPMed gnomAD |
|
CA1087592 rs747336821 |
472 | R>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed |
|
rs769145729 CA1087593 |
472 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
CA341933132 rs1334591796 |
474 | G>V | No |
ClinGen TOPMed gnomAD |
|
|
CA341933160 rs1212235500 |
476 | S>G | No |
ClinGen gnomAD |
|
|
rs145963778 CA1087595 |
476 | S>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs145963778 CA1087594 |
476 | S>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA341933190 rs1345729881 |
477 | G>D | No |
ClinGen TOPMed |
|
|
rs1452699956 CA341933215 |
479 | S>A | No |
ClinGen gnomAD |
|
|
CA1087596 rs769836532 |
479 | S>F | No |
ClinGen ExAC gnomAD |
|
|
CA341933288 COSM675477 rs1193905962 |
481 | I>V | lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated NCI-TCGA TOPMed gnomAD |
|
rs766621452 CA1087600 |
485 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs760401547 CA1087602 |
486 | S>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA341933524 rs1326818782 |
486 | S>P | No |
ClinGen TOPMed |
|
|
rs764008438 CA1087603 |
488 | S>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA341933613 rs1358672146 |
489 | G>A | No |
ClinGen gnomAD |
|
|
CA1087606 rs757308798 |
493 | A>P | No |
ClinGen ExAC gnomAD |
|
|
CA341933763 rs1558301139 |
494 | Q>R | No |
ClinGen Ensembl |
|
|
rs764789691 CA1087607 |
495 | V>M | No |
ClinGen ExAC gnomAD |
|
|
rs1172680874 CA341933809 |
496 | T>A | No |
ClinGen TOPMed |
|
|
rs1180353028 CA341933849 |
498 | K>E | No |
ClinGen TOPMed |
|
|
CA1087611 rs779584257 |
499 | A>E | No |
ClinGen ExAC gnomAD |
|
|
rs1488956772 CA341934055 |
501 | V>A | No |
ClinGen gnomAD |
|
|
rs1220798373 CA341934048 |
501 | V>M | No |
ClinGen TOPMed gnomAD |
|
|
CA341934112 rs1571008347 |
502 | E>V | No |
ClinGen Ensembl |
|
|
rs776808513 CA29544250 |
503 | P>S | No |
ClinGen TOPMed |
|
|
CA341934389 rs753093664 |
505 | V>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1087638 rs753093664 |
505 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1087639 rs756548247 |
507 | L>F | No |
ClinGen ExAC gnomAD |
|
|
rs369595384 COSM1688516 CA1087640 |
509 | R>C | skin [Cosmic] | No |
ClinGen cosmic curated ESP ExAC TOPMed gnomAD |
|
rs749852302 CA1087641 |
509 | R>H | No |
ClinGen ExAC gnomAD |
|
|
rs369595384 CA341934577 |
509 | R>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA341934609 rs1362412036 |
510 | P>S | No |
ClinGen gnomAD |
|
|
rs1317043371 CA341934661 |
511 | D>A | No |
ClinGen TOPMed |
|
|
rs145227602 CA1087644 |
514 | P>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs770912018 CA1087643 |
514 | P>T | No |
ClinGen ExAC gnomAD |
|
|
COSM3788677 CA29544576 rs948426480 |
515 | Q>H | urinary_tract [Cosmic] | No |
ClinGen cosmic curated Ensembl |
|
CA29544584 rs373292831 |
517 | P>S | No |
ClinGen ESP gnomAD |
|
|
CA341935016 rs1379650562 |
518 | P>L | No |
ClinGen gnomAD |
|
|
rs587626634 CA1087646 |
518 | P>S | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs909513820 CA29544606 |
519 | L>S | No |
ClinGen TOPMed gnomAD |
|
|
rs1303368528 CA341935053 |
520 | E>* | No |
ClinGen gnomAD |
|
|
rs1309913397 CA341935098 |
521 | E>K | No |
ClinGen gnomAD |
|
|
rs776500415 CA1087647 |
523 | S>I | No |
ClinGen ExAC gnomAD |
|
|
rs1243289425 CA341935175 |
523 | S>R | No |
ClinGen gnomAD |
|
|
rs761710169 CA1087648 |
525 | G>D | No |
ClinGen ExAC gnomAD |
|
|
CA1087649 rs769767244 |
526 | S>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA341935283 rs1205062927 |
527 | P>S | No |
ClinGen gnomAD |
|
|
rs762984350 CA1087651 |
528 | I>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1087650 rs150758573 |
528 | I>V | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs765787767 CA1087652 |
530 | D>H | No |
ClinGen ExAC gnomAD |
|
|
rs587740685 CA1087653 |
530 | D>V | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA341935377 rs1465434285 |
531 | P>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
rs145126650 CA1087655 |
532 | S>G | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA341935411 rs145126650 |
532 | S>R | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA341935443 rs1378363788 |
533 | F>C | No |
ClinGen gnomAD |
|
|
rs753003503 CA1087656 |
534 | S>L | No |
ClinGen ExAC gnomAD |
|
|
rs1402872813 CA341935556 |
535 | P>L | No |
ClinGen gnomAD |
|
|
CA341935581 rs1466514957 |
536 | L>P | No |
ClinGen gnomAD |
|
|
CA341935564 rs1184193329 |
536 | L>V | No |
ClinGen gnomAD |
|
|
rs754312824 CA1087659 |
538 | G>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs757804334 CA1087660 |
539 | E>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA341935642 rs1387941787 |
539 | E>Q | No |
ClinGen gnomAD |
|
|
CA341935700 rs1296464409 |
540 | T>A | No |
ClinGen TOPMed |
|
|
CA341935737 rs1325409250 |
541 | L>S | No |
ClinGen TOPMed gnomAD |
|
|
rs778818618 CA1087661 |
543 | M>I | No |
ClinGen ExAC gnomAD |
|
|
CA1087662 rs370044998 |
544 | L>P | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA1087664 rs780407802 |
546 | T>A | No |
ClinGen ExAC |
|
|
CA1087688 rs147880950 |
548 | T>A | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs147880950 CA1087687 |
548 | T>P | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA341938336 rs1285202012 |
549 | T>A | No |
ClinGen TOPMed |
|
|
rs774333574 CA1087689 |
549 | T>I | No |
ClinGen ExAC gnomAD |
|
|
CA29548688 rs779731734 |
551 | E>* | No |
ClinGen Ensembl |
|
|
rs199847455 CA29548693 |
552 | K>R | No |
ClinGen 1000Genomes |
|
|
CA341938477 rs1240847577 |
553 | L>F | No |
ClinGen TOPMed |
|
|
rs1227546261 CA341938548 |
556 | A>S | No |
ClinGen TOPMed |
|
|
rs1028690083 COSM1472598 CA29548709 |
558 | S>L | Variant assessed as Somatic; impact. breast [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated Ensembl NCI-TCGA |
|
CA1087693 rs775031654 |
559 | E>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA341938727 rs1304298115 |
561 | T>I | No |
ClinGen TOPMed |
|
|
rs760279547 CA1087694 |
562 | H>R | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA1087718 rs767000368 |
563 | H>E | No |
ClinGen ExAC gnomAD |
|
|
rs751636951 CA1087719 |
563 | H>L | No |
ClinGen ExAC gnomAD |
No associated diseases with Q99755
1 regional properties for Q99755
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Phosphatidylinositol-4-phosphate 5-kinase, core | 81 - 450 | IPR002498 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.1.68 | Phosphotransferases with an alcohol group as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| focal adhesion | A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ). |
| lamellipodium | A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments. |
| nuclear speck | A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| ruffle membrane | The portion of the plasma membrane surrounding a ruffle. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| 1-phosphatidylinositol-3-phosphate 5-kinase activity | Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H(+). |
| 1-phosphatidylinositol-4-phosphate 5-kinase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H(+). |
| 1-phosphatidylinositol-5-kinase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 5-phosphate + ADP + 2 H(+). |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| kinase binding | Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group. |
| phosphatidylinositol-3,4-bisphosphate 5-kinase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H(+). |
17 GO annotations of biological process
| Name | Definition |
|---|---|
| actin cytoskeleton reorganization | A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins. |
| activation of GTPase activity | Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP. |
| cell chemotaxis | The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). |
| cell migration | The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms. |
| fibroblast migration | Cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium. A fibroblast is a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. |
| focal adhesion assembly | The aggregation and bonding together of a set of components to form a focal adhesion, a complex of intracellular signaling and structural proteins that provides a structural link between the internal actin cytoskeleton and the ECM, and also function as a locus of signal transduction activity. |
| glycerophospholipid metabolic process | The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue. |
| keratinocyte differentiation | The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte. |
| phagocytosis | A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles. |
| phosphatidylinositol biosynthetic process | The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. |
| phosphatidylinositol phosphate biosynthetic process | The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate. |
| phospholipid biosynthetic process | The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester. |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
| protein localization to plasma membrane | A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. |
| regulation of phosphatidylinositol 3-kinase signaling | Any process that modulates the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade. |
| ruffle assembly | The aggregation, arrangement and bonding together of a set of components to form a ruffle, a projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. The formation of ruffles (also called membrane ruffling) is thought to be controlled by a group of enzymes known as Rho GTPases, specifically RhoA, Rac1 and cdc42. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q0P5F7 | PIP4K2C | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma | Bos taurus (Bovine) | PR |
| Q17QS4 | PIP5KL1 | Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 | Bos taurus (Bovine) | PR |
| Q8TBX8 | PIP4K2C | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma | Homo sapiens (Human) | PR |
| P78356 | PIP4K2B | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | Homo sapiens (Human) | PR |
| Q5T9C9 | PIP5KL1 | Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 | Homo sapiens (Human) | PR |
| Q91XU3 | Pip4k2c | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma | Mus musculus (Mouse) | PR |
| Q80XI4 | Pip4k2b | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | Mus musculus (Mouse) | PR |
| Q6U7H8 | Pip5kl1 | Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 | Mus musculus (Mouse) | PR |
| O88370 | Pip4k2c | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma | Rattus norvegicus (Rat) | PR |
| O48709 | PIP5K3 | Phosphatidylinositol 4-phosphate 5-kinase 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q56YP2 | PIP5K1 | Phosphatidylinositol 4-phosphate 5-kinase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SFB8 | PIP5K6 | Phosphatidylinositol 4-phosphate 5-kinase 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8L796 | PIP5K2 | Phosphatidylinositol 4-phosphate 5-kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q6GL14 | pip4k2c | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q6IQE1 | pip4k2c | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASASSGPSS | SVGFSSFDPA | VPSCTLSSAA | SGIKRPMASE | VLEARQDSYI | SLVPYASGMP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IKKIGHRSVD | SSGETTYKKT | TSSALKGAIQ | LGITHTVGSL | STKPERDVLM | QDFYVVESIF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FPSEGSNLTP | AHHYNDFRFK | TYAPVAFRYF | RELFGIRPDD | YLYSLCSEPL | IELCSSGASG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SLFYVSSDDE | FIIKTVQHKE | AEFLQKLLPG | YYMNLNQNPR | TLLPKFYGLY | CVQAGGKNIR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IVVMNNLLPR | SVKMHIKYDL | KGSTYKRRAS | QKEREKPLPT | FKDLDFLQDI | PDGLFLDADM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YNALCKTLQR | DCLVLQSFKI | MDYSLLMSIH | NIDHAQREPL | SSETQYSVDT | RRPAPQKALY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| STAMESIQGE | ARRGGTMETD | DHMGGIPARN | SKGERLLLYI | GIIDILQSYR | FVKKLEHSWK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ALVHDGDTVS | VHRPGFYAER | FQRFMCNTVF | KKIPLKPSPS | KKFRSGSSFS | RRAGSSGNSC |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ITYQPSVSGE | HKAQVTTKAE | VEPGVHLGRP | DVLPQTPPLE | EISEGSPIPD | PSFSPLVGET |
| 550 | 560 | ||||
| LQMLTTSTTL | EKLEVAESEF | TH |