AiPD: Autoinhibited Protein Database

Gene name	Pip5kl1 (Pipkh)
Protein name	Phosphatidylinositol 4-phosphate 5-kinase-like protein 1
Names	PI(4)P 5-kinase-like protein 1, PtdIns(4)P-5-kinase-like protein 1, Phosphatidylinositol phosphate kinase homolog, PIPKH
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:227733
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-170 (Predicted disordered autoinhibitory region) PR

1-170 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q6U7H8-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs256376981	70	V>I	No	EVA
rs3388538712	77	T>M	No	EVA
rs3388547244	86	L>Q	No	EVA
rs3388547240	121	Y>*	No	EVA
rs3388544125	201	K>Q	No	EVA
rs3388546249	213	T>S	No	EVA
rs3388544118	223	K>N	No	EVA
rs3388546654	226	N>D	No	EVA
rs28204228	227	I>V	No	EVA
rs3388548625	228	S>C	No	EVA
rs3388547474	242	L>F	No	EVA
rs3388548603	260	R>Q	No	EVA
rs3391444963	261	S>R	No	EVA
rs3391351787	263	F>L	No	EVA
rs3388545160	270	D>Y	No	EVA
rs218891683	298	I>S	No	EVA
rs3388545452	299	H>R	No	EVA
rs3388547221	301	S>F	No	EVA
rs243868821	312	V>A	No	EVA
rs3388545364	343	Y>*	No	EVA
rs255058581	363	V>L	No	EVA
rs3388541101	368	R>H	No	EVA
rs3388545499	387	C>R	No	EVA

Type	Name	Position	InterPro Accession
domain	Phosphatidylinositol-4-phosphate 5-kinase, core	37 - 394	IPR002498

		Description
EC Number
Subcellular Localization	Cytoplasm Membrane	Localized to large cytoplasmic vesicular structures
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cell projection	A prolongation or process extending from a cell, e.g. a flagellum or axon.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
1-phosphatidylinositol-4-phosphate 5-kinase activity	Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H(+).
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

Name	Definition
negative regulation of cell migration	Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
negative regulation of mitochondrial membrane potential	Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or extent of a mitochondrial membrane potential, the electric potential existing across any mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
negative regulation of protein phosphorylation	Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
phosphatidylinositol phosphate biosynthetic process	The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate.
phosphorylation	The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
positive regulation of apoptotic process	Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q0P5F7	PIP4K2C	Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	Bos taurus (Bovine)	PR
Q17QS4	PIP5KL1	Phosphatidylinositol 4-phosphate 5-kinase-like protein 1	Bos taurus (Bovine)	PR
Q99755	PIP5K1A	Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	Homo sapiens (Human)	PR
P78356	PIP4K2B	Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	Homo sapiens (Human)	PR
Q8TBX8	PIP4K2C	Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	Homo sapiens (Human)	PR
Q5T9C9	PIP5KL1	Phosphatidylinositol 4-phosphate 5-kinase-like protein 1	Homo sapiens (Human)	PR
Q91XU3	Pip4k2c	Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	Mus musculus (Mouse)	PR
Q80XI4	Pip4k2b	Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	Mus musculus (Mouse)	PR
O88370	Pip4k2c	Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	Rattus norvegicus (Rat)	PR
O48709	PIP5K3	Phosphatidylinositol 4-phosphate 5-kinase 3	Arabidopsis thaliana (Mouse-ear cress)	PR
Q56YP2	PIP5K1	Phosphatidylinositol 4-phosphate 5-kinase 1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SFB8	PIP5K6	Phosphatidylinositol 4-phosphate 5-kinase 6	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8L796	PIP5K2	Phosphatidylinositol 4-phosphate 5-kinase 2	Arabidopsis thaliana (Mouse-ear cress)	PR
Q6GL14	pip4k2c	Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q6IQE1	pip4k2c	Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	Danio rerio (Zebrafish) (Brachydanio rerio)	PR