AiPD: Autoinhibited Protein Database

Gene name	PIP5K3
Protein name	Phosphatidylinositol 4-phosphate 5-kinase 3
Names	AtPIP5K3, 1-phosphatidylinositol 4-phosphate kinase 3, Diphosphoinositide kinase 3, PtdIns(4)P-5-kinase 3
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT2G26420
EC number	2.7.1.68: Phosphotransferases with an alcohol group as acceptor
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

558-637 (Predicted disordered autoinhibitory region) PR

558-637 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-O48709-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
ENSVATH00249132	11	E>A	No	1000Genomes
tmp_2_11242163_C_G	26	S>T	No	1000Genomes
ENSVATH00249131	38	V>M	No	1000Genomes
tmp_2_11242088_A_C	51	V>G	No	1000Genomes
tmp_2_11242010_T_G	77	D>A	No	1000Genomes
ENSVATH14555538	91	S>N	No	1000Genomes
tmp_2_11241663_C_T	193	G>R	No	1000Genomes
tmp_2_11241588_T_C	218	T>A	No	1000Genomes
tmp_2_11241584_C_T	219	S>N	No	1000Genomes
ENSVATH13413914	253	P>Q	No	1000Genomes
ENSVATH05596893	263	T>S	No	1000Genomes
ENSVATH05596892	289	A>G	No	1000Genomes
ENSVATH13413912	291	S>N	No	1000Genomes
ENSVATH13413911	323	T>A	No	1000Genomes
ENSVATH05596890	324	A>T	No	1000Genomes
tmp_2_11241218_T_A	341	Y>F	No	1000Genomes
ENSVATH05596889	352	E>K	No	1000Genomes
tmp_2_11241176_T_C	355	H>R	No	1000Genomes
ENSVATH00249129	356	S>C	No	1000Genomes
tmp_2_11241095_G_A	382	A>V	No	1000Genomes
ENSVATH01900033	556	L>V	No	1000Genomes
ENSVATH13413873	608	R>K	No	1000Genomes
tmp_2_11239673_T_C	627	T>A	No	1000Genomes
tmp_2_11239669_C_G	628	W>S	No	1000Genomes
ENSVATH00249116	631	D>N	No	1000Genomes
ENSVATH05596869	636	S>L	No	1000Genomes
tmp_2_11239610_C_T	648	V>M	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	Phosphatidylinositol-4-phosphate 5-kinase, core	321 - 702	IPR002498
repeat	MORN repeat	56 - 80	IPR003409-1
repeat	MORN repeat	79 - 102	IPR003409-2
repeat	MORN repeat	102 - 126	IPR003409-3
repeat	MORN repeat	125 - 148	IPR003409-4
repeat	MORN repeat	148 - 171	IPR003409-5
repeat	MORN repeat	171 - 195	IPR003409-6
repeat	MORN repeat	194 - 215	IPR003409-7

		Description
EC Number	2.7.1.68	Phosphotransferases with an alcohol group as acceptor
Subcellular Localization	Cell membrane	Accumulates in a sterol-enriched, polar membrane domain during root hair initiation
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
apical plasma membrane	The region of the plasma membrane located at the apical end of the cell.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
1-phosphatidylinositol-4-phosphate 5-kinase activity	Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H(+).
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

Name	Definition
phosphatidylinositol phosphate biosynthetic process	The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate.
phosphorylation	The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
regulation of establishment of cell polarity	Any process that modulates the frequency, rate or extent of establishment of cell polarity.
root hair cell tip growth	Localized growth of a plant root hair tip by extension of the cell wall.
root hair elongation	The process in which the root hair grows longer.
root hair initiation	The process in which a protrusion or bulge is formed at the site of plant root hair outgrowth.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q0P5F7	PIP4K2C	Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	Bos taurus (Bovine)	PR
Q17QS4	PIP5KL1	Phosphatidylinositol 4-phosphate 5-kinase-like protein 1	Bos taurus (Bovine)	PR
Q8TBX8	PIP4K2C	Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	Homo sapiens (Human)	PR
P78356	PIP4K2B	Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	Homo sapiens (Human)	PR
Q5T9C9	PIP5KL1	Phosphatidylinositol 4-phosphate 5-kinase-like protein 1	Homo sapiens (Human)	PR
Q99755	PIP5K1A	Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	Homo sapiens (Human)	PR
Q80XI4	Pip4k2b	Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	Mus musculus (Mouse)	PR
Q91XU3	Pip4k2c	Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	Mus musculus (Mouse)	PR
Q6U7H8	Pip5kl1	Phosphatidylinositol 4-phosphate 5-kinase-like protein 1	Mus musculus (Mouse)	PR
O88370	Pip4k2c	Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	Rattus norvegicus (Rat)	PR
Q56YP2	PIP5K1	Phosphatidylinositol 4-phosphate 5-kinase 1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SFB8	PIP5K6	Phosphatidylinositol 4-phosphate 5-kinase 6	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8L796	PIP5K2	Phosphatidylinositol 4-phosphate 5-kinase 2	Arabidopsis thaliana (Mouse-ear cress)	PR
Q6GL14	pip4k2c	Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q6IQE1	pip4k2c	Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	Danio rerio (Zebrafish) (Brachydanio rerio)	PR