Q56YP2
PR
Gene name |
PIP5K1 (P5K1, At1g21980, F2E2.1) |
Protein name |
Phosphatidylinositol 4-phosphate 5-kinase 1 |
Names |
AtPIP5K1, 1-phosphatidylinositol 4-phosphate kinase 1, Diphosphoinositide kinase 1, PtdIns(4)P-5-kinase 1 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G21980 |
EC number |
2.7.1.68: Phosphotransferases with an alcohol group as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q56YP2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q56YP2-F1 | Predicted | AlphaFoldDB |
29 variants for Q56YP2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH04619488 | 32 | F>I | No | 1000Genomes | |
| ENSVATH04619489 | 37 | E>D | No | 1000Genomes | |
| tmp_1_7735201_C_A | 50 | P>Q | No | 1000Genomes | |
| ENSVATH04619490 | 76 | P>L | No | 1000Genomes | |
| tmp_1_7735336_A_G | 95 | K>R | No | 1000Genomes | |
| tmp_1_7735435_A_G | 128 | E>G | No | 1000Genomes | |
| tmp_1_7735510_C_T | 153 | T>I | No | 1000Genomes | |
| tmp_1_7735536_C_T | 162 | H>Y | No | 1000Genomes | |
| ENSVATH01084791 | 189 | V>L | No | 1000Genomes | |
| tmp_1_7735628_T_A | 192 | N>K | No | 1000Genomes | |
| tmp_1_7735687_T_A | 212 | V>D | No | 1000Genomes | |
| tmp_1_7735766_T_A | 238 | D>E | No | 1000Genomes | |
| ENSVATH04619496 | 324 | R>P | No | 1000Genomes | |
| ENSVATH01084802 | 375 | I>V | No | 1000Genomes | |
| tmp_1_7736342_C_G | 399 | T>S | No | 1000Genomes | |
| ENSVATH00036502 | 433 | K>E | No | 1000Genomes | |
| ENSVATH01084805 | 445 | R>C | No | 1000Genomes | |
| tmp_1_7736698_G_A | 462 | D>N | No | 1000Genomes | |
| ENSVATH04619508 | 490 | C>S | No | 1000Genomes | |
| tmp_1_7737008_A_C | 494 | N>H | No | 1000Genomes | |
| ENSVATH01084807 | 511 | G>R | No | 1000Genomes | |
| ENSVATH01084808 | 518 | V>I | No | 1000Genomes | |
| ENSVATH11751142 | 532 | R>Q | No | 1000Genomes | |
| ENSVATH11751217 | 565 | S>A | No | 1000Genomes | |
| ENSVATH04619511 | 622 | G>S | No | 1000Genomes | |
| ENSVATH13941123 | 635 | G>D | No | 1000Genomes | |
| tmp_1_7738047_A_G | 666 | K>R | No | 1000Genomes | |
| ENSVATH11751281 | 678 | Q>H | No | 1000Genomes | |
| ENSVATH00036513 | 723 | A>T | No | 1000Genomes |
No associated diseases with Q56YP2
8 regional properties for Q56YP2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Phosphatidylinositol-4-phosphate 5-kinase, core | 349 - 749 | IPR002498 |
| repeat | MORN repeat | 79 - 103 | IPR003409-1 |
| repeat | MORN repeat | 102 - 125 | IPR003409-2 |
| repeat | MORN repeat | 125 - 149 | IPR003409-3 |
| repeat | MORN repeat | 148 - 171 | IPR003409-4 |
| repeat | MORN repeat | 171 - 194 | IPR003409-5 |
| repeat | MORN repeat | 194 - 218 | IPR003409-6 |
| repeat | MORN repeat | 217 - 240 | IPR003409-7 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.1.68 | Phosphotransferases with an alcohol group as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| 1-phosphatidylinositol-4-phosphate 5-kinase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H(+). |
| actin filament binding | Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. |
| actin monomer binding | Binding to monomeric actin, also known as G-actin. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| phosphatidylinositol phosphate kinase activity | Catalysis of the reaction: ATP + a phosphatidylinositol phosphate = ADP + a phosphatidylinositol bisphosphate. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| phosphatidylinositol phosphate biosynthetic process | The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate. |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q0P5F7 | PIP4K2C | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma | Bos taurus (Bovine) | PR |
| Q17QS4 | PIP5KL1 | Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 | Bos taurus (Bovine) | PR |
| Q8TBX8 | PIP4K2C | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma | Homo sapiens (Human) | PR |
| P78356 | PIP4K2B | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | Homo sapiens (Human) | PR |
| Q5T9C9 | PIP5KL1 | Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 | Homo sapiens (Human) | PR |
| Q99755 | PIP5K1A | Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha | Homo sapiens (Human) | PR |
| Q80XI4 | Pip4k2b | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | Mus musculus (Mouse) | PR |
| Q91XU3 | Pip4k2c | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma | Mus musculus (Mouse) | PR |
| Q6U7H8 | Pip5kl1 | Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 | Mus musculus (Mouse) | PR |
| O88370 | Pip4k2c | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma | Rattus norvegicus (Rat) | PR |
| O48709 | PIP5K3 | Phosphatidylinositol 4-phosphate 5-kinase 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SFB8 | PIP5K6 | Phosphatidylinositol 4-phosphate 5-kinase 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8L796 | PIP5K2 | Phosphatidylinositol 4-phosphate 5-kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q6GL14 | pip4k2c | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q6IQE1 | pip4k2c | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSDSEEDEEE | EEASEVILSS | VVQKKKKKNL | RFGEEVERRD | GLVLLAQSTP | MVRSRSQGTT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RRVTPTPLVD | VEKPLPNGDL | YIGSFSGGFP | HGSGKYLWKD | GCMYEGDWKR | GKASGKGKFS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| WPSGATYEGE | FKSGRMEGFG | TFTGADGDTY | RGTWVADRKH | GHGQKRYANG | DFYEGTWRRN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LQDGRGRYVW | RNGNQYTGEW | RSGVISGKGL | LVWPNGNRYE | GLWENGIPKG | NGVFTWSDGS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SCVGAWNESN | IMRSFFNGVE | KNDLIVGNRK | RSSVDSGAGS | LGGEKVFPRI | CIWESDGEAG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DITCDIIDNV | EASMIYRDRI | SVDRDGFRQF | KKNPCWFNGE | AKKPGQTISK | GHKKYDLMLN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LQLGIRYSVG | KHASIVRDLK | QTDFDPKEKF | WTRFPPEGTK | TTPPHQSVDF | RWKDYCPLVF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RRLRELFQVD | PAKYMLAICG | NDALRELSSP | GKSGSFFYLT | QDDRFMIKTV | KKSEVKVLLR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| MLPSYYKHVC | QYENSLVTRF | YGVHCVKPVG | GQKTRFIVMG | NLFCSEYRIQ | RRFDLKGSSH |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GRSTAKPEGE | IDETTTLKDL | DLNFSFRLQR | NWYQELMKQI | KRDCEFLEAE | RIMDYSLLVG |
| 610 | 620 | 630 | 640 | 650 | 660 |
| VHFRDDNTGE | KMGLSPFVLR | SGRIDSYQNE | KFMRGCRFLE | AELQDMDRIL | AGRKPSIRLG |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ANMPAKAERM | ARRSDFDQYS | SGGASYPSHG | EMYEVVLYFG | VIDILQDYDI | TKKIEHAYKS |
| 730 | 740 | 750 | |||
| LQADPASISA | VDPKLYSKRF | RDFISRIFIE | EG |