AiPD: Autoinhibited Protein Database

Gene name	Cpn1
Protein name	Carboxypeptidase N catalytic chain
Names	CPN, Carboxypeptidase N polypeptide 1, Carboxypeptidase N small subunit
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:93721
EC number	3.4.17.3: Metallocarboxypeptidases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

387-457 (Predicted disordered autoinhibitory region) PR

387-457 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9JJN5-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389540779	11	L>P	No	EVA
rs3389540815	17	F>L	No	EVA
rs3389546040	20	P>T	No	EVA
rs3389546029	45	I>T	No	EVA
rs3389546098	114	I>V	No	EVA
rs226465568	132	D>A	No	EVA
rs3389508621	146	G>R	No	EVA
rs214852067	176	N>Y	No	EVA
rs3389535164	183	L>Q	No	EVA
rs3389550765	227	D>E	No	EVA
rs3409476441	234	F>*	No	EVA
rs3412989279	237	P>H	No	EVA
rs3409711577	240	T>P	No	EVA
rs3409269456	241	S>A	No	EVA
rs3408891415	243	S>C	No	EVA
rs3389550801	276	P>L	No	EVA
rs3389546045	348	D>E	No	EVA
rs3389535197	384	T>P	No	EVA
rs3389550749	385	Y>C	No	EVA
rs3389543564	405	P>H	No	EVA
rs243025539	430	G>S	No	EVA
rs3389556625	438	K>M	No	EVA
rs3389536848	441	R>L	No	EVA

Type	Name	Position	InterPro Accession
domain	GPCR, rhodopsin-like, 7TM	32 - 358	IPR017452

		Description
EC Number	3.4.17.3	Metallocarboxypeptidases
Subcellular Localization	Secreted, extracellular space
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
extracellular space	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

Name	Definition
carboxypeptidase activity	Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain.
metallocarboxypeptidase activity	Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
zinc ion binding	Binding to a zinc ion (Zn).

Name	Definition
bradykinin catabolic process	The chemical reactions and pathways resulting in the breakdown of the peptide bradykinin.
peptide metabolic process	The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.
protein catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
protein processing	Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.
response to glucocorticoid	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P04836	CPE	Carboxypeptidase E	Bos taurus (Bovine)	PR
Q2KJ83	CPN1	Carboxypeptidase N catalytic chain	Bos taurus (Bovine)	PR
Q8QGP3	CPZ	Carboxypeptidase Z	Gallus gallus (Chicken)	PR
Q8IUX7	AEBP1	Adipocyte enhancer-binding protein 1	Homo sapiens (Human)	PR
O75976	CPD	Carboxypeptidase D	Homo sapiens (Human)	PR
Q8N436	CPXM2	Inactive carboxypeptidase-like protein X2	Homo sapiens (Human)	PR
Q66K79	CPZ	Carboxypeptidase Z	Homo sapiens (Human)	PR
Q96SM3	CPXM1	Probable carboxypeptidase X1	Homo sapiens (Human)	PR
P14384	CPM	Carboxypeptidase M	Homo sapiens (Human)	PR
O89001	Cpd	Carboxypeptidase D	Mus musculus (Mouse)	PR
Q9Z100	Cpxm1	Probable carboxypeptidase X1	Mus musculus (Mouse)	PR
Q80V42	Cpm	Carboxypeptidase M	Mus musculus (Mouse)	PR
Q9D2L5	Cpxm2	Inactive carboxypeptidase-like protein X2	Mus musculus (Mouse)	PR
Q640N1	Aebp1	Adipocyte enhancer-binding protein 1	Mus musculus (Mouse)	PR
A2RUV9	Aebp1	Adipocyte enhancer-binding protein 1	Rattus norvegicus (Rat)	PR
Q9EQV8	Cpn1	Carboxypeptidase N catalytic chain	Rattus norvegicus (Rat)	PR