AiPD: Autoinhibited Protein Database

Gene name	CPE
Protein name	Carboxypeptidase E
Names	CPE, Carboxypeptidase H, CPH, Enkephalin convertase, Prohormone-processing carboxypeptidase
Species	Bos taurus (Bovine)
KEGG Pathway	bta:280753
EC number	3.4.17.10: Metallocarboxypeptidases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

254-331 (Predicted disordered autoinhibitory region) PR

254-331 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-P04836-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs456742286	25	A>P	No	EVA
rs470515301	26	E>V	No	EVA
rs432802035	35	A>G	No	EVA
rs1116425083	58	L>P	No	EVA
rs452638483	100	E>*	No	EVA
rs473131322	148	T>P	No	EVA
rs455392821	160	G>A	No	EVA
rs441760506	160	G>R	No	EVA
rs475208122	161	F>L	No	EVA
rs443795754	165	A>P	No	EVA
rs458125194	170	E>D	No	EVA
	255	Y>H	No
rs463982368	278	Q>H	No	EVA
rs439557610	279	S>I	No	EVA
rs471010720	279	S>R	No	EVA
rs434206233	304	D>E	No	EVA
rs434699463	368	I>L	No	EVA
rs435183101	373	R>Q	No	EVA
rs1114781374	380	R>Q	No	EVA
rs444465262	406	D>Y	No	EVA
rs210567645	414	V>I	No	EVA
rs716791655	425	P>L	No	EVA
rs475569712	446	F>I	No	EVA
rs444347458	453	E>K	No	EVA
rs451574662	453	E>V	No	EVA
rs471422638	456	E>D	No	EVA
rs439564363	458	E>D	No	EVA
rs439969348	460	E>A	No	EVA
rs460239686	466	W>C	No	EVA
rs442450617	476	F>Q	No	EVA

Type	Name	Position	InterPro Accession
domain	Activin types I and II receptor domain	28 - 111	IPR000472
domain	Protein kinase domain	190 - 481	IPR000719
active_site	Serine/threonine-protein kinase, active site	318 - 330	IPR008271

		Description
EC Number	3.4.17.10	Metallocarboxypeptidases
Subcellular Localization	Cytoplasmic vesicle, secretory vesicle Cytoplasmic vesicle, secretory vesicle membrane ; Peripheral membrane protein Secreted	Associated with the secretory granule membrane through direct binding to lipid rafts in intragranular conditions
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
extracellular space	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
secretory granule membrane	The lipid bilayer surrounding a secretory granule.
transport vesicle membrane	The lipid bilayer surrounding a transport vesicle.

Name	Definition
cell adhesion molecule binding	Binding to a cell adhesion molecule.
metallocarboxypeptidase activity	Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
neurexin family protein binding	Binding to a neurexin, a synaptic cell surface protein related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals.
zinc ion binding	Binding to a zinc ion (Zn).

Name	Definition
cardiac left ventricle morphogenesis	The process in which the left cardiac ventricle is generated and organized.
insulin processing	The formation of mature insulin by proteolysis of the precursor preproinsulin. The signal sequence is first cleaved from preproinsulin to form proinsulin; proinsulin is then cleaved to release the C peptide, leaving the A and B chains of mature insulin linked by disulfide bridges.
peptide hormone secretion	The regulated release of a peptide hormone from a cell.
peptide metabolic process	The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.
protein localization to membrane	A process in which a protein is transported to, or maintained in, a specific location in a membrane.
protein localization to secretory granule	A process in which a protein is transported to, or maintained in, a location within a secretory granule.
protein processing	Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.
Wnt signaling pathway	The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q2KJ83	CPN1	Carboxypeptidase N catalytic chain	Bos taurus (Bovine)	PR
Q8QGP3	CPZ	Carboxypeptidase Z	Gallus gallus (Chicken)	PR
Q8IUX7	AEBP1	Adipocyte enhancer-binding protein 1	Homo sapiens (Human)	PR
O75976	CPD	Carboxypeptidase D	Homo sapiens (Human)	PR
Q8N436	CPXM2	Inactive carboxypeptidase-like protein X2	Homo sapiens (Human)	PR
Q66K79	CPZ	Carboxypeptidase Z	Homo sapiens (Human)	PR
Q96SM3	CPXM1	Probable carboxypeptidase X1	Homo sapiens (Human)	PR
P14384	CPM	Carboxypeptidase M	Homo sapiens (Human)	PR
Q80V42	Cpm	Carboxypeptidase M	Mus musculus (Mouse)	PR
O89001	Cpd	Carboxypeptidase D	Mus musculus (Mouse)	PR
Q9JJN5	Cpn1	Carboxypeptidase N catalytic chain	Mus musculus (Mouse)	PR
Q9Z100	Cpxm1	Probable carboxypeptidase X1	Mus musculus (Mouse)	PR
Q9D2L5	Cpxm2	Inactive carboxypeptidase-like protein X2	Mus musculus (Mouse)	PR
Q640N1	Aebp1	Adipocyte enhancer-binding protein 1	Mus musculus (Mouse)	PR
Q9EQV8	Cpn1	Carboxypeptidase N catalytic chain	Rattus norvegicus (Rat)	PR
A2RUV9	Aebp1	Adipocyte enhancer-binding protein 1	Rattus norvegicus (Rat)	PR