Q2KJ83
Gene name |
CPN1 |
Protein name |
Carboxypeptidase N catalytic chain |
Names |
CPN, Carboxypeptidase N polypeptide 1, Carboxypeptidase N small subunit |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:536753 |
EC number |
3.4.17.3: Metallocarboxypeptidases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q2KJ83
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q2KJ83-F1 | Predicted | AlphaFoldDB |
No variants for Q2KJ83
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q2KJ83 | |||||
No associated diseases with Q2KJ83
1 regional properties for Q2KJ83
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | GPCR, rhodopsin-like, 7TM | 70 - 333 | IPR017452 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.4.17.3 | Metallocarboxypeptidases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| metallocarboxypeptidase activity | Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. |
| zinc ion binding | Binding to a zinc ion (Zn). |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| peptide metabolic process | The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. |
| protein processing | Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein. |
16 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P04836 | CPE | Carboxypeptidase E | Bos taurus (Bovine) | PR |
| Q8QGP3 | CPZ | Carboxypeptidase Z | Gallus gallus (Chicken) | PR |
| Q8IUX7 | AEBP1 | Adipocyte enhancer-binding protein 1 | Homo sapiens (Human) | PR |
| O75976 | CPD | Carboxypeptidase D | Homo sapiens (Human) | PR |
| Q8N436 | CPXM2 | Inactive carboxypeptidase-like protein X2 | Homo sapiens (Human) | PR |
| Q66K79 | CPZ | Carboxypeptidase Z | Homo sapiens (Human) | PR |
| Q96SM3 | CPXM1 | Probable carboxypeptidase X1 | Homo sapiens (Human) | PR |
| P14384 | CPM | Carboxypeptidase M | Homo sapiens (Human) | PR |
| Q80V42 | Cpm | Carboxypeptidase M | Mus musculus (Mouse) | PR |
| O89001 | Cpd | Carboxypeptidase D | Mus musculus (Mouse) | PR |
| Q9Z100 | Cpxm1 | Probable carboxypeptidase X1 | Mus musculus (Mouse) | PR |
| Q9D2L5 | Cpxm2 | Inactive carboxypeptidase-like protein X2 | Mus musculus (Mouse) | PR |
| Q640N1 | Aebp1 | Adipocyte enhancer-binding protein 1 | Mus musculus (Mouse) | PR |
| Q9JJN5 | Cpn1 | Carboxypeptidase N catalytic chain | Mus musculus (Mouse) | PR |
| A2RUV9 | Aebp1 | Adipocyte enhancer-binding protein 1 | Rattus norvegicus (Rat) | PR |
| Q9EQV8 | Cpn1 | Carboxypeptidase N catalytic chain | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSDLVSIFLH | LLLFKLVAPV | TFRHHRYDDL | VRMLYKVHNE | CPHITRVYSI | GRSVKGRHLY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VLEFSDYPGI | HEPLEPEVKY | VGNMHGNEVL | GRELLLQLSE | FLCEEFRNRN | QRIVRLVEDT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RIHIMPSMNP | DGYEVAAAAQ | ERDISGYLVG | RNNANGVDLN | RNFPDLNTYI | YYNEKNGGPN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HHFPLPDNWK | SQVEPETQAV | IQWIRSFNFV | LSANLHGGAV | VANYPYDKSL | GHRVRGFRRT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ANTPTPDDKL | FQKLAKIYSY | AHGWMHQGWN | CGDYFPDGIT | NGASWYSLSK | GMQDFNYLHT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NCFEITLELS | CDKFPLQGEL | QREWLGNREA | LIQFLEQVHQ | GIKGMVRDEN | YNNLADAVIS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VGGINHDVTS | GAHGDYFRLL | LPGTYTVTAT | APGFDPETVS | VTVGPAEPKL | VNFQLKRSTP |
| 430 | 440 | 450 | 460 | ||
| QAAPKRRIPN | SGHRGRVLPK | KVQPRAARKK | ETMMKQPQRG | PA |