P14384
PR
Gene name |
CPM |
Protein name |
Carboxypeptidase M |
Names |
CPM |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:1368 |
EC number |
3.4.17.12: Metallocarboxypeptidases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for P14384
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1UWY | X-ray | 300 A | A | 18-443 | PDB |
| AF-P14384-F1 | Predicted | AlphaFoldDB |
278 variants for P14384
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
CA238595330 rs773911120 |
2 | D>A | No |
ClinGen ExAC TOPMed |
|
|
rs765398939 CA6679219 |
2 | D>E | No |
ClinGen ExAC gnomAD |
|
|
CA6679220 rs773911120 |
2 | D>G | No |
ClinGen ExAC TOPMed |
|
|
CA385898470 rs1285971854 |
4 | P>L | No |
ClinGen TOPMed |
|
|
CA385898466 rs1347272115 |
5 | C>Y | No |
ClinGen TOPMed |
|
|
rs904621041 CA238595329 |
8 | L>R | No |
ClinGen TOPMed gnomAD |
|
|
rs747262757 CA6679215 |
18 | L>M | No |
ClinGen ExAC gnomAD |
|
|
rs775211362 CA6679214 |
19 | D>G | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 19 | D>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1401508985 CA385898365 |
21 | N>S | No |
ClinGen gnomAD |
|
|
CA6679213 rs771913214 |
22 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
VAR_048600 rs7978197 CA6679212 |
24 | R>H | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
CA385898342 rs7978197 |
24 | R>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs747386704 CA385898338 |
25 | Q>P | No |
ClinGen Ensembl |
|
|
rs747386704 CA238595326 |
25 | Q>R | No |
ClinGen Ensembl |
|
|
CA385898323 rs1203047875 |
27 | G>E | No |
ClinGen TOPMed |
|
|
CA385898314 rs1423881283 |
28 | M>I | No |
ClinGen gnomAD |
|
|
rs1592708718 CA385898295 |
31 | F>V | No |
ClinGen Ensembl |
|
|
rs780241067 CA6679206 |
36 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA385898258 rs1238598118 |
36 | A>V | No |
ClinGen gnomAD |
|
|
rs568959442 CA6679205 |
37 | Q>R | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs141809246 CA385898202 |
44 | H>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA6679201 rs765708241 |
47 | S>N | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA238595323 rs1022359876 |
48 | I>F | No |
ClinGen Ensembl |
|
|
CA238595322 rs988639737 |
48 | I>T | No |
ClinGen Ensembl |
|
|
CA6679200 rs762417629 |
50 | K>R | No |
ClinGen ExAC gnomAD |
|
|
CA6679199 rs753797758 |
52 | V>M | No |
ClinGen ExAC gnomAD |
|
|
CA6679198 rs764250441 |
54 | G>S | No |
ClinGen ExAC gnomAD |
|
|
CA385709387 rs779343663 |
56 | N>K | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 59 | V>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1360847103 CA385709349 |
61 | V>A | No |
ClinGen gnomAD |
|
|
rs1592661093 CA385709352 |
61 | V>I | No |
ClinGen Ensembl |
|
|
rs766232836 CA238499833 |
63 | G>R | No |
ClinGen Ensembl |
|
|
rs764078716 CA6679180 |
64 | R>Q | Variant assessed as Somatic; 4.62e-05 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA6679181 rs754429697 |
64 | R>W | No |
ClinGen ExAC gnomAD |
|
|
rs760786418 CA6679179 |
67 | K>E | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
| TCGA novel | 67 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 68 | E>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA238499795 rs1041764773 |
71 | I>S | No |
ClinGen Ensembl |
|
|
rs946111671 CA238499789 |
72 | G>R | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 87 | T>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA6679156 rs751865131 |
88 | V>I | No |
ClinGen ExAC gnomAD |
|
|
rs1445152090 CA385709122 |
89 | G>W | No |
ClinGen gnomAD |
|
|
CA6679155 rs766079955 |
90 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
CA238487886 rs984733960 COSM239433 |
90 | R>W | prostate [Cosmic] | No |
ClinGen cosmic curated Ensembl |
|
CA238487862 rs149301581 |
97 | I>T | No |
ClinGen ESP TOPMed |
|
|
CA6679151 rs539259654 |
97 | I>V | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs200159655 CA6679149 |
99 | Y>C | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs200159655 CA385709062 |
99 | Y>F | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA6679150 rs200159655 |
99 | Y>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA6679147 rs547105880 COSM2099374 |
101 | V>I | Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
rs1221875332 CA385709044 |
102 | T>I | No |
ClinGen TOPMed |
|
|
CA6679146 rs771177894 |
104 | D>E | No |
ClinGen ExAC gnomAD |
|
|
CA385709034 rs1473817298 |
104 | D>N | No |
ClinGen gnomAD |
|
|
rs1245713092 CA385709029 |
104 | D>V | No |
ClinGen TOPMed |
|
|
CA385709008 rs1436244285 |
107 | D>E | No |
ClinGen gnomAD |
|
|
CA385709013 rs749617350 |
107 | D>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6679145 rs749617350 |
107 | D>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6679143 rs528640395 |
114 | I>M | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs371647855 CA6679142 |
115 | N>S | Variant assessed as Somatic; 4.619e-05 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs748665239 CA6679141 |
116 | S>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA385708944 rs1592645897 |
117 | T>P | No |
ClinGen Ensembl |
|
|
rs200449803 CA6679140 |
118 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA385708936 rs1357820788 |
119 | I>L | No |
ClinGen gnomAD |
|
|
CA6679139 rs755115719 |
119 | I>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA6679138 rs751697670 |
121 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA385708896 COSM1705911 rs1374110714 |
124 | S>F | skin [Cosmic] | No |
ClinGen cosmic curated gnomAD |
| TCGA novel | 125 | M>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs758569335 CA6679136 |
125 | M>K | No |
ClinGen ExAC gnomAD |
|
|
CA6679135 rs373601584 |
126 | N>S | No |
ClinGen ESP ExAC gnomAD |
|
|
CA385708884 rs373601584 |
126 | N>T | No |
ClinGen ESP ExAC gnomAD |
|
|
CA385708879 rs1393736332 |
127 | P>A | No |
ClinGen TOPMed gnomAD |
|
|
CA6679134 rs371394523 |
127 | P>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1393736332 CA385708880 |
127 | P>T | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 128 | D>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA6679132 rs776780426 |
130 | F>C | No |
ClinGen ExAC gnomAD |
|
|
CA6679130 rs7309831 VAR_048601 |
133 | V>I | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
CA238487731 rs7309831 |
133 | V>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs200109630 CA6679129 |
138 | C>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1421739313 CA385708804 |
138 | C>Y | No |
ClinGen TOPMed |
|
|
CA385708793 rs2228654 CA6679128 |
139 | Y>* | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1454083523 CA385708780 |
141 | S>T | No |
ClinGen gnomAD |
|
|
rs891753259 CA238487712 |
143 | G>R | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
CA238487697 rs1010019344 |
144 | R>K | No |
ClinGen TOPMed |
|
|
rs752185553 CA6679111 |
144 | R>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1592644145 CA385708748 |
145 | E>K | No |
ClinGen Ensembl |
|
|
rs1276252170 CA385708739 |
146 | N>D | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 146 | N>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1480421919 CA385708727 |
147 | Y>* | No |
ClinGen TOPMed |
|
|
rs140860259 CA6679110 |
147 | Y>C | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1426265636 CA385708705 |
150 | Y>C | No |
ClinGen TOPMed |
|
|
CA6679107 rs770112320 |
154 | R>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6679106 rs200496918 |
154 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
| TCGA novel | 155 | N>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs747472128 CA6679103 |
158 | D>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs941428418 CA238486007 |
162 | Y>C | No |
ClinGen TOPMed |
|
|
rs772112072 CA6679101 |
162 | Y>H | No |
ClinGen ExAC gnomAD |
|
|
CA385708601 rs1281236209 |
165 | V>I | No |
ClinGen TOPMed |
|
|
rs542005461 CA6679099 |
170 | E>D | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
| TCGA novel | 172 | V>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1211831366 CA385708523 |
176 | K>N | No |
ClinGen TOPMed |
|
|
rs1337753069 CA385708525 |
176 | K>R | No |
ClinGen TOPMed |
|
|
rs1292638463 CA385708516 |
177 | W>* | No |
ClinGen TOPMed |
|
|
CA6679094 rs752632758 |
177 | W>* | No |
ClinGen ExAC gnomAD |
|
|
CA6679093 rs377692592 |
182 | T>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 184 | V>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA6679092 rs751187379 |
184 | V>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs751187379 CA6679091 |
184 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6679089 rs762621752 |
185 | L>V | No |
ClinGen ExAC gnomAD |
|
|
CA6679088 rs776910788 |
188 | N>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6679087 rs764426969 |
190 | H>R | No |
ClinGen ExAC gnomAD |
|
|
CA385708430 rs1449280321 |
191 | G>C | No |
ClinGen TOPMed gnomAD |
|
|
rs1449280321 CA385708432 |
191 | G>S | No |
ClinGen TOPMed gnomAD |
|
|
CA385708427 rs1354338892 |
191 | G>V | No |
ClinGen gnomAD |
|
|
CA6679086 rs761242749 |
192 | G>V | No |
ClinGen ExAC gnomAD |
|
|
CA385708417 rs1424897458 |
193 | A>D | No |
ClinGen gnomAD |
|
|
rs1371664076 CA385708420 |
193 | A>T | No |
ClinGen TOPMed |
|
|
rs1424897458 CA385708416 |
193 | A>V | No |
ClinGen gnomAD |
|
|
rs772173576 COSM549733 CA385708408 |
195 | V>L | lung [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
rs772173576 CA6679084 |
195 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 196 | A>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 198 | Y>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1592643892 CA385708385 |
198 | Y>F | No |
ClinGen Ensembl |
|
|
rs1309486604 CA385708372 |
200 | F>S | No |
ClinGen TOPMed gnomAD |
|
|
rs1368395397 CA385708374 |
200 | F>V | No |
ClinGen gnomAD |
|
|
rs1411241379 CA385708355 |
202 | N>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
CA6679083 rs745895372 |
203 | G>S | No |
ClinGen ExAC |
|
|
rs1483347671 CA385708334 CA385708335 |
205 | Q>H | No |
ClinGen gnomAD |
|
|
rs1160392365 CA385708302 |
209 | A>S | No |
ClinGen TOPMed |
|
|
CA385708293 rs1238770439 |
210 | L>F | No |
ClinGen gnomAD |
|
|
CA6679071 rs141114510 |
210 | L>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA6679070 rs750145450 |
212 | S>F | No |
ClinGen ExAC gnomAD |
|
|
CA238485355 rs750829225 |
213 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
CA6679068 rs764491691 |
216 | T>M | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 217 | P>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 219 | D>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA6679066 rs775950249 |
226 | A>G | No |
ClinGen ExAC gnomAD |
|
|
CA385708186 rs775950249 |
226 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA385708180 rs767872359 |
227 | H>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6679065 rs767872359 |
227 | H>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA385708173 rs1592642967 |
228 | T>I | No |
ClinGen Ensembl |
|
|
CA6679064 rs542142468 |
228 | T>P | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA6679063 rs774516111 |
229 | Y>C | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 230 | A>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1421090455 CA385708121 |
236 | M>K | No |
ClinGen gnomAD |
|
|
rs1421090455 CA385708120 |
236 | M>T | No |
ClinGen gnomAD |
|
| TCGA novel | 239 | G>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs769607646 CA6679058 |
241 | E>K | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs993173804 CA238485242 |
243 | K>R | No |
ClinGen TOPMed |
|
| TCGA novel | 245 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA6679056 rs781069003 |
246 | M>V | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 248 | F>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1026729471 CA238485220 |
250 | N>S | No |
ClinGen Ensembl |
|
|
rs899289447 CA238485215 |
252 | V>D | No |
ClinGen Ensembl |
|
|
CA385707975 rs1592642891 |
256 | Y>S | No |
ClinGen Ensembl |
|
|
rs1006581715 CA385707970 |
257 | S>A | No |
ClinGen TOPMed |
|
|
CA238485199 rs1006581715 |
257 | S>T | No |
ClinGen TOPMed |
|
|
CA6679053 rs779537699 |
258 | W>C | No |
ClinGen ExAC gnomAD |
|
|
rs1407249519 CA385707942 |
261 | L>F | No |
ClinGen TOPMed |
|
|
rs755433068 CA6679029 |
265 | M>I | No |
ClinGen ExAC gnomAD |
|
|
CA238483295 rs752088545 |
271 | I>L | No |
ClinGen ExAC gnomAD |
|
|
rs752088545 CA6679028 |
271 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA385707849 rs1421369561 |
272 | W>* | No |
ClinGen gnomAD |
|
|
rs1172994241 CA385707837 |
274 | Q>P | No |
ClinGen gnomAD |
|
|
rs1172994241 COSM268942 CA385707836 |
274 | Q>R | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
| TCGA novel | 276 | F>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA6679027 rs766943066 |
277 | E>* | No |
ClinGen ExAC gnomAD |
|
|
rs763585354 CA6679026 |
279 | T>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA385707796 rs556887389 |
280 | L>M | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs761925876 CA6679023 |
280 | L>S | No |
ClinGen ExAC gnomAD |
|
|
rs768420844 CA385707783 |
282 | L>M | No |
ClinGen ExAC gnomAD |
|
|
rs768420844 CA6679021 |
282 | L>V | No |
ClinGen ExAC gnomAD |
|
|
rs1260551032 CA385707774 |
283 | S>L | No |
ClinGen TOPMed gnomAD |
|
|
rs538250941 CA6679020 |
289 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
rs144731700 CA6679019 |
289 | R>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs144731700 CA385707731 |
289 | R>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 291 | E>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA238483245 rs983239789 |
291 | E>Q | No |
ClinGen TOPMed |
|
| TCGA novel | 296 | F>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA6679017 rs745831691 |
297 | W>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6679016 rs140807579 |
299 | N>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA6679015 rs373408348 CA6679014 |
300 | N>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA385707644 rs1333259215 |
302 | A>T | No |
ClinGen gnomAD |
|
|
CA385707639 rs1466030752 |
302 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
CA385707637 rs1367375190 |
303 | S>P | No |
ClinGen TOPMed |
|
|
rs571167421 CA6679012 |
308 | I>M | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA238483201 rs754707168 |
308 | I>V | No |
ClinGen TOPMed |
|
|
rs751932785 CA6679011 |
311 | V>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1459653542 CA385707579 |
311 | V>L | No |
ClinGen TOPMed gnomAD |
|
|
CA385707546 rs1159564390 |
315 | V>I | No |
ClinGen gnomAD |
|
|
CA6678993 rs769504248 |
317 | G>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs772879813 CA6678994 |
317 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs772879813 CA6678995 |
317 | G>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6678992 rs747811470 |
321 | D>Y | No |
ClinGen ExAC gnomAD |
|
|
rs371003310 CA385707478 |
325 | N>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA385707472 rs1215481607 |
325 | N>K | No |
ClinGen gnomAD |
|
|
rs371003310 CA6678991 |
325 | N>Y | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA385707466 rs1319383201 |
326 | P>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA385707451 rs1350967520 |
329 | N>H | No |
ClinGen gnomAD |
|
|
rs758861984 CA6678990 |
329 | N>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA385707452 rs1350967520 |
329 | N>Y | No |
ClinGen gnomAD |
|
|
CA385707436 rs1365235176 |
331 | I>T | No |
ClinGen TOPMed |
|
| TCGA novel | 335 | Q>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1436960622 CA385707412 |
335 | Q>K | No |
ClinGen TOPMed |
|
|
CA385707407 rs1224118143 |
335 | Q>L | No |
ClinGen TOPMed gnomAD |
|
|
CA6678989 rs746341475 |
336 | D>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs779430298 CA6678988 |
338 | K>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs147258017 CA6678987 |
339 | H>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA385707381 rs1292200779 |
339 | H>Y | No |
ClinGen TOPMed |
|
|
rs911632640 CA238476546 |
343 | Y>C | No |
ClinGen TOPMed |
|
|
rs1321763506 CA385707321 |
347 | K>N | No |
ClinGen TOPMed gnomAD |
|
|
CA385707284 rs1319465079 |
352 | Y>F | No |
ClinGen gnomAD |
|
|
rs1362676028 CA385707288 |
352 | Y>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA385707256 rs1174850401 |
357 | P>A | No |
ClinGen gnomAD |
|
|
CA385707248 rs1478619265 |
358 | G>R | No |
ClinGen gnomAD |
|
|
rs1247770005 CA385707241 |
359 | S>F | No |
ClinGen TOPMed |
|
|
CA6678983 rs752985109 |
360 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
CA385707237 rs1192233472 |
360 | Y>H | No |
ClinGen gnomAD |
|
|
rs1184397493 CA385707218 |
362 | I>M | No |
ClinGen TOPMed |
|
|
rs781424205 CA6678964 |
364 | V>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs781424205 CA385707198 |
364 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA385707183 rs1196878793 |
366 | V>A | No |
ClinGen gnomAD |
|
|
CA385707169 rs1227964944 |
369 | H>N | No |
ClinGen gnomAD |
|
|
rs1441646806 CA385707166 |
369 | H>P | No |
ClinGen TOPMed gnomAD |
|
|
rs1441646806 CA385707165 |
369 | H>R | No |
ClinGen TOPMed gnomAD |
|
|
CA6678962 rs751298118 |
370 | D>E | No |
ClinGen ExAC gnomAD |
|
|
CA6678963 rs755183423 |
370 | D>N | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs1013742887 CA238474536 |
371 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
CA385707141 rs1376867143 |
373 | I>V | No |
ClinGen gnomAD |
|
|
CA385707130 rs1319618223 |
374 | T>R | No |
ClinGen TOPMed |
|
|
CA6678960 rs139235186 |
379 | P>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1191454154 CA385707091 |
380 | E>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
rs764807912 CA6678958 |
380 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA385707074 rs1411171977 |
383 | Q>E | No |
ClinGen gnomAD |
|
|
CA385707071 rs1259591892 |
383 | Q>L | No |
ClinGen TOPMed |
|
|
rs766289045 CA238474465 |
384 | N>K | No |
ClinGen Ensembl |
|
|
CA385707049 rs1185236277 |
386 | S>N | No |
ClinGen gnomAD |
|
|
rs1366655950 CA385707052 |
386 | S>R | No |
ClinGen TOPMed gnomAD |
|
|
CA6678957 rs761360372 |
386 | S>R | No |
ClinGen ExAC gnomAD |
|
|
CA6678956 rs776037058 |
387 | A>S | No |
ClinGen ExAC gnomAD |
|
|
CA6678955 rs768289010 |
389 | K>I | No |
ClinGen ExAC gnomAD |
|
|
CA238474419 rs944739447 |
391 | D>Y | No |
ClinGen Ensembl |
|
|
CA385706971 rs1458984670 |
393 | L>P | No |
ClinGen gnomAD |
|
|
CA385706948 rs1471793964 |
396 | F>L | No |
ClinGen Ensembl |
|
|
CA385706921 rs1220913507 |
398 | G>R | No |
ClinGen gnomAD |
|
|
rs202163169 CA6678953 |
401 | D>E | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
CA385706865 rs1402680314 |
402 | S>C | No |
ClinGen TOPMed |
|
|
CA385706853 rs1376659649 |
403 | I>M | No |
ClinGen gnomAD |
|
|
CA238474379 rs773598578 |
403 | I>T | No |
ClinGen Ensembl |
|
|
CA238474363 rs770283891 |
406 | S>* | No |
ClinGen Ensembl |
|
|
CA385706822 rs1344720749 |
407 | N>H | No |
ClinGen TOPMed |
|
|
rs771269967 CA6678952 |
408 | P>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6678950 rs778304935 |
411 | P>S | No |
ClinGen ExAC gnomAD |
|
|
CA6678949 rs570491377 |
412 | M>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1414698486 CA385706724 |
415 | L>P | No |
ClinGen TOPMed |
|
|
rs761928271 CA385706708 |
416 | Y>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA385706714 rs1357919158 |
416 | Y>C | No |
ClinGen gnomAD |
|
|
rs1347805300 CA385706719 |
416 | Y>H | No |
ClinGen gnomAD |
|
| TCGA novel | 419 | L>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA238474306 rs868766423 |
420 | P>S | No |
ClinGen Ensembl |
|
| TCGA novel | 421 | D>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs751787601 CA6678945 |
421 | D>H | No |
ClinGen ExAC gnomAD |
|
|
rs779894666 CA6678944 |
422 | H>N | No |
ClinGen ExAC gnomAD |
|
|
rs1375908187 CA385706616 |
425 | A>T | No |
ClinGen TOPMed |
|
|
CA385706612 rs1225118329 |
425 | A>V | No |
ClinGen TOPMed |
|
|
rs758307993 CA6678943 |
426 | T>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6678942 rs150803446 |
429 | S>T | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 431 | F>missing | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1166905799 CA385706506 |
433 | F>L | No |
ClinGen gnomAD |
|
|
CA385706501 rs1271084166 |
434 | L>S | No |
ClinGen gnomAD |
|
|
rs569139582 CA6678941 |
434 | L>V | No |
ClinGen ExAC gnomAD |
|
|
rs200495418 CA6678940 |
435 | V>E | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA385706492 rs1281840905 |
435 | V>L | No |
ClinGen TOPMed |
|
|
rs1281840905 CA385706494 |
435 | V>M | No |
ClinGen TOPMed |
|
|
CA6678938 rs763570499 |
436 | S>R | No |
ClinGen ExAC gnomAD |
|
|
CA385706440 rs1242756654 |
439 | H>Q | No |
ClinGen gnomAD |
|
|
rs1318086893 CA385706437 |
440 | I>V | No |
ClinGen gnomAD |
|
|
CA238474275 rs1050912685 COSM942915 |
441 | F>L | Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA TOPMed |
No associated diseases with P14384
1 regional properties for P14384
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | GPCR, rhodopsin-like, 7TM | 62 - 322 | IPR017452 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.4.17.12 | Metallocarboxypeptidases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchored component of membrane | The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. |
| cell surface | The external part of the cell wall and/or plasma membrane. |
| extracellular exosome | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| carboxypeptidase activity | Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain. |
| metallocarboxypeptidase activity | Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. |
| zinc ion binding | Binding to a zinc ion (Zn). |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| anatomical structure morphogenesis | The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form. |
| peptide metabolic process | The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. |
| protein processing | Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein. |
16 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P04836 | CPE | Carboxypeptidase E | Bos taurus (Bovine) | PR |
| Q2KJ83 | CPN1 | Carboxypeptidase N catalytic chain | Bos taurus (Bovine) | PR |
| Q8QGP3 | CPZ | Carboxypeptidase Z | Gallus gallus (Chicken) | PR |
| Q8N436 | CPXM2 | Inactive carboxypeptidase-like protein X2 | Homo sapiens (Human) | PR |
| Q96SM3 | CPXM1 | Probable carboxypeptidase X1 | Homo sapiens (Human) | PR |
| Q66K79 | CPZ | Carboxypeptidase Z | Homo sapiens (Human) | PR |
| Q8IUX7 | AEBP1 | Adipocyte enhancer-binding protein 1 | Homo sapiens (Human) | PR |
| O75976 | CPD | Carboxypeptidase D | Homo sapiens (Human) | PR |
| O89001 | Cpd | Carboxypeptidase D | Mus musculus (Mouse) | PR |
| Q9JJN5 | Cpn1 | Carboxypeptidase N catalytic chain | Mus musculus (Mouse) | PR |
| Q9Z100 | Cpxm1 | Probable carboxypeptidase X1 | Mus musculus (Mouse) | PR |
| Q9D2L5 | Cpxm2 | Inactive carboxypeptidase-like protein X2 | Mus musculus (Mouse) | PR |
| Q640N1 | Aebp1 | Adipocyte enhancer-binding protein 1 | Mus musculus (Mouse) | PR |
| Q80V42 | Cpm | Carboxypeptidase M | Mus musculus (Mouse) | PR |
| Q9EQV8 | Cpn1 | Carboxypeptidase N catalytic chain | Rattus norvegicus (Rat) | PR |
| A2RUV9 | Aebp1 | Adipocyte enhancer-binding protein 1 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDFPCLWLGL | LLPLVAALDF | NYHRQEGMEA | FLKTVAQNYS | SVTHLHSIGK | SVKGRNLWVL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VVGRFPKEHR | IGIPEFKYVA | NMHGDETVGR | ELLLHLIDYL | VTSDGKDPEI | TNLINSTRIH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IMPSMNPDGF | EAVKKPDCYY | SIGRENYNQY | DLNRNFPDAF | EYNNVSRQPE | TVAVMKWLKT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ETFVLSANLH | GGALVASYPF | DNGVQATGAL | YSRSLTPDDD | VFQYLAHTYA | SRNPNMKKGD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ECKNKMNFPN | GVTNGYSWYP | LQGGMQDYNY | IWAQCFEITL | ELSCCKYPRE | EKLPSFWNNN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KASLIEYIKQ | VHLGVKGQVF | DQNGNPLPNV | IVEVQDRKHI | CPYRTNKYGE | YYLLLLPGSY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IINVTVPGHD | PHITKVIIPE | KSQNFSALKK | DILLPFQGQL | DSIPVSNPSC | PMIPLYRNLP |
| 430 | 440 | ||||
| DHSAATKPSL | FLFLVSLLHI | FFK |