Q80V42
Gene name |
Cpm |
Protein name |
Carboxypeptidase M |
Names |
CPM |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:70574 |
EC number |
3.4.17.12: Metallocarboxypeptidases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q80V42
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q80V42-F1 | Predicted | AlphaFoldDB |
19 variants for Q80V42
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389129360 | 18 | L>M | No | EVA | |
| rs232633026 | 30 | A>T | No | EVA | |
| rs233948223 | 36 | A>S | No | EVA | |
| rs233920728 | 61 | V>L | No | EVA | |
| rs3389137107 | 64 | Q>* | No | EVA | |
| rs259901704 | 108 | P>L | No | EVA | |
| rs3389068207 | 135 | K>T | No | EVA | |
| rs3389068213 | 150 | Y>* | No | EVA | |
| rs3389068219 | 153 | N>K | No | EVA | |
| rs3389120887 | 182 | T>S | No | EVA | |
| rs3389130711 | 185 | L>F | No | EVA | |
| rs3389120843 | 206 | A>V | No | EVA | |
| rs3389124311 | 282 | L>M | No | EVA | |
| rs3389139396 | 296 | F>L | No | EVA | |
| rs3389127936 | 299 | D>V | No | EVA | |
| rs3389132395 | 308 | I>T | No | EVA | |
| rs3389120848 | 430 | L>Q | No | EVA | |
| rs257347274 | 431 | G>C | No | EVA | |
| rs3389068165 | 442 | F>L | No | EVA |
No associated diseases with Q80V42
Functions
| Description | ||
|---|---|---|
| EC Number | 3.4.17.12 | Metallocarboxypeptidases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchored component of membrane | The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. |
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| metallocarboxypeptidase activity | Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. |
| zinc ion binding | Binding to a zinc ion (Zn). |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| peptide metabolic process | The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. |
| protein processing | Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein. |
16 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P04836 | CPE | Carboxypeptidase E | Bos taurus (Bovine) | PR |
| Q2KJ83 | CPN1 | Carboxypeptidase N catalytic chain | Bos taurus (Bovine) | PR |
| Q8QGP3 | CPZ | Carboxypeptidase Z | Gallus gallus (Chicken) | PR |
| Q8IUX7 | AEBP1 | Adipocyte enhancer-binding protein 1 | Homo sapiens (Human) | PR |
| O75976 | CPD | Carboxypeptidase D | Homo sapiens (Human) | PR |
| Q8N436 | CPXM2 | Inactive carboxypeptidase-like protein X2 | Homo sapiens (Human) | PR |
| Q66K79 | CPZ | Carboxypeptidase Z | Homo sapiens (Human) | PR |
| Q96SM3 | CPXM1 | Probable carboxypeptidase X1 | Homo sapiens (Human) | PR |
| P14384 | CPM | Carboxypeptidase M | Homo sapiens (Human) | PR |
| Q9D2L5 | Cpxm2 | Inactive carboxypeptidase-like protein X2 | Mus musculus (Mouse) | PR |
| Q9Z100 | Cpxm1 | Probable carboxypeptidase X1 | Mus musculus (Mouse) | PR |
| Q640N1 | Aebp1 | Adipocyte enhancer-binding protein 1 | Mus musculus (Mouse) | PR |
| Q9JJN5 | Cpn1 | Carboxypeptidase N catalytic chain | Mus musculus (Mouse) | PR |
| O89001 | Cpd | Carboxypeptidase D | Mus musculus (Mouse) | PR |
| Q9EQV8 | Cpn1 | Carboxypeptidase N catalytic chain | Rattus norvegicus (Rat) | PR |
| A2RUV9 | Aebp1 | Adipocyte enhancer-binding protein 1 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDRARLWLGL | LLPVVAALDF | RYHHQEGMEA | FLKSVAQNYS | SITHLHSIGK | SVRGRNLWVL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VVGQTPKEHR | VGIPEFKYVA | NMHGDETVGR | ELLLHLIDYL | VSSYRKDPEI | THLIDSTRIH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IMPSMNPDGF | EAVQKPDCYY | SNGRENYNNY | DLNRNFPDAF | ENNNVTKQPE | TLAIMEWLKT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ETFVLSANLH | GGALVASYPF | DNGVQATGTL | LSRSLTPDDD | VFQHLAYTYA | SRNPNMTKGD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QCKNKRNFPN | GIINGYSWYP | LQGGMQDYNY | IWAQCFEITL | ELSCCKYPRE | EKLPLFWNDN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KASLIEYIKQ | VHLGVKGQVF | DQSGAPLPNV | IVEVQDRKHI | CPFRTNKLGE | YYLLLLPGSY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VINVTVPGHD | SYLTKLTIPG | KSQPFSALKK | DFHLPLRWQP | DSISVSNPSC | PMIPLYKFMP |
| 430 | 440 | ||||
| SHSAATKPSL | GVFFMTLLYV | FFK |